公开(公告)号：WO2010096657A1

公开(公告)日：2010-08-26

申请号：PCT/US2010/024742

申请日：2010-02-19

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  LO, Ying-Cheng ,  VISHNOI, Rohit

Inventor： LO, Ying-Cheng ,  VISHNOI, Rohit

IPC: A61M1/28

CPC classification number: A61M1/28 ,  A61M1/285 ,  A61M1/288

Abstract: A peritoneal dialysis method includes (i) connecting smaller and larger supply containers to a junction, the smaller and larger supply bags both full of dialysate; (ii) allowing the junction to be connected to a patient's transfer set; allowing the patient to drain through the junction; (iii) allowing the patient to fill from the smaller supply container; and (iv) allowing the patient to refill the smaller supply container from the larger supply container.

Abstract translation: 腹膜透析方法包括（i）将较小和较大的供应容器连接到交界处，较小和较大的充满透析液的供应袋; （ii）允许接头连接到患者的转移组件; 允许患者通过交界处排出; （iii）允许患者从较小的供应容器中填充; 和（iv）允许患者将更小的供应容器从较大的供应容器中重新填充。

公开(公告)号：WO2010096299A1

公开(公告)日：2010-08-26

申请号：PCT/US2010/023551

申请日：2010-02-09

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  FLANAGAN, Craig, T. ,  HURST, William, S. ,  SHEU, Lien-lung ,  BLOCK, Thomas, A. ,  WU, Haiming

Inventor： FLANAGAN, Craig, T. ,  HURST, William, S. ,  SHEU, Lien-lung ,  BLOCK, Thomas, A. ,  WU, Haiming

IPC: A61M16/10 ,  A61M16/18

CPC classification number: A61M16/104 ,  A61M11/04 ,  A61M16/0093 ,  A61M16/04 ,  A61M16/0833 ,  A61M16/1045 ,  A61M16/18 ,  A61M16/22 ,  A61M2016/1035 ,  A61M2202/0208 ,  A61M2202/03 ,  A61M2205/123 ,  A61M2205/505 ,  A61M2230/437 ,  A61M2202/0007

Abstract: A therapy utilizing inhaled anesthetic agents (such as desflurane, sevoflurane, isoflurane, or xenon) for the sedation of patients outside of the immediate perioperative space such as in the medical intensive care unit (MlCU) and the surgical intensive care unit (SlCU). The therapy includes controlled delivery of volatile anesthetic agents to patients undergoing ventilatory support on an ICU ventilator (12) over extended periods of time. A system (10) which provides for the delivery of anesthetic agents includes an anesthetic agent vaporizer element (14), an anesthetic agent reflector (18), and a plug-in cassette (16) which contains both a cartridge (20) housing liquid phase volatile anesthetic agent and an anesthetic (LA) vapor scrubbing medium (S).

Abstract translation: 使用吸入麻醉剂（如地氟烷，七氟烷，异氟烷或氙气）治疗立即围手术期外的患者镇静的疗法，如医疗重症监护病房（MlCU）和手术重症监护室（SlCU）。 该疗法包括在长时间在ICU通气机（12）上经受通气支持的患者控制递送挥发性麻醉剂。 提供麻醉剂递送的系统（10）包括麻醉剂蒸发器元件（14），麻醉剂反射器（18）和插入式盒（16），其插入容纳液体的盒（20） 相位挥发性麻醉剂和麻醉（LA）蒸气洗涤介质（S）。

公开(公告)号：WO2010059959A2

公开(公告)日：2010-05-27

申请号：PCT/US2009/065367

申请日：2009-11-20

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  LO, Ying-Cheng ,  DING, Yuanpang Samuel

Inventor： LO, Ying-Cheng ,  DING, Yuanpang Samuel

IPC: A61M1/28 ,  B01D61/32

CPC classification number: A61M1/28 ,  A61M39/20 ,  A61M2205/10 ,  A61M2205/12 ,  A61M2205/121 ,  A61M2205/505 ,  A61M2205/7536

Abstract: A medical fluid or dialysis system includes an auto-connection mechanism that connects connectors from the supply bags to dialysis cassette ports or cassette supply lines. The system provides for multiple, e.g., four, supply bags, which can be connected to a manifold of the auto-connection mechanism. Tip protecting caps that protect the supply line ends and cassette ports or cassette supply line ends are made to be compatible with the auto-connection mechanism. The auto-connection mechanism removes all the caps and connects the supply lines to the cassette. At least one roller occluder is provided that occludes the supply tubing prior to the tip protecting caps being removed. The roller occludes prevent medical dialysis fluid from spilling out of the supply lines between the time that the caps are removed and connection to the cassette is made.

Abstract translation: 医疗流体或透析系统包括自动连接机构，其将来自供应袋的连接器连接到透析盒端口或盒供应线。 该系统提供多个（例如四个）供应袋，其可连接到自动连接机构的歧管。 保护电源线末端和盒式磁带端口或盒式磁带供电线末端的保护盖可以与自动连接机制兼容。 自动连接机制将所有盖帽取下并将供应线连接到盒带。 提供至少一个滚轮封堵器，在移除顶端保护帽之前封堵供应管。 滚筒堵塞防止医用透析液在取下盖子和与盒子连接之间溢出供应管线。

公开(公告)号：WO2010056663A2

公开(公告)日：2010-05-20

申请号：PCT/US2009/063859

申请日：2009-11-10

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  OH, Seik ,  KIM, Kwan

Inventor： OH, Seik ,  KIM, Kwan

IPC: A61M5/145

CPC classification number: A61M5/14244 ,  A61M5/1452 ,  A61M5/148 ,  A61M2005/14268

Abstract: A portable infusion device is provided that includes a cylindrical housing having a housing end, an inflatable cartridge sized to fit within the housing and a piston located within the housing. The cartridge can include a cartridge end having an inlet and an outlet. The cartridge end can be connected to an inflatable portion and be configured to be releasably secured to the housing end when the cartridge is inserted into the housing through the housing end. The piston can include at least one biasing device positioned to apply a constant force to the inflatable portion to expel a medical fluid from the cartridge.

Abstract translation: 提供了一种便携式输液装置，其包括具有壳体端部的圆柱形壳体，尺寸适合装配在壳体内的可充气药筒以及位于壳体内的活塞。 盒可以包括具有入口和出口的盒端。 药筒端部可以连接到可膨胀部分并且构造成当药筒通过壳体端部插入壳体中时可释放地固定到壳体端部。 活塞可以包括至少一个偏置装置，该偏置装置被定位成对可充气部分施加恒定的力以从药筒中排出药液。

公开(公告)号：WO2010054819A1

公开(公告)日：2010-05-20

申请号：PCT/EP2009/008071

申请日：2009-11-12

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  HAEMMERLE, Thomas ,  URBAN, Carsten ,  GRUBER, Franz

Inventor： HAEMMERLE, Thomas ,  URBAN, Carsten ,  GRUBER, Franz

IPC: C12Q1/68

CPC classification number: C12Q1/689 ,  C12Q1/6848 ,  C12Q1/6851 ,  C12Q2523/113 ,  C12Q2521/107

Abstract: The present invention relates to a method and a kit for the detection of low abundance RNA species in a biological sample and to a method and a kit for the detection of a mycoplasma contamination in a biological sample.

Abstract translation: 本发明涉及用于检测生物样品中低丰度RNA物种的方法和试剂盒，以及用于检测生物样品中支原体污染物的方法和试剂盒。

公开(公告)号：WO2010054238A1

公开(公告)日：2010-05-14

申请号：PCT/US2009/063610

申请日：2009-11-06

Applicant: BAXTER INTERNATIONAL INC. ,  UNIVERSITY OF CONNECTICUT ,  PIKAL, Michael ,  TCHESSALOV, Serguei ,  BJORNSON, Erik ,  JAMEEL, Feroz ,  BESMAN, Marc

Inventor： PIKAL, Michael ,  TCHESSALOV, Serguei ,  BJORNSON, Erik ,  JAMEEL, Feroz ,  BESMAN, Marc

IPC: A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K9/00 ,  A61K38/37

CPC classification number: A61K38/37 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26

Abstract: A Factor VIII (FVIII) composition formulated such that NaCl is not present in the final formulation or is present in trace amounts, which allows for a concomitant reduction in the lyophilization cycle time and increased stability of the lyophilized FVIII.

Abstract translation: 配制的因子VIII（FVIII）组合物使得NaCl不存在于最终制剂中或以微量存在，这允许冻干周期时间的伴随减少和冻干FVIII的稳定性增加。

公开(公告)号：WO2010051207A2

公开(公告)日：2010-05-06

申请号：PCT/US2009/061589

申请日：2009-10-22

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  WATKINS, Randolph, H. ,  MALIEKKAL, Shincy ,  KAROOR, Sujatha ,  WURGLER, Steven, J. ,  SMITH, Katrina

Inventor： WATKINS, Randolph, H. ,  MALIEKKAL, Shincy ,  KAROOR, Sujatha ,  WURGLER, Steven, J. ,  SMITH, Katrina

IPC: B01D61/24

CPC classification number: A61M1/1623 ,  A61M1/26 ,  A61M1/265 ,  A61M1/3472 ,  A61M1/3479 ,  B01D63/16 ,  B01D65/08 ,  B01D2315/02 ,  B01D2321/2033

Abstract: Systems and methods for performing hemodialysis to remove metabolic waste from the blood of a patient are disclosed. The systems and methods preferably comprise at (east one blood processing apparatus that receives whole blood from a patient. Cellular blood components are removed from the whole blood by hemoftitration, to provide filtered plasma comprising metabolic waste that is substantially reduced of blood cells. The cellular blood components may be returned to the patient. The filtered plasma comprising waste may be removed from the blood processing apparatus through a waste path for further processing in a separate apparatus, or in the same apparatus in a second stage processing procedure to remove metabolic waste components and excess water from the plasma by hemodialysis. At least one of the hemofiltration and hemodialysis processing apparatus comprises a Taylor vortex-enhanced separation apparatus.

Abstract translation: 公开了用于进行血液透析以从患者的血液中除去代谢废物的系统和方法。 该系统和方法优选地包括（东一个血液处理装置，其接收来自患者的全血），通过蒸发法从全血中除去细胞血液成分，以提供包含基本上减少血细胞的代谢废物的过滤血浆，细胞 可以将血液成分返回给患者，包含废物的过滤等离子体可以通过废物路径从血液处理设备中移除，以便在单独的设备中进行进一步处理，或者在第二阶段处理程序中的同一设备中去除代谢废物成分 血液透析中的至少一种血液透析和血液透析处理装置包括泰勒涡旋增强分离装置。

公开(公告)号：WO2010045645A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/061185

申请日：2009-10-19

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A ,  DONOFRIO, Anthony ,  MOTLAGH, Delara ,  AMRANI, David, L. ,  COHEN, Amy

Inventor： DONOFRIO, Anthony ,  MOTLAGH, Delara ,  AMRANI, David, L. ,  COHEN, Amy

IPC: C12N5/00

CPC classification number: C12N5/0653 ,  C12N2509/00

Abstract: Provided herein are methods of efficiently obtaining large numbers of viable, freshly isolated cells from small amounts of adipose tissue, as well as methods of enriching or selecting for target cell populations found therein. In certain embodiments, the method of obtaining a population of cells from adipose tissue comprises incubating the adipose tissue in a solution comprising an enzyme at a concentration which is at least 200 U/ml solution and not more than about 319 U/ml solution. In some embodiments, the method is devoid of any steps which expand the population of cells obtained. In certain aspects, the method further comprises positive or negative selection steps for obtaining an enriched population of target cells from adipose tissue. Related methods of preparing a pharmaceutical composition comprising cells for administration to a patient and methods of treating a disease or medical condition in a patient are further provided herein.

Abstract translation: 本文提供了从少量脂肪组织有效地获得大量可行的，新鲜分离的细胞的方法，以及对其中发现的靶细胞群进行富集或选择的方法。 在某些实施方案中，从脂肪组织获得细胞群的方法包括将脂肪组织在包含浓度为至少200U / ml且不超过约319U / ml溶液的酶的溶液中孵育。 在一些实施方案中，该方法没有扩大获得的细胞群体的任何步骤。 在某些方面，该方法还包括用于从脂肪组织获得富集的靶细胞群的阳性或阴性选择步骤。 本文还提供制备包含用于给患者的细胞的药物组合物的相关方法和治疗患者的疾病或医学病症的方法。

公开(公告)号：WO2010011441A1

公开(公告)日：2010-01-28

申请号：PCT/US2009/047581

申请日：2009-06-17

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  MULLER, Matthew, R.

Inventor： MULLER, Matthew, R.

IPC: A61M1/36

CPC classification number: A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3661 ,  A61M2205/13 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3592

Abstract: A connection of a patient's vascular system to an extra corporeal blood treatment machine is monitored to ensure the patient's safety during a procedure. The procedure may be hemodialysis, apheresis, plasmapheresis, a coronary by-pass operation, or other procedure. To ensure safe electrical connection, a contact (44) and a return (46) are connected via a conductive connection into the extra corporeal blood circuit. A current is then generated between the contact (44) and the return (46) and is monitored ba a non-contact sensor (49) near an access site of the patient. If the current or other quantity related to the current changes significantly, a signal is sent to the machine or a controller to notify a caregiver or a medical professional. The signal may also be sent to immediately stop a blood pump or other component of the machine.

Abstract translation: 监测患者血管系统与额外体外血液处理机的连接，以确保患者在手术过程中的安全。 该程序可以是血液透析，单采血浆置换术，血浆置换术，冠状动脉旁路手术或其他手术。 为了确保安全的电气连接，触点（44）和返回（46）通过导电连接连接到额外的体液血液回路中。 然后在触点（44）和返回器（46）之间产生电流，并且被监视为患者接近部位附近的非接触传感器（49）。 如果与当前相关的当前或其他数量显着变化，则将信号发送到机器或控制器以通知护理人员或医疗专业人员。 也可以发送信号以立即停止血液泵或机器的其他部件。

公开(公告)号：WO2010006137A1

公开(公告)日：2010-01-14

申请号：PCT/US2009/050062

申请日：2009-07-09

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  YU, Anping ,  CHILDERS, Robert, W. ,  CIZMAN, Borut

Inventor： YU, Anping ,  CHILDERS, Robert, W. ,  CIZMAN, Borut

IPC: A61M1/28 ,  G06F19/00

CPC classification number: G06F19/3456 ,  A61M1/1601 ,  A61M1/28 ,  A61M1/281 ,  A61M1/282 ,  A61M1/287 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2209/01 ,  B01D61/32 ,  G06F19/00 ,  G06F19/3418

Abstract: In one embodiment an automated peritoneal dialysis ("APD") machine (104) includes: at least one pump; a logic implementer storing a plurality of therapy prescriptions by which to operate the at least one pump, each therapy prescription pre-approved for a particular patient; and an input device (160) operating with the logic implementer to allow the patient to select one of the therapy prescriptions for a particular therapy. In another embodiment, the input device operating with the logic implementer allows a doctor/clinician to select or approve one of the therapy prescriptions to be run on the APD machine. In a further embodiment, the logic implementer is programmed to select or suggest one of the therapy prescriptions to be run on the is APD machine.

Abstract translation: 在一个实施例中，自动腹膜透析（“APD”）机器（104）包括：至少一个泵; 存储多个用于操作所述至少一个泵的治疗处方的逻辑实现器，为特定患者预先批准的每个治疗处方; 以及与逻辑实现者一起操作的输入设备（160），以允许患者选择用于特定治疗的治疗处方之一。 在另一个实施例中，与逻辑实施器一起操作的输入设备允许医生/临床医生选择或批准在APD机器上运行的治疗处方之一。 在另一实施例中，逻辑实现器被编程为选择或建议要在APD机器上运行的治疗处方之一。