公开(公告)号：WO2023027732A1

公开(公告)日：2023-03-02

申请号：PCT/US2021/048044

申请日：2021-08-27

Applicant: SPINTECH, INC.

Inventor： KOKENY, Paul David ,  HAACKE, Ewart Mark

IPC: G01R33/56 ,  A61B5/055 ,  G01R33/48 ,  G01R33/561 ,  G01R33/563

Abstract: A magnetic resonance imaging (MRI) system can include a processor and a memory. The processor can receive an acquired magnetic resonance (MR) dataset having a first signal-to-noise ratio (SNR). The processor can extract, from the acquired MR dataset, a first set of values corresponding to a first variable having a second SNR and a second set of values corresponding to a second variable. The processor can apply a constraint function that includes a function of the first variable and the second variable. The processor can minimize a cost function according to the constraint function to generate a cost function solution. The processor can input the first variable and the second variable into the cost function solution to generate a modified first variable having a third SNR, the third SNR being greater than the second SNR.

公开(公告)号：WO2023014924A1

公开(公告)日：2023-02-09

申请号：PCT/US2022/039490

申请日：2022-08-04

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

Inventor： HAM, Donhee ,  ROSEN, Bruce ,  SONG, Yi-Qiao

IPC: G01N15/10 ,  G01N24/08 ,  G01R33/30 ,  G01R33/34 ,  G01R33/46 ,  G01R33/48

Abstract: A magnetic field monitoring system can include a host system that generates a magnetic field. The magnetic field monitoring system can include a plurality of sensor assemblies disposed apart from each other within the host system. Each of the plurality of sensor assemblies can include a coil wound around a sample and an integrated circuit coupled with the coil. The integrated circuit can perform one or more MR measurements of the sample using one or more pulse sequences.

公开(公告)号：WO2022233719A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/061438

申请日：2022-04-29

Applicant: OTTO-VON-GUERICKE-UNIVERSITY MAGDEBURG

Inventor： KAUFMANN, Jörn ,  LIEBE, Thomas

IPC: A61B5/055 ,  G01R33/48 ,  G06T7/00 ,  A61B5/00

Abstract: In at least one embodiment, the method for detecting nerve fibers (NF) in a brain (B) of a patient comprises: - receiving position information indicative for the position of a certain brain region (BR) of the brain, - tracking nerve fibers starting from the position of the certain brain region in order to determine the nerve fibers connecting the certain brain region with other brain regions by using the position information and structural brain data, wherein - the structural brain data are indicative for the distribution of nerve fibers in the brain.

公开(公告)号：WO2022198034A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020928

申请日：2022-03-18

Applicant: RESONANCE RESEARCH, INC.

Inventor： HETHERINGTON, Hoby P.

IPC: G01R33/58 ,  G01R33/48 ,  G01R33/483 ,  G01R33/36 ,  A61B5/055

Abstract: A system and method of generating Radio Frequency (RF) pulses RF(t) in a Multi-band (MB) Magnetic Resonance Imaging (MRI) system is presented. The method includes determining a dirac comb function, the period of the comb function determining the frequency separation of the excitation bands. The method further includes determining a single band frequency selective pulse, defining the envelope of a pulse of RF(t), and the shape of individual excitation frequency bands in the frequency domain. The method further includes determining the shape of RF(t) during each period, and is used to modulate uniformity and/or number of individual excitation bands in the frequency domain. RF(t) pulses are generated in the MRI system simultaneously with an MRI gradient so as to simultaneously excite multiple slices within a subject, wherein the RF(t) pulse create a spin response.

公开(公告)号：WO2022183988A1

公开(公告)日：2022-09-09

申请号：PCT/CN2022/077989

申请日：2022-02-25

Applicant: THE UNIVERSITY OF HONG KONG

Inventor： WU, Ed Xuekui ,  XIE, Linshan ,  HU, Jiahao ,  ZHAO, Yujiao ,  MAN, Christopher

IPC: G06N3/04 ,  A61B5/055 ,  G01R33/48

Abstract: Systems and methods for improving magnetic resonance imaging relate to reconstructing multi-slice images based on sharing the strong structural similarities between adjacent image slices. In addition, a joint denoising method exploits these structural similarities. In part the reconstruction is based on use of a residual neural networks and denoising is achieved with a deep learning based strategy. The system and method have proved useful in both simulation and in vivo brain experiments, demonstrating significant noise reduction in all images and revealing more microstructural details in quantitative diffusion maps.

公开(公告)号：WO2022161838A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/051181

申请日：2022-01-20

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： MATTERS, Marco ,  HUIJBERS, Willem ,  LAMERICHS, Rudolf Mathias Johannes Nicolaas ,  VAN EE, Raymond ,  LEUFKENS, Timmy Robertus Maria ,  WESTERINK, Joanne Henriëtte Desirée Monique ,  MENA BENITO, Maria Estrella

IPC: G01R33/48

Abstract: The present invention relates to a method (10) for monitoring the performance of a predetermined test task executed by a subject during an fMRI examination. The method comprises acquiring (11) a timeseries of fMRI images and providing (12) a sensory stimulus to the subject during the acquisition in accordance with the predetermined test task. The method comprises determining (13), after the sensory stimulus, an activity measure indicative of brain activity in at least one predetermined region of interest, and generating (14) at least one signal when the activity measure is indicative of a poor performance of and/or compliance to the predetermined test task. The signal is generated during the acquisition of the time series and/or before removing the subject from the magnetic resonance imaging system. Further aspects of the invention relate to computer program products, computer systems and MRI systems.

公开(公告)号：WO2022056394A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/050088

申请日：2021-09-13

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： XU, Zhen ,  NOLL, Douglas ,  HALL, Timothy, L.

IPC: A61N7/02 ,  A61B5/055 ,  A61B90/00 ,  G01R33/48

Abstract: A transcranial magnetic resonance (MR)-guided histotripsy (tcMRgHt) system is provided. Using electronic steering only, the tcMRgHt system is configured to create lesions of 25.5 mm in the transverse plane and 50 mm in the axial plane through the skull of a patient. This disclosure provides the design, fabrication, acoustic characterization, and MR compatibility assessment of tcMRgHt systems for histotripsy.

公开(公告)号：WO2022022836A1

公开(公告)日：2022-02-03

申请号：PCT/EP2020/071673

申请日：2020-07-31

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.

Inventor： FRAHM, Jens ,  VOIT, Dirk ,  KALENTEV, Oleksandr

IPC: G01R33/563 ,  G01R33/48 ,  G01R33/483 ,  G01R33/561 ,  G01R33/56

Abstract: A method for creating multiple sequences of diffusion-weighted magnetic resonance (MR) images of an object is described, wherein each of said sequences of MR images represents the same series of contiguous cross-sectional slices covering a volume of the object. The method comprises (a) providing multiple sequences of sets of image raw data being collected with the use of at least one radiofrequency receiver coil of a magnetic resonance imaging device, wherein each set of image raw data includes data samples being generated with a combined diffusion-weighted spin-echo and single-shot stimulated-echo sequence with diffusion-encoding gradients, (b) subjecting a sequence of sets of image raw data generated with diffusion-encoding gradients of zero strength or lower strength to a regularized nonlinear inverse reconstruction process to provide a sequence of coil sensitivities and MR images with no or lower diffusion weighting, and (c) subjecting all se- quences of sets of image raw data with diffusion-encoding gradients of zero or lower strength as well as of higher strength to a regularized linear inverse reconstruction process, to provide a sequence of MR images with no or lower diffusion weighting and a sequence of MR images with higher strength, each of the MR images representing one of the cross-sectional slices and being created by using the sensitivity of the at least one receiver coil determined in step (b) for the same cross-sectional slice and in dependency on a difference between a current image content estimation and an image content estimation of a neighboring cross-sectional slice. Furthermore, an MRI device for creating a sequence of diffusion-weighted MR images of an object is described.

公开(公告)号：WO2021247857A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035693

申请日：2021-06-03

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： NING, Lipeng ,  RATHI, Yogesh ,  JI, Yang ,  GAGOSKI, Borjan

IPC: G01R33/48 ,  G01R33/563 ,  G01R33/20 ,  G01R33/44 ,  G01R33/46 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/56341

Abstract: Scan time in diffusion-relaxation magnetic resonance imaging ("MRI") is reduced by implementing time-division multiplexing ("TDM"). In general, time-shifted radio frequency ("RF") pulses are used to excite two or more imaging volumes. These RF pulses are applied to induce separate echoes for each slice. Diffusion MRI data can thus be acquired with different echo times, or alternatively with the same echo time, in significantly reduced overall scan time. Multidimensional correlations between diffusion and relaxation parameters can be estimated from the resulting data.

公开(公告)号：WO2021239217A1

公开(公告)日：2021-12-02

申请号：PCT/EP2020/064580

申请日：2020-05-26

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.

Inventor： FRAHM, Jens ,  VOIT, Dirk

IPC: G01R33/48 ,  G01R33/483 ,  G01R33/561

Abstract: A method for creating, in particular acquiring and reconstructing, a sequence of magnetic resonance (MR) images of an object (1), said sequence of MR images representing a series of cross-sectional slices (2) of the object (1), comprises (a) providing a series of sets of image raw data including an image content of the MR images to be reconstructed, said image raw data being collected with at least one radiofrequency receiver coil of a magnetic resonance imaging (MRI) device, wherein each set of image raw data includes a plurality of data samples being generated in an imaging plane with a gradient-echo sequence that spatially encodes an MRI signal received with the at least one radiofrequency receiver coil using a non-Cartesian k-space trajectory, each set of image raw data comprises a set of homogeneously distributed lines in k-space with equivalent spatial frequency content, the lines of each set of image raw data cross the center of k-space and cover a continuous range of spatial frequencies, the positions of the lines of each set of image raw data differ in successive sets of image raw data, and the number of lines of each set of image raw data is selected such that each set of image raw data is undersampled below a sampling rate limit defined by the Nyquist-Shannon sampling theorem, and (b) subjecting the sets of image raw data to a regularized nonlinear inverse reconstruction process to provide the sequence of MR images, wherein each of the MR images is created by a simultaneous estimation of a sensitivity of the at least one receiver coil and the image content and in dependency on a difference between a current estimation of the sensitivity of the at least one receiver coil and the image content and a preceding estimation of the sensitivity of the at least one receiver coil and the image content, wherein said cross-sectional slices (2) of the object (1) are contiguous cross-sectional slices (2) with a predetermined slice thickness, each set of said image raw data represents one of said contiguous cross-sectional slices (2), and the position of each cross-sectional slice is shifted by a slice shift Δ perpendicular to the imaging plane in order to cover a volume of the object (1).