公开(公告)号：WO2005095403A3

公开(公告)日：2005-12-01

申请号：PCT/US2005010494

申请日：2005-03-29

Applicant: INTERMUNE INC ,  BLATT LAWRENCE M ,  WENGLOWSKY STEVEN M ,  ANDREWS STEVEN W ,  CONDROSKI KEVIN R ,  JIANG YUTONG ,  KENNEDY APRIL L ,  DOHERTY GEORGE A ,  JOSEY JOHN A ,  STENGEL PETER J ,  WOODARD BENJAMIN T ,  MADDURU MACHENDER R

Inventor： BLATT LAWRENCE M ,  WENGLOWSKY STEVEN M ,  ANDREWS STEVEN W ,  CONDROSKI KEVIN R ,  JIANG YUTONG ,  KENNEDY APRIL L ,  DOHERTY GEORGE A ,  JOSEY JOHN A ,  STENGEL PETER J ,  WOODARD BENJAMIN T ,  MADDURU MACHENDER R

IPC: A61K31/495 ,  A61P31/12 ,  C07D487/00 ,  C07D487/04 ,  C07K5/08 ,  C07K5/083 ,  C07D209 ,  C07D245

CPC classification number: C07K5/0804 ,  C07D487/04

Abstract: The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供了大环化合物以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗黄病毒感染的方法，包括丙型肝炎病毒感染和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

公开(公告)号：WO2005051304A3

公开(公告)日：2005-06-09

申请号：PCT/US2004/039094

申请日：2004-11-19

Applicant: ARRAY BIOPHARMA INC. ,  MITCHELL, Ian, S. ,  SPENCER, Keith, L. ,  STENGEL, Peter ,  HAN, Yongxin ,  KALLAN, Nicholas, C. ,  MUNSON, Mark ,  VIGERS, Guy, P., A. ,  BLAKE, James ,  PISCOPIO, Anthony ,  JOSEY, John ,  MILLER, Scott ,  XIAO, Dengming ,  XU, Riu ,  RAO, Chang ,  WANG, Bin ,  BERNACKI, April, L.

Inventor： MITCHELL, Ian, S. ,  SPENCER, Keith, L. ,  STENGEL, Peter ,  HAN, Yongxin ,  KALLAN, Nicholas, C. ,  MUNSON, Mark ,  VIGERS, Guy, P., A. ,  BLAKE, James ,  PISCOPIO, Anthony ,  JOSEY, John ,  MILLER, Scott ,  XIAO, Dengming ,  XU, Riu ,  RAO, Chang ,  WANG, Bin ,  BERNACKI, April, L.

IPC: A61K31/53 ,  A61K31/519 ,  A61K31/496 ,  C07D257/12 ,  C07D253/00 ,  C07D401/00

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：WO2005051304A2

公开(公告)日：2005-06-09

申请号：PCT/US2004039094

申请日：2004-11-19

Applicant: ARRAY BIOPHARMA INC ,  MITCHELL IAN S ,  SPENCER KEITH L ,  STENGEL PETER ,  HAN YONGXIN ,  KALLAN NICHOLAS C ,  MUNSON MARK ,  VIGERS GUY P A ,  BLAKE JAMES ,  PISCOPIO ANTHONY ,  JOSEY JOHN ,  MILLER SCOTT ,  XIAO DENGMING ,  XU RIU ,  RAO CHANG ,  WANG BIN ,  BERNACKI APRIL L

Inventor： MITCHELL IAN S ,  SPENCER KEITH L ,  STENGEL PETER ,  HAN YONGXIN ,  KALLAN NICHOLAS C ,  MUNSON MARK ,  VIGERS GUY P A ,  BLAKE JAMES ,  PISCOPIO ANTHONY ,  JOSEY JOHN ,  MILLER SCOTT ,  XIAO DENGMING ,  XU RIU ,  RAO CHANG ,  WANG BIN ,  BERNACKI APRIL L

IPC: A61K20060101 ,  A61K31/496 ,  A61K31/519 ,  A61K31/53 ,  A61K

CPC classification number: C07D239/94 ,  B41M3/008 ,  B44F1/10 ,  C07D231/56 ,  C07D237/28 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  G09F13/16 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/25 ,  Y10T428/31507 ,  Y10T428/31551 ,  Y10T428/31786 ,  Y10T428/31855

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract translation: 本发明提供包括分解对映异构体，非对映异构体，溶剂化物和药学上可接受的盐的化合物，其包含式为：A-L-CR，其中CR为环状核心基团，L为连接基团，A如本文所定义。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

公开(公告)号：WO2006117306A1

公开(公告)日：2006-11-09

申请号：PCT/EP2006/061781

申请日：2006-04-24

Applicant: F. HOFFMANN-LA ROCHE AG ,  BLAKE, James F. ,  FELL, Jay Bradford ,  FISCHER, John P. ,  HENDRICKS, Robert Than ,  SPENCER, Stacey Renee ,  STENGEL, Peter J.

Inventor： BLAKE, James F. ,  FELL, Jay Bradford ,  FISCHER, John P. ,  HENDRICKS, Robert Than ,  SPENCER, Stacey Renee ,  STENGEL, Peter J.

IPC: C07D417/04 ,  C07D417/14 ,  A61K31/416 ,  A61P31/12

CPC classification number: C07D417/06 ,  C07D417/04 ,  C07D417/14

Abstract: Compounds having the formula (I) wherein A, m and R 1 are herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process.

Abstract translation: 本文定义的具有式（I）的化合物，其中A，m和R 1是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了抑制肝炎复制的组合物和方法，制备该方法中使用的化合物和合成中间体的方法。

公开(公告)号：WO2007093541A1

公开(公告)日：2007-08-23

申请号：PCT/EP2007/051162

申请日：2007-02-07

Applicant: F. HOFFMANN-LA ROCHE AG ,  FELL, Jay Bradford ,  MOHR, Peter ,  STENGEL, Peter J.

Inventor： FELL, Jay Bradford ,  MOHR, Peter ,  STENGEL, Peter J.

IPC: C07D417/04 ,  C07D513/04 ,  A61K31/5415 ,  A61K31/542 ,  A61P31/14

CPC classification number: C07D417/04 ,  C07D513/04

Abstract: Compounds having the formula Ia or Ib wherein R 1 , R 2 , R 3 and R 4 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

Abstract translation: 具有式Ia或Ib的化合物，其中R 1，R 2，R 3和R 4定义如上所定义 本文是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。

公开(公告)号：WO2006021340A1

公开(公告)日：2006-03-02

申请号：PCT/EP2005/008855

申请日：2005-08-16

Applicant: F.HOFFMANN-LA ROCHE AG ,  BLAKE, James, F. ,  FELL, Jay, Bradford ,  FISCHER, John, P. ,  ROBINSON, John, E. ,  SPENCER, Stacey, Renee ,  STENGEL, Peter, J. ,  HENDRICKS, Robert, Than

Inventor： BLAKE, James, F. ,  FELL, Jay, Bradford ,  FISCHER, John, P. ,  ROBINSON, John, E. ,  SPENCER, Stacey, Renee ,  STENGEL, Peter, J. ,  HENDRICKS, Robert, Than

IPC: C07D417/04

CPC classification number: C07D471/04 ,  C07D413/06 ,  C07D417/04 ,  C07D495/04

Abstract: Compounds having the formula I wherein A, m and R 1 are herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication. Also disclosed are processes for making the compounds and synthetic intermediates used in the process (I).

Abstract translation: 具有式I的化合物，其中A，m和R

公开(公告)号：WO2005095403A2

公开(公告)日：2005-10-13

申请号：PCT/US2005/010494

申请日：2005-03-29

Applicant: INTERMUNE, INC. ,  BLATT, Lawrence M. ,  WENGLOWSKY, Steven M. ,  ANDREWS, Steven W. ,  CONDROSKI, Kevin R. ,  JIANG, Yutong ,  KENNEDY, April L. ,  DOHERTY, George A. ,  JOSEY, John A. ,  STENGEL, Peter J. ,  WOODARD, Benjamin T. ,  MADDURU, Machender R.

Inventor： BLATT, Lawrence M. ,  WENGLOWSKY, Steven M. ,  ANDREWS, Steven W. ,  CONDROSKI, Kevin R. ,  JIANG, Yutong ,  KENNEDY, April L. ,  DOHERTY, George A. ,  JOSEY, John A. ,  STENGEL, Peter J. ,  WOODARD, Benjamin T. ,  MADDURU, Machender R.

IPC: C07D487/00

CPC classification number: C07K5/0804 ,  C07D487/04

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供了通式I-XIX的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗黄病毒感染的方法，包括丙型肝炎病毒感染和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。