公开(公告)号：WO2009110487A1

公开(公告)日：2009-09-11

申请号：PCT/JP2009/054017

申请日：2009-03-04

Applicant: 国立大学法人東京大学 ,  長野 哲雄 ,  浦野 泰照 ,  安保 真裕

Inventor： 長野 哲雄 ,  浦野 泰照 ,  安保 真裕

IPC: C07D311/82 ,  G01N31/00 ,  G01N31/22

CPC classification number: C07D311/82 ,  G01N31/22 ,  G01N2021/7786 ,  Y10T436/206664

Abstract: 　下記の式(IA)又は(IB)（R 1 は電子吸引性置換基を示し、R 2 及びR 3 は水素原子又はハロゲン原子を示し；R 4 及びR 5 は水素原子、アルキルカルボニル基、又はアルキルカルボニルオキシメチル基を示し、R 6 は水素原子又はアルキル基を示す〕で表される化合物又はその塩、及び該化合物又はその塩を含む過酸化水素測定用試薬。

Abstract translation: 公开了由式（IA）或（IB）表示的化合物[其中R 1表示吸电子取代基; R2和R3独立地表示氢原子或卤素原子; R4和R5独立地表示氢原子，烷基羰基或烷基羰氧基甲基; R6表示氢原子或烷基]或其​​盐。 还公开了用于测量过氧化氢的试剂，其包含该化合物或其盐。 （IA）（IB）

公开(公告)号：WO2005089375A3

公开(公告)日：2009-04-09

申请号：PCT/US2005008746

申请日：2005-03-14

Applicant: S S C I INC ,  CHILDS SCOTT L ,  MOUGIN PATRICIA ,  STAHLY BARBARA C

Inventor： CHILDS SCOTT L ,  MOUGIN PATRICIA ,  STAHLY BARBARA C

IPC: G01N31/00 ,  B01D9/00 ,  B01D9/02 ,  G01N21/00

CPC classification number: B01D9/00 ,  B01D9/0077 ,  C07C217/72 ,  C30B7/00 ,  Y10T436/25875

Abstract: The present disclosure relates to crystallizing a chemical substance(s) using ultrasound. Methods are provided for screening a chemical substance according to its solid forms by using ultrasound to generate new or unusual solid forms. Methods are also provided for crystallizing a chemical substance by novel techniques that include sonication. The present disclosure also relates to cocrystallization using ultrasound. Methods are provided for preparing cocrystals of an active agent and a guest by sonicating and crystallizing. Methods are also provided for screening a sample according to solid state phases (such as cocrystals and salts) and include generating a cocrystal from the sample using ultrasound.

Abstract translation: 本公开涉及使用超声波结晶化学物质。 提供了通过使用超声波来生成新的或不寻常的固体形式来根据其固体形式筛选化学物质的方法。 还提供了用于通过包括超声处理的新技术使化学物质结晶的方法。 本公开还涉及使用超声波的共结晶。 提供了通过声波和结晶来制备活性剂和客体的共晶的方法。 还提供了用于根据固态相（例如共晶和盐）筛选样品的方法，并且包括使用超声从样品中产生共晶。

公开(公告)号：WO2007140401A3

公开(公告)日：2008-12-24

申请号：PCT/US2007069963

申请日：2007-05-30

Applicant: UNIV INDIANA RES & TECH CORP ,  PREDICTIVE PHYSIOLOGY AND MEDI ,  CLEMMER DAVID E ,  KOENIGER STORMY L ,  MERENBLOOM SAMUEL I ,  VALENTINE STEPHEN J ,  NAYLOR STEPHEN

Inventor： CLEMMER DAVID E ,  KOENIGER STORMY L ,  MERENBLOOM SAMUEL I ,  VALENTINE STEPHEN J ,  NAYLOR STEPHEN

IPC: G01N33/543 ,  B01D59/44 ,  G01J1/00 ,  G01N1/00 ,  G01N21/00 ,  G01N23/00 ,  G01N30/02 ,  G01N31/00 ,  G01N31/22 ,  G01N33/00 ,  H01J49/00

CPC classification number: G01N33/50

Abstract: A method of operating an analyte separation instrument (10, 14) is provided. The instrument (10, 14) has a first gate (G1) and a second gate (G2-GF) separated by a distance. The first gate (G1) is activated to allow entrance of a packet of a mixture of analytes from an analyte source (12) therein. The packet of analytes is allowed to separate between the first and second gates (G1, G2-GF) as a function of a first analyte characteristic. The second gate (G2-GF) is activated at a plurality of successive discrete time periods after activating the first gate (G1) and before reactivating the first gate (G1) to allow passage therethrough of a corresponding plurality of discrete analyte groups separated from each of other according to the function of the first analyte characteristic.

Abstract translation: 提供了一种操作分析物分离仪（10,14）的方法。 仪器（10,14）具有分开一定距离的第一门（G1）和第二门（G2-GF）。 第一门（G1）被激活以允许来自分析物源（12）的分析物的混合物的包的入口。 允许分析物的分组作为第一分析物特征的函数在第一和第二门（G1，G2-GF）之间分离。 第二栅极（G2-GF）在激活第一栅极（G1）之后并且在重新激活第一栅极（G1）之前在多个连续的离散时间段被激活，以允许从每个栅极（G1）分离的对应的多个分立的分析物群 根据第一分析物特征的功能。

公开(公告)号：WO2008045323A3

公开(公告)日：2008-11-27

申请号：PCT/US2007021399

申请日：2007-10-08

Applicant: HEALTH RESEARCH INC ,  US GOV HEALTH & HUMAN SERV ,  MOHLER JAMES L ,  TITUS MARK ,  TOMER KENNETH

Inventor： MOHLER JAMES L ,  TITUS MARK ,  TOMER KENNETH

IPC: G01N31/00 ,  G01N33/03 ,  G01N33/26

CPC classification number: G01N33/743 ,  G01N30/724

Abstract: Provided is a method for determining the presence or amount of 5-a-dihydro-3-keto steroids (ADKSs) comprising the steps of preparing a sample for chromatographic separation, subjecting the sample to chromatographic separation, subjecting the chromatographically separated sample to atmospheric pressure photoionization (APPI), and detecting the amount of alkylated parent ions using mass spectrometry or methylated daughter ions by mass spectrometry after collisionally induced dissociation of the alkylated parent ions. Tandem mass spectrometry of ADKSs with a 6-member A ring and a 3-keto group using APPI and methanol as the alkoxy donor will produce methylated daughter ions with a mass/charge ratio of 85.0. Quantitation of this alkylated daughter ion provides a method to detect very low levels of ADKSs such as DHT. This method can also be used for the simultaneous detection of ADKSs and non-ADKSs.

Abstract translation: 本发明提供一种确定5-α-二氢-3-酮甾族化合物（ADKSs）的存在或量的方法，其包括以下步骤：制备用于色谱分离的样品，对样品进行色谱分离，使色谱分离的样品经受大气压 光离子化（APPI），并且在碰撞诱导的烷基化母离子离解之后使用质谱法检测烷基化母体离子的量或通过质谱法检测甲基化子离子。 使用APPI和甲醇作为烷氧基供体的具有6员A环和3-酮基的ADKS的串联质谱将产生质荷比为85.0的甲基化子离子。 这种烷基化子离子的定量提供了检测非常低水平的ADKS如DHT的方法。 此方法也可用于同时检测ADKS和非ADKS。

公开(公告)号：WO2008140473A2

公开(公告)日：2008-11-20

申请号：PCT/US2007/022656

申请日：2007-10-26

Applicant: POLESTAR TECHNOLOGIES, INC. ,  MICHEELS, Ronald, H. ,  SHASHIDHAR, Ranganathan ,  CARPENTER, Karen, K.

Inventor： MICHEELS, Ronald, H. ,  SHASHIDHAR, Ranganathan ,  CARPENTER, Karen, K.

IPC: G01J3/00 ,  G01N31/00

CPC classification number: G01N21/359 ,  G01J3/42 ,  G01J2003/1213 ,  G01N21/3577

Abstract: A system and method for non-invasively inspecting one or more vessels capable of transmitting IR light containing liquid is provided, which uses a near-infrared (NIR) imaging device in combination with one or two NIR light sources, a diffuser plate, and an optical wavelength selecting means is provided for selecting one or more wavelength bands. In addition, the system may further comprise a computer processing means, a computer database containing known absorbance values, and a computer application, such that the system may compare the collected spectroscopic data to known spectroscopic data, and identify the liquid contained within the inspected vessel. The inspection method of the present invention measures a transmission or reflection image of one or more vessels being inspected at one or more narrow wavelength intervals in the NIR spectral range that corresponds to a peak absorbance wavelength of water, organic liquids, and explosive compositions.

Abstract translation: 提供了一种用于非侵入性地检查一个或多个能够透射包含液体的IR光的器皿的系统和方法，其使用近红外（NIR）成像器件与一个或两个NIR光 源，扩散板和光波长选择装置，用于选择一个或多个波长带。 此外，该系统可以进一步包括计算机处理装置，含有已知吸光度值的计算机数据库和计算机应用程序，使得该系统可以将收集的光谱数据与已知的光谱数据进行比较，并且识别包含在被检查的容器内的液体 。 本发明的检查方法在NIR光谱范围内的一个或多个窄波长间隔处测量一个或多个被检查的容器的透射或反射图像，其对应于水，有机液体和爆炸性组合物的峰值吸收波长。 / p>

公开(公告)号：WO2008066672A3

公开(公告)日：2008-10-02

申请号：PCT/US2007023429

申请日：2007-11-06

Applicant: BETH ISRAEL HOSPITAL ,  OETTGEN PETER ,  RIGBY ALAN ,  LIBERMANN TOWIA

Inventor： OETTGEN PETER ,  RIGBY ALAN ,  LIBERMANN TOWIA

IPC: G01N33/48 ,  G01N31/00 ,  G06G7/48 ,  G06G7/58

CPC classification number: C40B30/02

Abstract: The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target transcription factor and/or proteins downstream of this target protein comprises the screening of small molecule libraries using in silico high throughput docking for candidate small molecules/agents that are selectively identified for their ability to target and disrupt the transcription factor-DNA interface through unique transcription factor and/or DNA descriptors that are defined within a pharmacophore, and then testing/evaluating the candidate agents identified above through one or more in vitro assays for their ability to modulate transcription factor function including expression of this target protein and/or proteins that are downstream of the target transcription factor.

Abstract translation: 本发明涉及鉴定能够调节转录因子功能的小分子候选试剂的方法，使得该靶标蛋白下游的靶转录因子和/或蛋白质的功能/表达包括使用计算机内高通量筛选小分子文库 通过独特的转录因子和/或在药效团中定义的DNA描述子选择性鉴定其靶向和破坏转录因子-DNA界面的能力的候选小分子/试剂的对接，然后测试/评估上述鉴定的候选试剂 通过一种或多种体外测定其调节转录因子功能的能力，包括该靶标蛋白和/或靶转录因子下游的蛋白的表达。

公开(公告)号：WO2008001833A8

公开(公告)日：2008-09-25

申请号：PCT/JP2007062965

申请日：2007-06-28

Applicant: SAKURA COLOR PROD CORP ,  SANO KYOKO ,  INOUE HIROSHI

Inventor： SANO KYOKO ,  INOUE HIROSHI

IPC: G01N31/00 ,  G01N21/78 ,  G01N31/22

CPC classification number: G01N31/224

Abstract: An ink composition and method by which dissolved ozone which can be contained in a liquid to be examined can be more easily detected/determined with higher certainty. The method, which is for detecting dissolved ozone contained in a liquid to be examined, comprises (1) a step in which an ink composition for dissolved-ozone detection comprising at least one water-soluble dye selected among anthraquinone dyes, azo dyes, methine dyes, oxazine dyes, triarylmethane dyes, and xanthene dyes and water is dropped into the liquid to be examined and (2) a step in which the ink composition dropped is examined for a color change.

Abstract translation: 可以更容易地检测/确定可以包含在待检液体中的溶解臭氧的墨组合物和方法。 用于检测待检液体中含有的溶解臭氧的方法包括（1）一种用于溶解 - 臭氧检测的油墨组合物，该组合物包含至少一种选自蒽醌染料，偶氮染料，次甲基 染料，恶嗪染料，三芳基甲烷染料和x吨染料和水滴入待检液体中，和（2）检查墨滴组合物的颜色变化。

公开(公告)号：WO2008011387B1

公开(公告)日：2008-09-18

申请号：PCT/US2007073625

申请日：2007-07-16

Applicant: BIO RAD LABORATORIES ,  CARVER FRANKLIN J ,  GRANIER LORRAINE

Inventor： CARVER FRANKLIN J ,  GRANIER LORRAINE

IPC: G01N31/00 ,  G01N33/48

CPC classification number: G01N33/96 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/107497 ,  Y10T436/200833 ,  Y10T436/25 ,  Y10T436/2525

Abstract: Red blood cells from a vertebrate are treated to make them effective components of a hematology control, allowing the control to be used for detecting all blood cell components, including white blood cells and platelets. The treatment includes the use of a fixative under limited conditions of concentration and exposure time, and the resulting red blood cells are stable but lysable in a hematology instrument and have a reduced tendency to form particulates.

公开(公告)号：WO2008097892A3

公开(公告)日：2008-08-14

申请号：PCT/US2008/052894

申请日：2008-02-04

Applicant: BIOKIT, S.A. ,  TALMER, Mark ,  DAHLSTROM, Paul

Inventor： TALMER, Mark ,  DAHLSTROM, Paul

IPC: G01N21/00 ,  G01N31/00 ,  G01N33/00

Abstract: An apparatus and methods for dispensing sample holders for use in an automated sample analyzer is disclosed herein. The apparatus for dispensing sample holders includes a rotating carousel for housing stack of sample holders. Stacks of sample holders from the rotating carousel are fed into a chute where sample holders contact a set of rotating members having helical threads thereon. The helically threaded rotating members engage the sample containers and separate each sample holder from the remaining sample holders in the stack by rotation of the helically threaded rotating members. The sample holder can then be transferred for use in an automated sample analyzer.

公开(公告)号：WO2008093722A1

公开(公告)日：2008-08-07

申请号：PCT/JP2008/051388

申请日：2008-01-30

Applicant: アークレイ株式会社 ,  米原 聡 ,  稲村 範郎

Inventor： 米原 聡 ,  稲村 範郎

IPC: G01N31/00 ,  G01N21/78 ,  G01N31/22

CPC classification number: G01N31/22 ,  C09B11/08 ,  C09B21/00 ,  C09B29/103 ,  C09B29/366 ,  C09B67/0033 ,  C09B67/0041 ,  C09B67/0089 ,  G01N21/78 ,  G01N2021/7783 ,  Y10T436/141111 ,  Y10T436/145555

Abstract: 　フェノチアジン誘導体色素を、最大吸収を示す波長より長波長側でも検出することを可能とするフェノチアジン誘導体色素検出方法を提供する。フェノチアジン誘導体色素を含む反応系に、5-ヒドロキシ-１-(4-スルホフェニル)-4-(4-スルホフェニルアゾ)ピラゾール-3-カルボン酸塩、6-ヒドロキシ-5-(4-スルホフェニルアゾ)-2-ナフタレンスルホン酸塩、3-ヒドロキシ-4-(4-スルホナフチルアゾ)-2，7-ナフタレンジスルホン酸塩、7-ヒドロキシ-8-(4-スルホナフチルアゾ)-1，3-ナフタレンジスルホン酸塩、3’，6’-ジヒドロキシ-2’，4’，5’，7’-テトラヨードスピロ[イソベンゾフラン-1(3H），9’-(9H)キサンテン]-3-オン塩、3’，6’－ジヒドロキシ-2’，4’，5’，7’-テトラブロモ-4，5，6，7，-テトラクロロスピロ[イソベンゾフラン-1（3H），9’-[9H］キサンテン]-3-オン塩、4，5，6，7-テトラクロロ-3’，6’-ジヒドロキシ-2’，4’，5’，7’-テトラヨードスピロ[イソベンゾフラン-1（3H），9’-［9H］キサンテン]-3-オン塩またはフラボノイド系色素を添加した後、波長610～730ｎｍにおける吸光度測定によりフェノチアジン誘導体色素を検出する。

Abstract translation: 公开了一种吩噻嗪衍生物染料检测方法，其能够在比出现最大吸收峰的波长更长的波长处检测吩噻嗪衍生物染料。 加入含有吩噻嗪衍生物染料的反应体系，加入5-羟基-1-（4-磺基苯基）-4-（4-磺苯基偶氮）吡唑-3-羧酸盐，6-羟基-5-（4-磺苯基偶氮） -2-萘磺酸盐，3-羟基-4-（4-磺基萘基偶氮）-2,7-萘二磺酸盐，7-羟基-8-（4-磺基萘基偶氮）-1,3-萘二磺酸盐，3' 6'-二羟基-2'，4'，5'，7'-四碘螺[异苯并呋喃-1（3H），9' - （9H）呫吨] -3-酮盐，3'，6'-二羟基-2' ，4'，5'，7'-四溴-4,5,6,7-四氯螺[异苯并呋喃-1（3H），9' - [9H]呫吨] -3-酮盐， 7-四氯-3'，6'-二羟基-2'，4'，5'，7'-四碘螺[异苯并呋喃-1（3H），9'- [9H-]呫吨] -3-酮盐或类黄酮染料 。 随后，通过测量反应体系在610至730nm波长处的吸光度来检测吩噻嗪衍生物染料。