公开(公告)号：WO2005043177A3

公开(公告)日：2005-09-09

申请号：PCT/US2004036032

申请日：2004-10-29

Applicant: CALIFORNIA INST OF TECHN ,  BARBIC MLADEN

Inventor： BARBIC MLADEN

IPC: G01R20060101 ,  G01V3/00

CPC classification number: G01R33/3808 ,  G01R33/341 ,  G01R33/381 ,  G01R33/421

Abstract: A magnetic-resonance imaging system including a magnetic-resonance sensor including at least one magneto-resistive element; and a sample disposed adjacent to the magnetic-resonance sensor and configurable to generate a magnetic-resonance signal, wherein the magneto-resistive element is configured to generate a magnetic field in response to a current driven through the magneto-resistive element, the magnetic field being configured to polarize spins of the sample, and detect a magnetic-resonance signal from precession of the spins.

Abstract translation: 一种磁共振成像系统，包括包含至少一个磁阻元件的磁共振传感器; 以及与所述磁共振传感器相邻设置的并且可配置为产生磁共振信号的样本，其中所述磁阻元件被配置为响应于驱动通过所述磁阻元件的电流产生磁场，所述磁场 被配置为偏振样品的旋转，并且检测来自旋转进动的磁共振信号。

公开(公告)号：WO2005043177A2

公开(公告)日：2005-05-12

申请号：PCT/US2004/036032

申请日：2004-10-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  BARBIC, Mladen

Inventor： BARBIC, Mladen

IPC: G01R

CPC classification number: G01R33/3808 ,  G01R33/341 ,  G01R33/381 ,  G01R33/421

Abstract: A magnetic-resonance imaging system including a magnetic-resonance sensor including at least one magneto-resistive element; and a sample disposed adjacent to the magnetic-resonance sensor and configurable to generate a magnetic-resonance signal, wherein the magneto-resistive element is configured to generate a magnetic field in response to a current driven through the magneto-resistive element, the magnetic field being configured to polarize spins of the sample, and detect a magnetic-resonance signal from precession of the spins.

Abstract translation: 包括磁共振传感器的磁共振成像系统，所述磁共振传感器包括至少一个磁阻元件; 以及样品，所述样品与所述磁共振传感器相邻设置并且可配置为产生磁共振信号，其中所述磁阻元件被配置为响应于通过所述磁致电阻元件驱动的电流而产生磁场，所述磁场 被配置为极化样品的自旋，并检测自旋进动的磁共振信号。

公开(公告)号：WO2003061470A1

公开(公告)日：2003-07-31

申请号：PCT/US2003/001511

申请日：2003-01-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SCHERER, Axel ,  BARBIC, Mladen

Inventor： SCHERER, Axel ,  BARBIC, Mladen

IPC: A61B5/055

CPC classification number: G01R33/5604 ,  B82Y15/00 ,  G01R33/285

Abstract: The invention combines (A) capabilities in fabrication, characterization, and manipulation of single domain magnetic nanostructures, with (B) the use of binding chemistry of biological molecules to modify the magnetic nanostructures into magnetic sensors (40) and magnetically controllable nanoprobes (70). A biological characterization scheme is realized by combining nanomanipulation and observation of small magnetic structures in fluids. By coating nanomagnets with biological molecules, ultra-small, highly sensitive and robust biomagnetic devices are defined, and molecular electronics and spin electronics are combined. When these nano-sensors are integrated into microfluidic channels, highly efficient single-molecule detection chips for rapid diagnosis and analysis of biological agents are constructed.

Abstract translation: 本发明结合了（A）制备，表征和操作单畴磁性纳米结构的能力，（B）使用生物分子的结合化学将磁性纳米结构修饰成磁性传感器（40）和磁性可控纳米探针（70） 。 通过组合纳米操作和观察流体中的小磁性结构来实现生物表征方案。 通过用生物分子涂覆纳米磁体，定义了超小型，高灵敏度和鲁棒的生物磁性器件，并结合了分子电子学和自旋电子学。 当这些纳米传感器集成到微流体通道中时，构建了用于快速诊断和分析生物制剂的高效单分子检测芯片。

公开(公告)号：WO2009046139A1

公开(公告)日：2009-04-09

申请号：PCT/US2008/078495

申请日：2008-10-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  BARBIC, Mladen ,  SCHERER, Axel

Inventor： BARBIC, Mladen ,  SCHERER, Axel

IPC: A61B6/03 ,  H01B5/00

CPC classification number: A61B6/504 ,  G01R33/3415 ,  G01R33/345 ,  G01R33/4824

Abstract: Tomographic imaging using an imaging sensor that lias a stupe-like shape is disclosed where a stripe sensor is mechanical!) scanned over a sample at different angles f or a single stripe detector imaging, linear motion and angular rotation are required Single stripe sensor imaging may be performed using an elongated inductive coil detector B\ utilizing an array of parallel stnpe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation, only, eliminating the requirement for linear motion, e g with parallel coils array Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited αnl\ by the thickness (smaller parameter) of the sensor Multiple sensor families can be produced where this imaging technique max be beneficial such as magneto-resistix- e. inductiv e, SQl UD, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (Mill).

Abstract translation: 使用成像传感器进行的层析成像，其中披露了具有类似形状的成像传感器，其中条纹传感器是机械的！）在不同角度f扫描样本或单条条纹检测器成像，线性运动和角旋转需要单条纹传感器成像 可以使用细长的感应线圈检测器B 1执行，利用可以单独寻址的平行stnpe传感器的阵列，可以旋转执行二维成像，仅消除线性运动的需求，例如使用平行线圈阵列成像 具有特定宽度和厚度（宽度比厚度大得多）的条纹型传感器是传感器的厚度（较小的参数）限制的分辨率。可以在最大限度的有效成像技术的情况下生成多个传感器系列， 电阻 电感，SQ1 UD和霍尔效应传感器，特别是在磁共振成像领域（Mill）。

公开(公告)号：WO2005117240A2

公开(公告)日：2005-12-08

申请号：PCT/US2005/018592

申请日：2005-05-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  GHARIB, Morteza ,  RINDERKNECHT, Derek ,  BARBIC, Mladen

Inventor： GHARIB, Morteza ,  RINDERKNECHT, Derek ,  BARBIC, Mladen

IPC: H02K7/09

CPC classification number: H02K41/031 ,  A61M2205/0244 ,  F04B19/006 ,  F04B43/043 ,  F04B43/12 ,  H02K7/14 ,  H02K33/16 ,  H02K99/20

Abstract: An electromagnetic actuator for a microfluidic pump of the type that causes periodic pinching and releasing against the walls of a fluidic channel, e.g., a tube. At least one permanent magnet is placed against the walls of the fluidic channel, and located in an area with magnetic fields, produced by coils that are radially symmetric to the channel. The permanent magnet is cause to press and release against the wall of the fluid channel to cause a fluid flow through the channel.

Abstract translation: 一种用于微流体泵的电磁致动器，其导致周期性地夹紧和释放流体通道（例如管）的壁。 至少一个永磁体被放置在流体通道的壁上，并且位于具有与通道径向对称的线圈产生的具有磁场的区域中。 永磁体是使流体通道的壁压下并释放以使流体流过通道。

公开(公告)号：WO2014124040A1

公开(公告)日：2014-08-14

申请号：PCT/US2014/014925

申请日：2014-02-05

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY ,  INSTITUTE OF EXPERIMENTAL MEDICINE OF THE HUNGARIAN ACADEMY OF SCIENCES ,  HOWARD HUGHES MEDICAL INSTITUTE ,  MEDINTZ, Igor, L. ,  ANDRASFALVY, Bertalan, K. ,  SUSUMU, Kimihiro ,  DELEHANTY, James, B. ,  HUSTON, Alan, L. ,  MACKLIN, John, J. ,  BARBIC, Mladen

Inventor： MEDINTZ, Igor, L. ,  ANDRASFALVY, Bertalan, K. ,  SUSUMU, Kimihiro ,  DELEHANTY, James, B. ,  HUSTON, Alan, L. ,  MACKLIN, John, J. ,  BARBIC, Mladen

IPC: C12M1/42 ,  C12N13/00

CPC classification number: G01N33/48728 ,  B01L3/021 ,  B01L2300/168 ,  C03C17/003 ,  C03C17/009 ,  C03C17/22 ,  C03C2217/28 ,  C12M35/02

Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.

Abstract translation: 玻璃移液器如用于电生理记录的电极涂覆有量子点。 这大大有助于观察玻璃移液管的能力，特别是在组织中，因为量子点在用于在几百微米的深度处可视化物体的双光子照明下提供优异的性能。

公开(公告)号：WO2005121838A3

公开(公告)日：2006-11-16

申请号：PCT/US2005019980

申请日：2005-06-07

Applicant: CALIFORNIA INST OF TECHN ,  BARBIC MLADEN

Inventor： BARBIC MLADEN

IPC: G01V3/00 ,  G01R33/20

CPC classification number: G01R33/20

Abstract: The reversible transverse susceptibility of magnetic nanoparticles is used to achieve magnetic flux amplification in magnetic resonance settings. Nanoparticles having substantially uniaxial or unidirectional magnetic anisotropy and a reversible transverse susceptibility in the presence of the high DC magnetic field provide either or both of an amplification of the generated signal of an inductive coil or the detected signal of an inductive coil.

Abstract translation: 使用磁性纳米颗粒的可逆横向磁化率来实现磁共振设置中的磁通量放大。 在存在高DC磁场的情况下具有基本上单轴或单向磁各向异性和可逆横向磁化率的纳米颗粒提供感应线圈的产生信号的放大或感应线圈的检测信号中的一个或两者。

公开(公告)号：WO2005121838A2

公开(公告)日：2005-12-22

申请号：PCT/US2005/019980

申请日：2005-06-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  BARBIC, Mladen

Inventor： BARBIC, Mladen

IPC: G01V3/00

CPC classification number: G01R33/20

Abstract: The reversible transverse susceptibility of magnetic nanoparticles is used to achieve magnetic flux amplification in magnetic resonance settings. Nanoparticles having substantially uniaxial or unidirectional magnetic anisotropy and a reversible transverse susceptibility in the presence of the high DC magnetic field provide either or both of an amplification of the generated signal of an inductive coil or the detected signal of an inductive coil.

Abstract translation: 使用磁性纳米颗粒的可逆横向磁化率来实现磁共振设置中的磁通量放大。 具有大直径单向或单向磁各向异性的纳米颗粒和存在高DC磁场的可逆横向磁化率提供感应线圈的产生信号的放大或感应线圈的检测信号中的一个或两者。

公开(公告)号：WO2007081730A1

公开(公告)日：2007-07-19

申请号：PCT/US2007/000141

申请日：2007-01-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  BARBIC, Mladen ,  SCHERER, Axel

Inventor： BARBIC, Mladen ,  SCHERER, Axel

IPC: G01R33/48

CPC classification number: G01R33/48 ,  G01R33/30 ,  G01R33/3808 ,  G01R33/383

Abstract: Systems and methods for obtaining two- and three-dimensional magnetic resonance images by using azimuthally symmetric dipolar magnetic fields from magnetic spheres . A complete two- or three- dimensional structured rendering of a sample can be obtained without the motion of the sample relative to the sphere. Magnetic spheres in the range of 100 μm and 100 nm are used with samples that are approximately one-tenth as large as the magnetic sphere . Sequential positioning of the integrated sample-sphere system in an external magnetic field being much larger than the magnetic field of the sphere (e.g. 10T) at various angular orientations provides all the required imaging slices for successful computerized tomographic image reconstruction. The requirement to scan the sample relative to the magnetic tip is eliminated. Resolutions approaching atomic dimensions are expected to be obtained.

Abstract translation: 通过使用磁球的方位角对称偶极磁场获得二维和三维磁共振图像的系统和方法。 可以获得样品的完整的二维或三维结构渲染，而不需要样品相对于球体的运动。 使用范围为100μm和100 nm的磁性球体，其面积大约为磁球的十分之一。 集成的样品球系统在外部磁场中的顺序定位比各种角度取向上的球体（例如10T）大得多，为成功的计算机断层图像重建提供了所有所需的成像切片。 消除了相对于磁头扫描样品的要求。 预计将获得接近原子尺寸的分辨率。

公开(公告)号：WO2005117240A3

公开(公告)日：2007-02-01

申请号：PCT/US2005018592

申请日：2005-05-25

Applicant: CALIFORNIA INST OF TECHN ,  GHARIB MORTEZA ,  RINDERKNECHT DEREK ,  BARBIC MLADEN

Inventor： GHARIB MORTEZA ,  RINDERKNECHT DEREK ,  BARBIC MLADEN

IPC: F04B17/03 ,  F04B17/00 ,  F04B19/00 ,  F04B43/00 ,  F04B43/04 ,  F04B43/12 ,  H02K7/09 ,  H02K7/14 ,  H02K41/03

CPC classification number: H02K41/031 ,  A61M2205/0244 ,  F04B19/006 ,  F04B43/043 ,  F04B43/12 ,  H02K7/14 ,  H02K33/16 ,  H02K99/20

Abstract: An electromagnetic actuator for a microfluidic pump of the type that causes periodic pinching and releasing against the walls of a fluidic channel, e.g., a tube. At least one permanent magnet is placed against the walls of the fluidic channel, and located in an area with magnetic fields, produced by coils that are radially symmetric to the channel. The permanent magnet is cause to press and release against the wall of the fluid channel to cause a fluid flow through the channel.

Abstract translation: 一种用于微流体泵的电磁致动器，其导致周期性地夹紧和释放流体通道（例如管）的壁。 至少一个永磁体被放置在流体通道的壁上，并且位于具有与通道径向对称的线圈产生的具有磁场的区域中。 永磁体是使流体通道的壁压下并释放以使流体流过通道。