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    AN IMMUNOASSAY FOR THE DIAGNOSIS OF VIRAL INFECTIONS
    62.
    发明申请
    AN IMMUNOASSAY FOR THE DIAGNOSIS OF VIRAL INFECTIONS 审中-公开
    用于诊断病毒感染的免疫试剂

    公开(公告)号：WO2017144174A1

    公开(公告)日：2017-08-31

    申请号：PCT/EP2017/000249

    申请日：2017-02-22

    Applicant: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG

    Inventor： STEINHAGEN, Katja ,  DEERBERG, Andrea ,  LATTWEIN, Erik ,  RADZIMSKI, Christiane ,  BÖTHFÜR, Jana

    IPC: G01N33/569 ,  A61K39/12 ,  C07K14/08

    CPC classification number: G01N33/569 ,  C12N2770/24122 ,  G01N2333/185 ,  G01N2469/20 ,  Y02A50/53 ,  Y02A50/60

    Abstract: The present inventions relates to a polypeptide, preferably a dimer and/or hexamer thereof, more preferably a dimer, comprising a sequence selected from the group comprising SEQ ID NO1, SEQ ID NO2, SEQ ID NO3, SEQ ID NO4, SEQ ID NO5, SEQ ID NO6, SEQ ID NO7, SEQ ID NO8, SEQ ID NO19 and SEQ ID NO9 or a variant thereof, preferably SEQ ID NO1 or a variant thereof, for the diagnosis of a disease, a diagnostically useful carrier comprising a means for specifically capturing an antibody to SEQ ID N01 in a sample from a subject, a kit comprising the diagnostically useful carrier, and a method, preferably for diagnosing a disease, comprising the step detecting in a sample from a subject the presence or absence of an antibody to SEQ ID NO1.

    Abstract translation: 本发明涉及多肽，优选其二聚体和/或六聚体，更优选二聚体，其包含选自下组的序列：SEQ ID NO1，SEQ ID NO2，SEQ ID NO3， SEQ ID NO4，SEQ ID NO5，SEQ ID NO6，SEQ ID NO7，SEQ ID NO8，SEQ ID NO19和SEQ ID NO9或其变体，优选SEQ ID NO1或其变体，用于诊断疾病，诊断 其包含用于特异性捕获来自受试者的样品中的SEQ ID NO：1的抗体的工具，包含该诊断上有用的载体的试剂盒以及优选用于诊断疾病的方法，该方法包括在来自受试者的样品中检测 存在或不存在针对SEQ ID NO1的抗体。

    PERSONALIZED DELIVERY VECTOR-BASED IMMUNOTHERAPY AND USES THEREOF
    64.
    发明申请
    PERSONALIZED DELIVERY VECTOR-BASED IMMUNOTHERAPY AND USES THEREOF 审中-公开
    个性化交付矢量的免疫及其用途

    公开(公告)号：WO2016191545A1

    公开(公告)日：2016-12-01

    申请号：PCT/US2016/034301

    申请日：2016-05-26

    Applicant: ADVAXIS, INC.

    Inventor： PETIT, Robert ,  PERRY, Kyle ,  PRINCIOTTA, Michael F. ,  O'CONNOR, Daniel J.

    IPC: A61K48/00 ,  A61K38/16 ,  C07K14/195 ,  C12N15/74

    CPC classification number: C07K14/195 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/523 ,  C12N15/62 ,  C12N2710/20034 ,  Y02A50/491 ,  Y02A50/492 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/54 ,  Y02A50/55 ,  Y02A50/58 ,  Y02A50/60

    Abstract: This invention provides a system of providing and creating personalized immunotherapeutic compositions for a subject having a disease or condition, including therapeutic immunotherapy delivery vectors and methods of making the same comprising gene expression constructs expressing peptides associated with one or more neo-epitopes or peptides containing mutations that are specific to a subject's cancer or unhealthy tissue. A delivery vector of this invention includes bacterial vectors including Listeria bacterial vectors; or viral vectors, peptide immunotherapy vectors; or DNA immunotherapy vectors, comprising one or more fusion proteins comprising one or more peptides comprising one or more neo-epitopes present in disease-bearing biological samples obtained from the subject. This invention also provides methods of using the same for inducing an immune response against a disease or condition, including a tumor or cancer, or an infection, or an autoimmune disease or an organ transplant rejection in the subject.

    Abstract translation: 本发明提供了一种为具有疾病或病症的受试者提供和创造个性化的免疫治疗组合物的系统，包括治疗性免疫治疗递送载体及其制备方法，其包含表达与一个或多个新表位或肽相关的肽的基因表达构建体，其含有突变 这是特定于受试者的癌症或不健康的组织。 本发明的递送载体包括细菌载体，包括李斯特菌属细菌载体; 或病毒载体，肽免疫治疗载体; 或DNA免疫治疗载体，其包含一种或多种包含一种或多种包含存在于从受试者获得的患有疾病的生物样品中的新表位的肽的融合蛋白。 本发明还提供了使用其来诱导针对受试者中包括肿瘤或癌症，感染或自身免疫疾病或器官移植排斥的疾病或病症的免疫应答的方法。

    NUCLEIC ACID SEQUENCING BY ELECTROCHEMICAL DETECTION
    65.
    发明申请
    NUCLEIC ACID SEQUENCING BY ELECTROCHEMICAL DETECTION 审中-公开
    通过电化学检测进行核酸序列测序

    公开(公告)号：WO2013022778A1

    公开(公告)日：2013-02-14

    申请号：PCT/US2012/049585

    申请日：2012-08-03

    Applicant: IBIS BIOSCIENCES, INC. ,  HUFF, Jeffrey ,  DAVIS, Graham ,  HAYDEN, Mark A. ,  ECKER, David J. ,  WANG, Dan ,  COLLIER, Gordon Bruce

    Inventor： HUFF, Jeffrey ,  DAVIS, Graham ,  HAYDEN, Mark A. ,  ECKER, David J. ,  WANG, Dan ,  COLLIER, Gordon Bruce

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  G01N27/3275 ,  G01N27/333 ,  G01N27/447 ,  G01N27/44756 ,  Y02A50/59 ,  Y02A50/60 ,  C12Q2565/607 ,  C12Q2563/113 ,  C12Q2563/116

    Abstract: Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in pH to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode. Moreover, in some embodiments the device further comprises a reference electrode. Performing the sequencing reaction involves moving solutions and other fluids (e.g., samples, nucleotide solutions, wash solutions) into and out of the reaction vessel. Thus, in some embodiments, the device further comprises a tube or other transport mechanism or pathway attached t the reaction vessel.

    Abstract translation: 本文提供了与测序核酸有关的技术，特别但并非排他地涉及使用pH变化监测碱添加的用于合成序列的装置，方法和系统。 在一些实施方案中，电化学氢离子传感器是微制造的混合金属氧化物电极，在一些实施方案中，电化学氢离子传感器是膜电极。 此外，在一些实施例中，该装置还包括参考电极。 执行测序反应包括将溶液和其它流体（例如，样品，核苷酸溶液，洗涤溶液）移入和移出反应容器。 因此，在一些实施例中，该装置还包括与反应容器连接的管或其它输送机构或通路。

    METHOD FOR DETECTION OF ANTIGEN-SPECIFIC ANTIBODIES IN BIOLOGICAL SAMPLES
    68.
    发明申请
    METHOD FOR DETECTION OF ANTIGEN-SPECIFIC ANTIBODIES IN BIOLOGICAL SAMPLES 审中-公开
    用于检测生物样品中抗原特异性抗体的方法

    公开(公告)号：WO2010036470A1

    公开(公告)日：2010-04-01

    申请号：PCT/US2009/054916

    申请日：2009-08-25

    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION ,  BASILE, Alison, Jane

    Inventor： BASILE, Alison, Jane

    IPC: G01N33/543 ,  G01N33/68

    CPC classification number: G01N33/6854 ,  G01N33/564 ,  G01N33/569 ,  G01N33/585 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/57 ,  Y02A50/60

    Abstract: Disclosed herein is a rapid and universal assay for the detection of antigen- specific antibodies in biological samples. The assay allows for the detection of antigen-specific antibodies in any species, including species for which secondary antibodies or antisera have not been developed or are not available. Biological samples to be tested are directly labeled, such as with biotin, and contacted with antigen-bound microp articles. The presence of antigen-specific antibodies in the biological samples is detected using a binding partner for the label, such as a biotin binding partner, conjugated to a detectable label, such as a fluorophore. This improved test provides a total antibody assay that is capable of detecting all classes of antibodies simultaneously.

    Abstract translation: 本文公开了用于检测生物样品中抗原特异性抗体的快速和通用测定。 该测定允许检测任何物种中的抗原特异性抗体，包括其中二级抗体或抗血清尚未开发或不可用的物种。 待测试的生物样品被直接标记，例如用生物素标记，并与抗原结合的微型物品接触。 使用与可检测标记例如荧光团缀合的标记物例如生物素结合配偶体的结合配偶体检测生物样品中抗原特异性抗体的存在。 该改进的测试提供能够同时检测所有类别的抗体的总抗体测定。

    REAL TIME DETECTION OF MOLECULES, CELL AND PARTICLES USING PHOTONIC BANDGAP STRUCTURES
    70.
    发明申请
    REAL TIME DETECTION OF MOLECULES, CELL AND PARTICLES USING PHOTONIC BANDGAP STRUCTURES 审中-公开
    使用光子带结构实时检测分子，细胞和颗粒

    公开(公告)号：WO2008051287A2

    公开(公告)日：2008-05-02

    申请号：PCT/US2007/008731

    申请日：2007-04-06

    Applicant: AMERIGENICS. INC. ,  BEATTIE, Kenneth, L. ,  TONUCCI, Ronald, J.

    Inventor： BEATTIE, Kenneth, L. ,  TONUCCI, Ronald, J.

    IPC: G02B6/00

    CPC classification number: G01N21/77 ,  G01N21/05 ,  G01N33/54373 ,  G01N2021/0346 ,  G01N2021/7783 ,  Y02A50/51 ,  Y02A50/60

    Abstract: Provided herein is a photonic bandgap (PBG) detector effective to detect inorganic molecules, organic biomolecules or biopolymers, cells, subcellular organelles, and particles. The PBG detector utilizes photonic crystals having a binding agent attached to channel surfaces comprising the crystals to selectively bind a molecule, cell or particle of interest so that an increase in light transmission is detectably induced within the photonic bandgap upon binding. Also provided are methods of optically detectiing an analyte and of identifying the presence of a cell or a particle in a biological sample.

    Abstract translation: 本文提供了有效检测无机分子，有机生物分子或生物聚合物，细胞，亚细胞细胞器和颗粒的光子带隙（PBG）检测器。 PBG检测器利用光子晶体，其具有连接到包含晶体的通道表面的结合剂，以选择性地结合感兴趣的分子，细胞或颗粒，使得在结合时在光子带隙内可检测地诱导光透射的增加。 还提供了光学检测分析物和鉴定生物样品中细胞或颗粒的存在的方法。

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