公开(公告)号：WO2023288241A8

公开(公告)日：2023-01-19

申请号：PCT/US2022/073671

申请日：2022-07-13

Applicant: GENENTECH, INC.

Inventor： GAMPA, Gautham ,  HOSSEINI, Iraj ,  HUSENI, Mahrukh ,  KOERBER, James, Thomas ,  PAYANDEH, Jian, Mehr-dean ,  RUTZ, Sascha ,  SUN, Yonglian ,  CHIU, Cecilia, Pui Chi ,  DELFINO, Teresita, Arenzana

IPC: C07K16/28 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/507 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2827 ,  C07K16/2866 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure provides anti-CCR8 antibodies, and compositions and methods of their preparation and use.

公开(公告)号：WO2022233764A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/061661

申请日：2022-05-02

Applicant: UCB BIOPHARMA SRL

Inventor： LIGHTWOOD, Daniel John ,  KADIU, Irena ,  BHATTA, Pallavi ,  SPILIOTOPOULOS, Anastasios ,  ELLIOTT, Peter Charles ,  KEANEY, James Martin ,  DELKER, Silvia L. ,  ABENDROTH, Jan

IPC: C07K16/28 ,  A61P25/28 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to antibodies binding to TREM1 and inhibiting its interaction with one or more of its natural ligands. Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such are also provided.

公开(公告)号：WO2022216223A1

公开(公告)日：2022-10-13

申请号：PCT/SG2021/050497

申请日：2021-08-25

Applicant: INTRA-IMMUSG PRIVATE LIMITED (SG)

Inventor： ZENG, Qi

IPC: C07K16/10 ,  A61K39/395 ,  A61P31/14 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K39/12 ,  A61K39/42 ,  C07K14/005 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The present invention relates to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) N-protein and/or an immunogenic fragment thereof and uses thereof. The invention includes an antibody capable of binding to the SARS-CoV-2 N-protein or antigen-binding fragment thereof and uses thereof

公开(公告)号：WO2022167816A2

公开(公告)日：2022-08-11

申请号：PCT/GB2022/050307

申请日：2022-02-04

Applicant: OXFORD UNIVERSITY INNOVATION LIMITED

Inventor： SCREATON, Gavin ,  MONGKOLSAPAYA, Juthathip

IPC: A61P31/14 ,  C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to antibodies capable of binding to the spike protein of coronavirus SARS-CoV-2, and methods and uses thereof in the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19.

公开(公告)号：WO2022159675A8

公开(公告)日：2022-07-28

申请号：PCT/US2022/013273

申请日：2022-01-21

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： FAUSTMAN, Denise L.

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/46 ,  C07K16/2878 ,  C07K2317/34 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/76

Abstract: The disclosure features antagonistic TNFR superfamily polypeptides, such as antibodies and antigen-binding fragments thereof, and the use of these polypeptides to inhibit the downstream signaling of TNFR superfamily members. The antibodies and antigen-binding fragments thereof can be used to treat a wide variety of cancers, infectious diseases, autoimmune disorders, obesity, type 2 diabetes, neurological disorders, and osteoporosis.

公开(公告)号：WO2022057696A2

公开(公告)日：2022-03-24

申请号：PCT/CN2021/117134

申请日：2021-09-08

Applicant: 中南大学湘雅医院

Inventor： 李晓照

IPC: C12N15/62 ,  C07K19/00 ,  C12N15/70 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/20 ,  C07K2319/35 ,  C07K2319/40

Abstract: 本发明公开了一种重组蛋白的编码序列、重组蛋白及其单克隆抗体的制备方法。该重组蛋白包含6xHis、S Tag、Trx和GST四种标签蛋白表位，并结合大肠杆菌偏爱密码子将该重组氨基酸序列转换为对应的核苷酸序列，通过分子生物学技术制备重组抗原，免疫小鼠，通过酶联免疫等筛选平台分别获得针对四种标签蛋白的优质单克隆细胞株。

公开(公告)号：WO2022013225A1

公开(公告)日：2022-01-20

申请号：PCT/EP2021/069469

申请日：2021-07-13

Applicant: PRECIRIX N.V.

Inventor： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  MASSA, Sam

IPC: C07K16/28 ,  A01K67/027 ,  A61K47/68 ,  G01N33/574 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A01K67/0275 ,  A61K2039/505 ,  A61K51/1027 ,  A61K51/1093 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/70 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to the field of antibody fragments, which specifically binds an epitope of human folate receptor alpha (FOLR1) and which may be linked to an entity such as a moiety. The antibody fragment and the compound formed may be used for therapy or diagnostic purposes.

公开(公告)号：WO2022010798A1

公开(公告)日：2022-01-13

申请号：PCT/US2021/040348

申请日：2021-07-02

Applicant: KIROMIC BIOPHARMA, INC.

Inventor： PICCOTTI, Lucia ,  MIRANDOLA, Leonardo ,  CHIRIVA-INTERNATI, Maurizio ,  SPENCER, David ,  WANG, Xiaohong ,  CHEN, Yibin

IPC: A61K35/17 ,  A61K39/00 ,  C07K16/30 ,  A61K39/0011 ,  A61K48/005 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/03 ,  C07K2319/33 ,  C12N15/86 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2321 ,  C12N2501/999 ,  C12N2510/00 ,  C12N2740/13043 ,  C12N5/0636 ,  C12N5/0646

Abstract: The technology relates in part to binding molecules that specifically bind to a polypeptide that is the Isoform 2 of mesothelin, or that specifically bind to an antigenic determinant (epitope) of the isoform 2 of mesotheiin, or that specificaiiy bind to polypeptides containing an antigenic determinant (epitope) of the isoform 2 of mesotheiin, chimeric PD1 receptors that bind to PD ligands such as PDLs, to polynucleotides including vectors that encode such binding molecules, to ceils presenting such binding molecules and to methods of making such cells, to humanized forms of the binding molecules, and to methods of using such binding molecules, such as for treating cancers (e.g., ovarian cancers and mesotheliomas), including cancers in which the Isoform 2 of mesotheiin is specifically expressed and/or upregulated relative to normal tissues.

公开(公告)号：WO2021259927A2

公开(公告)日：2021-12-30

申请号：PCT/EP2021/066989

申请日：2021-06-22

Applicant: ZELARION MALTA LIMITED

Inventor： BERGLUND, David ,  BERGLUND, Erik ,  SELLBERG, Felix ,  BINDER, Christian

IPC: A61K38/17 ,  A61K39/395 ,  A61P37/06 ,  C07K16/28 ,  A61K38/1774 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2806 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/71

Abstract: Provided herein are improved anti-CD2 antibodies and methods for their use in the treatment and/or prevention of chronic or acute disorders of the immune system. Also provided herein are methods for treating or preventing an immune related disorder or disease in a subject by administering an anti-CD2 antibody or an antigen-binding fragment thereof and a CTLA-4 co-stimulation blockade. Compositions for use with these methods and kits are also disclosed.

公开(公告)号：WO2021248244A1

公开(公告)日：2021-12-16

申请号：PCT/CA2021/050791

申请日：2021-06-10

Applicant: RAPID NOVOR, INC.

Inventor： LE BIHAN, Thierry ,  MA, Bin ,  TAYLOR, Paul ,  YAO, Chenyu ,  LIU, Qixin ,  REITZEL, Chelsea ,  GOROSPE, Kayle Kathleen Marie ,  LIYASOVA, Mariya

IPC: C07K16/42 ,  C07K1/107 ,  C07K1/22 ,  C07K16/00 ,  C07K7/06 ,  C07K7/08 ,  C12P21/06 ,  C07K16/06 ,  C07K16/065 ,  C07K2317/34 ,  C07K2317/565

Abstract: Methods and reagents to obtaining a sample enriched in peptides comprising the third complementarity-determining region of the heavy chain (CDRH3) of immunoglobulins, such as IgGs, are described. These methods are based on the use of targeted protease digestion of immunoglobulins and affinity purification of CDRH3 peptides using specific antibodies. Such methods and reagents are useful for analyzing the immunoglobulin repertoire.