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    COMPUTER PROGRAM PRODUCTS, SYSTEMS AND METHODS FOR INFORMATION DISCOVERY AND RELATIONAL ANALYSES
    71.
    发明申请
    COMPUTER PROGRAM PRODUCTS, SYSTEMS AND METHODS FOR INFORMATION DISCOVERY AND RELATIONAL ANALYSES 审中-公开
    计算机程序产品，信息发现和关系分析的系统和方法

    公开(公告)号：WO2004027706A1

    公开(公告)日：2004-04-01

    申请号：PCT/US2003/029042

    申请日：2003-09-19

    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  GARNER, Harold, R. ,  WREN, Jonathan, D.

    Inventor： GARNER, Harold, R. ,  WREN, Jonathan, D.

    IPC: G06N5/04

    CPC classification number: G06N5/022 ,  G06F19/24 ,  G06F19/28 ,  Y02A90/26

    Abstract: The present invention is a system, method for accessing domains of information to identify heretofore unknown relationships between disparate sources of data (7) to seek and obtain knowledge (18), the invention includes a source of data with one or more domains of information, an Object-Relationship Database (53) for integrating objects from one or more domains of information and a knowledge discovery engine (54) where relationships between two or more objects are identified, retrieved, grouped, ranked, filtered and numerically evaluated.

    Abstract translation: 本发明是一种用于访问信息领域的系统，方法，用于识别不同的数据源（7）之间的未知关系以寻求和获得知识（18），本发明包括具有一个或多个信息域的数据源， 用于集成来自一个或多个信息域的对象的对象关系数据库（53）和知识，检索，分组，排序，过滤和数字评估的两个或多个对象之间的关系的知识发现引擎（54）。

    PROCESS FOR PRODUCTION OF NANOPARTICLES AND MICROPARTICLES BY SPRAY FREEZING INTO LIQUID
    73.
    发明申请
    PROCESS FOR PRODUCTION OF NANOPARTICLES AND MICROPARTICLES BY SPRAY FREEZING INTO LIQUID 审中-公开
    通过喷雾冷冻成液体生产纳米颗粒和微生物的方法

    公开(公告)号：WO2002060411A2

    公开(公告)日：2002-08-08

    申请号：PCT/US2002/002894

    申请日：2002-01-30

    Applicant: BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

    Inventor： WILLIAMS, Robert, O., III ,  JOHNSTON, Keith, P. ,  YOUNG, Timothy, J. ,  ROGERS, True, L. ,  BARRON, Melisa, K. ,  YU, Zhongshui ,  HU, Jiahui

    IPC: A61K9/00

    CPC classification number: F26B5/065 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/1688 ,  A61K9/1694 ,  F25B19/005 ,  F25C1/00 ,  F25D2400/30 ,  F26B3/08

    Abstract: The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles.

    Abstract translation: 本发明提供了可以溶解的材料的微粒和纳米粒子的制造系统和方法。 本发明的系统和方法提供更快的冷冻时间，其又产生更均匀的粒度分布，较小的颗粒，具有增加的孔隙率的颗粒和颗粒组分的更加紧密的混合。 本发明的系统和方法还产生比常规方法具有更大表面积的颗粒。 本发明的一种形式提供了制备颗粒的方法。 将有效成分与水，一种或多种溶剂或其组合混合，并将所得混合物通过位于或低于低温液体水平的绝缘喷嘴喷雾。 喷雾产生冷冻颗粒。

    IMPACT INSTRUMENT
    74.
    发明申请
    IMPACT INSTRUMENT 审中-公开
    影响仪器

    公开(公告)号：WO1998017442A1

    公开(公告)日：1998-04-30

    申请号：PCT/US1997018661

    申请日：1997-10-16

    Applicant: BOARD OF REGENTS/UNIVERSITY OF TEXAS SYSTEM

    Inventor： BOARD OF REGENTS/UNIVERSITY OF TEXAS SYSTEM ,  SCHRODER, Kurt, A.

    IPC: B25G01/01

    CPC classification number: A63B49/08 ,  A63B53/14 ,  A63B60/00 ,  A63B60/06 ,  A63B60/08 ,  A63B60/10 ,  A63B60/12 ,  A63B60/54 ,  A63B2102/02 ,  A63B2102/32 ,  B25D1/00 ,  B25D1/04 ,  B25G1/01

    Abstract: An impact instrument (200) for delivering an impulse to an object. The impact instrument (200) may include an impact surface (202) for contacting the object and an elongated member (204) extending from the impact surface (202) that terminates in an end. The elongated member (204) may include a grasping region in the vicinity of the end. When the instrument is grasped within the grasping region, the center of percussion of the instrument preferably coincides with the impact surface (202). The instrument may also contain pivoting grasping member disposed on the elongated member. A cavity (212, 214, 216, 218, 220) is preferably formed between the grasping member (206) and the elongated member (204) and may contain compressible material. The grasping member (206) may rigidly contact the elongated member (204) at an ideal pivot point (208). The grasping member (206) is preferably adapted to pivot with respect to the elongated member (204) at the ideal pivot point (208). The pivoting of the grasping member (206) preferably increases the amount of impulse delivered to an object, decreases vibration experienced by the user of the instrument, and reduces counter-rotational forces imparted from the instrument to the user. The impact instrument (200) may be a hammer, ax, golf club, tennis racket, or similar device.

    Abstract translation: 一种用于将冲击传递到物体的冲击仪器（200）。 冲击仪器（200）可以包括用于接触物体的冲击表面（202）和从终止于终端的冲击表面（202）延伸的细长构件（204）。 细长构件（204）可以包括在端部附近的抓握区域。 当把持器被夹持在抓握区域内时，仪器的冲击中心优选地与冲击表面（202）重合。 仪器还可以包括设置在细长构件上的枢转抓握构件。 空腔（212,214,216,218,220）优选地形成在抓握构件（206）和细长构件（204）之间，并且可以包含可压缩材料。 抓握构件（206）可以在理想枢转点（208）处与细长构件（204）刚性接触。 抓握构件（206）优选地适于在理想枢转点（208）处相对于细长构件（204）枢转。 抓握构件（206）的枢转优选地增加输送到物体的冲击量，降低仪器用户所经历的振动，并减少从仪器向用户施加的反向旋转力。 冲击仪器（200）可以是锤子，斧头，高尔夫球杆，网球拍或类似装置。

    INHIBITORS OF DUAL LEUCINE ZIPER (DLK) KINASE FOR THE TREATMENT OF DISEASE
    77.
    发明申请
    INHIBITORS OF DUAL LEUCINE ZIPER (DLK) KINASE FOR THE TREATMENT OF DISEASE 审中-公开
    双亮氨酸拉链（DLK）激酶抑制剂用于治疗疾病

    公开(公告)号：WO2018044808A1

    公开(公告)日：2018-03-08

    申请号：PCT/US2017/048941

    申请日：2017-08-28

    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

    Inventor： SOTH, Michael, J. ,  JONES, Philip ,  RAY, James ,  LIU, Gang ,  LE, Kang ,  CROSS, Jason

    IPC: A61K31/44 ,  A61K31/4178 ,  C07D401/04

    Abstract: Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (DLK) kinase (MAP3K12), pharmaceutical compositions, and methods of treatment of DLK-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g. Alzheimer's disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia, progressive supranuclear palsy, Lewy body disease, Kennedy's disease, and other related conditions), from neuropathies resulting from neurological damage (chemotherapy -induced peripheral neuropathy, diabetic neuropathy, and related conditions) and from cognitive disorders caused by pharmacological intervention (e.g. chemotherapy induced cognitive disorder, also known as chemobrain).

    Abstract translation: 本文公开了抑制双亮氨酸拉链（DLK）激酶（MAP3K12）的激酶活性的化合物，药物组合物以及治疗DLK介导的疾病例如由创伤引起的神经疾病的方法 中枢神经系统和外周神经系统神经元损伤（例如中风，创伤性脑损伤，脊髓损伤）或由慢性神经变性疾病（例如阿尔茨海默氏病，额颞叶痴呆，帕金森病，亨廷顿病，肌萎缩侧索硬化，脊髓小脑 共济失调，进行性核上性麻痹，路易体疾病，肯尼迪氏病和其它相关病症），神经病损伤（化学疗法诱导的周围神经病，糖尿病性神经病和相关病症）和由药理学干预（例如化学疗法 诱导认知障碍，也称为化学细胞）。

    NANO/MICRO SCALE POROUS STRUCTURED ALLOYS USING SELECTIVE ALLOYING PROCESS BASED ON ELEMENTAL POWDERS
    78.
    发明申请
    NANO/MICRO SCALE POROUS STRUCTURED ALLOYS USING SELECTIVE ALLOYING PROCESS BASED ON ELEMENTAL POWDERS 审中-公开
    纳米/微米级多孔结构合金的基于元素粉末的选择性合金化工艺

    公开(公告)号：WO2018017581A1

    公开(公告)日：2018-01-25

    申请号：PCT/US2017/042619

    申请日：2017-07-18

    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

    Inventor： HU, Yingbin ,  LI, Jianzhi

    IPC: B22F1/00 ,  B22F3/00 ,  B22F3/105

    Abstract: A method of forming titanium boron alloys includes forming a mixture of elemental titanium with elemental boron and heating the mixture with a laser, wherein a power level of the laser is set such that reaction of the elemental titanium with the elemental boron to form a titanium-boron alloy is initiated and self-sustaining.

    Abstract translation: 形成钛硼合金的方法包括形成元素钛与元素硼的混合物并用激光加热该混合物，其中激光的功率水平被设定为使得元素钛与 元素硼形成钛 - 硼合金开始并自我维持。

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