公开(公告)号：WO2005006958A8

公开(公告)日：2005-06-23

申请号：PCT/US2004022384

申请日：2004-07-12

Applicant: ISIS PHARMACEUTICALS INC ,  BENNETT C FRANK ,  DOBIE KENNETH W ,  JAIN RAVI

Inventor： BENNETT C FRANK ,  DOBIE KENNETH W ,  JAIN RAVI

IPC: A61B20060101 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC classification number: C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of CEACAM1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding CEACAM1 Methods of using these compounds for modulation of CEACAM1 expression and for diagnosis and treatment of disease associated with expression of CEACAM1 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节CEACAM1的表达。 组合物包含靶向编码CEACAM1的核酸的寡核苷酸。提供了使用这些化合物调节CEACAM1表达的方法和用于诊断和治疗与CEACAM1表达相关的疾病的方法。

公开(公告)号：WO2004048531A3

公开(公告)日：2005-04-28

申请号：PCT/US0337445

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: C12N5/02 ,  C12N9/12 ,  C12Q1/68 ,  A01N43/04 ,  A61K31/07 ,  C07H21/04

CPC classification number: C12N9/1205

Abstract: Compounds, compositions and methods are provided for modulating the expression of death-associated protein kinase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding death-associated protein kinase 1. Methods of using these compounds for modulation of death-associated protein kinase 1 expression and for diagnosis and treatment of disease associated with expression of death-associated protein kinase 1 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节死亡相关蛋白激酶1的表达。该组合物包含针对编码死亡相关蛋白激酶的核酸的寡核苷酸1.使用这些化合物调节死亡相关蛋白激酶1的方法 提供了与死亡相关蛋白激酶1表达相关的疾病的表达和诊断和治疗。

公开(公告)号：WO2004048524A3

公开(公告)日：2005-04-28

申请号：PCT/US0337347

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS INC ,  BENNETT FRANK C ,  DOBIE KENNETH W

Inventor： BENNETT FRANK C ,  DOBIE KENNETH W

IPC: A01N43/04 ,  A61K31/70 ,  A61K48/00 ,  C07H21/04 ,  C12N20060101 ,  C12N5/00 ,  C12Q1/68

CPC classification number: C07H21/04 ,  A61K48/00

Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT2. Methods of using these compounds for modulation of STAT2 expression and for diagnosis and treatment of disease associated with expression of STAT2 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节STAT2的表达。 组合物包含靶向编码STAT2的核酸的寡核苷酸。 提供了使用这些化合物调节STAT2表达和用于诊断和治疗与STAT2表达相关的疾病的方法。

公开(公告)号：WO2004048523A3

公开(公告)日：2005-02-24

申请号：PCT/US0337346

申请日：2003-11-21

Applicant: ISIS PHARMACEUTICALS INC ,  MONIA BRETT P ,  DOBIE KENNETH W ,  PANASCI LAWRENCE

Inventor： MONIA BRETT P ,  DOBIE KENNETH W ,  PANASCI LAWRENCE

IPC: C12N5/02 ,  C12N15/113 ,  C12Q1/68 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04 ,  C12N15/88 ,  C12P19/34

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of Ku86. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Ku86. Methods of using these compounds for modulation of Ku86 expression and for diagnosis and treatment of disease associated with expression of Ku86 are provided.

Abstract translation: 提供化合物，组合物和方法用于调节Ku86的表达。 组合物包含针对编码Ku86的核酸的寡核苷酸。 提供了使用这些化合物调节Ku86表达和用于诊断和治疗与Ku86表达相关的疾病的方法。

公开(公告)号：WO2004005461A3

公开(公告)日：2004-11-04

申请号：PCT/US0320309

申请日：2003-06-25

Applicant: ISIS PHARMACEUTICALS INC ,  BHANOT SANJAY ,  DOBIE KENNETH W

Inventor： BHANOT SANJAY ,  DOBIE KENNETH W

IPC: A61K38/00 ,  C07H21/04 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C12N15/86 ,  C12P19/34

CPC classification number: C12N15/1136 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding insulin-like growth factor 2. Methods of using these compounds for modulation of insulin-like growth factor 2 expression and for treatment of diseases associated with expression of insulin-like growth factor 2 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节胰岛素样生长因子2的表达。组合物包含靶向编码胰岛素样生长因子2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节 提供胰岛素样生长因子2表达和用于治疗与胰岛素样生长因子2的表达相关的疾病。

公开(公告)号：WO2004055162A3

公开(公告)日：2004-10-07

申请号：PCT/US0339436

申请日：2003-12-11

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: C07H21/04 ,  C12N15/113 ,  A61K48/00 ,  C07H21/00 ,  C12Q1/68

CPC classification number: C07H21/00 ,  C07H21/04 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/01003 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.

Abstract translation: 提供化合物，组合物和方法用于调节内皮脂肪酶的表达。 组合物包含靶向编码内皮脂肪酶的核酸的寡核苷酸。 提供了使用这些化合物调节内皮脂肪酶表达和用于诊断和治疗与内皮脂肪酶表达相关的疾病的方法。

公开(公告)号：WO2004046325A3

公开(公告)日：2004-07-15

申请号：PCT/US0336574

申请日：2003-11-14

Applicant: ISIS PHARMACEUTICALS INC ,  DOBIE KENNETH W

Inventor： DOBIE KENNETH W

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  A61K48/00 ,  C12N15/00

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y207/01037 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of serine/threonine kinase 16. The compositions comprise oligonucleotides, targeted to nucleic acid encoding serine/threonine kinase 16. Methods of using these compounds for modulation of serine/threonine kinase 16 expression and for diagnosis and treatment of disease associated with expression of serine/threonine kinase 16 are provided.

Abstract translation: 提供了调节丝氨酸/苏氨酸激酶16表达的化合物，组合物和方法。所述组合物包含靶向编码丝氨酸/苏氨酸激酶16的核酸的寡核苷酸。使用这些化合物调节丝氨酸/苏氨酸激酶16表达的方法和 提供了与丝氨酸/苏氨酸激酶16表达相关的疾病的诊断和治疗。

公开(公告)号：WO2004005554A3

公开(公告)日：2004-03-04

申请号：PCT/US0320821

申请日：2003-07-02

Applicant: ISIS PHARMACEUTICALS INC ,  BENNETT C FRANK ,  DOBIE KENNETH W

Inventor： BENNETT C FRANK ,  DOBIE KENNETH W

IPC: A61K38/00 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/68 ,  C07H21/00

CPC classification number: C12N15/113 ,  A61K38/00 ,  C07H21/04 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Livin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Livin. Methods of using these compounds for modulation of Livin expression and for treatment of diseases associated with expression of Livin are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节Livin的表达。 组合物包含靶向编码Livin的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Livin表达和治疗与Livin表达相关的疾病的方法。

公开(公告)号：WO2005006958A2

公开(公告)日：2005-01-27

申请号：PCT/US2004022384

申请日：2004-07-12

Applicant: ISIS PARMACEUTICALS INC ,  BENNETT C FRANK ,  DOBIE KENNETH W ,  JAIN RAVI

Inventor： BENNETT C FRANK ,  DOBIE KENNETH W ,  JAIN RAVI

IPC: A61B20060101 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61B

CPC classification number: C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of CEACAM1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding CEACAM1 Methods of using these compounds for modulation of CEACAM1 expression and for diagnosis and treatment of disease associated with expression of CEACAM1 are provided. I

Abstract translation: 提供化合物，组合物和方法用于调节CEACAM1的表达。 组合物包含靶向编码CEACAM1的核酸的寡核苷酸。提供了使用这些化合物调节CEACAM1表达的方法和用于诊断和治疗与CEACAM1表达相关的疾病的方法。 一世

公开(公告)号：WO2004048534A3

公开(公告)日：2005-11-17

申请号：PCT/US0337493

申请日：2003-11-21

Applicant: ISIS PARMACEUTICALS INC ,  DOBIE KENNETH W ,  WARD DONNA T

Inventor： DOBIE KENNETH W ,  WARD DONNA T

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/04 ,  A61K48/00 ,  C12N15/00

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y207/01037 ,  C12N2310/3525

Abstract: Compounds, compositions and methods are provided for modulating the expression of cytokine-inducible kinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding cytokine-inducible kinase. Methods of using these compounds for modulation of cytokine-inducible kinase expression and for diagnosis and treatment of disease associated with expression of cytokine-inducible kinase are provided.

Abstract translation: 提供化合物，组合物和方法用于调节细胞因子诱导型激酶的表达。 组合物包含靶向编码细胞因子诱导型激酶的核酸的寡核苷酸。 提供了使用这些化合物调节细胞因子诱导型激酶表达和用于诊断和治疗与细胞因子诱导型激酶表达相关的疾病的方法。