公开(公告)号：WO2018089863A1

公开(公告)日：2018-05-17

申请号：PCT/US2017/061202

申请日：2017-11-11

Applicant: BENNES, INC. ,  ROSS, Benjamin, F. ,  GIN, Jerry, B.

Inventor： ROSS, Benjamin, F. ,  GIN, Jerry, B.

IPC: A61K9/68 ,  A61P25/00 ,  A61K36/185 ,  A61P25/06

Abstract: Lozenges comprising ethyl cellulose and cannabinoids for rapid and efficient delivery of medical cannabinoids are provided. The lozenge is suitable for administration of the cannabinoid(s) through the oral mucosa to the bloodstream. Embodiments of the lozenge are disclosed that comprise additives which alleviate other issues related to administration of cannabinoids. Additives disclosed include xanthan gum to alleviate dry mouth syndrome, essential oils for flavoring and anti-bacterial activities, zinc for breath improvement, permeation enhancers and alkali metal bicarbonates for reducing acidity in the mouth. Methods for manufacture of the lozenges and its use in treatment of disease conditions are provided.

Abstract translation: 提供了包含乙基纤维素和大麻素的锭剂，用于快速和高效地输送医疗大麻素。 锭剂适用于通过口腔粘膜向血流施用大麻素。 公开了锭剂的实施方案，其包含缓解与施用大麻素有关的其他问题的添加剂。 所公开的添加剂包括用于减轻口干综合症的黄原胶，用于调味和抗菌活性的精油，用于改善呼吸的锌，渗透促进剂和碱金属碳酸氢盐用于减少口腔中的酸度。 提供了制造锭剂的方法及其在治疗疾病状况中的用途。

公开(公告)号：WO2009042968A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/078020

申请日：2008-09-26

Applicant: BENNES, INC. ,  GIN, Jerry, B. ,  ROSS, Benjamin, F.

Inventor： GIN, Jerry, B. ,  ROSS, Benjamin, F.

IPC: A61K9/22

CPC classification number: A61K31/135 ,  A61K8/02 ,  A61K8/731 ,  A61K8/922 ,  A61K9/0056 ,  A61K31/185 ,  A61K31/34 ,  A61K31/40 ,  A61K31/415 ,  A61K31/44 ,  A61K31/555 ,  A61K31/60 ,  A61K33/30 ,  A61K36/534 ,  A61K36/54 ,  A61K36/61 ,  A61K36/752 ,  A61K47/38 ,  A61K2800/5422 ,  A61Q11/00

Abstract: Aspects of the invention include a sustained release dosage form that can be administered to an oral cavity, e.g., the mouth. In certain embodiments, the sustained release dosage form is formulated as a lozenge or gum that may be administered to an oral cavity of a user for the purpose of dissolving over a prolonged period of time and thereby delivering an essential oil component therein. In certain embodiments, the sustained release dosage form includes a beneficial agent and, therefore, not only provides for the prolonged delivery of an essential oil component to an oral cavity, but also provides for the sustained release of a beneficial agent thereto. In certain embodiments, the sustained release dosage form includes a biocompatible, water-insoluble polymer, e.g., ethylcellulose and an essential oil component, which are combined in such a manner so as to produce a dosage form that substantially dissolves over a prolonged period of time when positioned within an aqueous environment, such as an oral cavity of a user. In certain embodiments, the sustained release dosage form may include an additional water soluble agent, such as gum arabic, which may be included so as to further provide the dosage form with a desired dissolution characteristic. In certain embodiments, the dosage form may also include a beneficial agent to be delivered to the mouth. Methods of formulating such dosage forms and administering them to an oral cavity for the treatment of an adverse condition are also provided herein.

Abstract translation: 本发明的方面包括可以施用于口腔例如口腔的持续释放剂型。 在某些实施方案中，持续释放剂型被配制为可以施用于使用者的口腔的长柄剂或口香糖，以便在长时间内溶解，从而在其中输送精油成分。 在某些实施方案中，持续释放剂型包括有益剂，因此不仅提供将精油组分延长递送至口腔，而且还提供有益剂向其持续释放。 在某些实施方案中，持续释放剂型包括生物相容的水不溶性聚合物，例如乙基纤维素和精油组分，其以这样的方式组合以产生在延长的时间段内基本溶解的剂型 当定位在水性环境（例如使用者的口腔）内时。 在某些实施方案中，持续释放剂型可以包括额外的水溶性试剂，例如阿拉伯树胶，其可以包括以进一步提供具有期望的溶解特性的剂型。 在某些实施方案中，剂型还可以包括要递送至口腔的有益剂。 本文还提供了将这种剂型配制并将其施用于口腔以治疗不良状况的方法。

公开(公告)号：WO2004070017A2

公开(公告)日：2004-08-19

申请号：PCT/US2004/003181

申请日：2004-02-04

Applicant: BENNES, INC. ,  GIN, Jerry, B. ,  ROSS, Benjamin, F.

Inventor： GIN, Jerry, B. ,  ROSS, Benjamin, F.

IPC: C12N

CPC classification number: A23G3/368 ,  A23G3/362 ,  A23G3/54 ,  A23L27/72 ,  A23L33/165 ,  A23V2002/00 ,  A61K9/0056 ,  Y10S514/959 ,  A23V2200/224 ,  A23V2250/51088 ,  A23V2250/264 ,  A23V2250/1642

Abstract: Flavored dosage forms, e.g., lozenges and gums, are provided for sustained release of a flavoring agent in the mouth. The dosage forms provide sustained release by virtue of a wet matrix formed by admixture of a biocompatible, hydrophilic, water-insoluble polymer such as ethylcellulose and a flavoring agent, particularly an essential oil or a constituent thereof, e.g., a terpene or sesquiterpene. The dosage forms may also include a second beneficial agent in addition to the flavoring agent. Exemplary such beneficial agents include ionizable zinc compounds and other cold remedies, local anesthetic and anti-infective agents, diet aids, fluoride-releasing compounds, and nicotine. The dosage forms, when formulated as lozenges, may be somewhat adhesive or substantially nontacky, depending primarily on the molecular weight of the hydrophilic polymer. Adhesive lozenges can serve as dosage forms that adhere to the teeth or gums for delivery of a beneficial agent thereto. Methods for using the dosage forms to provide sustained release of a flavoring agent and optionally deliver a second beneficial agent are also provided, as are methods for treating the common cold, treating a sore throat, facilitating weight loss, and assisting in smoking cessation.

Abstract translation: 提供调味剂剂型，例如锭剂和牙龈，用于在口中持续释放调味剂。 剂型由于通过生物相容性，亲水性，水不溶性聚合物如乙基纤维素和调味剂，特别是精油或其组分（例如萜烯或倍半萜烯）的混合而形成的湿基质提供持续释放。 除了调味剂之外，剂型还可以包括第二有益剂。 示例性的这种有益剂包括可离子化锌化合物和其他冷治疗剂，局部麻醉剂和抗感染剂，饮食助剂，氟化物释放化合物和尼古丁。 配制成锭剂时，剂型可能有些粘稠或基本上不粘，主要取决于亲水性聚合物的分子量。 胶粘剂锭剂可以用作粘附到牙齿或牙龈上以递送有益剂的剂型。 还提供了使用剂型提供调味剂的持续释放和任选地递送第二有益剂的方法，以及治疗感冒，治疗喉咙痛，促进体重减轻和协助戒烟的方法。

公开(公告)号：WO2017062522A1

公开(公告)日：2017-04-13

申请号：PCT/US2016/055596

申请日：2016-10-05

Applicant: BENNES INC. ,  GIN, Jerry B. ,  ROSS, Benjamin F.

Inventor： GIN, Jerry B. ,  ROSS, Benjamin F.

IPC: G01N30/90 ,  B01L3/00 ,  G01N33/558 ,  G01N30/91

CPC classification number: G01N33/558 ,  A61B10/0051 ,  A61B2010/0003 ,  G01N30/91 ,  G01N2800/18

Abstract: A dry mouth test is provided comprising placing a wickable test strip in the mouth of a subject to collect salivary fluid. Distance migrated by the saliva over a specific period of time correlates with the production of saliva and dryness of the mouth. A marker dye is optionally used on the strip which co-migrates with the saliva front and aids in indicating the distance saliva migrates on the strip. A graduated migration scale is printed on the strip to indicate the distance traveled by the saliva. Saliva production is measured with or without stimulation of the salivary glands.

Abstract translation: 提供口干试验，包括将可检测的试纸条置于受试者的口中以收集唾液。 唾液在一段特定的时期内迁移的距离与唾液的产生和口腔干燥有关。 标记染料任选地用于与唾液前沿共同迁移的条上，并有助于指示唾液在条带上迁移的距离。 在条上打印出一个刻度的迁移量表，以表示唾液行进的距离。 唾液生产是用或不刺激唾液腺来测量的。

公开(公告)号：WO2009042969A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/078022

申请日：2008-09-26

Applicant: BENNES, INC. ,  GIN, Jerry, B. ,  ROSS, Benjamin, F.

Inventor： GIN, Jerry, B. ,  ROSS, Benjamin, F.

IPC: A61K9/22

CPC classification number: A61K36/534 ,  A61K9/0056 ,  A61K9/205 ,  A61K9/2054 ,  A61K31/315 ,  A61K36/54 ,  A61K36/61 ,  A61K36/752

Abstract: Aspects of the invention include a sustained release dosage form that can be administered to an oral cavity, e.g., the mouth. In certain embodiments, the sustained release dosage form is formulated as a lozenge or gum that may be administered to an oral cavity for the purpose of providing lubrication therein. In certain embodiments, the sustained release dosage form not only provides lubrication to a mucosal surface of an oral cavity, but also provides for the sustained release of a flavoring and/or beneficial agent. Accordingly, in certain embodiments, the sustained release dosage form includes a water-insoluble polymer, e.g., ethylcellulose, an essential oil component, and an effective amount of a film forming binder, e.g., xanthan gum. In certain embodiments, the effective amount of the film forming binder and the type of film forming binder are selected so as to provide the sustained release dosage with the capability of lubricating one or more mucosal surfaces within an oral cavity when the dosage form is positioned therein. In certain embodiments, the sustained release dosage form is formulated in a manner sufficient to form a matrix that includes the various components of the sustained release dosage form, such that when positioned in an oral cavity the matrix slowly dissolves and thereby lubricates the oral cavity and/or delivers a flavoring and/or beneficial agent thereto. Methods of formulating such dosage forms and administering them to an oral cavity for the treatment of an adverse condition are also provided.

Abstract translation: 本发明的方面包括可以施用于口腔例如口腔的持续释放剂型。 在某些实施方案中，持续释放剂型被配制为可以施用于口腔以便在其中提供润滑的锭剂或口香糖。 在某些实施方案中，持续释放剂型不仅提供对口腔粘膜表面的润滑，而且还提供调味剂和/或有益剂的持续释放。 因此，在某些实施方案中，缓释剂型包括水不溶性聚合物，例如乙基纤维素，精油组分和有效量的成膜粘合剂，例如黄原胶。 在某些实施方案中，选择有效量的成膜粘合剂和成膜粘合剂的类型，以便当剂型位于其中时提供具有在口腔内润滑一个或多个粘膜表面的能力的持续释放剂量 。 在某些实施方案中，持续释放剂型以足以形成包含缓释剂型的各种组分的基质的方式配制，使得当定位在口腔中时，基质缓慢溶解并由此润滑口腔， /或向其递送调味剂和/或有益剂。 还提供了将这种剂型配制并将其施用于口腔以治疗不良状况的方法。

公开(公告)号：WO2004070017A3

公开(公告)日：2005-01-27

申请号：PCT/US2004003181

申请日：2004-02-04

Applicant: BENNES INC ,  GIN JERRY B ,  ROSS BENJAMIN F

Inventor： GIN JERRY B ,  ROSS BENJAMIN F

IPC: A23G3/00 ,  A23G3/36 ,  A23G3/54 ,  A23L1/22 ,  A23L1/304 ,  A61K9/00 ,  A61K9/22

CPC classification number: A23G3/368 ,  A23G3/362 ,  A23G3/54 ,  A23L27/72 ,  A23L33/165 ,  A23V2002/00 ,  A61K9/0056 ,  Y10S514/959 ,  A23V2200/224 ,  A23V2250/51088 ,  A23V2250/264 ,  A23V2250/1642

Abstract: Flavored dosage forms, e.g., lozenges and gums, are provided for sustained release of a flavoring agent in the mouth. The dosage forms provide sustained release by virtue of a wet matrix formed by admixture of a biocompatible, hydrophilic, water-insoluble polymer such as ethylcellulose and a flavoring agent, particularly an essential oil or a constituent thereof, e.g., a terpene or sesquiterpene. The dosage forms may also include a second beneficial agent in addition to the flavoring agent. Exemplary such beneficial agents include ionizable zinc compounds and other cold remedies, local anesthetic and anti-infective agents, diet aids, fluoride-releasing compounds, and nicotine. The dosage forms, when formulated as lozenges, may be somewhat adhesive or substantially nontacky, depending primarily on the molecular weight of the hydrophilic polymer. Adhesive lozenges can serve as dosage forms that adhere to the teeth or gums for delivery of a beneficial agent thereto. Methods for using the dosage forms to provide sustained release of a flavoring agent and optionally deliver a second beneficial agent are also provided, as are methods for treating the common cold, treating a sore throat, facilitating weight loss, and assisting in smoking cessation.

Abstract translation: 提供调味剂剂型，例如锭剂和牙龈，用于在口中持续释放调味剂。 剂型由于通过生物相容性，亲水性，水不溶性聚合物如乙基纤维素和调味剂，特别是精油或其组分（例如萜烯或倍半萜烯）的混合而形成的湿基质提供持续释放。 除了调味剂之外，剂型还可以包括第二有益剂。 示例性的这种有益剂包括可离子化锌化合物和其他冷治疗剂，局部麻醉剂和抗感染剂，饮食助剂，氟化物释放化合物和尼古丁。 配制成锭剂时，剂型可能有些粘稠或基本上不粘，主要取决于亲水性聚合物的分子量。 胶粘剂锭剂可以用作粘附到牙齿或牙龈上以递送有益剂的剂型。 还提供了使用剂型提供调味剂的持续释放和任选地递送第二有益剂的方法，以及治疗感冒，治疗喉咙痛，促进体重减轻和协助戒烟的方法。