Abstract:
The present invention relates to vehicles for delivering macromolecules into cells. More particularly, embodiments of the invention relate to compounds and methods for binding and compacting nucleic acids into nanoparticles for transferring the polynucleotides into cells and which can be configured to provide a mechanism for visualization of the delivery vehicles on the nm/µm scale by microscopy and on the sub-mm scale by magnetic resonance imaging. Polycations according to embodiments of the invention have been designed to contain repeated oligoethyleneamines, for binding and compacting nucleic acids into nanoparticles, and lanthanide (Ln) chelates (for example, using luminescent europium Eu3+ and paramagnetic gadolinium Gd3+). Especially preferred, are structures chelated with either Eu3+ or Gd3+ for microscopy or MRI imaging, respectively. Such chelated lanthanides allow the visualization of the delivery vehicle both on the nm/µm scale by way of microscopy and on the sub-mm scale using MRI.
Abstract:
The present disclosure relates to a high molecular weight, monoesterified polyimide polymer. One method as described herein relates to making the high molecular weight, monoesterified polyimide polymer. According to its broadest aspect, the method for making the high molecular weight, monoesterified polyimide polymer comprises the following steps: (a) preparing a polyimide polymer comprising carboxylic acid functional groups from a reaction solution comprising monomers and at least one solvent; and (b) treating the polyimide polymer with a diol at esterification conditions in the presence of dehydrating conditions to form a monoesterified polyimide polymer, wherein the dehydrating conditions at least partially remove water produced during step (b). Such high molecular weight, monoesterified polyimide polymers are useful in forming crosslinked polymer membranes for the separation of fluid mixtures.
Abstract:
A fund transmitta! system includes a first agent portal module for receiving funds from a first entity to initiate a first fund transaction. The system includes a transaction network and a transaction processor. The first agent portal module routes the first fund transaction to the transaction processor via the transaction network. The transaction processor supplies an authorization code associated with the first fund transaction to the first entity. The first entity provides the authorization code to a second entity. The system includes a second agent portal module that receives the authorization code from the second entity to initiate a second fund transaction. The second agent portal module routes the authorization code to the transaction processor via the transaction network. The transaction processor approves the second fund transaction in accordance with the authorization code. Upon approval, the second agent portal module supplies the funds to the second entity.
Abstract:
This invention refers to a novel process for the synthesis of polyethylene imine (PEI)-based pigment dispersants characterized by a "grafting from" approach, allowing the manufacture of solvent based dispersant systems. The polyethylene imine (PEI)-based pigment dispersant can be presented by the formula (I) X-(T) m -P-(T) n -H wherein P is a polyethyleneimine (PEI) backbone; T is a residue -CO-A-O- wherein A is C 2 -C 12 alkylene optionally substituted with C 1 -C 6 alkyl with the proviso that each linkage between P and T is an amide bond and each linkage between X and T is an ester bond, X is a modifier or terminator residue R-CO- wherein R is a linear or branched, saturated or unsaturated alkanecarboxylic acids having from 1 to 22 carbon atoms or an unsaturated fatty acid residue or a hydroxycarboxylic residue or a polyester residue obtained from polycondensation of hydroxycarboxylic acids, or an acid terminated polyether; n, m independently are a number from 1 to 100.
Abstract:
The present invention provides novel block copolycarbonates comprising residues from a hydroxy terminated polyetherimide or polyimide, residues from a dihydroxy compound, and residues from an activated carbonate. In a preferred embodiment of the present invention the polyetherimide or polyimide blocks exhibit high M w while the resulting block copolycarbonate exhibits a single T g . The novel block copolycarbonates of the present invention are produced under melt polymerization conditions in the presence an activated carbonate source.
Abstract:
The invention provides a compound of formula (I) in which R and R are independently hydrogen, (C1-C7)-alkyl, (C2-C7)-alkenyl, or (C2-C7)-alkynyl; X and X can be independently present or absent, and if present are independently (C1-C7)-alkylene or (C2-C7)-alkenylene; Y and Y are independently (C4-C8)-cycloalkylene or (C4-C8)-cycloalkenylene, which are unsubstituted or substituted by up to four identical or different radicals selected from (C1-C7)-alkyl, (C2-C7)-alkenyl, or carboxyl; and Z is (C1-C12)-alkylene; (C2-C12)-alkenylene; D-E-F, where D and F are independently (C1-C12)-alkylene or (C2-C12)-alkenylene, and E is (C4-C8)-cycloalkylene or (C4-C8)-cycloalkenylene, which are unsubstituted or substituted by up to four identical or different radicals selected from (C1-C7)-alkyl or (C2-C7)-alkenyl; or G-H-I, where G and I are independently (C1-C12)-alkylene or (C2-C12)-alkenylene, and H is N-(C1-C7)-alkyl; N-(C2-C7)-alkenyl; N-(C4-C8)-cycloalkyl or N-(C4-C8)-cycloalkenyl, which are unsubstituted or substituted by up to four identical or different radicals selected from (C1-C7)-alkyl or (C2-C7)-alkenyl; or N-(C1-C7)-alkyl-(C4-C8)-cycloalkyl, which is unsubstituted or substituted by up to four identical or different radicals selected from (C1-C7)-alkyl or (C2-C7)-alkenyl.