公开(公告)号：WO99058160A1

公开(公告)日：1999-11-18

申请号：PCT/NL1999/000284

申请日：1999-05-07

IPC: A61F9/007 ,  A61F2/14 ,  A61F9/00 ,  A61K49/00 ,  A61P27/12

CPC classification number: A61K49/006

Abstract: The invention relates to a method for performing a capsulorhexis, wherein a lens capsule is stained using at least one dye, which dye is capable of staining tissue without diffusing through said tissue.

Abstract translation: 本发明涉及一种用于进行撕囊术的方法，其中使用至少一种染料使透镜胶囊染色，该染料能够染色组织而不扩散通过所述组织。

公开(公告)号：WO1999025388A1

公开(公告)日：1999-05-27

申请号：PCT/US1997020981

申请日：1997-11-13

Applicant: ZILA, INC. ,  BURKETT, Douglas, D.

Inventor： ZILA, INC.

IPC: A61K49/00

CPC classification number: G01N1/30 ,  A61K49/006 ,  C07D279/18 ,  C09B21/00 ,  C12Q2304/18

Abstract: Novel biological stain compositions that are adapted for human in vivo topical application. In particular, novel Toluidine Blue O, TBO, dye products, products which contain TBO and specific TBO derivatives are disclosed.

Abstract translation: 适用于人体内局部应用的新型生物染色组合物。 特别地，公开了新型甲苯胺蓝O，TBO，染料产品，含有TBO和特定TBO衍生物的产品。

公开(公告)号：WO99013917A1

公开(公告)日：1999-03-25

申请号：PCT/US1998/019248

申请日：1998-09-15

IPC: A61K49/00

CPC classification number: A61K49/0058 ,  A61K49/0013 ,  A61K49/0043 ,  A61K49/006

Abstract: Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is marked to enhance visibility. In a first embodiment, the orifice is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; cadhedrins, such as E cadhedrin; and epithelial membrane antigens. In a second embodiment, a dye is injected into the base of the nipple and preferentially accumulates at at least some of the orifices. Other marking techniques are also described. Marking of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.

Abstract translation: 描述了用于定位，标记和访问乳房导管的方法，套件和装置。 标记到一个或多个导管网络的孔口以增强可视性。 在第一个实施方案中，使用特定的结合物质（通常是针对存在于孔口上的组织标记物的抗体）标记孔。 示例性组织标志物包括存在于导管上皮上的那些，例如细胞角蛋白，包括细胞角蛋白8和细胞角蛋白18; 院士，如E小学生; 和上皮膜抗原。 在第二实施方案中，将染料注入到乳头的基部中，并且优选地在至少一些孔口处积聚。 还描述了其他标记技术。 导管孔的标记允许可靠地识别和进入可能存在于单独乳房中的多个导管网络中的每一个。

公开(公告)号：WO2018004105A1

公开(公告)日：2018-01-04

申请号：PCT/KR2017/002069

申请日：2017-02-24

Applicant: 서울대학교 산학협력단 ,  한국과학기술연구원

Inventor： 이강원 ,  정윤 ,  라메쉬수비에 ,  박귀덕

IPC: A61K49/18 ,  A61K49/00 ,  G01N33/58

CPC classification number: A61K49/00 ,  A61K9/0014 ,  A61K9/1075 ,  A61K47/36 ,  A61K49/006 ,  A61K49/0078 ,  A61K49/18 ,  G01N33/57492 ,  G01N33/58

Abstract: 본 발명의 일 양상은 유상 성분; 계면활성제; 및 수상 성분을 포함하고, 상기 수상 성분은 수용성 활성 성분; 다당류; 및 히알루론산을 포함하는 나노 에멀전 및 이의 제조 방법에 관한 것이다.

Abstract translation: 本发明的一个方面涉及一种水包油组分; 表面活性剂; 和水相组分，其中水相组分包含水溶性活性组分; 多糖; 透明质酸及其制造方法。

公开(公告)号：WO2016205211A1

公开(公告)日：2016-12-22

申请号：PCT/US2016/037395

申请日：2016-06-14

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： NAGAI, Shigemi ,  NAGAI, Masazumi

IPC: A61K8/24 ,  A61K6/033 ,  A61K6/087 ,  A61K6/10 ,  G01N33/52 ,  C01B25/37 ,  A61C5/04 ,  A61C19/04 ,  B65D81/32

CPC classification number: A61K6/002 ,  A61B5/0088 ,  A61B5/4547 ,  A61C9/0006 ,  A61C17/00 ,  A61C19/063 ,  A61C19/066 ,  A61K6/007 ,  A61K6/083 ,  A61K6/087 ,  A61K6/10 ,  A61K8/24 ,  A61K8/37 ,  A61K8/466 ,  A61K49/006 ,  A61K2800/43 ,  A61K2800/434 ,  A61K2800/45 ,  A61K2800/58 ,  A61K2800/88 ,  A61Q11/00

Abstract: Disclosed are methods for detecting demineralization of a surface of a tooth, comprising a) contacting the tooth of a subject with an orally acceptable, binding composition comprising a binding agent that binds to a demineralized surface of the tooth; b) removing unbound binding compound; c) contacting the tooth with an orally acceptable, detector composition comprising a probe compound that reacts with the binding agent to form a visually detectable reaction product; and d) detecting formation of the reaction product as an indication of the presence or extent of surface demineralization of the tooth. Systems, kits, and compositions for practicing the methods are also provided.

Abstract translation: 公开了用于检测牙齿表面脱矿质的方法，其包括：a）使受试者的牙齿与口服可接受的结合组合物接触，所述组合物包含与牙齿的去矿质化表面结合的粘合剂; b）除去未结合的化合物; c）使所述牙齿与口腔可接受的检测器组合物接触，所述组合物包含与所述结合剂反应以形成视觉上可检测的反应产物的探针化合物; 和d）检测反应产物的形成，作为牙齿表面脱矿质的存在或程度的指示。 还提供了用于实施该方法的系统，试剂盒和组合物。

公开(公告)号：WO2015114548A1

公开(公告)日：2015-08-06

申请号：PCT/IB2015/050667

申请日：2015-01-29

Applicant: COSMO TECHNOLOGIES LIMITED

Inventor： MORO, Luigi ,  FRIMONTI, Enrico ,  LONGO, Luigi Maria

IPC: A61K49/00 ,  A61K9/00 ,  A61K9/107

CPC classification number: A61K49/006 ,  A61K9/10 ,  A61K47/20 ,  A61K47/34

Abstract: The present invention provides a novel liquid composition in the form of an emulsion or microemulsion for rectal administration comprising at least one dye, at least one emulsifier, and at least one physiologically acceptable excipient, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum. Preferably, said diagnostic endoscopic procedure of sigmoid colon and/or rectum is an anoscopy, a proctoscopy, a rectoscopy and/or a sigmoidoscopy.

Abstract translation: 本发明提供了一种用于直肠给药的乳液或微乳液形式的新型液体组合物，其包含至少一种染料，至少一种乳化剂和至少一种生理上可接受的赋形剂，以及其在乙状结肠和 /或直肠。 优选地，乙状结肠和/或直肠的所述诊断性内窥镜程序是阴道镜，直肠镜检查，直肠镜检查和/或乙状结肠镜检查。

公开(公告)号：WO2015042534A3

公开(公告)日：2015-05-14

申请号：PCT/US2014056804

申请日：2014-09-22

Applicant: CHILDRENS NAT MEDICAL CT

Inventor： SHEKHAR RAJ ,  AZIZIAN MAHDI ,  CHENG PENG ,  MAHAN LAWRENCE ,  WHITTINGTON ABBY ,  BICKFORD LISSETT

IPC: A61M25/16

CPC classification number: A61B5/066 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/0095 ,  A61B5/064 ,  A61B5/489 ,  A61B5/6842 ,  A61B8/0841 ,  A61B8/5207 ,  A61B19/5244 ,  A61B2576/00 ,  A61K49/006 ,  A61M5/007 ,  A61M5/14276 ,  A61M25/0105 ,  A61M2039/0238 ,  A61M2205/04 ,  A61M2240/00

Abstract: Described herein are systems and corresponding methods to place and further monitor an implanted medical device. The implanted device includes a fluorescent material that is disposed on a portion of a tip of the device. The system also includes a skin patch having one or more infrared light detectors configured to detect light radiation from the fluorescent material on the implanted device located beneath a skin surface of living tissue. The system further includes an image processing module that is configured to construct an image of the implanted device and its surroundings. The processor further registers and analyzes the position of the implanted device and provides an appropriate feedback signal to a monitoring station.

Abstract translation: 这里描述的是用于放置和进一步监视植入式医疗装置的系统和相应的方法。 植入装置包括设置在装置的尖端的一部分上的荧光材料。 该系统还包括具有一个或多个红外光检测器的皮肤贴片，该红外光检测器被配置为检测位于生物体组织皮肤表面下方的植入装置上的荧光材料的光辐射。 该系统还包括图像处理模块，其被配置为构建植入装置及其周围的图像。 处理器进一步登记和分析植入装置的位置，并向监测站提供适当的反馈信号。

公开(公告)号：WO2014178468A1

公开(公告)日：2014-11-06

申请号：PCT/KR2013/004297

申请日：2013-05-15

Applicant: 주식회사 지니스

Inventor： 김현진 ,  홍성출 ,  정혜종 ,  주민규 ,  조해국 ,  홍유진

IPC: A61K9/16 ,  A61K47/36 ,  A61K31/555 ,  A61P35/00

CPC classification number: A61K31/706 ,  A61K9/19 ,  A61K9/5123 ,  A61K9/5169 ,  A61K9/5192 ,  A61K31/282 ,  A61K31/337 ,  A61K31/409 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/48284 ,  A61K47/48892 ,  A61K49/006 ,  A61K49/0093 ,  A61K2300/00

Abstract: 본 발명은 암 조직에 대한 표적지향성이 향상된 특징을 가지는 항암나노입자 및 이의 제조방법에 관한 것으로서, 더욱 상세하게는 항암제, 나노입자 기저재로 혈청알부민 및 표적지향물질로 포르피린계 화합물이 비공유적으로 결합된 표적지향증폭형 항암나노입자 및 이의 제조방법에 관한 것이다. 본 발명에 따른 표적지향증폭형 항암나노입자는, 항암제, 기저재 혈청알부민, 표적지향물질 포르피린 이 3가지 성분들이 비공유결합적으로 구성되기 때문에, 항암나노입자에서 흔히 나타나는 독성 부작용, 항암제 약효 감소와 표적지향성 감소를 막을 수 있고, 나노입자가 더욱 안정화되고, 표적지향물질인 포르핀의 화학구조가 전혀 변형되지 않아 포르피린 고유기능인 활성산소 형성기능이 살아있어 전자기파 조사시 암 표적지향성이 증폭되는 효과를 가진다. 이상의 효과들이 복합적으로 작용하여 본 발명의 표적지향증폭형 나노입자는 항암제의 암 전달율/표적화율을 극대화시켜, 초기는 물론 말기 암에서도 효과적인 치료를 기대할 수 있다.

Abstract translation: 本发明涉及具有改善的癌组织靶特异性的抗癌纳米颗粒及其制备方法，更具体地涉及具有扩增靶特异性的抗癌纳米颗粒，其中抗癌药物，作为纳米颗粒基材的血清白蛋白和卟啉 - 作为目标特异性材料的基础化合物是非共价键合的，及其制备方法。 以本发明的抗癌药物，作为基质的血清白蛋白和作为目标特异性物质的卟啉不经过扩增靶特异性的抗癌纳米颗粒非共价结合，因此可以防止毒副作用 抗癌药物的功效降低，抗癌纳米颗粒中经常出现的靶特异性降低，纳米颗粒进一步稳定，并且由于作为内在功能的活性氧形成功能，在电磁波照射期间放大癌靶特异性 的卟啉，由于对卟啉的化学结构没有变化，这是目标特异性材料。 该效果以多种方式起作用，从而使本发明的扩增靶特异性的抗癌药物中的抗癌药物的肿瘤转移/靶向效率最大化，从而可期待早期和末期癌症中的有效治疗。

公开(公告)号：WO2013132396A1

公开(公告)日：2013-09-12

申请号：PCT/IB2013/051635

申请日：2013-03-01

Applicant: DEL PRETE, Antonio ,  SANSEVERINO, Renato ,  SCETTA, Daniele ,  CARUSO, Ciro ,  TROISI, Salvatore

Inventor： CARUSO, Ciro ,  TROISI, Salvatore

IPC: A61K49/00

CPC classification number: A61K49/0021 ,  A61B3/16 ,  A61K49/006

Abstract: The present invention relates to a substance selected in the group consisting of riboflavin,its esters, salts and hydrates thereof, for use in an ophthalmic diagnostic method.

Abstract translation: 本发明涉及用于眼科诊断方法的由核黄素，其酯，盐和水合物组成的组中选择的物质。

公开(公告)号：WO2013041810A9

公开(公告)日：2013-08-15

申请号：PCT/FR2012052101

申请日：2012-09-20

Applicant: ARCADOPHTA

Inventor： REBOUL GERARD

IPC: A61K31/045 ,  A61K31/655 ,  A61K33/14 ,  A61K33/42 ,  A61K49/00 ,  A61P27/02

CPC classification number: A61K49/0071 ,  A61K49/006

Abstract: The invention relates to a stable composition for ophthalmic dying, suitable for sterilization in an autoclave, comprising the following in an aqueous solution: - at least a dye, - at least a water-soluble polyol with formula H(HCOH)nH, where n is a whole number greater than 3, for use in either of the two following methods: an ophthalmic surgical treatment method and a diagnosis method.

Abstract translation: 本发明涉及适用于高压釜灭菌的稳定组合物，其中包括以下水溶液：至少一种染料，至少一种具有式H（HCOH）nH的水溶性多元醇，其中n 是大于3的整数，用于以下两种方法之一：眼科手术治疗方法和诊断方法。