公开(公告)号：WO2015127168A2

公开(公告)日：2015-08-27

申请号：PCT/US2015/016759

申请日：2015-02-20

申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

发明人： DONAHUE, Amber C. ,  PENG, Yen-lin

IPC分类号： H05B3/02

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Provided herein are methods for detecting and discriminating BRAF V600 mutations. Also provided herein are methods for diagnosis, prognosis, management, and treatment decisions of BRAF V600 mutation-related diseases or conditions.

摘要翻译： 本文提供了检测和鉴别BRAF V600突变的方法。 本文还提供了BRAF V600突变相关疾病或病症的诊断，预后，管理和治疗决定的方法。

公开(公告)号：WO2015116578A1

公开(公告)日：2015-08-06

申请号：PCT/US2015/013061

申请日：2015-01-27

申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

发明人： JONES, Daniel ,  ARVAI, Kevin J. ,  HSU, Ya-Hsuan

IPC分类号： G01N33/574 ,  G01N33/50

CPC分类号： G01N33/57419 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/47 ,  G01N2333/916 ,  G01N2800/52 ,  G01N2800/56

摘要： Methods and kits for detecting alternating spatial expression of PTEN and, optionally, SMAD4, CD44, and/or TP53 in colonic tumors are described. The methods and kits are useful for identifying a cancer stem cell (CSC)-like zone within a colonic tumor, identifying an adenoma-adenocarcinoma (Ad-ACA) transition zone in a colorectal cancer (CRC) tumor, identifying a CRC tumor that contains high-grade adenoma and/or early adenocarcinoma regions, identifying CSCs in a CRC tumor, diagnosing a subject with high-grade colon adenoma and/or early adenocarcinoma, and determining the likelihood that a colonic tumor in a subject will undergo invasive transformation if left untreated.

摘要翻译： 描述了用于检测结肠肿瘤中PTEN和任选的SMAD4，CD44和/或TP53的交替空间表达的方法和试剂盒。 方法和试剂盒可用于鉴定结肠肿瘤中的癌干细胞（CSC）样区域，鉴定结肠直肠癌（CRC）肿瘤中的腺瘤 - 腺癌（Ad-ACA）过渡区，鉴定包含 高级腺瘤和/或早期腺癌区域，鉴定CRC肿瘤中的CSCs，诊断具有高级结肠腺瘤和/或早期腺癌的受试者，并确定受试者中的结肠肿瘤如果留下将经历侵入性转化的可能性 未经处理的。

公开(公告)号：WO2015042526A1

公开(公告)日：2015-03-26

申请号：PCT/US2014/056777

申请日：2014-09-22

申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED ,  AYE, Michael

发明人： AYE, Michael ,  NAIR, Lakshmi ,  VINCENT, Heather ,  MAI, Huong ,  TABB, Michelle ,  EXNER, Maurice

IPC分类号： C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N21/6428 ,  G01N2021/6432 ,  G01N2021/6441

摘要： Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) in a sample wherein the methods involve detecting a S. aureus-specific nucleic acid sequence, mecA and mecC, in the sample. Kits for determining the presence of MRSA in a sample are also provided.

摘要翻译： 公开了在样品中鉴定耐甲氧西林金黄色葡萄球菌（MRSA）的方法，其中所述方法涉及检测样品中金黄色葡萄球菌特异性核酸序列mecA和mecC。 还提供了用于确定样品中MRSA存在的试剂盒。

公开(公告)号：WO2014074501A1

公开(公告)日：2014-05-15

申请号：PCT/US2013/068456

申请日：2013-11-05

申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

发明人： NAIDES, Stanley, J. ,  MIKULA, Marian, Jr. ,  ABU HANTASH, Feras, M.

IPC分类号： C12Q1/00 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/245 ,  G01N2800/60

摘要： Provided herein are methods for identifying a renal transplant patient as likely suffering renal graft rejection, comprising determining the expression level of one or more genes selected from the group consisting of ABL1, NK1, NK3, GZMB, PRF1, FOXP3 and CXCL10 in a sample isolated from a patient and identifying the patient as likely suffering renal graft rejection if at least one of the one or more genes is overexpressed in the sample. Once a patient that suffers renal graft rejection is identified, the disclosure also provides methods for treating the rejection.

摘要翻译： 本文提供了用于鉴定肾移植患者可能患有肾移植排斥的方法，包括在分离的样品中测定选自ABL1，NK1，NK3，GZMB，PRF1，FOXP3和CXCL10的一种或多种基因的表达水平 如果所述一种或多种基因中的至少一种在样品中过表达，则鉴定患者可能患有肾移植物排斥反应。 鉴定出患有肾移植排斥反应的患者，本公开还提供了治疗排斥反应的方法。

公开(公告)号：WO2011053331A1

公开(公告)日：2011-05-05

申请号：PCT/US2009/062949

申请日：2009-11-02

申请人： ORBIS HEALTH SOLUTIONS LLC ,  SCHWAMBERGER, Gunter ,  WAGNER, Thomas, E. ,  YU, Xianzhong

发明人： SCHWAMBERGER, Gunter ,  WAGNER, Thomas, E. ,  YU, Xianzhong

IPC分类号： A61K47/48 ,  A61K9/51 ,  A61K39/385

CPC分类号： A61K9/5184 ,  A61K9/1652 ,  A61K9/1664 ,  A61K9/5068 ,  A61K9/5176 ,  A61K39/00 ,  A61K47/16 ,  A61K47/18 ,  A61K47/34 ,  A61K47/46 ,  A61K47/61 ,  A61K2039/60 ,  A61K2039/6087

摘要： Described are a method and a composition for delivery of a protein to an antigen presenting cell. The composition is composed of a polypeptide component, a buffering component and a particle to be phagocytized. In one embodiment, the antigen presenting cell is aa macrophage or a dendritic cell and the particle to be phagocytized is from a natural source, such as from a microbial source. The composition itself, or cells pretreated with the composition, are useful for strategies in vaccine development.

摘要翻译： 描述了将蛋白质递送至抗原呈递细胞的方法和组合物。 该组合物由多肽组分，缓冲组分和待吞噬的颗粒组成。 在一个实施方案中，抗原呈递细胞是巨噬细胞或树突状细胞，并且被吞噬的颗粒来自天然来源，例如来自微生物源。 组合物本身或用组合物预处理的细胞可用于疫苗开发中的策略。

公开(公告)号：WO2023039005A2

公开(公告)日：2023-03-16

申请号：PCT/US2022/042808

申请日：2022-09-07

申请人： ALIGOS THERAPEUTICS, INC.

发明人： BEIGELMAN, Leonid ,  RAJWANSHI, Vivek Kumar ,  HOSSBACH, Markus ,  PANDEY, Rajendra K. ,  HONG, Jin ,  ELTEPU, Laxman ,  MONTERO, Saul Martinez ,  DE COSTA, N. Tilani S.

IPC分类号： C07H21/02 ,  C07D473/16 ,  C07D239/54 ,  C07D307/20 ,  C07H19/09 ,  C07H19/19 ,  C07H19/067 ,  C07H19/167 ,  C07H21/00

摘要： Described are short interfering nucleic acid (siNA) molecules comprising modified nucleotides, compositions, and methods and uses thereof.

公开(公告)号：WO2022099060A2

公开(公告)日：2022-05-12

申请号：PCT/US2021/058320

申请日：2021-11-05

申请人： ALIGOS THERAPEUTICS, INC.

发明人： MCGOWAN, David Craig ,  RABOISSON, Pierre Jean-Marie Bernard ,  VANDYCK, Koen ,  DEVAL, Jerome ,  BEIGELMAN, Leonid

IPC分类号： C07D403/12 ,  A61K31/53 ,  A61P1/16 ,  A61P5/16

摘要： Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

公开(公告)号：WO2020243490A2

公开(公告)日：2020-12-03

申请号：PCT/US2020/035212

申请日：2020-05-29

申请人： ALIGOS THERAPEUTICS, INC.

发明人： BEIGELMAN, Leonid ,  PANDEY, Rajendra K. ,  RAJWANSHI, Vivek Kumar ,  SMITH, David Bernard ,  HONG, Jin

IPC分类号： A61K31/7088 ,  C12N15/113

摘要： The disclosure includes antisense oligonucleotides, including gapmer antisense oligonucleotides, along with methods of making and use, e.g., against HBV.

公开(公告)号：WO2020227549A1

公开(公告)日：2020-11-12

申请号：PCT/US2020/031904

申请日：2020-05-07

申请人： ALIGOS THERAPEUTICS, INC.

发明人： VANDYCK, Koen ,  RABOISSON, Pierre, Jean-Marie, Bernard ,  MCGOWAN, David ,  DEVAL, Jerome

IPC分类号： A61P5/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  A61K31/53 ,  C07D401/10 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04

摘要： Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula lIa, IIb, IlIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.

公开(公告)号：WO2018186953A1

公开(公告)日：2018-10-11

申请号：PCT/US2018/020446

申请日：2018-03-01

申请人： SERAXIS, INC.

发明人： RUST, William L.

IPC分类号： A61P5/48 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54

摘要： Described are macro-capsules and barriers that can be used to prepare therapeutic cell implants, methods of encapsulating therapeutic cells, and methods of using the encapsulated cells in the treatment of disease.