公开(公告)号：WO2011050459A1

公开(公告)日：2011-05-05

申请号：PCT/CA2010/001689

申请日：2010-10-27

Applicant: VERITAS THERAPEUTICS INC. ,  LEVY, Gary ,  SELZNER, Markus

Inventor： LEVY, Gary ,  SELZNER, Markus

IPC: A61K39/395 ,  A61K31/7088 ,  A61P9/10 ,  G01N33/53

CPC classification number: G01N33/5064 ,  A61K31/7088 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/76 ,  G01N2333/75

Abstract: The present disclosure provides a method of treating or preventing hepatic ischemia and reperfusion injury in an animal comprising administering an effective amount of an FGL2-FcγRIIB inhibitor to an animal in need thereof. Also provided herein are uses, compositions and screening assays for FGL2- FcγRIIB inhibitors useful in treating hepatic ischemia and reperfusion injury.

Abstract translation: 本公开内容提供了在动物中治疗或预防肝缺血和再灌注损伤的方法，包括向有需要的动物施用有效量的FGL2-FcγRIIB抑制剂。 本文还提供了可用于治疗肝缺血和再灌注损伤的FGL2-FcγRIIB抑制剂的用途，组合物和筛选试验。

公开(公告)号：WO2010132890A9

公开(公告)日：2011-03-24

申请号：PCT/US2010035152

申请日：2010-05-17

Applicant: SRU BIOSYSTEMS INC ,  SHAMAH STEVEN ,  LAING LANCE G ,  YUZHAKOV ALEXANDER ,  WAGNER RICK ,  ABODEELY MARLA ,  ROCKNEY BENNET ,  SCHULZ STEPHEN C ,  PADALIA ZINKAL ,  GETMAN MICHAEL ,  SANDBERG ERIC

Inventor： SHAMAH STEVEN ,  LAING LANCE G ,  YUZHAKOV ALEXANDER ,  WAGNER RICK ,  ABODEELY MARLA ,  ROCKNEY BENNET ,  SCHULZ STEPHEN C ,  PADALIA ZINKAL ,  GETMAN MICHAEL ,  SANDBERG ERIC

IPC: G01N33/543 ,  G01N33/50 ,  G01N33/566

CPC classification number: G01N33/54373 ,  G01N21/7743 ,  G01N33/5044 ,  G01N33/5064 ,  G01N33/5073

Abstract: The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.

Abstract translation: 本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。

公开(公告)号：WO2010062650A2

公开(公告)日：2010-06-03

申请号：PCT/US2009062371

申请日：2009-10-28

Applicant: HARVARD COLLEGE ,  HU GUO-FU

Inventor： HU GUO-FU

IPC: C12Q1/68 ,  G01N33/15 ,  G01N33/53

CPC classification number: G01N33/5011 ,  A61K31/00 ,  A61K31/7036 ,  A61K45/06 ,  C12Q1/6883 ,  C12Q2600/118 ,  G01N33/5064 ,  G01N33/57415 ,  G01N33/57434 ,  G01N2800/52 ,  A61K2300/00

Abstract: Provided herein are compositions containing neamine, or a composition containing an agent that possesses one or more activities of neamine, and the research, diagnostic and therapeutic uses of such compounds, such as for the treatment of cancer.

Abstract translation: 本文提供含有neamine或含有具有一种或多种neamine活性的试剂的组合物以及这些化合物的研究，诊断和治疗用途的组合物，例如用于治疗癌症的组合物。

公开(公告)号：WO2010014622A2

公开(公告)日：2010-02-04

申请号：PCT/US2009/051978

申请日：2009-07-28

Applicant: FONDAZIONE ISTITUTO FIRC DI ONCOLOGICA MOLECOLARE (IFOM) ,  DEJANA, Elisabetta ,  LIEBNER, Stefan ,  GERAGHTY, Erin

Inventor： DEJANA, Elisabetta ,  LIEBNER, Stefan

IPC: G01N33/48 ,  C12N5/00 ,  C12M3/00

CPC classification number: G01N33/5064 ,  C12N5/069 ,  C12N2501/415 ,  C12N2503/02 ,  C12N2533/54

Abstract: An in vitro blood brain barrier (BBB) model is provided as well as in vitro methods for screening molecules for the ability to pass through the BBB or the ability to tighten the endothelial cell junctions in the BBB.

Abstract translation: 提供了一种体外血脑屏障（BBB）模型以及体外筛选分子穿过血脑屏障（BBB）的能力的方法。 BBB或能够收紧BBB中的内皮细胞连接。

公开(公告)号：WO2009137630A1

公开(公告)日：2009-11-12

申请号：PCT/US2009/043051

申请日：2009-05-06

Applicant: WINTHERIX LLC ,  HOOD, John ,  BARROGA, Charlene, F. ,  CARSON, Dennis ,  LU, Desheng

Inventor： HOOD, John ,  BARROGA, Charlene, F. ,  CARSON, Dennis ,  LU, Desheng

IPC: C12Q1/68

CPC classification number: G01N33/57426 ,  G01N33/5023 ,  G01N33/5064 ,  G01N33/57419 ,  G01N33/6872 ,  G01N2333/82

Abstract: Provided herein are methods for screening compounds for their ability to modulate Wnt signaling in cancer cells.

Abstract translation: 本文提供了筛选化合物在癌细胞中调节Wnt信号传导能力的方法。

公开(公告)号：WO2009131963A2

公开(公告)日：2009-10-29

申请号：PCT/US2009/041182

申请日：2009-04-21

Applicant: ABBOTT LABORATORIES ,  ADAMCZYK, Maciej, B. ,  BRASHEAR, Roy, Jeffrey ,  MATTINGLY, Phillip, G.

Inventor： ADAMCZYK, Maciej, B. ,  BRASHEAR, Roy, Jeffrey ,  MATTINGLY, Phillip, G.

IPC: G01N33/50

CPC classification number: G01N33/5064 ,  C12Q1/26

Abstract: A method of assessing whether or not erythrocytes are suitable for transfusion into a recipient comprising (i) assaying a sample of erythrocytes for free choline, and (ii) comparing the level of free choline in the sample with the level of free choline deemed suitable for transfusion therapies; and a kit for use in such a method comprising at least one reagent for assaying the sample, instructions for conducting the assaying of the sample, and guidelines for assessing the suitability of the erythrocytes for transfusion.

Abstract translation: 评估红细胞是否适合输血到接受者的方法，包括（i）测定免费胆碱的红细胞样品，和（ii）比较样品中游离胆碱水平与被认为适合的免费胆碱水平 输血疗法; 以及用于这种方法的试剂盒，其包含至少一种用于测定样品的试剂，用于进行样品测定的说明书，以及用于评估红细​​胞用于输血的适用性的准则。

公开(公告)号：WO2009085209A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/013899

申请日：2008-12-19

Applicant: VASGENE THERAPEUTICS, INC. ,  GILL, Parkash ,  LIU, Ren ,  KRASNOPEROV, Valery

Inventor： GILL, Parkash ,  LIU, Ren ,  KRASNOPEROV, Valery

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K38/177 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/5011 ,  G01N33/5064 ,  A61K2300/00

Abstract: In certain embodiments, this present invention provides methods of identifying and using agonists and antagonists of Delta-like 4 (Dll4) signaling.

Abstract translation: 在某些实施方案中，本发明提供了鉴定和使用δ样4（Dll4）信号传导的激动剂和拮抗剂的方法。

公开(公告)号：WO2007143211A3

公开(公告)日：2008-11-06

申请号：PCT/US2007013230

申请日：2007-06-04

Applicant: BIOSEEK INC ,  KUNKEL ERIC J ,  HYTOPOULOS EVANGELOS ,  PLAVEC IVAN

Inventor： KUNKEL ERIC J ,  HYTOPOULOS EVANGELOS ,  PLAVEC IVAN

IPC: A61F13/00 ,  A61F2/00 ,  A61F2/06

CPC classification number: C12Q1/02 ,  A61K31/13 ,  A61K31/135 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/517 ,  A61K31/519 ,  A61K31/565 ,  A61K45/06 ,  A61L31/16 ,  G01N33/5061 ,  G01N33/5064 ,  G01N2800/323

Abstract: Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.

Abstract translation: 通过在一组测定中测定测试剂来测定抑制或预防再狭窄的药剂，以测量测试剂对细胞增殖，血栓形成，组织造型和炎症的影响。 使用本发明的组合物提供再狭窄的治疗。

公开(公告)号：WO2008112195A1

公开(公告)日：2008-09-18

申请号：PCT/US2008/003152

申请日：2008-03-10

Applicant: BIOSEEK, INC. ,  KUNKEL, Eric, J. ,  ROSLER, Elen, S. ,  PRIVAT, Sylvie ,  MELROSE, Jennifer, E.

Inventor： KUNKEL, Eric, J. ,  ROSLER, Elen, S. ,  PRIVAT, Sylvie ,  MELROSE, Jennifer, E.

IPC: G01N33/50 ,  G06F19/00 ,  A61K31/00 ,  C12Q1/00

CPC classification number: G01N33/6893 ,  G01N33/5055 ,  G01N33/5064 ,  G01N33/5067 ,  G01N2800/085 ,  G01N2800/10 ,  G01N2800/382

Abstract: Agents that stabilize and/or prevent fibrosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on matrix deposition and remodeling, epithelial health, and inflammation. Treatment for fibrosis is provided using compositions of the invention.

Abstract translation: 稳定和/或预防纤维化的药物通过在测定电池中测定试剂来测定测试剂对基质沉积和重塑，上皮健康和炎症的影响来鉴定。 使用本发明的组合物提供纤维化的治疗。

公开(公告)号：WO2008110570A1

公开(公告)日：2008-09-18

申请号：PCT/EP2008/052933

申请日：2008-03-12

Applicant: MEDIZINISCHE UNIVERSITÄT GRAZ ,  STRUNK, Dirk ,  ROHDE, Eva ,  BARTMANN, Christina ,  SCHALLMANN, Katharina

Inventor： STRUNK, Dirk ,  ROHDE, Eva ,  BARTMANN, Christina ,  SCHALLMANN, Katharina

IPC: G01N33/50 ,  C12N5/06

CPC classification number: C12N5/0692 ,  C12N2501/165 ,  G01N33/5005 ,  G01N33/5064

Abstract: The present invention provides a simple and rapid method for determining colony forming units (CFU) of endothelial progenitor cells (EPC). Furthermore, a method for identifying compounds exerting an effect on those CFU of EPC is provided. The present invention also provides medium for culturing endothelial cells which is comprised of EGM-2, hydrocortisone and VEGF as well as human platelet lysate (HPL) as supplement.

Abstract translation: 本发明提供了一种用于测定内皮祖细胞（EPC）的集落形成单位（CFU）的简单且快速的方法。 此外，提供了鉴定对EPC的CFU产生影响的化合物的方法。 本发明还提供用于培养由EGM-2，氢化可的松和VEGF以及人血小板裂解物（HPL）作为补充物的内皮细胞的培养基。