公开(公告)号：WO2007137258A2

公开(公告)日：2007-11-29

申请号：PCT/US2007069461

申请日：2007-05-22

Applicant: UNIV NEW YORK STATE RES FOUND ,  UNIV CITY ,  AARON DIAMOND AIDS RES CT FOR ,  TSUJI MORIYA ,  CHEN GUANGWU ,  FRANCK RICHARD ,  YANG GUANGLI

Inventor： TSUJI MORIYA ,  CHEN GUANGWU ,  FRANCK RICHARD ,  YANG GUANGLI

IPC: A61K31/7008

CPC classification number: C07H13/06 ,  A61K31/7004 ,  A61K31/7028 ,  A61K31/7042 ,  C07H7/00 ,  C07H15/06

Abstract: The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.

Abstract translation: 本发明涉及新型合成的C-糖脂，其选择性诱导特征在于增强的IL-12分泌和增加树突状细胞活化的Th1型免疫应答。 因此，本发明的化合物可直接用作治疗感染，癌症，细胞增殖性疾病和自身免疫性疾病。