公开(公告)号：WO2006113643A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014440

申请日：2006-04-18

Applicant: AMGEN FREMONT INC. ,  BABCOOK, John ,  RATHANASWAMI, Palaniswami ,  FOORD, Orit ,  KANG, Jaspal, S.

Inventor： BABCOOK, John ,  RATHANASWAMI, Palaniswami ,  FOORD, Orit ,  KANG, Jaspal, S.

IPC: C07K16/24

CPC classification number: C07K16/244 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present embodiments are related to high-affinity antibodies directed to IL-8, methods of making and characterizing such antibodies and uses of such antibodies. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided.

Abstract translation: 本实施方案涉及针对IL-8的高亲和力抗体，制备和表征此类抗体的方法及其用途。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。

公开(公告)号：WO2004050683A8

公开(公告)日：2005-07-28

申请号：PCT/US0338281

申请日：2003-12-02

Applicant: ABGENIX INC ,  BABCOOK JOHN S ,  KANG JASPAL S ,  FOORD ORIT ,  GREEN LARRY ,  FENG XIAO ,  KLAKAMP SCOTT ,  HAAK-FRENDSCHO MARY ,  RATHANASWAMI PALANISWAMI ,  PIGOTT CRAIG ,  LIANG MEINA L ,  LEE ROZANNE ,  MANCHULENCHO KATHY ,  FAGGIONI RAFFAELLA ,  SENALDI GIORGIO ,  SU QIAOJUAN JANE

Inventor： BABCOOK JOHN S ,  KANG JASPAL S ,  FOORD ORIT ,  GREEN LARRY ,  FENG XIAO ,  KLAKAMP SCOTT ,  HAAK-FRENDSCHO MARY ,  RATHANASWAMI PALANISWAMI ,  PIGOTT CRAIG ,  LIANG MEINA L ,  LEE ROZANNE ,  MANCHULENCHO KATHY ,  FAGGIONI RAFFAELLA ,  SENALDI GIORGIO ,  SU QIAOJUAN JANE

IPC: C07K16/24 ,  C07K16/00 ,  A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Abstract translation: 针对抗原TNFa的抗体和这种抗体的用途。 特别是针对抗原TNFa的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

公开(公告)号：WO2004050683A3

公开(公告)日：2005-04-14

申请号：PCT/US0338281

申请日：2003-12-02

Applicant: ABGENIX INC ,  BABCOOK JOHN S ,  KANG JASPAL S ,  FOORD ORIT ,  GREEN LARRY ,  FENG XIAO ,  KLAKAMP SCOTT ,  HAAK-FRENDSCHO MARY ,  RATHANASWAMI PALANISWAMI ,  PIGOTT CRAIG ,  LIANG MEINA L ,  LEE ROZANNE ,  MANCHULENCHO KATHY ,  FAGGIONI RAFFAELLA ,  SENALDI GIORGIO ,  SU QIAOJUAN JANE

Inventor： BABCOOK JOHN S ,  KANG JASPAL S ,  FOORD ORIT ,  GREEN LARRY ,  FENG XIAO ,  KLAKAMP SCOTT ,  HAAK-FRENDSCHO MARY ,  RATHANASWAMI PALANISWAMI ,  PIGOTT CRAIG ,  LIANG MEINA L ,  LEE ROZANNE ,  MANCHULENCHO KATHY ,  FAGGIONI RAFFAELLA ,  SENALDI GIORGIO ,  SU QIAOJUAN JANE

IPC: C07K16/24 ,  C07K16/00 ,  A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Abstract translation: 针对抗原TNFα的抗体和这些抗体的用途。 特别是针对抗原TNFα的完全人类单克隆抗体。 编码核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR's）的连续重链和轻链序列的序列，特别是FR1至FR4或CDR1至CDR3 。 表达此类免疫球蛋白分子和单克隆抗体的杂交瘤或其他细胞系。

公开(公告)号：WO2004050683A2

公开(公告)日：2004-06-17

申请号：PCT/US2003/038281

申请日：2003-12-02

Applicant: ABGENIX, INC. ,  BABCOOK, John, S. ,  KANG, Jaspal, S. ,  FOORD, Orit ,  GREEN, Larry ,  FENG, Xiao ,  KLAKAMP, Scott ,  HAAK-FRENDSCHO, Mary ,  RATHANASWAMI, Palaniswami ,  PIGOTT, Craig ,  LIANG, Meina, L. ,  LEE, Rozanne ,  MANCHULENCHO, Kathy ,  FAGGIONI, Raffaella ,  SENALDI, Giorgio ,  QIAOJUAN, Jane, Su

Inventor： BABCOOK, John, S. ,  KANG, Jaspal, S. ,  FOORD, Orit ,  GREEN, Larry ,  FENG, Xiao ,  KLAKAMP, Scott ,  HAAK-FRENDSCHO, Mary ,  RATHANASWAMI, Palaniswami ,  PIGOTT, Craig ,  LIANG, Meina, L. ,  LEE, Rozanne ,  MANCHULENCHO, Kathy ,  FAGGIONI, Raffaella ,  SENALDI, Giorgio ,  QIAOJUAN, Jane, Su

IPC: C07K

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies directed to the antigen TNFa and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFa. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

Abstract translation: 针对抗原TNFa的抗体和这种抗体的用途。 特别是针对抗原TNFa的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 杂交瘤或表达这种免疫球蛋白分子的其它细胞系和单克隆抗体。

公开(公告)号：WO2004016769A2

公开(公告)日：2004-02-26

申请号：PCT/US2003/026232

申请日：2003-08-19

Applicant: ABGENIX, INC. ,  GUDAS, Jean, M. ,  HAAK-FRENDSCHO, Mary ,  FOORD, Orit ,  LIANG, Meina, L. ,  AHLUWALIA, Kiran ,  BHAKTA, Sunil

Inventor： GUDAS, Jean, M. ,  HAAK-FRENDSCHO, Mary ,  FOORD, Orit ,  LIANG, Meina, L. ,  AHLUWALIA, Kiran ,  BHAKTA, Sunil

IPC: C12N

CPC classification number: C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565

Abstract: Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract translation: 本文描述的本发明的实施方案涉及针对抗原单核细胞化学引诱物蛋白-1（MCP-1）的抗体以及此类抗体的用途。 具体而言，根据一些实施方案，提供了针对抗原MCP-1的完全人类单克隆抗体。 编码核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，尤其是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4或CDR1至CDR3 ，提供。 还提供了表达此类免疫球蛋白分子和单克隆抗体的杂交瘤或其他细胞系。

公开(公告)号：WO2012112943A1

公开(公告)日：2012-08-23

申请号：PCT/US2012/025726

申请日：2012-02-17

Applicant: STEM CENTRX, INC. ,  FOORD, Orit ,  DYLLA, Scott J. ,  STULL, Robert A. ,  BANKOVICH, Alex ,  LAZETIC, Alexandra Leida Liana ,  BERNSTEIN, Jeffrey

Inventor： FOORD, Orit ,  DYLLA, Scott J. ,  STULL, Robert A. ,  BANKOVICH, Alex ,  LAZETIC, Alexandra Leida Liana ,  BERNSTEIN, Jeffrey

IPC: C07K16/30

CPC classification number: C07K16/32 ,  A61K47/6803 ,  A61K47/6851 ,  C07K16/30 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C12N2740/15043

Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.

Abstract translation: 提供了新型调节剂，包括抗体及其衍生物，以及使用这些调节剂治疗过度增殖性疾病的方法。

公开(公告)号：WO2012078813A2

公开(公告)日：2012-06-14

申请号：PCT/US2011/063834

申请日：2011-12-07

Applicant: STEM CENTRX, INC. ,  BANKOVICH, Alex ,  FOORD, Orit ,  HAMPL, Johannes ,  DYLLA, Scott, J.

Inventor： BANKOVICH, Alex ,  FOORD, Orit ,  HAMPL, Johannes ,  DYLLA, Scott, J.

IPC: A61K39/395 ,  C07K16/22 ,  C07K16/40 ,  G01N33/574 ,  C07K16/30 ,  A61K49/00

CPC classification number: C07K16/18 ,  A61K38/47 ,  A61K47/64 ,  A61K47/6455 ,  A61K47/6811 ,  A61K47/6815 ,  A61K47/6855 ,  A61K47/6867 ,  A61K47/6869 ,  A61K47/6891 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3061 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12Y302/02022 ,  G01N33/574

Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.

Abstract translation: 提供了新的调节剂，包括抗体及其衍生物，以及使用这些调节剂治疗过度增殖性疾病的方法。

公开(公告)号：WO2012031273A2

公开(公告)日：2012-03-08

申请号：PCT/US2011050439

申请日：2011-09-02

Applicant: STEM CENTRX INC ,  DYLLA SCOTT J ,  FOORD ORIT ,  STULL ROBERT A ,  ANDERSON WADE C ,  OHSHIMA SAIYOU

Inventor： DYLLA SCOTT J ,  FOORD ORIT ,  STULL ROBERT A ,  ANDERSON WADE C ,  OHSHIMA SAIYOU

IPC: A61K39/395

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K39/39558 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  A61K2300/00

Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.

公开(公告)号：WO2012027723A1

公开(公告)日：2012-03-01

申请号：PCT/US2011/049458

申请日：2011-08-26

Applicant: STEM CENTRX, INC ,  STULL, Robert, A. ,  DYLLA, Scott, J. ,  FOORD, Orit ,  AUJAY, Monette

Inventor： STULL, Robert, A. ,  DYLLA, Scott, J. ,  FOORD, Orit ,  AUJAY, Monette

IPC: A61K39/395 ,  C07K16/22 ,  C07K16/40

CPC classification number: C07K16/40 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C12N9/14 ,  G01N33/6893

Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.

Abstract translation: 提供了新型调节剂，包括抗体及其衍生物，以及使用这些调节剂治疗过度增殖性疾病的方法。

公开(公告)号：WO2006124269A2

公开(公告)日：2006-11-23

申请号：PCT/US2006016786

申请日：2006-05-04

Applicant: AMGEN FREMONT INC ,  KELLERMANN SIRID-AIMEE ,  BELOUSKI SHELLEY SIMS ,  GREEN LARRY L ,  FOORD ORIT

Inventor： KELLERMANN SIRID-AIMEE ,  BELOUSKI SHELLEY SIMS ,  GREEN LARRY L ,  FOORD ORIT

IPC: G01N33/574 ,  A61K39/395 ,  C07H21/04 ,  C07K16/30 ,  C12N5/06 ,  C12P21/06

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  G01N33/566 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/70546 ,  G01N2800/065 ,  G01N2800/122

Abstract: The present invention relates to antibodies directed to very late antigen-1 ("VLA-1") and uses of such antibodies. For example human monoclonal antibodies directed to VLA-1 are described. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

Abstract translation: 本发明涉及针对非常晚的抗原-1（“VLA-1”）的抗体和这种抗体的用途。 例如描述了针对VLA-1的人单克隆抗体。 提供了分离的多核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。