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公开(公告)号：WO2023091727A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050506
申请日：2022-11-18
发明人： YOON, Jeong-yeol
IPC分类号： C12Q1/70
摘要： The present disclosure provides kits and methods for detecting and/or quantifying coronavirus from aerosols and droplets.
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2.发明申请
公开(公告)号：WO2023086364A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/049368
申请日：2022-11-09
发明人： SUTPHIN, George , ESPEJO, Luis
IPC分类号： A61K31/196 , A61K31/19 , A61K31/195 , A61K31/185
摘要： A composition containing 3-hydroxyanthanilic acid (3HAA) and a compound that alters iron homeostasis (an iron chelator or an iron supplement). The combination may be used as a new antibiotic drug. Combining 3HAA with iron chelation may have the dual benefit of inhibiting pathogen growth while repressing the pathological hyperinflammatory response in septic individuals. The combination may be effective at preserving food by preventing bacterial growth.
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公开(公告)号：WO2023069767A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047509
申请日：2022-10-22
发明人： ASPINWALL, Craig , KE, Chen-Yi , HAN, Minhui , ZACHER, Brian
IPC分类号： C09K11/06 , A61K51/04 , A61K51/12 , C07F1/08 , C07F1/10 , C07F3/04 , C07F3/06 , C07F5/06 , C07F7/24 , C09K11/07
摘要： This present disclosure is directed to methods for detecting and quantifying radioisotopes ( e.g., radiopharmaceuticals) in a liquid and compositions involving the same. Metal-organic frameworks (MOFs) can be synthesized and used for measuring low-energy radioisotope decay from alpha-emitter, beta-emitters, and gamma emitters directly in water. Zirconium metal organic framework particles are disclosed herein.
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公开(公告)号：WO2023069671A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047359
申请日：2022-10-21
摘要： Provided herein are compositions and methods for diagnosing, prognosing, and treating neurodegenerative diseases in a male and female subject at risk of or diagnosed with a neurodegenerative disease. In particular, provided herein are customized metabolite analyses for characterizing and treating neurodegenerative diseases in specific subject groups from a sample from said subject.
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公开(公告)号：WO2023043737A1
公开(公告)日：2023-03-23
申请号：PCT/US2022/043365
申请日：2022-09-13
发明人： PYUN, Dong Chul , NORWOOD, Robert , NJARDARSON, Jon , KANG, Kyung-Seok , GLASS, Richard , LEE, Taeheon , OLIKAGU, Chisom , CAROTHERS, Kyle
IPC分类号： C08G75/23 , C08F20/20 , C08G75/045
摘要： A polymers includes the reaction product of a mixture of a chalcogenide halide and one or more organic compounds comprising an unsaturated carbon-carbon bond under reaction conditions sufficient to produce the polymer, wherein the chalcogenide halide comprises a sulfur monohalide, a sulfur dihalide, a selenium monohalide, a selenium dihalide, a selenium tetrahalide, or a combination of any two or more thereof. Such sulfur-containing polymers have a high refractive index and high Abbe number and are suitable for use in variety of applications relating to optical devices.
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公开(公告)号：WO2023028257A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/041565
申请日：2022-08-25
发明人： CHANG, Rui , WANG, Wei , RONALDSON, Patrick T. , HE, Qianying , LIU, Yanyun , VIJAYAN, Ramachandran
IPC分类号： A61K45/06 , A61P25/24 , C12N5/0783 , A61P25/28 , C12N5/071
摘要： This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising one or more of agents capable of protecting neurons from cell death and unregulated microglia phagocytic activity.
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公开(公告)号：WO2023014638A1
公开(公告)日：2023-02-09
申请号：PCT/US2022/039017
申请日：2022-08-01
发明人： ZENHAUSERN, Frederic , NORDQUIST, Alan , THOMAS, Baiju , BARRETT, Matthew , LACOMBE, Jerome , HARRIS, Ashlee
摘要： Provided herein are stretch devices and related methods for controlled three-dimensional stretching of scaffolds supported on a stretchable substrate. A stretchable substrate is capable of receiving the three-dimensional scaffold, and a stretchable substrate holder is configured to connect to the stretchable substrate. An actuator is connected to the stretchable substrate holder to exert a cyclic stretch on the stretchable substrate and periodically stretch the three-dimensional scaffold connected to the stretchable substrate. A sample holder is configured to immerse the three-dimensional scaffold in a tissue culture media.
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公开(公告)号：WO2023004048A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/037887
申请日：2022-07-21
发明人： CHALIFOUX, Brandon , ARNOLD, Ian , LAVERTY, Kevin
摘要： Methods for determining laser pulse positions for shaping an optical element may comprise: determining a stress field for at least a portion of a substrate, wherein the stress field comprises at least three components of stress, wherein the stress field comprises a plurality of stress states for the at least a portion of the substrate; determining, based at least on the stress field and a calibration model, a spot density over the at least a portion of the substrate; determining, based on the spot density, a laser spot position allocation that arranges a number of laser pulses into a minimum number of lines that achieves the spot density; and causing, based on the laser spot position allocation, output of a machine program that coordinates a rotation stage, beam shaping, a translation stage, and a laser firing parameter for surface shaping of the at least a portion of the substrate.
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公开(公告)号：WO2022271494A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/033518
申请日：2022-06-15
发明人： PAU, Stanley , BRADY, David
摘要： A diffractive optical element configured as a lens having such an aperture function that causes light incident onto such lens to form a multiplicity of focal points (whether real or virtual) that do not lie along the same axis transverse to the surface of such lens, thereby simultaneously forming a multiplicity of spatially-independent optical images distributed transversely to a normal drawn to a surface of such lens. A method of using such diffractive optical element.
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10.发明申请
公开(公告)号：WO2022251159A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030646
申请日：2022-05-24
发明人： KUPINSKI, Meredith
摘要： Methods, devices and systems for estimating polarization characteristics of materials based on partial polarimetry are described. One example method for estimating polarization characteristics of a material includes illuminating the material with incident light, which can be unpolarized or have a particular polarization state. Two polarimetric measurements are conducted based on the interaction of the incident light with the material. The two polarimetric measurements detect light having orthogonal polarization states, and the interaction of the incident light with the material includes a depolarizing interaction. The method additionally includes determining an estimated coherency matrix eigenvalue and an estimated Mueller matrix throughput parameter using the first and the second polarimetric measurements, and determining an estimate of a full depolarizing Mueller matrix by extrapolating a reduced-rank Mueller matrix to obtain all sixteen elements of the depolarizing Mueller matrix that identifies the polarization characteristics of the material.
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