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    Antibodies directed to parathyroid hormone (PTH) and uses thereof
    3.
    发明申请
    Antibodies directed to parathyroid hormone (PTH) and uses thereof 审中-公开
    针对甲状旁腺激素（PTH）的抗体及其用途

    公开(公告)号：WO2005016111A3

    公开(公告)日：2006-05-04

    申请号：PCT/US0325161

    申请日：2003-08-08

    Applicant: ROSKOS LORIN ,  FOLTZ IAN ,  KING CHADWICK T ,  ABGENIX INC

    Inventor： ROSKOS LORIN ,  FOLTZ IAN ,  KING CHADWICK T

    IPC: A61K39/395 ,  C07K16/26

    CPC classification number: C07K16/26 ,  A01K2217/075 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

    Abstract: Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

    Abstract translation: 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和此类抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。

    ANTIBODIES TO MAdCAM
    4.
    发明申请
    ANTIBODIES TO MAdCAM 审中-公开
    抗体对MAdCAM

    公开(公告)号：WO2005067620A2

    公开(公告)日：2005-07-28

    申请号：PCT/US2005000370

    申请日：2005-01-07

    Applicant: PFIZER ,  ABGENIX INC ,  PFIZER LTD ,  PULLEN NICHOLAS ,  MOLLOY ELIZABETH ,  KELLERMANN SIRID-AIMEE ,  GREEN LARRY L ,  HAAK-FRENDSCHO MARY

    Inventor： PULLEN NICHOLAS ,  MOLLOY ELIZABETH ,  KELLERMANN SIRID-AIMEE ,  GREEN LARRY L ,  HAAK-FRENDSCHO MARY

    IPC: A61K39/395 ,  C07K16/28 ,  C12N5/06

    CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K14/70503 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56972 ,  G01N33/6854 ,  G01N2333/70503 ,  G01N2333/70546

    Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.

    Abstract translation: 本发明涉及特异性结合MAdCAM，优选人MAdCAM的人抗体及其抗原结合部分的抗体，其功能是抑制MAdCAM。 本发明还涉及人抗MAdCAM抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗MAdCAM抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗MAdCAM抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗MAdCAM抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。

    ANTIBODIES DIRECTED TO PARATHYROID HORMONE (PTH) AND USES THEREOF
    5.
    发明申请
    ANTIBODIES DIRECTED TO PARATHYROID HORMONE (PTH) AND USES THEREOF 审中-公开
    针对PARATHYROID HORMONE（PTH）的抗体及其用途

    公开(公告)号：WO2005016111A2

    公开(公告)日：2005-02-24

    申请号：PCT/US2003/025161

    申请日：2003-08-08

    Applicant: ABGENIX, INC. ,  ROSKOS, Lorin ,  FOLTZ, Ian ,  KING, Chadwick, T.

    Inventor： ROSKOS, Lorin ,  FOLTZ, Ian ,  KING, Chadwick, T.

    IPC: A61B

    CPC classification number: C07K16/26 ,  A01K2217/075 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

    Abstract: Embodiments of the invention described herein relate to antibodies directed to the antigen parathyroid hormone (PTH) and uses of such antibodies. In particular, in some embodiments, there are provided fully human monoclonal antibodies directed to the antigen PTH. In further embodiments, nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided.

    Abstract translation: 本文描述的本发明的实施方案涉及针对抗原甲状旁腺激素（PTH）的抗体和此类抗体的用途。 特别地，在一些实施方案中，提供针对抗原PTH的完全人单克隆抗体。 在另外的实施方案中，编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于横跨框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。

    SYSTEM AND METHOD FOR CLEAVING ANTIBODIES
    7.
    发明申请
    SYSTEM AND METHOD FOR CLEAVING ANTIBODIES 审中-公开
    用于清除抗体的系统和方法

    公开(公告)号：WO2004035608A2

    公开(公告)日：2004-04-29

    申请号：PCT/US2003/033121

    申请日：2003-10-17

    Applicant: ABGENIX, INC.

    Inventor： ZAPATA, Gerardo, A.

    IPC: C07K

    CPC classification number: C07K16/00 ,  C07K2317/21 ,  C07K2317/54

    Abstract: The present invention is related to a method for producing antibody fragments. In particular, the invention involves a method for the production of F(ab')2 fragments. The method comprises concentration of cell culture media and activation of endogenous enzymes present in the cell culture media by adjusting the temperature and pH.

    Abstract translation: 本发明涉及生产抗体片段的方法。 特别地，本发明涉及一种生产F（ab'）2片段的方法。 该方法包括通过调节温度和pH来浓缩细胞培养基和活化存在于细胞培养基中的内源性酶。

    TREATMENT OF RENAL CARCINOMA USING ANTIBODIES AGAINST THE EGFR
    8.
    发明申请
    TREATMENT OF RENAL CARCINOMA USING ANTIBODIES AGAINST THE EGFR 审中-公开
    使用反对EGFR的抗体治疗肾脏癌

    公开(公告)号：WO03099205A2

    公开(公告)日：2003-12-04

    申请号：PCT/US0315734

    申请日：2003-05-19

    Applicant: ABGENIX INC ,  SCHWAB GISELA ,  YANG XIAO-DONG

    Inventor： SCHWAB GISELA ,  YANG XIAO-DONG

    IPC: C07K16/22 ,  C07K16/28 ,  A61K

    CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21

    Abstract: Methods of treating renal carcinoma are described using fully human monoclonal antibodies ABX-EGF against the epidermal growth factor receptor (EGFr) and antigen binding fragments thereof. Methods of using these renal carcinoma treatments specifically as a monotherapy are also described. In addition, a kit and an article of manufacture for the treatment of renal carcinoma treatment are provided.

    Abstract translation: 使用针对表皮生长因子受体（EGFr）的完全人单克隆抗体ABX-EGF及其抗原结合片段描述治疗肾癌的方法。 还描述了将这些肾癌治疗特异性地用作单一疗法的方法。 另外，提供了用于治疗肾癌治疗的试剂盒和制品。

    ANTIBODIES AGAINST THE MUC18 ANTIGEN
    10.
    发明申请
    ANTIBODIES AGAINST THE MUC18 ANTIGEN 审中-公开

    公开(公告)号：WO2003057838A3

    公开(公告)日：2003-07-17

    申请号：PCT/US2002/041581

    申请日：2002-12-26

    Applicant: ABGENIX, INC.

    Inventor： GUDAS, Jean

    IPC: C07H21/04

    Abstract: The present invention relates generally to the generation and characterization of anti-MUC18 monoclonal antibodies. The invention further relates to the use of such anti-MUC18 antibodies in the diagnosis and treatment of disorders associated with increased activity of MUC18, in particular, tumors, such as melanomas.

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