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公开(公告)号：WO2022245877A1
公开(公告)日：2022-11-24
申请号：PCT/US2022/029705
申请日：2022-05-17
Applicant: CURIA IP HOLDINGS, LLC
Inventor： ZABEL, Brian, A. , GE, Xiaomei , LUO, Dan , ZHANG, Ling , KANNEGANTI, Vydehi , YU, Joyce , YANG, Sophie , TU, Hua , ZHAO, Lequn
Abstract: Embodiments include monoclonal antibodies (mAbs) that recognize SARS-Cov-2 spike protein. The mAbs are capable of distinguishing among variants of the virus. The present disclosure also provides a composition and methods of making and using such a composition for treating, preventing, and/or detecting SARS-CoV-2 infection.
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公开(公告)号：WO2022226060A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025536
申请日：2022-04-20
Applicant: VANDERBILT UNIVERSITY
Inventor： CROWE, JR., James E. , GILCHUK, Pavlo
Abstract: The present disclosure is directed to an antibody cocktail comprising antibodies that bind to and protect subjects again multiple ebolavirus strains and methods for use thereof.
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公开(公告)号：WO2022224271A1
公开(公告)日：2022-10-27
申请号：PCT/IN2022/050371
申请日：2022-04-18
Applicant: BHARAT SERUMS AND VACCINES LIMITED
Inventor： FERNANDES, Aldon , KAUNDINYA, John , MURZELLO, Kripa
IPC: A61K39/215 , C07K16/00 , C07K16/10 , A61P31/14
Abstract: The present invention discloses polyclonal antibody F(ab')2 fragments against spike protein or variants thereof of SARS-CoV-2 and a process for obtaining them from hyperimmunized equines. The disclosed polyclonal antibody F(ab')2 fragments exhibit better neutralizing activity against different SARS-CoV-2 RBD variants and can be used for the treatment of coronavirus disease in a subject.
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公开(公告)号：WO2022204202A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/021415
申请日：2022-03-22
Applicant: VIR BIOTECHNOLOGY, INC.
Inventor： CORTI, Davide , DE MARCO, Anna , PINTO, Dora , PIZZUTO, Matteo Samuele
Abstract: The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to S proteins of sarbecoviruses (including, in some embodiments, multiple sarbecoviruses) and, in certain embodiments, are capable of neutralizing infection by multiple sarbecoviruses.
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公开(公告)号：WO2022188829A1
公开(公告)日：2022-09-15
申请号：PCT/CN2022/080100
申请日：2022-03-10
Applicant: 上海君实生物医药科技股份有限公司 , 苏州君盟生物医药科技有限公司
Abstract: 一种新型冠状病毒的抗体及其用途。提供了特异性结合SARS-CoV-2或其变体的受体结合结构域(RBD)的抗体或其抗原结合片段。还提供编码抗体或其抗原结合片段的核酸分子，用于表达该抗体或其抗原结合片段的载体和宿主细胞，以及抗体或其抗原结合片段的治疗和诊断方法和用途。
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Patent Agency Ranking
公开(公告)号：WO2022178255A2
公开(公告)日：2022-08-25
申请号：PCT/US2022/016986
申请日：2022-02-18
Inventor： CASELLAS, Rafael Cristian , XU, Jianliang
IPC: C07K16/10 , G01N33/53 , C07K2317/22 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: Single-domain antibodies against SARS-CoV-2 are provided. The single-domain antibodies have been shown to have neutralizing activity against SARS-CoV-2 and can be used as a diagnostic and/or therapeutic in patients with coronavirus infection, such as COVID-19; and in diseases and disorders related to, or resulting from, coronavirus infection.
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公开(公告)号：WO2022178216A2
公开(公告)日：2022-08-25
申请号：PCT/US2022/016926
申请日：2022-02-18
Applicant: COTROPIA, Joseph , CHANDRA, Gaurav
Inventor： COTROPIA, Joseph , CHANDRA, Gaurav
IPC: C07K16/10 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76
Abstract: Provided are highly conserved antigens and epitopes of SARS-CoV-2 that can be used in vaccines and to produce bindings proteins (e.g., antibodies) for treating, preventing, or reducing the risks of infections caused by β-coronaviruses such as SARS-CoV-2, and as targets for detecting SARS-CoV-2 infection.
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公开(公告)号：WO2022162012A2
公开(公告)日：2022-08-04
申请号：PCT/EP2022/051776
申请日：2022-01-26
Applicant: ETH ZURICH , INSTITUTE FOR RESEARCH IN BIOMEDICINE
Inventor： SALLUSTO, Federica , LANZAVECCHIA, Antonio , CASSOTTA, Antonino , LOW, Jun Siong , JERAK, Josipa
IPC: A61P31/14 , C07K16/10 , C07K14/165 , A61K39/12 , C07K2317/21 , C07K2317/33 , C07K2317/92 , C12N2770/20034
Abstract: The present invention relates to antibodies, and antigen binding fragments thereof, that bind to the spike (S) protein of coronaviruses. The antibodies, and antigen binding fragments thereof, broadly target coronaviruses, including different alpha- and betacoronaviruses. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the treatment and diagnosis of coronavirus infection. Furthermore, a recombinant peptide, polypeptide or protein comprising the epitope, to which the antibodies bind to, is provided, which may be useful in vaccination.
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公开(公告)号：WO2022161597A1
公开(公告)日：2022-08-04
申请号：PCT/EP2021/051744
申请日：2021-01-26
Applicant: ETH ZURICH , INSTITUTE FOR RESEARCH IN BIOMEDICINE
Inventor： SALLUSTO, Federica , LANZAVECCHIA, Antonio , CASSOTTA, Antonino , LOW, Jun Siong
Abstract: The present invention provides a method for rapid identification of a B cell capable of producing a cross-reactive antibody. Based thereon, the sequences of the variable regions of the cross-reactive antibody may be identified and cloned into an expression vector for expression of said cross-reactive antibody. The cross-reactive antibody may be used in the treatment of diseases. Furthermore, its epitope may be identified, e.g. to design vaccines eliciting an immune response comprising cross-reactive antibodies.
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公开(公告)号：WO2022161491A1
公开(公告)日：2022-08-04
申请号：PCT/CN2022/074998
申请日：2022-01-29
Applicant: 中国科学院上海巴斯德研究所 , 中科南京生命健康高等研究院
Abstract: 本发明提供了针对SARS-CoV-2病毒具有中和效果的单克隆抗体。同时，本发明提供了对所述抗体的中和能力与结合能力的检测方法。本发明抗体的制备过程简单、产物纯度高且为全人IgG抗体，并且本发明的抗体与SARS-CoV-2病毒具有较强的中和效果。
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