公开(公告)号：WO2012034037A3

公开(公告)日：2013-05-02

申请号：PCT/US2011051031

申请日：2011-09-09

Applicant: HAMILTON STORAGE TECHNOLOGIES INC ,  COLLINS SCOTT ,  HUNT FRANK ,  WARHURST JULIAN ,  ZANDI BRUCE

Inventor： COLLINS SCOTT ,  HUNT FRANK ,  WARHURST JULIAN ,  ZANDI BRUCE

IPC: F25D25/00 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N35/04 ,  A01N1/0236 ,  A01N1/0252 ,  B01L7/50 ,  B01L9/06 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2300/021 ,  B01L2300/04 ,  B65G1/00 ,  F17C3/085 ,  F25D25/00 ,  F25D25/04 ,  G01N1/42 ,  G01N35/0099 ,  G01N2035/00346 ,  G01N2035/00435 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0462

Abstract: An automated storage and retrieval system for storing chemical and biological samples includes freezer chests maintained at an ultra-low temperature (e.g. -80°C) or a cryogenic temperature. The freezer chests are located within a refrigerated (e.g. -20°C) enclosure (10). Samples are loaded through a wall of the enclosure and are then transferred to an input/output buffer section (38) in an ultra-low temperature or cryogenic freezer chest (11) that is thermally segregated (40) from a long-term storage section (36) in the same freezer. Specialized input/output cassettes are used for transferring the samples through an input/output module (14) into the system.

Abstract translation: 用于存储化学和生物样品的自动化存储和检索系统包括保持在超低温（例如-80℃）或低温温度的冷冻箱。 冷冻箱位于冷藏（例如-20℃）的外壳（10）内。 样品通过外壳的壁装载，然后转移到超低温或低温冷冻箱（11）中的输入/输出缓冲部分（38），该冷冻箱（11）从长期储存部分（40）热分离（40） （36）在同一个冷柜。 专用输入/输出盒用于将样品通过输入/输出模块（14）传送到系统中。

公开(公告)号：WO2012034037A2

公开(公告)日：2012-03-15

申请号：PCT/US2011/051031

申请日：2011-09-09

Applicant: HAMILTON STORAGE TECHNOLOGIES, INC. ,  COLLINS, Scott ,  HUNT, Frank ,  WARHURST, Julian ,  ZANDI, Bruce

Inventor： COLLINS, Scott ,  HUNT, Frank ,  WARHURST, Julian ,  ZANDI, Bruce

IPC: F25D25/00

CPC classification number: G01N35/04 ,  A01N1/0236 ,  A01N1/0252 ,  B01L7/50 ,  B01L9/06 ,  B01L2200/026 ,  B01L2200/04 ,  B01L2300/021 ,  B01L2300/04 ,  B65G1/00 ,  F17C3/085 ,  F25D25/00 ,  F25D25/04 ,  G01N1/42 ,  G01N35/0099 ,  G01N2035/00346 ,  G01N2035/00435 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0462

Abstract: An automated storage and retrieval system for storing chemical and biological samples includes freezer chests maintained at an ultra-low temperature (e.g. -80°C) or a cryogenic temperature. The freezer chests are located within a refrigerated (e.g. -20°C) enclosure. Samples are loaded through a wall of the enclosure and are then transferred to an input/output buffer section in an ultra-low temperature or cryogenic freezer chest that is thermally segregated from a long-term storage section in the same freezer. Specialized input/output cassettes are used for transfemng the samples through an input/output module into the system.

Abstract translation: 用于存储化学和生物样品的自动化存储和检索系统包括保持在超低温（例如-80℃）或低温温度的冷冻箱。 冷藏柜位于冷藏（例如-20°C）的外壳内。 样品通过外壳的壁装载，然后转移到超低温或低温冷冻箱中的输入/输出缓冲区，该冷冻箱与相同冷冻箱中的长期储存部分热分离。 专用输入/输出盒用于将样品通过输入/输出模块传输到系统中。

公开(公告)号：WO2011067309A1

公开(公告)日：2011-06-09

申请号：PCT/EP2010/068682

申请日：2010-12-02

Applicant: WHATMAN INTERNATIONAL LTD ,  SHOEMAKER, Philip, Alexander ,  FINEHOUT, Erin ,  GRIFFIN, Weston, Blaine

Inventor： SHOEMAKER, Philip, Alexander ,  FINEHOUT, Erin ,  GRIFFIN, Weston, Blaine

IPC: C12M1/16 ,  G01N1/28 ,  G01N35/04

CPC classification number: G01N1/286 ,  G01N2001/288 ,  G01N2035/042

Abstract: Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.

Abstract translation: 用于冲切用于生物样品的多孔基材片的自动方法和系统，包括：将所述多孔基材装载到包括模头和开口的支撑件上; 在至少z方向上移动容器支撑件以相对于支撑件定位容器，使得容器中的开口对齐并且基本上与支撑件中的开口齐平; 致动冲压头，使冲头通过冲模，从而从多孔基材上冲出一块; 并且致动顶针以将冲压件从多孔基底支撑件推出并进入与支撑件中的开口对准的容器中。

公开(公告)号：WO2010001023A3

公开(公告)日：2010-10-07

申请号：PCT/FR2009051068

申请日：2009-06-05

Applicant: NOVILOIRE SA ,  PHILIPPON MICHEL ,  BERNAY SEBASTIEN

Inventor： PHILIPPON MICHEL ,  BERNAY SEBASTIEN

IPC: G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC classification number: B01L9/50 ,  B01L9/523 ,  B01L2200/141 ,  B25J15/0033 ,  B25J15/0042 ,  G01N35/0099 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N2035/042 ,  Y10S901/31 ,  Y10S901/36

Abstract: The clamp comprises first and second arms (76, 78) able to move relative to one another along a gripping direction (Z) between a first position of gripping, and a first position of releasing, the first biological sample holder (10). The first arm (76) comprises a first groove (98); the second arm (78) comprises a second groove (100); when the first and second arms (76, 78) are in the first release position, the first and second grooves (98, 100) are spaced apart from one another in the gripping direction (Z); when the first and second arms (76, 78) are in the first gripping position, the first and second grooves (98, 100) are brought towards one another in the gripping direction (Z) and are face to face so as to be able to hold the lateral edges (14, 16) of the biological sample holder (10), in order to grip the biological sample holder (10) by clasping the lateral edges (14, 16) in the gripping direction (Z).

Abstract translation: 该夹具包括第一和第二臂（76,78），第一和第二臂能够在第一抓握位置和第一生物样本保持器（10）释放的第一位置之间沿着抓握方向（Z）相对于彼此移动。 第一臂（76）包括第一凹槽（98）; 第二臂78包括第二凹槽100; 当第一和第二臂（76,78）处于第一释放位置时，第一和第二凹槽（98,100）在夹持方向（Z）上彼此间隔开; 当第一和第二臂76,78处于第一夹持位置时，第一和第二凹槽98,100在夹持方向Z上彼此相向并且面对面以便能够 以保持生物样本保持器（10）的侧边缘（14,16），以便通过沿着抓持方向（Z）夹住侧边缘（14,16）来夹持生物样本保持器（10）。

公开(公告)号：WO2010016860A3

公开(公告)日：2010-08-12

申请号：PCT/US2009003010

申请日：2009-05-13

Applicant: BIO MERIEUX INC ,  COLIN BRUNO ,  IAKIMOVA YANELI ,  KETSENBURG KEVIN G ,  ROBBINS DAVID M ,  BELLET STEPHANE

Inventor： COLIN BRUNO ,  IAKIMOVA YANELI ,  KETSENBURG KEVIN G ,  ROBBINS DAVID M ,  BELLET STEPHANE

IPC: B01L9/00 ,  B65G57/30 ,  C12M1/20 ,  C12M1/22

CPC classification number: C12M23/48 ,  C12M23/10 ,  G01N35/04 ,  G01N2035/042 ,  G01N2035/0425

Abstract: A holding structure for holding a plurality of culture plates (12) in a stacked arrangement includes a feature (44) for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting of the bottom culture plate from the adjacent culture plate facilitates withdrawal of the bottom culture plate from the base via a robotic plate transfer mechanism. The de-nesting feature can be entirely passive, such as ramps formed in the base of the holding structure.

Abstract translation: 用于将多个培养板（12）保持为堆叠布置的保持结构包括用于将底部培养板从其上方的板上嵌套的特征（44）。 去嵌套特征优选地是一种促使板相对于其上方的板横向移动的结构。 来自相邻培养板的底部培养板的解嵌有助于通过机器人板转移机构将底部培养板从基底中取出。 去嵌套特征可以是完全无源的，例如形成在保持结构的基部中的斜面。

公开(公告)号：WO2010016860A2

公开(公告)日：2010-02-11

申请号：PCT/US2009/003010

申请日：2009-05-13

Applicant: BIOMERIEUX, INC. ,  COLIN, Bruno ,  IAKIMOVA, Yaneli ,  KETSENBURG, Kevin, G. ,  ROBBINS, David, M. ,  BELLET, Stephane

Inventor： COLIN, Bruno ,  IAKIMOVA, Yaneli ,  KETSENBURG, Kevin, G. ,  ROBBINS, David, M. ,  BELLET, Stephane

IPC: B01L9/00 ,  C12M1/22 ,  C12M1/20

CPC classification number: C12M23/48 ,  C12M23/10 ,  G01N35/04 ,  G01N2035/042 ,  G01N2035/0425

Abstract: A holding structure for holding a plurality of culture plates in a stacked arrangement includes a feature for de-nesting the bottom culture plate from the plate above it. The de-nesting feature is preferably a structure which urges a plate to move laterally relative to the plate above it. The de-nesting of the bottom culture plate from the adjacent culture plate facilitates withdrawal of the bottom culture plate from the base via a robotic plate transfer mechanism. The de-nesting feature can be entirely passive, such as ramps formed in the base of the holding structure.

Abstract translation: 用于保持多个培养板的堆叠布置的保持结构包括用于将底部培养板从其上方的板上嵌套的特征。 去嵌套特征优选地是一种促使板相对于其上方的板横向移动的结构。 来自相邻培养板的底部培养板的解嵌有助于通过机器人板转移机构将底部培养板从基底中取出。 去嵌套特征可以是完全无源的，例如形成在保持结构的基部中的斜面。

公开(公告)号：WO2010009339A1

公开(公告)日：2010-01-21

申请号：PCT/US2009/050887

申请日：2009-07-16

Applicant: ACCURI CYTOMETERS, INC. ,  KEHRER, Aaron ,  BAIR, Nathaniel, C.

Inventor： KEHRER, Aaron ,  BAIR, Nathaniel, C.

IPC: B01L3/02

CPC classification number: G01N35/04 ,  G01N15/14 ,  G01N35/0099 ,  G01N35/1011 ,  G01N2035/042 ,  G01N2035/0494

Abstract: A plate handling system for a sampling device with a drawtube that includes a vertical actuation system that adjusts the vertical distance between the drawtube and a sample tray, a horizontal linkage system that positions a sample tray in a horizontal plane, and a drive system that drives the rotational motion of the horizontal linkage system. The horizontal linkage system includes a base arm that rotates about a base joint, and a sample arm that rotates about a sample arm joint on the base arm.

Abstract translation: 一种用于具有拉管的取样装置的板处理系统，其包括调节拉管和样品托盘之间的垂直距离的垂直致动系统，将样品盘定位在水平平面中的水平联动系统和驱动系统 水平联动系统的旋转运动。 水平联动系统包括围绕基座接头旋转的基座臂和围绕基座臂上的样品臂接头旋转的样品臂。

公开(公告)号：WO2007087183A2

公开(公告)日：2007-08-02

申请号：PCT/US2007000961

申请日：2007-01-12

Applicant: BIO RAD LABORATORIES ,  CHU DANIEL Y

Inventor： CHU DANIEL Y

IPC: E21B23/00

CPC classification number: B01L9/50 ,  B01L9/523 ,  B01L2300/0829 ,  G01N35/0099 ,  G01N35/028 ,  G01N2035/042 ,  G01N2035/0493

Abstract: A multi-well plate such as a microtiter plate is secured from its well side in a manner that corrects or compensates for any deviations of the plate base from a planar configuration. This is achieved by an apparatus that includes an array of posts with exposed tips that define a plane, a plurality of movable collets that, when appropriately actuated, seize the walls of selected wells, and a biasing means to urge the collets in a direction that forces the wells of the microtiter plate against the exposed tips of the posts.

Abstract translation: 诸如微量滴定板的多孔板从孔侧以固定或校正板基与平面构型的任何偏差的方式固定。 这通过一种装置实现，该装置包括具有限定平面的暴露尖端的柱阵列，当适当地致动时抓住选定孔的壁的多个可动夹头，以及偏压装置，以沿着 迫使微量滴定板的孔抵靠柱的露出尖端。

公开(公告)号：WO2005045749B1

公开(公告)日：2005-07-14

申请号：PCT/US2004035844

申请日：2004-10-27

Applicant: ROBODESIGN INTERNATIONAL INC ,  GANZ BRIAN L ,  MOULDS JOHN ANDREW ,  BROVOLD CHRISTOPHER T ,  JEWELL DAVID W ,  MICKLEY MANDEL W ,  ADAMS JOHN A

Inventor： GANZ BRIAN L ,  MOULDS JOHN ANDREW ,  BROVOLD CHRISTOPHER T ,  JEWELL DAVID W ,  MICKLEY MANDEL W ,  ADAMS JOHN A

IPC: B01L9/00 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G06K9/00

CPC classification number: G01N35/0099 ,  B01J2219/00315 ,  B01J2219/00322 ,  B01J2219/00328 ,  B01J2219/00707 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L9/523 ,  B01L2300/0829 ,  G01N35/028 ,  G01N2035/00752 ,  G01N2035/042 ,  G01N2035/0425

Abstract: A device and method for the automated storage and retrieval of trays holding subject matter. A computer system (105) is programmed to control a storage gantry to move the trays between a storage rack and an automated machine. In a preferred embodiment, the subject matter in the trays is a plurality of micro-well plates (125A-125F)in which microscopic crystals may be growing and the automated machine is configured to inspect and classify microscopic crystals. The automated machine has an indexing device for sequentially placing microscopic crystals in camera-view of a camera (135, 155) and a control computer is programmed to control the indexing device and to cause the camera to take images of the microscopic crystals and then transfer the images to a classifying processor where the images are classified. In a preferred embodiment, the microscopic crystals are protein crystals that have been grown in the wells of micro-well plates.

Abstract translation: 一种用于自动存储和检索保持主题的托盘的装置和方法。 计算机系统（105）被编程为控制存储机架以在存储架和自动机之间移动托盘。 在优选实施例中，托盘中的主题是多个微孔板（125A-125F），其中微晶体可能在生长，并且自动化机器被配置为检查和分类微观晶体。 自动化机器具有用于将微晶晶体顺序地放置在相机（135,155）的相机视图中的分度装置，并且控制计算机被编程以控制分度装置并使相机拍摄微晶晶体的图像，然后传送 将图像分发到分类处理器。 在优选的实施方案中，微观结晶是已经在微孔板的孔中生长的蛋白质晶体。

公开(公告)号：WO2005045749A1

公开(公告)日：2005-05-19

申请号：PCT/US2004/035844

申请日：2004-10-27

Applicant: ROBODESIGN INTERNATIONAL, INC. ,  GANZ, Brian, L. ,  MOULDS, John, Andrew ,  BROVOLD, Christopher, T. ,  JEWELL, David, W. ,  MICKLEY, Mandel, W. ,  ADAMS, John, A.

Inventor： GANZ, Brian, L. ,  MOULDS, John, Andrew ,  BROVOLD, Christopher, T. ,  JEWELL, David, W. ,  MICKLEY, Mandel, W. ,  ADAMS, John, A.

IPC: G06K9/00

CPC classification number: G01N35/0099 ,  B01J2219/00315 ,  B01J2219/00322 ,  B01J2219/00328 ,  B01J2219/00707 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L9/523 ,  B01L2300/0829 ,  G01N35/028 ,  G01N2035/00752 ,  G01N2035/042 ,  G01N2035/0425

Abstract: A device and method for the automated storage and retrieval of trays holding subject matter. A computer system (105) is programmed to control a storage gantry to move the trays between a storage rack and an automated machine. In a preferred embodiment, the subject matter in the trays is a plurality of micro-well plates (125A-125F)in which microscopic crystals may be growing and the automated machine is configured to inspect and classify microscopic crystals. The automated machine has an indexing device for sequentially placing microscopic crystals in camera-view of a camera (135, 155) and a control computer is programmed to control the indexing device and to cause the camera to take images of the microscopic crystals and then transfer the images to a classifying processor where the images are classified. In a preferred embodiment, the microscopic crystals are protein crystals that have been grown in the wells of micro-well plates.

Abstract translation:

一种用于自动存储和检索容纳主题的托盘的设备和方法。 计算机系统（105）被编程为控制存储机架以在存储机架和自动机器之间移动托盘。 在一个优选实施例中，托盘中的主题是多个微孔板（125A-125F），其中微观晶体可以在其中生长，并且自动机器被配置为检查和分类微观晶体。 自动化机器具有用于顺序地将微观晶体放置在照相机（135,155）的照相机视图中的分度装置，并且控制计算机被编程以控制分度装置并使照相机拍摄微观晶体的图像，然后转移 将图像发送到图像被分类的分类处理器。 在一个优选的实施方案中，微观晶体是已经在微孔板的孔中生长的蛋白质晶体。