公开(公告)号：WO2023072405A1

公开(公告)日：2023-05-04

申请号：PCT/EP2021/080177

申请日：2021-10-29

申请人： BIO-Y A/S ,  UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF

发明人： KRISTENSEN, Peter ,  MINOR, Peter ,  SCHUMACHER, Udo

IPC分类号： A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/40 ,  G01N33/574 ,  A61K2039/505 ,  A61K33/00 ,  A61K45/06 ,  C07K16/2803 ,  C07K2317/569

摘要： Provided herein are antibodies capable of binding to YKL-40. These YKL-40 antibodies are suitable for the treatment of cancer or for delaying the progression of cancer if applied with an additional anti-cancer drug.

公开(公告)号：WO2023067138A1

公开(公告)日：2023-04-27

申请号：PCT/EP2022/079374

申请日：2022-10-21

申请人： LAVA THERAPEUTICS N.V.

发明人： VAN DER VLIET, Johannes Jelle ,  PARREN, Paul Willem Henri Ida ,  RUBEN, Jurjen Matthijs ,  ENSING, Erik

IPC分类号： A61K31/663 ,  A61K35/17 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  A61K31/675 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/57 ,  A61K39/39558 ,  C07K16/2809 ,  C07K16/2833 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/75

摘要： The present invention relates to novel uses of gamma delta T-cell activating antibodies, in particular uses of such antibodies in patients that are also being treated, or have recently been treated, with aminobisphosphonates, or other inhibitors of the mevalonate pathway that inhibit farnesyl pyrophosphate synthase or an enzyme further downstream in the mevalonate pathway.

公开(公告)号：WO2023057601A1

公开(公告)日：2023-04-13

申请号：PCT/EP2022/077873

申请日：2022-10-06

申请人： BIOTALYS NV

发明人： REVETS, Hilde Adi Pierrette

IPC分类号： C12N15/82 ,  C07K16/14 ,  C07K2317/33 ,  C07K2317/569 ,  C07K2317/76 ,  C12N15/8282

摘要： The present invention relates to a composition comprising at least one polypeptide, which polypeptide comprises the amino acid sequence set out in SEQ ID NO: 1 or an amino acid sequence having at least about 80% sequence identify thereto and which polypeptide is capable of binding to a fungus. The invention further relates to a composition comprising at least one polypeptide, which polypeptide comprises a CDR1 region having the amino acid sequence set out in SEQ ID NO: 2, a CDR2 region having the amino acid sequence set out in SEQ ID NO: 3, and a CDR3 region having the amino acid sequence set out in SEQ ID NO: 4 and which polypeptide is capable of binding to a fungus. The compositions may be used as anti-fungal compositions.

公开(公告)号：WO2023283111A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/035871

申请日：2022-06-30

申请人： TRIUMVIRA IMMUNOLOGICS USA, INC.

发明人： BADER, Andreas ,  HELSEN, Christopher W. ,  IP, Philbert ,  BENATAR, Tania

IPC分类号： C07K14/705 ,  C07K16/40 ,  C07K14/47 ,  A61K38/51 ,  A61P35/04 ,  A61K2039/505 ,  C07K14/70514 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2319/03 ,  C07K2319/70 ,  C12Y406/01002

摘要： GUCY2C T cell antigen coupler (TAC) polypeptides having (i) an antigen-binding domain that binds GUCY2C, (ii) an antigen-binding domain that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide are provided.

公开(公告)号：WO2022221120A8

公开(公告)日：2022-10-20

申请号：PCT/US2022/023783

申请日：2022-04-07

申请人： BIO-TECHNE CORPORATION ,  RESNIK, Ernesto Rubin ,  BAJER, Anna Agnieszka ,  MUNSHI, Cyrus B. ,  BOSTROM, Kerri Ann ,  BONNEVIER, Jody ,  GOETZ, Christine Andrea

发明人： RESNIK, Ernesto Rubin ,  BAJER, Anna Agnieszka ,  MUNSHI, Cyrus B. ,  BOSTROM, Kerri Ann ,  BONNEVIER, Jody ,  GOETZ, Christine Andrea

IPC分类号： C07K16/10 ,  A61P31/14 ,  A61K39/395 ,  C07K2317/22 ,  C07K2317/33 ,  C07K2317/569 ,  C07K2317/76

摘要： Anti-SARS-CoV-specific llama single domain antibodies, methods of making and characterizing those antibodies, and methods of using those antibodies are described herein. In some embodiments, the antibodies may bind to both SARS-CoV-1 and SARS-CoV-2. In some embodiments, the antibodies bind to S1 of the spike protein of SARS-CoV-2 including, for example, to the receptor binding domain (RBD) of S1. In some embodiments, the antibodies may block the binding of SARS-CoV-1 and/or SARS-CoV-2 to ACE-2.

公开(公告)号：WO2022162165A2

公开(公告)日：2022-08-04

申请号：PCT/EP2022/052087

申请日：2022-01-28

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER

发明人： GÖRLICH, Dirk ,  AKSU, Metin ,  GÜTTLER, Thomas ,  RYMARENKO, Oleh ,  REES, Renate ,  GREGOR, Kathrin ,  TAXER, Waltraud

IPC分类号： A61K39/00 ,  A61K39/215 ,  C07K14/165 ,  C07K16/10 ,  C12N7/02 ,  C07K17/02 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K39/12 ,  C07K14/005 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/82 ,  C07K2319/21 ,  C07K2319/35 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20051

摘要： The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co- expressed with or fused to a 'fold promoter', which may be a VHH antibody recognizing the said protein.

公开(公告)号：WO2022147463A2

公开(公告)日：2022-07-07

申请号：PCT/US2021/073173

申请日：2021-12-29

申请人： ALAMAR BIOSCIENCES, INC.

发明人： YIN, Yiyuan ,  LUO, Yuling ,  GRZYBOWSKI, Adrian

IPC分类号： A61P35/00 ,  C07K16/10 ,  C07K16/28 ,  C07K16/40 ,  C07K16/1054 ,  C07K16/2863 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/62 ,  C07K2317/92

摘要： Provided herein, in some aspects, are binding molecules including co-binders having high affinity and/or high specificity to a target. In other aspects, provided herein are compositions, methods of making, and methods of using the binding molecules taught herein, such as diagnostic and therapeutic methods of use involving the co-binders taught herein

公开(公告)号：WO2022120388A2

公开(公告)日：2022-06-09

申请号：PCT/US2021/072745

申请日：2021-12-03

申请人： TIDAL THERAPEUTICS, INC.

发明人： ALI, Mir ,  BOESCH, Austin Wayne ,  DRUMMOND, Daryl Clark ,  KUHLMAN, William ,  NIELSEN, Ulrik

IPC分类号： C12N15/88 ,  A61K9/127 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/03 ,  A61K47/18 ,  A61K47/20 ,  A61K47/543 ,  A61K47/60 ,  A61K47/6849 ,  A61K47/6929 ,  A61K48/0041 ,  A61K48/005 ,  A61K9/1272 ,  A61P11/00 ,  B82Y30/00 ,  B82Y40/00 ,  B82Y5/00 ,  C07K16/2803 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/2845 ,  C07K16/2896 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/569 ,  C07K2317/622 ,  C12N15/113

摘要： Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

公开(公告)号：WO2022081460A8

公开(公告)日：2022-04-21

申请号：PCT/US2021/054381

申请日：2021-10-11

申请人： JANSSEN BIOTECH, INC.

发明人： HARVILLA, Paul B. ,  BORROK, III, Martin Jack ,  TAMOT, Ninkka

IPC分类号： C07K16/28 ,  C07K16/30 ,  C12N5/07 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68 ,  A61K9/0019 ,  A61K9/0073 ,  A61P1/00 ,  A61P29/00 ,  A61P3/10 ,  A61P31/00 ,  A61P35/00 ,  C07K16/18 ,  C07K16/283 ,  C07K2317/33 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2317/94

摘要： Single domain antibodies that bind to plgR are described. The single domain antibodies may compete with IgA binding to plgR, or alternatively, the single domain antibodies may compete with IgA binding to plgR. The single domain antibodies may be coupled to therapeutic agents so as to facilitate delivery of the therapeutic agent to the mucosal layer via plgR-mediated transcytosis. The therapeutic agent can be, e.g, a small molecule or large molecule such as an antibody.

公开(公告)号：WO2022079270A1

公开(公告)日：2022-04-21

申请号：PCT/EP2021/078664

申请日：2021-10-15

申请人： UNIVERSITÉ D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES

发明人： DONO, Rosanna ,  MAINA, Flavio ,  BONJEAN, Rémi ,  BATY, Daniel ,  CHAMES, Patrick ,  KERFELEC, Brigitte

IPC分类号： C07K16/30 ,  C07K2317/22 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

摘要： The present disclosure relates to anti-GPC4 single domain antibodies (sdAb) and variants thereof, notably linked directly or not to a compound of interest, multivalent binding compounds or chimeric antigen receptor and to their use in therapy or as diagnostic and/or detection compounds.