公开(公告)号：WO2019126114A1

公开(公告)日：2019-06-27

申请号：PCT/US2018/066150

申请日：2018-12-18

申请人： THALER, Allison

发明人： THALER, Allison

IPC分类号： A61B5/024 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0205 ,  A61M5/172

CPC分类号： A61M5/14248 ,  A61B5/145 ,  A61B5/4839 ,  A61B5/4845 ,  A61B5/681 ,  A61M5/1723 ,  A61M2005/14204 ,  A61M2005/14252 ,  A61M2005/14272 ,  A61M2205/3553 ,  A61M2205/502 ,  A61M2210/083 ,  A61M2230/20

摘要： A device for treating drug overdoses generally includes a sensor to measure a physiological parameter of a subject that varies with use of a drug, a delivery mechanism for delivering an antidote to the drug, and a processor. The processor receives a signal from the sensor, monitors the physiological parameter, and identifies an overdose indicator therefrom. Upon identifying the overdose indicator, the processor automatically causes the delivery mechanism to deliver the antidote. The device can be used to treat opioid overdoses by monitoring the subject's blood oxygen saturation and delivering an opioid antagonist ( e.g. Naloxone) if the subject's blood oxygen saturation drops to a value indicative of impending respiratory arrest and/or unconsciousness. The device can be wearable ( e.g. , wrist-worn).

公开(公告)号：WO2019118053A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/055506

申请日：2018-10-11

申请人： STC. UNM ,  BARKHUFF, Daniel ,  BACA, Justin T. ,  ZINK, Peter ,  WARRICK, Brandon

发明人： BARKHUFF, Daniel ,  BACA, Justin T. ,  ZINK, Peter ,  WARRICK, Brandon

IPC分类号： A61M5/142 ,  A61M5/20

CPC分类号： A61M5/14248 ,  A61M5/1723 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/31591 ,  A61M2005/14252 ,  A61M2005/206 ,  A61M2205/18

摘要： An auto-injection system is having an injector, one or more sensors, and a controller, the controller activates the injector when the sensors detect a predetermined condition.

公开(公告)号：WO2019090016A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058839

申请日：2018-11-02

申请人： BOSTON SCIENTIFIC SCIMED, INC.

发明人： KOYA, Vijay ,  CLARK, Bryan Allen ,  SRIVASTAVA, Kyle Harish ,  GOVEA, Michael X. ,  ANNONI, Elizabeth Mary

IPC分类号： A61N1/36

CPC分类号： A61B5/14532 ,  A61B5/0093 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/4839 ,  A61M5/14248 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2230/201 ,  A61N1/3606 ,  A61N1/36135

摘要： A system may include a controller operably connected to a diabetic therapy delivery system. The controller may be configured to: receive therapy inputs including a therapy input indicative of a glucose measure; determine a therapy input index using the at least one therapy input including the therapy input indicative of a glucose measure; map the determined therapy input index to a graded glucose control; and set the graded glucose control based on the mapped graded glucose control for the determined therapy input index, wherein the graded glucose control includes at least one of a neuromodulation target, a neuromodulation type, or at least one neuromodulation parameter value. The diabetic therapy delivery system may be configured to deliver the therapy for graded glucose control using the graded glucose control that was set based on the mapped graded glucose control.

公开(公告)号：WO2019005686A1

公开(公告)日：2019-01-03

申请号：PCT/US2018/039330

申请日：2018-06-25

申请人： ABBOTT DIABETES CARE INC.

发明人： HAYTER, Gary, Alan ,  BUDIMAN, Erwin, Satrya

IPC分类号： G06F19/00

CPC分类号： A61M5/1723 ,  A61M5/14244 ,  A61M2005/14208 ,  A61M2205/3303 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G16H20/17 ,  G16H40/63 ,  G16H50/20 ,  G16H50/70

摘要： A system for managing a patient's glucose level includes a glucose sensor to generate and store data signals for measurements of the patient's glucose level made by the glucose sensor; an insulin pump; and sensor electronics operatively coupled to the glucose sensor, the sensor electronics comprising a memory storing one or more predetermined characteristics associated with the sensor electronics; and a computing device in electronic communication with the sensor electronics. The computing device comprises a processor configured to operate the sensor electronics to (i) receive the generated data signals, (ii) obtain the one or more predetermined sensor characteristics from the memory and (iii) execute a closed-loop algorithm to provide insulin delivery instructions to an insulin pump by at least using the data signals and predetermined characteristics.

公开(公告)号：WO2017123525A1

公开(公告)日：2017-07-20

申请号：PCT/US2017/012806

申请日：2017-01-10

申请人： BIGFOOT BIOMEDICAL, INC.

发明人： MAZLISH, Bryan ,  BREWER, Jeffrey ,  DESBOROUGH, Lane ,  BLOCK, Jennifer ,  WEISHAR, Robert ,  SCHACHTELY, Alan

IPC分类号： G06F19/00

CPC分类号： G06F19/3468 ,  A61M5/1723 ,  A61M2205/18 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

摘要： A diabetes management system including a pump for dispensing a medicant and a control device for controlling the pump includes a user interface for controlling functions of the pump and providing information related to operation of the pump and other information. The user interface can display blood glucose information and insulin dosing data such that a user can appropriately act on the information and/or gain confidence that the diabetes management system is operating appropriately to manage the disease. User interfaces provided herein can include displays of current and projected glucose values, bolus calculators, charts displaying glucose levels and/or insulin delivery data, system maintenance reminders, system status information, patient configuration input screens, and log-in screens. Diabetes management systems can include insulin pumps, continuous glucose monitors, blood glucose monitors, mobile computing devices, servers, and/or other insulin delivery devices (e.g., insulin pens)

摘要翻译： 包括用于分配药物的泵和用于控制泵的控制装置的糖尿病管理系统包括用于控制泵的功能并提供与泵的操作相关的信息和其他信息的用户界面。 用户界面可以显示血糖信息和胰岛素剂量数据，使得用户可以适当地对信息采取行动和/或获得糖尿病管理系统正在适当地操作以管理疾病的信心。 此处提供的用户界面可以包括当前和预测葡萄糖值的显示，推注计算器，显示葡萄糖水平和/或胰岛素输送数据的图表，系统维护提醒，系统状态信息，患者配置输入屏幕和登录屏幕。 糖尿病管理系统可以包括胰岛素泵，连续葡萄糖监测器，血糖监测器，移动计算设备，服务器和/或其他胰岛素递送设备（例如胰岛素笔）

公开(公告)号：WO2017095776A1

公开(公告)日：2017-06-08

申请号：PCT/US2016/063924

申请日：2016-11-29

申请人： CARDIAC PACEMAKERS, INC.

发明人： SAHA, Sunipa ,  THAKUR, Pramodsingh Hirasingh

IPC分类号： A61B5/0402 ,  A61M5/00

CPC分类号： A61M5/1723 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/0402 ,  A61B5/4848 ,  A61B7/04 ,  A61B2562/0204 ,  A61B2562/0247 ,  A61M5/00 ,  A61M5/14276 ,  A61M2230/04 ,  A61M2230/63 ,  A61N1/36585 ,  A61N1/3956 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3456

摘要： In some examples, a method of adjusting a cardiovascular medication administration protocol for a subject includes receiving heart contractility surrogate information, obtained from a sensor configured to sense information about a heart of the subject, during a specified acute time period following an initiation or change in medication administration to the subject, determining, using a comparator circuit, whether the heart contractility surrogate information indicates an occurrence of at least a specified change in heart contractility during the specified acute time period following the initiation or change in medication administration to the subject, and adjusting the medication administration protocol using the determination of whether the heart contractility surrogate information indicates the occurrence of at least the specified change in heart contractility during the specified acute time period following the initiation or change in medication administration to the subject.

摘要翻译： 在一些示例中，调节用于受试者的心血管药物施用方案的方法包括：接收心脏收缩性替代信息，该心脏收缩性替代信息从被配置为感测关于受试者的心脏的信息的传感器获得， 在对受试者施用药物开始或改变之后的一段时间内，使用比较电路确定心脏收缩性替代信息是否指示在开始或改变之后的特定急性时间段期间心脏收缩性的至少特定改变的发生 在向受试者施用药物中，以及使用确定心脏收缩性替代信息是否表明在开始或改变药物施用之后的特定急性时间段内至少发生了心脏收缩性的指定变化来调整药物施用方案， 该 主题。

公开(公告)号：WO2017091624A1

公开(公告)日：2017-06-01

申请号：PCT/US2016/063420

申请日：2016-11-22

申请人： INSULET CORPORATION

发明人： O'CONNOR, Jason ,  ALLIS, Daniel ,  NAZZARO, David ,  BUSSIERE, John ,  D'ARCO, John

IPC分类号： A61J7/04

CPC分类号： A61M5/1723 ,  A61M5/14248 ,  A61M2205/27 ,  A61M2205/3569 ,  A61M2205/3584 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/8206 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

摘要： Systems and methods for automatically delivering medication to a user. A sensor coupled to a user can collect information regarding the user. A controller can use the collected information to determine an amount of medication to provide the user. The controller can instruct a drug delivery device to dispense the medication to the user. The drug delivery device can be a wearable insulin pump that is directly coupled to the user. The controller can be part of or implemented in a cellphone. A user can be required to provide a confirmation input to allow a determined amount of insulin to be provided to the user based on detected glucose levels of the user. The sensor, controller, and drug delivery device can communicate wirelessly.

摘要翻译：

用于向用户自动递送药物的系统和方法。 耦合到用户的传感器可以收集关于用户的信息。 控制器可以使用所收集的信息来确定向用户提供的药物量。 控制器可以指示药物输送装置将药物分配给用户。 药物输送装置可以是直接连接至使用者的可佩带胰岛素泵。 控制器可以是手机的一部分或实施。 可以要求用户提供确认输入以允许基于检测到的用户的葡萄糖水平向用户提供确定量的胰岛素。 传感器，控制器和药物输送装置可以无线通信。

公开(公告)号：WO2017087888A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062920

申请日：2016-11-18

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  LEVINE, Andy H. ,  KANZLER, Christoph, Matthias ,  GUY, Aymeric ,  MIRANDA, Daniel, Leo ,  MOONEY, Joseph ,  ZAPOTOK, Adam ,  BERRY, Samel ,  LAM, Huy ,  SABATÉ DEL RÍO, Jonathan

发明人： LEVINE, Andy H. ,  KANZLER, Christoph, Matthias ,  GUY, Aymeric ,  MIRANDA, Daniel, Leo ,  MOONEY, Joseph ,  ZAPOTOK, Adam ,  BERRY, Samel ,  LAM, Huy ,  SABATÉ DEL RÍO, Jonathan ,  OSBORNE, John ,  KARABAS, Mustafa ,  DUNNE, Alan ,  NIEMI, James ,  MATTHEWS, Benjamin ,  INGBER, Donald, E. ,  HENRY, Olivier ,  INDIC, Premananda Pai

IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B5/08 ,  A61B5/145 ,  A61M5/00 ,  A61M5/20 ,  A61M37/00

CPC分类号： A61M5/1723 ,  A61B5/00 ,  A61B5/02 ,  A61B5/0452 ,  A61B5/08 ,  A61B5/0809 ,  A61B5/0826 ,  A61B5/113 ,  A61B5/1135 ,  A61B5/145 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/7264 ,  A61B5/7278 ,  A61K31/137 ,  A61M5/00 ,  A61M5/14248 ,  A61M5/20 ,  A61M5/2053 ,  A61M37/00 ,  A61M37/0015 ,  A61M2005/1726 ,  A61M2005/206 ,  A61M2205/18 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/587 ,  A61M2205/8206 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/30 ,  A61M2230/50 ,  A61M2230/63 ,  A61M2230/65

摘要： A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

摘要翻译： 生理传感器模块包括至少一个可佩戴传感器，其被配置用于佩戴在人体部位上并用于测量至少一个生物信号。 该模块还包括至少一个控制器，其通信地耦合到可佩戴传感器并且被配置为从可佩戴传感器接收生物信号。 控制器还被配置为实时处理生物信号，从生物信号提取一个或多个临床特征，并基于临床特征确定过敏反应的检测。

公开(公告)号：WO2017055441A1

公开(公告)日：2017-04-06

申请号：PCT/EP2016/073245

申请日：2016-09-29

申请人： SEIRATHERM GMBH

发明人： ROTH, Matthias ,  REICHTHALHAMMER, Thomas

IPC分类号： A61M5/44

CPC分类号： A61M5/1723 ,  A61M5/1407 ,  A61M5/1414 ,  A61M5/16831 ,  A61M5/16877 ,  A61M5/445 ,  A61M2005/1726 ,  A61M2202/0413 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2230/005

摘要： The invention provides a device controlling and managing administration of infusion fluid for temperature regulation therapy, comprising at least one flow control unit for regulating flow rate of infusion fluid, at least one control unit for receiving input signals and providing output signals, wherein the control unit is configured to receive input signals that define infusion fluid to be administered or which is being administered, and store such information, and provide output signals to control electrolyte content of the infusion fluid based on said received input signals. A modified method for controlling and managing administration of infusion fluid for temperature regulation therapy is also provided.

摘要翻译： 本发明提供了一种控制和管理用于温度调节治疗的输注液的管理的装置，包括至少一个用于调节输液的流速的流量控制单元，用于接收输入信号和提供输出信号的至少一个控制单元，其中控制单元 被配置为接收限定要施用的输注流体或正在施用的输注信号并存储这些信息的输入信号，并且基于所述接收的输入信号提供输出信号以控制输注流体的电解质含量。 还提供了用于控制和管理用于温度调节治疗的输注液的管理的修改方法。

公开(公告)号：WO2017034865A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/047227

申请日：2016-08-16

申请人： MEDTRONIC MINIMED, INC.

发明人： ROY, Anirban

IPC分类号： A61M5/172 ,  A61M5/145 ,  A61M5/142

CPC分类号： A61M5/1723 ,  A61M5/1452 ,  A61M2005/14208 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/702 ,  A61M2230/005 ,  A61M2230/201

摘要： Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.

摘要翻译： 提供输液系统，输液装置和相关操作方法。 操作输注装置以输送影响使用者身体中的生理状况的大量液体的示例性方法包括基于生理状况的测量值来识别由推注量的生理状况产生的残留值 流体，并通过调整影响推注量的初始比例来确定后续推注的更新比例，以补偿残余值。 更新的比率可以存储在数据存储元件中，以用于确定替代初始比值的后续推注量。