公开(公告)号：WO2011141607A1

公开(公告)日：2011-11-17

申请号：PCT/ES2011/070336

申请日：2011-05-10

Applicant: UNIVERSITAT DE BARCELONA ,  ALONSO CASANOVAS, Oscar ,  DIÉGUEZ BARRIENTOS, Ángel

Inventor： ALONSO CASANOVAS, Oscar ,  DIÉGUEZ BARRIENTOS, Ángel

IPC: H02P7/28 ,  H02P11/00 ,  H02P11/04

CPC classification number: H02P21/22

Abstract: La presente invención se refiere a un circuito controlador eléctrico para suministrar energía a un dispositivo consumidor de energía, el circuito controlador eléctrico incluye una unidad de control para producir las señales de control salientes, una unidad de control para recibir la tensión de entrada de una fuente de alimentación y las señales de control entrantes producidas a partir de las señales de control salientes, dicha unidad de control para producir la tensión de salida a partir de la tensión de entrada de acuerdo a las señales de control entrantes; y medios de conexión para suministrar la tensión de salida del dispositivo consumidor de energía. Dicho circuito controlador comprende, al menos, un transistor para recibir la tensión de entrada de la fuente de alimentación.

Abstract translation: 本发明涉及一种用于向功耗装置供电的电驱动电路，所述电路包括：用于产生输出控制信号的控制单元; 用于从电源接收输入电压的控制单元和从输出控制信号产生的输入控制信号，所述控制单元旨在根据输入的控制信号从输入电压产生输出电压; 以及用于提供电力消耗装置的输出电压的连接装置。 此外，驱动器电路包括用于从电源接收输入电压的至少一个晶体管。

公开(公告)号：WO2023046283A1

公开(公告)日：2023-03-30

申请号：PCT/EP2021/076120

申请日：2021-09-22

Applicant: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) ,  UNIVERSITAT DE BARCELONA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ,  PROVINCIAL HEALTH SERVICES AUTHORITY

Inventor： SALVATELLA GIRALT, Xavier ,  RIERA ESCALÉ, Antoni ,  FRIGOLÉ VIVAS, Marta ,  SÁNCHEZ ZARZALEJO, Carolina ,  RUFFONI, Alessandro ,  VERDAGUER ESPAULELLA, Francesc Xavier ,  SADAR, Marianne Dorothy ,  BANUELOS, Carmen Adriana ,  MAWJI, Nasrin

IPC: A61K31/09 ,  A61K31/519 ,  A61P5/26 ,  A61P5/28 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I) and their use for modulating the transcriptional activity of the androgen receptor and its splice variants for treating various indications including prostate cancer

公开(公告)号：WO2023021174A1

公开(公告)日：2023-02-23

申请号：PCT/EP2022/073151

申请日：2022-08-19

Applicant: INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) ,  UNIVERSITAT DE BARCELONA ,  HOSPITAL CLÍNIC DE BARCELONA ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Inventor： MAUREL SANTASUSANA, Joan ,  CASCANTE SERRATOSA, Marta ,  PEDROSA EGUILAZ, Leire ,  FOGUET COLL, Carles ,  THOMSON OKATSU, Timothy ,  POSTIGO, Antonio ,  BENITEZ RIBAS, Daniel ,  CAMPS POLO, Jordi

IPC: C12Q1/6886

Abstract: The present invention provides a method for deciding a check-point inhibitor (ICI)-based therapy, for a patient suffering from cancer, the method comprising the steps: a) measuring the expression level of the following markers: TGFB1, ZEB1, FAP, ZEB2, GLUL, ENTPD1, GOT1, LDHA, TWIST1, and GLS, in an isolated cancerous biological tissue sample from the patient; b) determining which markers are differentially expressed; and c) classifying the sample, depending on the markers differentially expressed, in one of the following clusters: cluster 1: when ZEB1, ZEB2, ENTPD1, FAP and GLUL are up-regulated; cluster 2: when GLS is upregulated; and LDHA, GOT1, ZEB1, ZEB2 and ENTPD1 are downregulated; and cluster 3: when GOT1 is upregulated and TGFB1 and TWIST 1 are downregulated.

公开(公告)号：WO2022243519A1

公开(公告)日：2022-11-24

申请号：PCT/EP2022/063734

申请日：2022-05-20

Applicant: UNIVERSITAT AUTÒNOMA DE BARCELONA ,  UNIVERSITAT DE BARCELONA ,  FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Inventor： ROIG SORIANO, Joan ,  CHILLON RODRIGUEZ, Miguel ,  BOSCH MERINO, Assumpció ,  PALLÀS LLIBERIA, Mercè ,  GASPAR GRIÑAN, Christian

IPC: A61K38/47 ,  A61K48/00 ,  A61P19/08 ,  A01K2227/105 ,  A01K2267/03 ,  A61K48/005 ,  A61K48/0075 ,  C12N15/86 ,  C12N2750/14143 ,  C12Y302/01031

Abstract: The present invention provides a polypeptide consisting of sequence SEQ ID NO: 1, or a variant thereof consisting of a sequence at least 85% identical to SEQ ID NO: 1, for use in the prevention and/or treatment of a bone disorder. The invention also provides nucleic acid sequence that encodes the polypeptide, a gene construct comprising the nucleic acid sequence, or an expression vector comprising the gene construct, for said use. The polypeptide, nucleic acid sequence, gene construct, or expression vector of the invention may be administered in the form of a pharmaceutical composition together with at least one pharmaceutically acceptable excipient, diluent or carrier.

公开(公告)号：WO2022175384A1

公开(公告)日：2022-08-25

申请号：PCT/EP2022/053938

申请日：2022-02-17

Applicant: FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR ,  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  UNIVERSITAT DE BARCELONA

Inventor： GALLEGO SALA, José ,  CANTERO CAMACHO, Ángel ,  SIMBA LAHUASI, Álvaro ,  GARCÍA-SASTRE, Adolfo ,  ROSALES RAMÍREZ, Romel ,  WHITE, Kris M. ,  MARCHÁN SANCHO, Vicente ,  CHUMILLAS VICEDO, Sergi

IPC: A61K31/138 ,  A61K31/14 ,  A61P31/14 ,  A61K31/155 ,  A61K31/40 ,  A61K31/409 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/454 ,  A61K31/47 ,  A61K31/495 ,  A61K31/517 ,  A61K31/5375 ,  C07C217/18

Abstract: The present invention relates to the use of small organic compounds, or a salt or solvate thereof, for the treatment and/or prevention of viral infections by RNA-viruses, preferably from the family Coronaviridae, Orthomyxoviridae, Filoviridae, Flaviviridae, Retroviridae and Togaviridae, such as SARS-CoV-2.

公开(公告)号：WO2022023499A1

公开(公告)日：2022-02-03

申请号：PCT/EP2021/071340

申请日：2021-07-29

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  UNIVERSITAT DE BARCELONA ,  CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P.

Inventor： SAMITIER MARTÍ, Josep ,  MIR LLORENTE, Mònica ,  DULAY BACENA, Samuel ,  RIVAS TORCATES, Lourdes Josefina ,  MISERERE, Sandrine ,  PÉREZ LÓPEZ, Briza ,  LOPEZ DE MIGUEL, Manuel ,  PALACIO BONET, Francisco

IPC: G01N27/416 ,  G01N27/49

Abstract: An electrochemical sensor system for sensing analytical reactions and biological operations is provided. The electrochemical sensor system comprises: an amperometric sensor comprising two electrodes, wherein the electrodes comprise a working electrode and a reference electrode, wherein the amperometric sensor includes no other electrodes and a potentiometric sensor comprising a working electrode and a reference electrode, wherein the potentiometric sensor includes no other electrodes, wherein the reference electrode of the potentiometric sensor is coupled to ground, wherein the working electrode of the amperometric sensor is electrically coupled to the reference electrode of the potentiometric sensor, wherein the amperometric sensor is configured to receive an excitation voltage between the working electrode of the amperometric sensor and the reference electrode of the amperometric sensor such that the received excitation voltage is used as a reference voltage of the potentiometric sensor via the reference electrode of the potentiometric sensor.

公开(公告)号：WO2021160707A1

公开(公告)日：2021-08-19

申请号：PCT/EP2021/053268

申请日：2021-02-11

Applicant: UNIVERSITAT DE BARCELONA ,  TECHNISCHE UNIVERSITÄT BRAUNSCHWEIG

Inventor： CASALS GUILLEN, Olga ,  MARKIEWICZ, Nicolai ,  FÀBREGA GALLEGO, Cristian ,  WAAG, Andreas Hans Wilhelm ,  PRADES GARCÍA, Juan Daniel

IPC: G01N21/64 ,  G01N21/78 ,  G01N21/77

Abstract: The sensing arrangement (1), comprising: - a sensing area (10), for accommodating a sensing substance (20) selected for experimenting an optical response as a response of an external stimulus; - a light emitter (11), for emitting light towards said sensing area (10); - a light receiver (12), for receiving a light from said sensing area (10); - a substrate (13) having a first substrate surface (131) and a second substrate surface (132); wherein, said light emitter (11) comprise a first LED (110) and said light receiver (12) comprise a second LED (120), both LEDs (110, 120) formed on said first substrate surface (131); and said sensing arrangement (1) further comprises a trench (14), formed between said first LED (110) and said second LED (120).

公开(公告)号：WO2021023721A1

公开(公告)日：2021-02-11

申请号：PCT/EP2020/071831

申请日：2020-08-03

Applicant: FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA ,  HOSPITAL CLINIC DE BARCELONA ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) ,  UNIVERSITAT DE BARCELONA

Inventor： MARTÍN ANTONIO, Beatriz ,  URBANO ISPIZUA, Álvaro ,  PÉREZ AMILL, Lorena ,  SUÑE RODRIGUEZ, Guillermo ,  JUAN OTERO, Manel

IPC: C07K16/28 ,  A61K39/00 ,  C07K14/725 ,  A61P35/02

Abstract: The present invention provides therapeutics for the treatment of Multiple myeloma. In particular, the present invention provides chimeric antigen receptor (CAR) T-cells that can target the B cell maturation antigen.

公开(公告)号：WO2021013933A1

公开(公告)日：2021-01-28

申请号：PCT/EP2020/070810

申请日：2020-07-23

Applicant: FUNDACIÓ ASSISTENCIAL DE MÚTUA DE TERRASSA FPC ,  UNIVERSITAT DE BARCELONA ,  FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL

Inventor： PÉREZ PORCUNA, Tomás María ,  COMELLA DEL BARRIO, Patricia ,  DOMINGUEZ BENITEZ, Jose Antonio ,  ABELLANA SANGRÀ, Rosa Mari

IPC: G01N33/569

Abstract: In vitro method for discriminating latent from active TB. The present invention refers to an in vitro method for the differential diagnosis between active TB, preferably early stages of TB, and LTBI.

公开(公告)号：WO2021009276A1

公开(公告)日：2021-01-21

申请号：PCT/EP2020/070108

申请日：2020-07-16

Applicant: UNIVERSITAT DE BARCELONA

Inventor： ÁLVAREZ CARULLA, Albert ,  MIRIBEL CATALÀ, Pedro Luis ,  MONTES CEBRIÁN, Yaiza ,  COLOMER FARRARONS, Jordi

IPC: H02J7/32 ,  G05F1/67 ,  H01M8/04858 ,  H01M8/04537 ,  H01M8/1009

Abstract: A self-powered system and a method for power extraction and measurement of energy-generator units are disclosed. The system comprises an energy generator unit (10) providing an electrical current I FC and a voltage V FC ; an instrumentation block (20) to measure the electrical current 1 FC , and a power management unit (30) connected to the energy generator unit (10) via a first input that collects the electrical current I FC , extracting an electrical power provided by the energy generator unit (10). The power management unit (30) also has a second input which is connected to a feedback element (40) connected to a voltage reference V REF , to the voltage V FC and to the instrumentation block (20). A variation of an equivalent input impedance of the power management unit (30) sets a given parameter of the energy generator unit (10) to a controlled given value and the instrumentation block (20) assists in the control of the parameter.