公开(公告)号：WO2008088469A2

公开(公告)日：2008-07-24

申请号：PCT/US2007024644

申请日：2007-11-30

Applicant: E SOC INC ,  KONDZOILKA DOUGLAS ,  JOHN VARGHESE

Inventor： KONDZOILKA DOUGLAS ,  JOHN VARGHESE

IPC: A61N1/05

CPC classification number: A61N1/372 ,  A61N1/025 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/375

Abstract: A brain stimulation device, including: a cranial chip (20) that is configured to be surgically implanted between a patient's scalp and skull; at least three stimulation leads (30) connected to the cranial chip, wherein each lead has a plurality of stimulation electrodes (32) thereon; control circuitry in the cranial chip for controlling the operation of the stimulation leads (30) and stimulation electrodes (32); and a power source in the cranial chip for powering the simulation leads (30) and the stimulation electrodes (32) and the control circuitry.

Abstract translation: 一种脑部刺激装置，包括：颅骨片（20），其被配置为手术植入在患者的头皮和颅骨之间; 至少三个连接到头盖芯片上的刺激引线（30），其中每个引线上具有多个刺激电极（32）;其中， 控制刺激引线（30）和刺激电极（32）的操作的头盖芯片中的控制电路; 以及用于为模拟引线（30）和刺激电极（32）和控制电路供电的头盖芯片中的电源。

公开(公告)号：WO2007121133A3

公开(公告)日：2008-06-26

申请号：PCT/US2007066220

申请日：2007-04-09

Applicant: NORTHSTAR NEUROSCIENCE INC ,  FOWLER BRAD ,  GLINER BRADFORD EVAN ,  HIMES DAVID

Inventor： FOWLER BRAD ,  GLINER BRADFORD EVAN ,  HIMES DAVID

IPC: A61N2/04

CPC classification number: A61N2/006 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082

Abstract: Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.

Abstract translation: 公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。 根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。 受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。 该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。 例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。 信号可以在亚阈值水平应用于皮层和/或皮质下区域。

公开(公告)号：WO2008073420A2

公开(公告)日：2008-06-19

申请号：PCT/US2007/025311

申请日：2007-12-11

Applicant: NORTHSTAR NEUROSCIENCE, INC. ,  GLINER, Bradford, Evan ,  FOWLER, Brad ,  HULVERSHORN, Justin ,  SLOAN, Leif, R.

Inventor： GLINER, Bradford, Evan ,  FOWLER, Brad ,  HULVERSHORN, Justin ,  SLOAN, Leif, R.

IPC: A61N2/02

CPC classification number: A61N1/36082 ,  A61N1/0531 ,  A61N2/006

Abstract: Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.

Abstract translation: 公开了用于治疗患者高渗性的系统和方法。 根据一个实施例的方法包括识别与患者中的高渗性相关的皮质靶神经群体，以及通过向目标神经群体施加电磁信号来减少或消除患者的高渗性。 在另外的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除另外的患者功能障碍。

公开(公告)号：WO2007124270A3

公开(公告)日：2008-05-08

申请号：PCT/US2007066334

申请日：2007-04-10

Applicant: MEDTRONIC INC ,  DREW TOUBY A ,  PANKEN ERIC J ,  WERDER JONATHAN C ,  CARLSON DAVID L

Inventor： DREW TOUBY A ,  PANKEN ERIC J ,  WERDER JONATHAN C ,  CARLSON DAVID L

IPC: A61B5/0456 ,  A61B5/0482 ,  A61N1/36 ,  A61N1/372 ,  G06K9/00

CPC classification number: A61B5/02405 ,  A61B5/0456 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/4094 ,  A61B5/7221 ,  A61B5/7275 ,  A61N1/36082 ,  A61N2/006 ,  G06K9/00543

Abstract: Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delviery components prior to the expected delivery of therapy.

Abstract translation: 公开了用于检测和/或治疗诸如癫痫发作的神经系统疾病的系统和方法。 本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。 本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。 本发明的其它实施方案包括通过在预期的治疗递送之前预热治疗偏爱成分来准备递送治疗。

公开(公告)号：WO2008052166A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/082681

申请日：2007-10-26

Applicant: WICAB, INC. ,  HOGLE, Richard ,  LEDERER, Scott

Inventor： HOGLE, Richard ,  LEDERER, Scott

IPC: A61N1/34

CPC classification number: A61N1/36103 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/37282 ,  G06F3/011 ,  G06F3/013 ,  G06F3/015

Abstract: The present invention relates to systems and methods for management of brain and body functions and sensory perception. For example, the present invention provides systems and methods of sensory substitution and sensory enhancement (augmentation) as well as motor control enhancement. The present invention also provides systems and methods of treating diseases and conditions, as well as providing enhanced physical and mental health and performance through sensory substitution, sensory enhancement, and related effects.

Abstract translation: 本发明涉及用于管理脑和身体功能和感觉知觉的系统和方法。 例如，本发明提供感官替代和感觉增强（增强）以及运动控制增强的系统和方法。 本发明还提供了治疗疾病和病症的系统和方法，以及通过感觉替代，感觉增强和相关效果来提供增强的身心健康和表现。

公开(公告)号：WO2008035344A2

公开(公告)日：2008-03-27

申请号：PCT/IL2007/001160

申请日：2007-09-20

Applicant: BAR-ILAN UNIVERSITY ,  YADID, Gal ,  FRIEDMAN, Alexander ,  ABELES, Moshe

Inventor： YADID, Gal ,  FRIEDMAN, Alexander ,  ABELES, Moshe

IPC: A61N1/32

CPC classification number: A61N1/36082

Abstract: The present invention discloses a device for Deep Brain Stimulation (DBS) therapy in a targeted site region of the brain. The targeted site region of the brain is the ventral tegmental area. Moreover, the device is used especially for treating chronic depression in a patient. The present invention also discloses a method for Deep Brain Stimulation (DBS) therapy in a targeted site region of the brain. The method comprises steps selected inter alia from (a) obtaining a device as defined above; (b) implanting the lead in the targeted site region of the brain; (c) implanting the neurostimulator under the skin; (d) connecting the lead to the neurostimulator by the extension; (e) electrically stimulating the targeted site region.

Abstract translation: 本发明公开了一种在大脑靶向部位区域进行深脑刺激（DBS）治疗的装置。 大脑的目标位置区域是腹侧被盖区域。 此外，该装置特别用于治疗患者的慢性抑郁症。 本发明还公开了一种在大脑靶向部位区域进行深脑刺激（DBS）治疗的方法。 该方法包括以下步骤：（a）获得如上所述的装置; （b）将铅植入脑的靶位点区域; （c）将神经刺激器植入皮肤下; （d）通过延伸将导线连接到神经刺激器; （e）电刺激目标部位区域。

公开(公告)号：WO2008018067A2

公开(公告)日：2008-02-14

申请号：PCT/IL2007/000983

申请日：2007-08-07

Applicant: ALPHA OMEGA ENGINEERING LTD. ,  FARAH, Maroun ,  YOUNIS, Imad

Inventor： FARAH, Maroun ,  YOUNIS, Imad

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/36082 ,  A61N1/0534

Abstract: Neural stimulation using various electrode configurations and/or anodic flow to control the stimulation effect. In some embodiments, a remote cathodal collecting electrode is used. In some embodiments, a multi-polar stimulation includes anodes on either side of a cathode.

Abstract translation: 使用各种电极配置和/或阳极流动来控制刺激效果的神经刺激。 在一些实施例中，使用远程阴极集电电极。 在一些实施例中，多极性刺激包括阴极两侧的阳极。

公开(公告)号：WO2007146287A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/013780

申请日：2007-06-11

Applicant: LEPTOS BIOMEDICAL, INC. ,  DOBAK, John, D.

Inventor： DOBAK, John, D.

IPC: A61N1/00

CPC classification number: A61N1/36007 ,  A61N1/00 ,  A61N1/36082

Abstract: Described are apparatus and methods for electrically modulating a nerve in a mammal. An electrical signal that includes a signal intensity pattern and a signal frequency pattern is delivered to a nerve. The combination of the signal intensity pattern and the signal frequency pattern is effective to result in weight loss, fat loss, and/or lean-mass gain, in a mammal. In some embodiments the nerve is modulated in response to a physiological parameter. In some embodiments, the physiological parameter is measured by a sensor.

Abstract translation: 描述了用于电动调节哺乳动物神经的装置和方法。 将包括信号强度图案和信号频率图案的电信号传送到神经。 在哺乳动物中，信号强度模式和信号频率模式的组合有效地导致体重减轻，脂肪减少和/或瘦体积增加。 在一些实施方案中，响应于生理参数调节神经。 在一些实施例中，生理参数由传感器测量。

公开(公告)号：WO2007089394A3

公开(公告)日：2007-11-29

申请号：PCT/US2007000344

申请日：2007-01-09

Applicant: CYBERONICS INC ,  MASCHINO STEVEN E ,  THOMPSON DAVID L

Inventor： MASCHINO STEVEN E ,  THOMPSON DAVID L

IPC: A61N1/00

CPC classification number: A61N2/008 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36071 ,  A61N1/36082

Abstract: A method, apparatus, and system for affecting neuromodulation based upon an evoking signal applied to a patient's body. An internal and/or external evoking and/or therapeutic signal is applied to a first target portion of a patient's body. Data relating to a physiological response resulting from the internal and/or external evoking and/or therapeutic signal is received. A neurotransmission characteristic of the patient's body is determined based upon the data relating to the physiological response. At least one parameter defining an electrical therapeutic signal provided by an implantable medical device is controlled based upon the determined neurotransmission characteristic to treat a disorder.

Abstract translation: 一种基于施加于患者身体的唤起信号来影响神经调节的方法，装置和系统。 内部和/或外部唤起和/或治疗信号被施加到患者身体的第一目标部分。 接收与由内部和/或外部唤起和/或治疗信号产生的生理反应有关的数据。 基于与生理反应相关的数据来确定患者身体的神经传递特性。 基于所确定的神经传递特征来控制由植入式医疗装置提供的定义电治疗信号的至少一个参数以治疗病症。

公开(公告)号：WO2007047852A3

公开(公告)日：2007-11-29

申请号：PCT/US2006040908

申请日：2006-10-18

Applicant: NORTHSTAR NEUROSCIENCE INC ,  FIRLIK ANDREW D ,  GLINER BRADFORD EVAN ,  SHEFFIELD W DOUGLAS ,  SLOAN LEIF R

Inventor： FIRLIK ANDREW D ,  GLINER BRADFORD EVAN ,  SHEFFIELD W DOUGLAS ,  SLOAN LEIF R

IPC: A61N1/00

CPC classification number: A61N1/36067 ,  A61B5/16 ,  A61B5/18 ,  A61B5/7275 ,  A61F2002/704 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/05 ,  A61M2205/50 ,  A61M2230/63 ,  A61N1/0531 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36139 ,  A61N1/372 ,  G06F19/3481

Abstract: Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.

Abstract translation: 公开了用于患者交互式神经刺激和/或化学物质递送的系统和方法。 根据本发明的一个实施例的方法包括通过向患者提供电磁信号和化学物质中的至少一个来影响患者的目标神经群体。 该方法还可以包括检测患者的至少一个特征，其特征至少与患者执行与影响目标神经群体相关联的辅助治疗任务的执行相关。 该方法还可以进一步包括至少部分地基于所检测到的特征来控制与目标神经群体受影响相关的至少一个参数。