公开(公告)号：WO2010019911A2

公开(公告)日：2010-02-18

申请号：PCT/US2009053932

申请日：2009-08-14

Applicant: UNIV TEXAS ,  UNIV SOUTHERN METHODIST ,  D MELLO SANTOSH R ,  BIEHL EDWARD A

Inventor： D MELLO SANTOSH R ,  BIEHL EDWARD A

IPC: C07D241/40 ,  A61K31/535 ,  A61P21/00 ,  C07D265/36 ,  C07D279/16 ,  C07D319/18 ,  C07D335/04

CPC classification number: C07D265/36 ,  C07D413/06

Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.

Abstract translation: 本发明包括用于抑制激酶活性以防止神经变性的组合物和方法，所述神经变性包括诸如阿尔茨海默氏病，帕金森病或亨廷顿舞蹈病的疾病，以及诸如缺血性中风等病症，所述方法包括向所述受试者提供治疗有效量的1， 4-苯并恶嗪化合物及其衍生物。

公开(公告)号：WO2010019911A3

公开(公告)日：2010-02-18

申请号：PCT/US2009/053932

申请日：2009-08-14

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SOUTHERN METHODIST UNIVERSITY ,  D'MELLO, Santosh, R. ,  BIEHL, Edward, A.

Inventor： D'MELLO, Santosh, R. ,  BIEHL, Edward, A.

IPC: C07D241/40 ,  C07D319/18 ,  C07D335/04 ,  C07D265/36 ,  C07D279/16 ,  A61K31/535 ,  A61P21/00

Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.