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公开(公告)号：WO2023039022A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/042837
申请日：2022-09-08
发明人： SONTAG, David , MURRAY, Luke, Scott , GOPINATH, Divya , AGRAWAL, Monica, Nayan , KARGER, David, R. , HORNG, Steven
摘要： A computer implemented method for managing medical information includes displaying a number of user interface elements within a graphical user interface, receiving medical information for a patient in a first user interface element of the user interface elements, processing the medical information to identify one or more semantic items, the one or more semantic items including a first semantic item, processing a medical record for the patient according to first semantic item, the processing including identifying a number of medical information items related to the first semantic item, and presenting at least some medical information items of the number of medical information items in a second user interface element configured to display medical information items related to the first semantic item.
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2.发明申请
公开(公告)号：WO2022271786A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034461
申请日：2022-06-22
发明人： HARIHARAN, Vignesh Narayan , KARUMANCHI, Ananth , KHVOROVA, Anastasia , DAVIS, Sarah , BISCANS, Annabelle
IPC分类号： C12N15/113
摘要： This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
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公开(公告)号：WO2022226396A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/026117
申请日：2022-04-25
申请人： GANNA BIO, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CHILDREN'S MEDICAL CENTER CORPORATION , BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： FLYNN, Ryan, A. , GOODMAN, Brian , LAWLOR, Ciaran , BISARIA, Namita , CUMMINGS, Richard, D. , WEI, Mohui , BERTOZZI, Carolyn, R.
摘要： The present disclosure relates to glyconucleic acids, such as glycoRNA and glycoDNA described herein. Provided are glycosylated ribonucleic acid (glycoRNA)-related methods and compositions.
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公开(公告)号：WO2022104153A2
公开(公告)日：2022-05-19
申请号：PCT/US2021/059263
申请日：2021-11-12
发明人： FLAUMENHAFT, Robert , LIN, Lin
IPC分类号： A61K31/352 , A61K31/353 , A61P31/12 , A61K45/06
摘要： The present application provides a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions containing the compound of Formula (I), and methods of using the compound of Formula (I) for treating viral infections and inhibiting thromobosis are also provided.
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5.发明申请
公开(公告)号：WO2022104047A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/059123
申请日：2021-11-12
IPC分类号： A61N5/06
摘要： The present disclosure generally relates, in certain embodiments, to light-based treatments. In some case, a subject having or at risk for a condition such as insomnia can be treated, e.g., with light, such as green light. Other conditions include sleep disorders such as sleep apnea and other indications. In some cases, the light that is administered to the subject may be green light, or the light may have a characteristic wavelength only in a wavelength range between 510 nm and 550 nm with a bandwidth no larger than 20 nm full-width-half- maximum. Other embodiments described herein are generally directed to systems for treating such conditions, kits for treating such conditions, or the like.
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公开(公告)号：WO2022099087A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/058352
申请日：2021-11-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： NGUYEN, Peter, Q. , SOENKSEN, Luis, Ruben Martinez , COLLINS, James, J. , DONGHIA, Nina, M. , ANGENENT-MARI, Nicolaas, M. , GUIXE, Helena, de Puig , HUANG, Ally , LEE, Rose, A. , ZHAO, Evan, M.
摘要： Embodiments of various aspects described herein are directed to an aqueous solution activated detection device. The device includes a carrier fluid reservoir, a sample collection unit, a sample processing unit including dried synthetic biological components, and a detection unit. The device can be integrated into a face mask for detection of airborne pathogens, viruses and toxins.
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7.发明申请
公开(公告)号：WO2022093712A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056497
申请日：2021-10-25
IPC分类号： C07D211/58 , C07D401/06 , C07D405/06
摘要： Provided herein are methods of preventing, mitigating, decreasing, reversing and/or treating Arrhythmogenic Cardiomyopathy (ACM) in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula I, a compounds of Formula II, or a compound of Formula III (I) (II), (III) wherein R1, R2, R3, n, R4, R4a, R5, m, R6, R7, and p are as defined herein.
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公开(公告)号：WO2022055991A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/049457
申请日：2021-09-08
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
发明人： TRAVERSO, Carlo Giovanni , BYRNE, James D. , BOYCE, Hannah , OTTERBEIN, Leo E. , GALLO, David J.
摘要： A pharmaceutical composition is described that includes a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel. Methods of using the pharmaceutical composition to treat an inflammatory disease or condition, and methods of making the pharmaceutical composition, are also described.
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公开(公告)号：WO2022051489A1
公开(公告)日：2022-03-10
申请号：PCT/US2021/048859
申请日：2021-09-02
发明人： LU, Kun Ping , ZHOU, Xiao Zhen
摘要： The present disclosure provides antibodies or antigen-binding fragments thereof that specifically bind to the cis conformation of phosphorylated-Threonine231 -Proline (pThr231-Pro) of tau protein. This disclosure also provides methods for treating a subject having or at risk of developing a neurological disorder. This disclosure includes related pharmaceutical compositions, polynucleotides, vectors, host cells, methods of production, methods of treatment, diagnostic methods, and kits.
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公开(公告)号：WO2021062217A1
公开(公告)日：2021-04-01
申请号：PCT/US2020/052811
申请日：2020-09-25
发明人： SAFFITZ, Jeffrey E.
IPC分类号： A61K31/404 , A61K31/606 , A61K31/7056 , A61K39/00 , A61K45/06
摘要： Described herein are, inter alia, methods for treating arrhythmogenic cardiomyopathy (ACM) using anti-inflammatory agents that IL-1β.
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