公开(公告)号：WO2005051304A3

公开(公告)日：2005-06-09

申请号：PCT/US2004/039094

申请日：2004-11-19

Applicant: ARRAY BIOPHARMA INC. ,  MITCHELL, Ian, S. ,  SPENCER, Keith, L. ,  STENGEL, Peter ,  HAN, Yongxin ,  KALLAN, Nicholas, C. ,  MUNSON, Mark ,  VIGERS, Guy, P., A. ,  BLAKE, James ,  PISCOPIO, Anthony ,  JOSEY, John ,  MILLER, Scott ,  XIAO, Dengming ,  XU, Riu ,  RAO, Chang ,  WANG, Bin ,  BERNACKI, April, L.

Inventor： MITCHELL, Ian, S. ,  SPENCER, Keith, L. ,  STENGEL, Peter ,  HAN, Yongxin ,  KALLAN, Nicholas, C. ,  MUNSON, Mark ,  VIGERS, Guy, P., A. ,  BLAKE, James ,  PISCOPIO, Anthony ,  JOSEY, John ,  MILLER, Scott ,  XIAO, Dengming ,  XU, Riu ,  RAO, Chang ,  WANG, Bin ,  BERNACKI, April, L.

IPC: A61K31/53 ,  A61K31/519 ,  A61K31/496 ,  C07D257/12 ,  C07D253/00 ,  C07D401/00

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：WO2005051304A2

公开(公告)日：2005-06-09

申请号：PCT/US2004039094

申请日：2004-11-19

Applicant: ARRAY BIOPHARMA INC ,  MITCHELL IAN S ,  SPENCER KEITH L ,  STENGEL PETER ,  HAN YONGXIN ,  KALLAN NICHOLAS C ,  MUNSON MARK ,  VIGERS GUY P A ,  BLAKE JAMES ,  PISCOPIO ANTHONY ,  JOSEY JOHN ,  MILLER SCOTT ,  XIAO DENGMING ,  XU RIU ,  RAO CHANG ,  WANG BIN ,  BERNACKI APRIL L

Inventor： MITCHELL IAN S ,  SPENCER KEITH L ,  STENGEL PETER ,  HAN YONGXIN ,  KALLAN NICHOLAS C ,  MUNSON MARK ,  VIGERS GUY P A ,  BLAKE JAMES ,  PISCOPIO ANTHONY ,  JOSEY JOHN ,  MILLER SCOTT ,  XIAO DENGMING ,  XU RIU ,  RAO CHANG ,  WANG BIN ,  BERNACKI APRIL L

IPC: A61K20060101 ,  A61K31/496 ,  A61K31/519 ,  A61K31/53 ,  A61K

CPC classification number: C07D239/94 ,  B41M3/008 ,  B44F1/10 ,  C07D231/56 ,  C07D237/28 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  G09F13/16 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/25 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供包括分解对映异构体，非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式为：A-L-CR，其中CR为环状核心基团，L为连接基团，A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。