公开(公告)号：WO2022081718A8

公开(公告)日：2022-04-21

申请号：PCT/US2021/054797

申请日：2021-10-13

申请人： FIVE PRIME THERAPEUTICS, INC.

发明人： BARBEE, Susannah, D. ,  YUAN, Shujun ,  MEURY, Marcel ,  PALUMBO, Alessandro ,  WONG, Terence ,  ZUBERBUHLER, Kathrin ,  FALKOWSKA, Emilia

IPC分类号： A61P35/00 ,  C07K16/28 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2866 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

摘要： This present invention provides anti-C-C chemokine type 8 (CCR8) antibodies and antigen binding fragments thereof, methods of making the antibodies or antigen binding fragments thereof, and methods of use thereof to bind to human CCR8 on CCR8 expressing cells, e.g. tumor-infiltrating Treg cells, to remove CCR8 expressing cells, e.g. tumor-infiltrating Treg cells, to reduce or inhibit tumor growth and/or to treat cancer.

公开(公告)号：WO2022013225A1

公开(公告)日：2022-01-20

申请号：PCT/EP2021/069469

申请日：2021-07-13

申请人： PRECIRIX N.V.

发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  MASSA, Sam

IPC分类号： C07K16/28 ,  A01K67/027 ,  A61K47/68 ,  G01N33/574 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A01K67/0275 ,  A61K2039/505 ,  A61K51/1027 ,  A61K51/1093 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/70 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention relates to the field of antibody fragments, which specifically binds an epitope of human folate receptor alpha (FOLR1) and which may be linked to an entity such as a moiety. The antibody fragment and the compound formed may be used for therapy or diagnostic purposes.

公开(公告)号：WO2022003169A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/068365

申请日：2021-07-02

申请人： SANOFI

发明人： SOMMERFELD, Mark ,  LANGER, Thomas ,  SCHWAHN, Uwe ,  DITTRICH, Werner ,  RUDOLPH, Christine ,  DREYER, Matthias ,  HÖLPER, Soraya ,  LANGE, Christian ,  LORENZ, Katrin

IPC分类号： C07K16/28 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61K39/00 ,  A61K2039/505 ,  A61K38/00 ,  A61K39/39541 ,  A61K47/62 ,  A61K47/6849 ,  A61K47/6871 ,  C07K14/605 ,  C07K16/2863 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/40 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2319/50 ,  C07K2319/75

摘要： Provided herein are FGFR1/KLB targeting agonistic antigen-binding proteins, or fragments thereof, having improved physico-chemical properties. Also provided herein are conjugates comprising an FGFR1/KLB targeting agonistic antigen-binding protein, or a fragment thereof, and at least one GLP-1R agonistic peptide. Further provided are pharmaceutical compositions comprising the antibody (or fragment thereof), or the conjugate provided herein, and the use of the antibody (or fragment thereof), or the use of the conjugate in medicine.

公开(公告)号：WO2021262662A1

公开(公告)日：2021-12-30

申请号：PCT/US2021/038394

申请日：2021-06-22

申请人： ELI LILLY AND COMPANY

发明人： CHEDID, Marcio ,  HEUER, Josef G.

IPC分类号： A61P25/00 ,  C07K16/22 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61P43/00 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： The present invention provides for therapeutic use of antibodies that bind human TGF- alpha and human Epiregulin in the treatment of chronic pain, and in particular chronic osteoarthritis pain, chronic diabetic neuropathy pain, or chronic low back pain.

公开(公告)号：WO2021255146A1

公开(公告)日：2021-12-23

申请号：PCT/EP2021/066354

申请日：2021-06-17

申请人： F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

发明人： FREIMOSER-GRUNDSCHOBER, Anne ,  GONZALEZ NICOLINI, Maria, Valeria ,  HOSSE, Ralf ,  KNAUPP, Alexander ,  MOESSNER, Ekkehard ,  RICHTER, Wolfgang ,  TROCHANOWSKA, Halina ,  UMAÑA, Pablo ,  WALDHAUER, Inja

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C07K16/2809 ,  C07K16/3007 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/70 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

摘要： The present invention generally relates to antibodies that bind to CD3 and CEA, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

公开(公告)号：WO2021255143A1

公开(公告)日：2021-12-23

申请号：PCT/EP2021/066348

申请日：2021-06-17

申请人： F. HOFFMANN-LA ROCHE AG ,  HOFFMANN-LA ROCHE INC.

发明人： BRUENKER, Peter ,  GEIGER, Martina ,  KLEIN, Christian ,  KNAUPP, Alexander

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/40 ,  A61P35/00 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/70 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

摘要： The present invention generally relates to bispecific antibodies that bind to CD3 and Folate Receptor 1 (FolR1), e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

公开(公告)号：WO2021247779A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035556

申请日：2021-06-02

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： GANGULY, Samit ,  HAMILTON, Jennifer ,  HERMAN, Gary ,  HOOPER, Andrea ,  ISA, Flonza ,  O'BRIEN, Meagan ,  SIVAPALASINGAM, Sumathi ,  TURNER, Kenneth ,  FORLEO NETO, Eduardo

IPC分类号： C07K16/10 ,  A61K39/215 ,  A61K39/00 ,  A61K2039/507 ,  A61K2039/54 ,  A61K31/706 ,  A61K39/42 ,  A61K45/06 ,  A61K9/0019 ,  A61P31/14 ,  C07K16/2866 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

摘要： The present invention provides methods for preventing and treating SARS-CoV-2 infections, COVID-19, or symptoms thereof. The methods of the invention feature the administration of one or more antigen-binding molecules (e.g., antibodies) that bind a surface protein of SARS-CoV-2 (e.g., spike protein).

公开(公告)号：WO2021226163A2

公开(公告)日：2021-11-11

申请号：PCT/US2021/030773

申请日：2021-05-05

申请人： DRAGONFLY THERAPEUTICS, INC.

发明人： BARUAH, Hemanta ,  CHANG, Gregory, P. ,  CHEUNG, Ann, F. ,  GRINBERG, Asya

IPC分类号： A61K39/395 ,  C07K16/00 ,  G01N33/53 ,  C07K16/28 ,  C07K16/30 ,  C07K47/48 ,  C07K16/2851 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92

摘要： Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting CLEC12A on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

公开(公告)号：WO2021222316A2

公开(公告)日：2021-11-04

申请号：PCT/US2021/029486

申请日：2021-04-27

申请人： TWIST BIOSCIENCE CORPORATION

发明人： SATO, Aaron ,  LIU, Qiang ,  YUAN, Tom

IPC分类号： A61K39/12 ,  A61K39/215 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/005 ,  C07K16/10 ,  C07K16/2896 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

公开(公告)号：WO2021207827A8

公开(公告)日：2021-10-21

申请号：PCT/CA2021/050481

申请日：2021-04-09

申请人： ZYMEWORKS INC.

发明人： PATTON, Daniel T. ,  FREIBURGER, Lee ,  SPRETER VON KREUDENSTEIN, Thomas ,  MILLS, David M. ,  VOLKERS, Gesa ,  UROSEV, Dunja ,  DUAN, Zhuang ,  HALVORSEN, Elizabeth ,  PRATAP, Harsh ,  CLAVETTE, Brandon ,  VON ROSSUM, Anna ,  ZWIERZCHOWSKI, Patricia ,  CHAN, Peter Wing Yiu ,  CHUI, Danny ,  JANCOWSKI, Sylwia ,  KANG, Sukhbir Singh ,  WICKMAN, Grant Raymond

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61K47/62 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N5/10 ,  C12P21/08 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2878 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

摘要： Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRα) antigen- binding domain, wherein the 4-1BB-binding domain and the FRα antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.