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    TARGETED PHAGE FOR BACTERIAL DETECTION AND DESTRUCTION
    62.
    发明申请
    TARGETED PHAGE FOR BACTERIAL DETECTION AND DESTRUCTION 审中-公开

    公开(公告)号：WO2020131192A3

    公开(公告)日：2020-06-25

    申请号：PCT/US2019/054361

    申请日：2019-10-02

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： CHEN, Irene ,  PENG, Huan ,  VERBANIC, Samuel

    IPC分类号： C12N7/00 ,  C12Q1/04 ,  G01N21/552 ,  G01N33/569 ,  G01N33/554 ,  A61K35/76 ,  A61K41/00 ,  A61P31/04

    摘要： Functionalized phages having customized host specificity and unique plasmonic properties. The phages are modified to target selected bacterial types, such as antibiotic resistant bacteria. The phages are functionalized with plasmonic nanoparticles, such as gold or silver nanorods, wherein the aggregation of these functionalized phages results in useful plasmonic resonance emissions that can be exploited for therapeutic, clinical, research, and analytical uses. In cell killing applications, excitation of phages adsorbed on target bacteria results in plasmonic resonance-mediated localized thermal effects, killing the target bacteria to which the phage are targeted and adsorbed, while sparing the surrounding host cells. This also destroys the phage, obviating potential complications from escaped phage. In detection applications, excitation of the functionalized phages results in plasmonic responses that strongly affect optical emissions. Functionalized phages selectively aggregate on target bacterial cells are excited, creating plasmonic resonance that enables detection and quantification.

    AAV TRIPLE-PLASMID SYSTEM
    63.
    发明申请
    AAV TRIPLE-PLASMID SYSTEM 审中-公开

    公开(公告)号：WO2020086881A1

    公开(公告)日：2020-04-30

    申请号：PCT/US2019/057916

    申请日：2019-10-24

    申请人： BAXALTA INCORPORATED ,  BAXALTA GMBH

    发明人： CHOI, Vivian ,  LI, Xing

    IPC分类号： A61K9/00 ,  A61K35/76 ,  A61K35/761 ,  A61K38/00 ,  A61K38/02 ,  A61K38/17

    摘要： A triple-plasmid system for producing recombinant adeno-associated viruses is disclosed. In one aspect, the invention is directed to a plasmid system for Recombinant Adeno-Associated Viral Vector (rAAV) production comprising: (i) a transgene-containing plasmid comprising at least one heterologous nucleic acid sequence flanked by a 5' and 3' AAV inverted terminal repeat (ITR) and a stuffer sequence outside of the ITRs; (ii) a plasmid comprising AAV replication (Rep) and capsid (Cap) gene sequences; and (iii) an adenovirus (Ad) helper plasmid.