公开(公告)号：WO2013049577A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/057930

申请日：2012-09-28

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC.

Inventor： ENGELL, Torgrim ,  GRIGG, Julian

IPC: C07B59/00 ,  B01J19/00 ,  H01L21/67

CPC classification number: G01T7/005 ,  C07B59/00 ,  C07B59/008 ,  G06F19/12

Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).

Abstract translation: 本发明涉及用于确保放射性药物在其合成期间的质量的校准和归一化系统和方法，例如在正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）中使用的放射性药物。

公开(公告)号：WO2013048954A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/056868

申请日：2012-09-24

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC.

Inventor： ENGELL, Torgrim ,  GRIGG, Julian ,  GAUSEMEL, Ingvil ,  DYRSTAD, Knut ,  SHALES, Johanthan R.

IPC: G06F19/00 ,  G21G1/00

CPC classification number: B01J19/0046 ,  G06F19/00 ,  G16H40/40 ,  G21G1/0005

Abstract: The present invention relates to calibration and normalization systems and methods for ensuring the quality of radiopharmaceuticals during the synthesis thereof, such as radiopharmaceuticals used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT).

Abstract translation: 本发明涉及用于确保放射性药物在其合成期间的质量的校准和归一化系统和方法，例如在正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）中使用的放射性药物。

公开(公告)号：WO2013043775A1

公开(公告)日：2013-03-28

申请号：PCT/US2012/056182

申请日：2012-09-20

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC.

Inventor： LUNDQVIST, Roger ,  THURFJELL, Nils, Lennart ,  LILJA, Johan

IPC: A61B6/00 ,  A61B6/03

CPC classification number: G06T7/003 ,  A61B6/037 ,  A61B6/501 ,  A61B6/5217 ,  G06T3/0068 ,  G06T7/337 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20004 ,  G06T2207/30016

Abstract: An adaptive template image for registering a PET or a SPECT image includes a template image model including variability of values for each voxel in a template image according to one or more control parameters.

Abstract translation: 用于登记PET或SPECT图像的自适应模板图像包括模板图像模型，其包括根据一个或多个控制参数的模板图像中的每个体素的值的变化性。

公开(公告)号：WO2012170602A1

公开(公告)日：2012-12-13

申请号：PCT/US2012/041204

申请日：2012-06-07

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  IDDON, Lisa ,  BHALLA, Rajiv ,  WILSON, Anthony

Inventor： IDDON, Lisa ,  BHALLA, Rajiv ,  WILSON, Anthony

IPC: B01D3/00

CPC classification number: B01D3/009 ,  B01J19/004 ,  B01J2219/00006 ,  B01J2219/00011

Abstract: A click chemistry process to be performed with an automated synthesis device using a synthesis cassette includes the steps of performing a chemical reaction in a first vessel at a first elevated temperature, heating the first vessel to a second elevated temperature to cause distillation, delivering a distilled reaction product from the first vessel to a second vessel, performing a click chemistry reaction with the distilled reaction product in the second vessel, purifying the click chemistry product, and formulating a final product from the purified click chemistry product. A cassette and a kit of parts for performing the process are also provided.

Abstract translation: 使用合成盒的自动化合成装置进行的点击化学方法包括以下步骤：在第一高温下在第一容器中进行化学反应，将第一容器加热至第二升高温度以进行蒸馏，输送蒸馏 从第一容器到第二容器的反应产物，与第二容器中的蒸馏反应产物进行点击化学反应，纯化点击化学产物，以及从纯化的点击化学产品制备最终产物。 还提供了用于执行该过程的盒和一组零件。

公开(公告)号：WO2012087912A1

公开(公告)日：2012-06-28

申请号：PCT/US2011/065803

申请日：2011-12-19

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  HISCOCK, Duncan ,  INDREVOLL, Bard ,  IVESON, Peter ,  GLASER, Matthias Eberhard ,  BHALLA, Rajiv ,  WILSON, Anthony

Inventor： HISCOCK, Duncan ,  INDREVOLL, Bard ,  IVESON, Peter ,  GLASER, Matthias Eberhard ,  BHALLA, Rajiv ,  WILSON, Anthony

IPC: A61K51/08 ,  A61K101/02 ,  C07K14/31

CPC classification number: A61K51/088 ,  C07K14/31

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract translation: 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

公开(公告)号：WO2012083094A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065307

申请日：2011-12-16

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  OSBORN, Nigel J.

Inventor： OSBORN, Nigel J.

IPC: G21F1/08 ,  G21F3/00 ,  G21F5/018 ,  G21G1/00

CPC classification number: B01J19/24 ,  A61K51/00 ,  G21F1/085 ,  G21F3/00 ,  G21F5/018 ,  G21F7/068 ,  G21G1/0005

Abstract: A shield collar (210, 410, 510) for a separations cartridge (116, 616) on a synthesis cassette may disengageably engage the separations cartridge so as to shield an operator from residual activity remaining in the separations cartridge after a synthesis operation.

Abstract translation: 用于合成盒上的分离盒（116,616）的屏蔽环（210,410,510）可以脱离接合分离盒，以便在合成操作之后屏蔽操作者残留在分离盒中的剩余活动。

公开(公告)号：WO2012040133A2

公开(公告)日：2012-03-29

申请号：PCT/US2011052239

申请日：2011-09-20

Applicant: GE HEALTHCARE LTD ,  IMPERIAL COLLEGE ,  MEDI PHYSICS INC ,  ABOAGYE ERIC OFORI ,  ROBINS EDWARD GEORGE ,  SMITH GRAHAM ,  ZHAO YONGJUN

Inventor： ABOAGYE ERIC OFORI ,  ROBINS EDWARD GEORGE ,  SMITH GRAHAM ,  ZHAO YONGJUN

IPC: C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/08 ,  C07C217/10

CPC classification number: C07C215/08 ,  C07B2200/05 ,  C07C217/10 ,  C07C309/73

Abstract: Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

Abstract translation: 用于正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）的新型放射性示踪剂与改变的胆碱代谢相关的疾病状态（例如，前列腺，乳腺，脑，食管，卵巢，子宫内膜，肺和 前列腺癌 - 原发性肿瘤，淋巴结转移或转移）。 本发明还描述了新型放射性示踪剂的中间体，前体，药物组合物，制备方法和使用方法。

公开(公告)号：WO2012024663A1

公开(公告)日：2012-02-23

申请号：PCT/US2011/048564

申请日：2011-08-22

Applicant: GE HEALTHCARE LIMITED ,  MEDI-PHYSICS, INC. ,  HANSTEEN, Ole Henrik ,  JAKOBSEN, Jan Borge ,  LINDGAARD, Svein-Erik ,  FRANCI, Xavier ,  ROED, Line ,  ANDERSEN, Arnfinn ,  JOHANSEN, Gro ,  KNUTTEL, Torsten ,  AUKLAND, Trond ,  HUSBYN, Mette

Inventor： HANSTEEN, Ole Henrik ,  JAKOBSEN, Jan Borge ,  LINDGAARD, Svein-Erik ,  FRANCI, Xavier ,  ROED, Line ,  ANDERSEN, Arnfinn ,  JOHANSEN, Gro ,  KNUTTEL, Torsten ,  AUKLAND, Trond ,  HUSBYN, Mette

IPC: G01N21/01

CPC classification number: G01N31/00 ,  B65B3/003 ,  G01N21/31 ,  G01N27/44717 ,  G01N30/6091 ,  G01N30/88 ,  G01N31/22 ,  G01N2030/77 ,  G01N2035/00158 ,  H01J49/00

Abstract: A quality control ("QC") system for PET or SPECT radiopharmaceuticals is disclosed that contains a disposable, no-leakage, self-contained QC cassette, which interfaces with the QC system. The QC system may include a shield that substantially surrounds the cassette such that the area and the cassette are both shielded. The QC cassette may contain shielding also. The QC cassette contains components for conducting one or more QC tests. These components include sensor and devices for performing various QC tests on radiopharmaceuticals. The QC system may contain a number of sub-systems and devices for supporting the QC tests. The QC system may produce a QC report containing the test results.

Abstract translation: 公开了一种用于PET或SPECT放射性药物的质量控制（“QC”）系统，其包含与QC系统接口的一次性，无泄漏，独立的QC盒。 QC系统可以包括基本上围绕盒的屏蔽，使得区域和盒都被屏蔽。 QC盒也可以包含屏蔽。 质量控制箱包含进行一次或多次QC测试的组件。 这些组件包括用于对放射性药物执行各种QC测试的传感器和设备。 QC系统可能包含许多支持QC测试的子系统和设备。 QC系统可以生成包含测试结果的QC报告。

公开(公告)号：WO2011126522A2

公开(公告)日：2011-10-13

申请号：PCT/US2010/059241

申请日：2010-12-07

Applicant: MEDI-PHYSICS, INC. ,  SHANKS, Charles ,  CORNELL, Richard ,  BOLENBAUGH, David W.

Inventor： SHANKS, Charles ,  CORNELL, Richard ,  BOLENBAUGH, David W.

IPC: G21G1/00

CPC classification number: G21G1/0005

Abstract: A multiple generator elution system for selectively eluting from a plurality of parent-daughter generators according to an elution schedule it calculates taking into account supply data, demand data, and available activity in each of the generators.

Abstract translation: 一种多发生器洗脱系统，用于根据其计算的多个母体 - 子代发生器，根据其计算的每个发生器中的供应数据，需求数据和可用活动来选择性洗脱。

公开(公告)号：WO2011079220A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/061874

申请日：2010-12-22

Applicant: MEDI-PHYSICS, INC. ,  HELLE, Kevin ,  REED, Jay

Inventor： HELLE, Kevin ,  REED, Jay

IPC: A61N5/10 ,  G21F5/00

CPC classification number: A61N5/1027 ,  A61N2005/1012

Abstract: A brachytherapy kit and process for delivering brachytherapy seeds, pre-loaded into needles, pre-loaded into a prostate grid, sterile packed for delivery to the end-user.

Abstract translation: 一种近距离放射线治疗套件和方法，用于递送近距离放射治疗种子，预装入针头，预装入前列腺网格，无菌包装以送达终端用户。