公开(公告)号：WO2007078463A1

公开(公告)日：2007-07-12

申请号：PCT/US2006/045374

申请日：2006-11-22

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  PILE-SPELLMAN, John ,  ERWIN, Lin

Inventor： PILE-SPELLMAN, John ,  ERWIN, Lin

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61F2007/0059 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M1/369 ,  A61M5/1723 ,  A61M5/44 ,  A61M2205/3368 ,  A61M2205/3606

Abstract: Methods and systems for infusing a cooled infusate to a target location in a patient are described. A temperature of the blood and infusate admixture upstream of the catheter as well as at other locations along the catheter may be monitored and a feedback system utilized to control the volume, temperature, and/or infusion rate of the infusate so as to achieve a predetermined temperature at the target location. The system may monitor or calculate hematocrit upstream of the catheter and adjust infusion so as to provide sufficient oxygenation of the blood and infusate admixture . The system may also monitor reflux of the infusate past a distal end of the catheter and reduce infusion upon the detection of reflux.

Abstract translation: 描述了用于将冷却的输注物输注到患者中的目标位置的方法和系统。 可以监测导管上游以及沿着导管的其他位置处的血液和输注物混合物的温度，并且可以使用反馈系统来控制输注液的体积，温度和/或输注速率，以达到预定的 目标位置的温度。 该系统可以监测或计算导管上游的血细胞比容，并调节输注，以便提供足够的血液和灌注混合物的氧合作用。 该系统还可以监测通过导管的远端的输液管的回流，并且在检测到回流时减少输注。

公开(公告)号：WO2006138729A2

公开(公告)日：2006-12-28

申请号：PCT/US2006/023856

申请日：2006-06-19

Applicant: IMCLONE SYSTEMS INCORPORATED ,  UNIVERSITY OF WASHINGTON ,  DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  LUDWIG, Dale, L. ,  PLYMATE, Stephen, R. ,  LOIZOS, Nick ,  HUBER, Jim ,  FATATIS, Alessandro

Inventor： LUDWIG, Dale, L. ,  PLYMATE, Stephen, R. ,  LOIZOS, Nick ,  HUBER, Jim ,  FATATIS, Alessandro

IPC: A61K38/17

CPC classification number: A61K38/17 ,  A61K39/395 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  A61K2300/00

Abstract: The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRα antagonist. The invention also provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRα, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.

Abstract translation: 本发明提供了通过施用IGF-1R拮抗剂和/或PDGFRa拮抗剂来治疗骨癌，特别是转移性骨癌的方法。 本发明还提供了结合人PDGFRa并中和受体活化的抗体。 本发明还提供了中和PDGFRa活化的方法，以及使用单独的抗生素或与其它药剂组合治疗具有肿瘤疾病的哺乳动物的方法。

公开(公告)号：WO2021262880A2

公开(公告)日：2021-12-30

申请号：PCT/US2021/038740

申请日：2021-06-23

Applicant: KADMON CORPORATION, LLC

Inventor： LU, Dan ,  POLONSKAYA, Zhanna ,  CHANG, Tzu-Pei ,  MARTOMO, Stella, A. ,  PATEL, Jeegar ,  MIYARA, Faical

IPC: A61P35/00 ,  C07K14/715 ,  C07K16/28 ,  C07K14/54 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/5443 ,  C07K14/7155 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/33 ,  C07K2319/75

Abstract: Provided herein are recombinant antibodies, antigen-binding fragments, and fusion proteins thereof useful for binding to and inhibiting programmed death 1 (PD-1), nucleic acid molecules encoding the same and therapeutic compositions thereof, as well as methods of using such antibodies, including the methods for enhancing T cell and NK cell function to increase cell and cytokine mediated immunity and methods of treatment of various immune dysfunction related disorders including cancer and infectious diseases.

公开(公告)号：WO2021118955A1

公开(公告)日：2021-06-17

申请号：PCT/US2020/063705

申请日：2020-12-08

Applicant: AGGAMIN LLC

Inventor： JOO, Woo, S. ,  LEE, Karen, M. ,  TAN, Adelene, Y. ,  DANIELS, Garrett, D. ,  KUSSIE, Paul

IPC: A61K39/395 ,  A61P9/00 ,  C07K16/28

Abstract: Disclosed are methods and apparatuses for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using ex vivo treatment with an anti-sEng antibody bound to a solid support in order to reduce blood levels of sEng. The present invention provides a method of treating or preventing a disorder associated with soluble Endoglin (sEng), such as a pregnancy-related hypertensive disorder, in a subject in need thereof comprising providing ex vivo to the subject anti-sEng antibodies or sEng-binding fragments thereof in an amount sufficient and for a time sufficient to decrease the subject's blood levels of sEng to treat or prevent the disorder associated with sEng in the subject.

公开(公告)号：WO2018161053A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/020795

申请日：2018-03-02

Applicant: MEIRAGTX, UK II LIMITED

Inventor： GUO, Xuecui

IPC: C12N15/113 ,  C12N15/11 ,  C12N15/115 ,  C12N15/63 ,  C12N15/86 ,  C12N15/67 ,  C12N15/861 ,  C12P19/34

Abstract: The present disclosure provides polynucleotide constructs for the modulation of target gene expression by aptamer-mediated ribonuclease cleavage of the target gene RNA and methods of using the constructs to modulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The polynucleotide constructs contains a ribonuclease substrate sequence (e.g., an RNase P substrate) and a riboswitch comprising an effector region and an aptamer such that when the aptamer binds a ligand, target gene expression occurs.

公开(公告)号：WO2018005712A1

公开(公告)日：2018-01-04

申请号：PCT/US2017/039846

申请日：2017-06-28

Applicant: GENEIUS BIOTECHNOLOGY, INC.

Inventor： SLANETZ, Alfred, E. ,  NAKAGAWA, Terry, Y. ,  HERRMAN, Marissa, A.

IPC: C12N5/078 ,  C12N5/0783 ,  C12N5/0786 ,  C07K14/54 ,  C07K14/55 ,  A61K35/17

Abstract: The invention relates to compositions comprising a heterogeneous population of T cells with reactivity to selected antigens that are useful for adoptive immunotherapy and methods for making the T cell compositions.

Abstract translation: 本发明涉及包含对选择的抗原具有反应性的异源T细胞群的组合物，其用于过继免疫治疗和制备T细胞组合物的方法。

公开(公告)号：WO2017136608A3

公开(公告)日：2017-08-10

申请号：PCT/US2017/016303

申请日：2017-02-02

Applicant: MEIRAGTX UK II LIMITED ,  MEIRAGTX, LLC

Inventor： VOLLES, Michael, J. ,  DANOS, Olivier, F. ,  BOYNE, Alex, K. ,  ZENNOU, Veronique ,  GUO, Xuecui

IPC: C12Q1/68 ,  C07H21/04 ,  C12P19/34 ,  C07H21/02 ,  C12N15/63 ,  C12N15/10

Abstract: The invention provides polynucleotide constructs for the regulation of gene expression by aptamer-based modulation of self-cleaving ribozymes and methods of using the constructs to regulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The invention further provides methods for making and using riboswitches that decrease target gene expression in response to an aptamer ligand as well as riboswitches that increase target gene expression in response to an aptamer ligand.

公开(公告)号：WO2017136562A3

公开(公告)日：2017-08-10

申请号：PCT/US2017/016230

申请日：2017-02-02

Applicant: KADMON CORPORATION, LLC

Inventor： ZHU, Zhenping ,  LU, Dan

IPC: A61K39/395 ,  C07K16/22 ,  C07K16/28

Abstract: Provided are bispecific binding proteins such as bispecific antibodies that bind to both human PD-L1 and human KDR. The bispecific binding proteins are useful for treating diseases and conditions characterized by immunosuppression and/or excessive angiogenesis.

公开(公告)号：WO2016210331A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/039370

申请日：2016-06-24

Applicant: KADMON CORPORATION, LLC

Inventor： OLSZEWSKI, Kellen ,  POYUROVSKY, Masha ,  BARSOTTI, Anthony ,  KIM, Ji-In ,  LIU, Kevin ,  MORRIS, Koi

IPC: C07D239/70 ,  A61K31/4155 ,  A61K31/505 ,  C07D231/16

CPC classification number: A61K31/5377 ,  A61K31/519 ,  A61K31/52 ,  C07D231/16 ,  C07D239/70 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D491/048 ,  C07D491/052 ,  C07D495/04 ,  C07D513/04 ,  Y02A50/409 ,  Y02A50/411

Abstract: Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

Abstract translation: 提供治疗哺乳动物感染性疾病的方法，其包括施用抑制葡萄糖摄取的化合物。 可能治疗的特殊传染病包括疟疾，利什曼病，非洲锥虫病，结核病，艾滋病毒，HCMV或疱疹病毒。 在第一方面，本发明的特征在于一种治疗哺乳动物感染性疾病的方法，包括向有需要的哺乳动物受试者施用治疗有效量的所述化合物或前药的化合物或前药，或其药学上可接受的盐或酯， 其中所述化合物是葡萄糖吸收的抑制剂。

公开(公告)号：WO2015013317A1

公开(公告)日：2015-01-29

申请号：PCT/US2014/047674

申请日：2014-07-22

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： SAMPSON, Nicole, S. ,  TAN, Li ,  PARKER, Kathlyn

IPC: C08F299/02 ,  A61K31/74 ,  C08F4/80 ,  C08F232/04

CPC classification number: C08G61/08 ,  A61K9/1075 ,  A61K31/74 ,  A61K47/32 ,  A61K47/58 ,  A61K47/59 ,  C08F232/04 ,  C08G61/12 ,  C08G61/128 ,  C08G2261/124 ,  C08G2261/126 ,  C08G2261/1424 ,  C08G2261/1426 ,  C08G2261/1428 ,  C08G2261/143 ,  C08G2261/1432 ,  C08G2261/145 ,  C08G2261/146 ,  C08G2261/148 ,  C08G2261/149 ,  C08G2261/226 ,  C08G2261/228 ,  C08G2261/418 ,  C08G2261/74 ,  C09D5/1637 ,  C09D165/00 ,  A61K2300/00

Abstract: The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. To demonstrate, polymers were synthesized and modified with a FRET pair (Trp/ Dansyl) post-polymerization.

Abstract translation: 本发明涉及聚合物和烯烃聚合领域，更具体地涉及烯烃易位聚合。 本发明提供区域性交替聚合物和合成这种聚合物的方法。 为了证明，聚合物被合成并用FRET对（Trp / Dansyl）后聚合改性。