公开(公告)号：WO2005005596A3

公开(公告)日：2005-01-20

申请号：PCT/IB2004/002237

申请日：2004-07-09

Applicant: CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI ,  GUANGDONG CENTER FOR DISEASE CONTROL AND PREVENTION ,  GUANGZHOU CENTER FOR DISEASE CONTROL AND PREVENTION ,  CHANGCHUN UNVERSITY OF AGRICULTURE AND ANIMAL SCIENCES ,  RUIJIN HOSPITAL AFFILIATED TO SHANGHAI SECOND MEDICAL UNIVERSITY ,  SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES ,  NANFANG HOSPITAL, FIRST MEDICAL UNIVERSITY OF PLA ,  GUANGDONG J-TECH SCIENCE DEVELOPMENT CO. LTD. ,  SECOND AFFILIATED HOSPITAL OF SUN YET-SEN UNIVERSITY ,  ZHAO, Guoping ,  XU, Rui, Heng ,  WU, Xinyan ,  TU, Cheng ,  SONG, Huai-Dong ,  LI, YiHong ,  HOU, Jinlin ,  XU, Jun ,  MIN, Jun

Inventor： ZHAO, Guoping ,  XU, Rui, Heng ,  WU, Xinyan ,  TU, Cheng ,  SONG, Huai-Dong ,  LI, YiHong ,  HOU, Jinlin ,  XU, Jun ,  MIN, Jun

IPC: C12Q1/68

Abstract: Severe Acute Respiratory Syndrome ("SARS") is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant evidence suggesting that the coronavirus responsible for the disease ("SARS-CoV") evolves during an outbreak, there is currently little data on the earliest strains of this coronavirus. The present invention is directed to the characterization of the genomic RNA sequences of these earliest SARS coronaviruses, to the identification of nucleotide positions within the SARS-CoV genomic RNA that are characteristic of the different evolutionary stages of the coronavirus, to kits based on these positions for use in diagnosis of the disease in patients, and for the development of vaccines to the disease based on the lowered virulence and contagiousness of these earliest strains of SARS-CoV.

公开(公告)号：WO2004089284A2

公开(公告)日：2004-10-21

申请号：PCT/US2004/010059

申请日：2004-04-01

Applicant: INTRADIGM CORPORATION ,  LU, Patrick, Y. ,  XIE, Frank, Y. ,  WOODLE, Martin, C. ,  LIU, Yijia ,  TANG, Quinn T. ,  XU, Jun

Inventor： LU, Patrick, Y. ,  XIE, Frank, Y. ,  WOODLE, Martin, C. ,  LIU, Yijia ,  TANG, Quinn T. ,  XU, Jun

IPC: A61K

CPC classification number: C12Q1/6886 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/475 ,  C07K14/71 ,  C07K16/30 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/12 ,  C12Q2600/112 ,  G01N33/57407 ,  G01N2500/00

Abstract: The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.

Abstract translation: 本发明涉及通过分别通过上调，沉默和/或下调基因如EGFR-RP，TRA1，MFGE8，TNFSF13和ZFP236来操纵靶基因表达来治疗癌症的方法。 该方法可用于通过增强作为靶标的基因（例如ICT1030）的蛋白质，肽药物和基因治疗方式的表达来治疗癌症和/或抑制肿瘤生长; 或通过RNA干扰来沉默和/或下调诸如针对抗体，小分子和其他抑制剂药物形态验证的ICT1024，ICT1025和ICT1031和ICB1003的靶标。

公开(公告)号：WO2004013310A3

公开(公告)日：2004-08-26

申请号：PCT/US0324587

申请日：2003-08-06

Applicant: INTRADIGM CORP ,  SCARIA PUTHUPPARAMPIL V ,  WOODLE MARTIN C ,  LU PATRICK Y ,  TANG QINGQUAN ,  XU JUN ,  XIE FRANK Y

Inventor： SCARIA PUTHUPPARAMPIL V ,  WOODLE MARTIN C ,  LU PATRICK Y ,  TANG QINGQUAN ,  XU JUN ,  XIE FRANK Y

IPC: C12N15/09 ,  A61K9/08 ,  A61K9/10 ,  A61K31/7105 ,  A61K35/76 ,  A61K47/34 ,  A61K47/42 ,  A61K48/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00 ,  C12N15/11 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34 ,  C12Q1/68

CPC classification number: A61K48/00 ,  C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/3513 ,  C12N2310/53 ,  C12N2320/32

Abstract: Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.

Abstract translation: 提供了通过RNA干扰在体内下调靶基因表达的方法和组合物。 该方法可用于基于基因的药物开发和人类疾病治疗的靶发现和验证。

公开(公告)号：WO9963942A3

公开(公告)日：2000-02-03

申请号：PCT/US9912935

申请日：1999-06-09

Applicant: UNIV ARIZONA STATE ,  PETTIT GEORGE R ,  XU JUN PING

Inventor： PETTIT GEORGE R ,  XU JUN-PING

IPC: A61K31/7028 ,  A61P35/00 ,  C07H15/04 ,  A01N43/04 ,  C07H15/00

CPC classification number: C07H15/04

Abstract: A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge agelas sp. led to isolation of a trace (7.42 x 10 % yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 mu g/ml to ovary OVCAR-3 GI50 2.8 mu g/ml) designated agelagalastatin (6). Agelagalastatin is the first example of a natural product containing a digalactofuranosyl unit.

Abstract translation: 一项人类癌细胞系生物测定指导性研究的西太平洋海绵as as 导致称为阿格列他他汀（6）的痕量（7.42×10 -6％产率）癌细胞生长抑制剂（肺NCI-H460 GI500.77μg/ ml至卵巢OVCAR-3 GI502.8μg/ ml）。 阿格列他汀是含有二氢呋喃糖基单元的天然产物的第一个例子。

公开(公告)号：WO2020132848A1

公开(公告)日：2020-07-02

申请号：PCT/CN2018/123344

申请日：2018-12-25

Applicant: INTEL CORPORATION ,  HOU, Chunyuan ,  LIANG, Ke ,  XU, Jun ,  LI, Si

Inventor： HOU, Chunyuan ,  LIANG, Ke ,  XU, Jun ,  LI, Si

IPC: G11C16/14

Abstract: A storage array includes multiple wordlines of storage cells that can be selectively charged to an erase voltage or an inhibit voltage. Control logic associated with the storage array can perform erase verify in stages. On a first erase verify pass, the control logic can set wordlines of an erase block or subblock to a first erase voltage. On a second erase verify pass, the control logic can trigger a second erase verify pulse and set passing wordlines to an inhibit voltage, and failing wordlines to a second erase voltage higher than the first voltage. Inhibiting the already passing wordlines can reduce threshold voltage differences among the wordlines.

公开(公告)号：WO2015009676A1

公开(公告)日：2015-01-22

申请号：PCT/US2014/046624

申请日：2014-07-15

Applicant: SONY CORPORATION ,  AUYEUNG, Cheung ,  XU, Jun ,  TABATABAI, Ali

Inventor： AUYEUNG, Cheung ,  XU, Jun ,  TABATABAI, Ali

IPC: H04N7/12

CPC classification number: H04N19/162 ,  H04N19/103 ,  H04N19/172 ,  H04N19/33 ,  H04N19/70

Abstract: An extension to the motion-constrained tile sets SEI message provides functionality to signal all tiles are independently decodable and to signal the ROIs that may have more than one tile per ROI. With this extension, the functionality to redefine any independently decodable region-of-interest in a CVS at a coding tree unit level based on user interactivity is enabled. The extension supports the interactivity utilized in various applications such as interactive Ultra High Definition Television (UHDTV), dynamic high-quality zoom-in application, interactive on-demand, e-learning, smart surveillance and many other applications. Additionally, the temporal MCTS SEI message is able to be used by an encoder for tiled streaming to signal explicitly to the decoder that the decoder need only to display the ROI.

Abstract translation: 运动限制瓦片组SEI消息的扩展提供了信号的功能，所有的瓦片都是可独立解码的，并且向每个ROI可能具有多于一个瓦片的ROI进行信号发送。 通过这种扩展，启用了基于用户交互性在编码树单元级别重新定义CVS中任何可独立解码的感兴趣区域的功能。 该扩展支持在各种应用中使用的交互性，例如交互式超高清晰度电视（UHDTV），动态高品质放大应用，交互式点播，电子学习，智能监控和许多其他应用。 此外，时间MCTS SEI消息能够被编码器用于平铺流，以明确地向解码器通知解码器仅需要显示ROI。

公开(公告)号：WO2014190498A1

公开(公告)日：2014-12-04

申请号：PCT/CN2013/076348

申请日：2013-05-28

Applicant: THOMSON LICENSING ,  ZHANG, Yanfeng ,  SHI, Yuntao ,  XU, Jun

Inventor： ZHANG, Yanfeng ,  SHI, Yuntao ,  XU, Jun

IPC: H04L12/24

CPC classification number: H04L67/42 ,  G06F11/3068 ,  G06F11/3419 ,  G06F11/3438 ,  G06F2201/865 ,  H04L67/34

Abstract: An application ranking calculating apparatus is configured to calculate ranking for an application based on usage information from client computers on which the application is adapted to operate, the usage information representing how the application is actually used in the client computers.

Abstract translation: 应用排名计算装置被配置为基于来自应用于其上运行的客户端计算机的使用信息来计算应用的排名，所述使用信息表示应用在客户端计算机中的实际应用。

公开(公告)号：WO2014091451A2

公开(公告)日：2014-06-19

申请号：PCT/IB2013060886

申请日：2013-12-12

Applicant: XU JUN

Inventor： XU JUN ,  MA RUZHENG

IPC: E01C1/00

CPC classification number: E01C1/00 ,  G07B15/06

Abstract: The present invention relates to the design of a multi-layered highway toll station. Specifically, the present invention relates to the optimization of the layout of each layer of toll lanes in a multi-layered highway toll station. Adjustment of the barrier configurations between each toll area allows for: the prompt creation of a new temporary high-speed lane when an accident occurs in a high-speed lane; and a temporary change to the direction in which tolls are collected in some toll areas, so as to adapt to heavy traffic flows.

Abstract translation: 本发明涉及多层高速公路收费站的设计。 具体地说，本发明涉及多层高速公路收费站各层收费线路布局的优化。 每个收费区之间的障碍物配置的调整允许：在高速车道发生事故时迅速创建新的临时高速车道; 并对一些收费区域收费的方向进行暂时的改变，以适应繁忙的交通流量。

公开(公告)号：WO2014089787A1

公开(公告)日：2014-06-19

申请号：PCT/CN2012/086469

申请日：2012-12-12

Applicant: XU, Jun

Inventor： XU, Jun ,  MA, Ruzheng ,  MAXU, Lulu

IPC: E01C1/00

CPC classification number: E01C1/00 ,  G07B15/06

Abstract: Conventional freeway toll stations are usually single-layered, and cannot allocate too many toll booths in a row. This invention is intended to accommodate enough toll booths within limited space in order to increase the capacity of a toll station. The solution is a multi-layered toll station, wherein 2, 3, 4, 5, 6, 7, 8, 9 or 10 booth clusters are included in each direction, and these booth clusters are connected by straight or S-shaped barriers at the opposite ends. Toll booths in each booth cluster share same entrance passage and same exit passage. The barriers are adjustable, so that the direction of a part of or a whole cluster can be reversed.

Abstract translation: 传统的高速公路收费站通常是单层的，不能分配太多的收费站。 本发明旨在在有限的空间内容纳足够的收费站，以增加收费站的容量。 该解决方案是一个多层收费站，其中每个方向都包括2,3,4,5,6,7,8,9或10个展位组，这些展位集群通过直线或S形屏障连接在 相反的两端。 每个展台集群的收费站共享同一入口通道和同一出口通道。 屏障是可调节的，使得一部分或整个簇的方向可以颠倒。

公开(公告)号：WO2013059652A1

公开(公告)日：2013-04-25

申请号：PCT/US2012/061111

申请日：2012-10-19

Applicant: SONY CORPORATION ,  AUYEUNG, Cheung ,  XU, Jun

Inventor： AUYEUNG, Cheung ,  XU, Jun

IPC: G06K9/00

CPC classification number: H04N19/18 ,  H04N19/13 ,  H04N19/157 ,  H04N19/91

Abstract: Reducing contexts of a significance map includes merging some of the adjacent partitions of the higher frequency transform coefficients into one partition so that the significance of the coefficients in a merged partition are encoded with the same contexts. To reduce the impact of merging on coding efficiency of 4 x 4 blocks, the partitions of the lower frequency AC components of 4 x 4 blocks are not merged. To reduce the impact of merging on coding efficiency, the DC component is not merged with any AC component.

Abstract translation: 减少重要性映射的上下文包括将较高频率变换系数的一些相邻分区合并成一个分区，使得合并分区中的系数的重要性用相同的上下文进行编码。 为了减少合并4×4块编码效率的影响，4×4块的较低频率AC分量的分区不会合并。 为了减少合并对编码效率的影响，DC组件不会与任何AC组件合并。