公开(公告)号：WO2014047463A3

公开(公告)日：2014-03-27

申请号：PCT/US2013/060970

申请日：2013-09-20

Applicant: BIOBLOCKS, INC.

Inventor： PALLAI, Peter, V. ,  WADE, Warren

IPC: C07D405/04 ,  C07D491/18 ,  C07D403/04 ,  C07D401/04 ,  C07D417/04 ,  C07D491/052 ,  C07D417/06 ,  C40B60/12 ,  C40B20/00 ,  C40B60/14 ,  C40B80/00 ,  G06F3/048 ,  G06F19/10 ,  G06F17/50

Abstract: In alternative embodiments the invention provides libraries of compounds, or drugs or drug candidates, manufactured and selected for having a desired property such as a biological or a chemical activity, and methods for making and using them. In one embodiment, the invention provides methods for identifying desirable compounds from very large compound sets using a compound fragment as the query. In alternative embodiments, the invention provides methods of making compounds, and libraries of compounds, using a "feasible reaction" growth scheme.

公开(公告)号：WO2014047463A2

公开(公告)日：2014-03-27

申请号：PCT/US2013060970

申请日：2013-09-20

Applicant: BIOBLOCKS INC

Inventor： PALLAI PETER V ,  WADE WARREN

IPC: C07D405/04

CPC classification number: G06F19/706 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D417/06 ,  C07D498/04 ,  C07D498/20 ,  C40B30/02 ,  G06F3/048

Abstract: In alternative embodiments the invention provides libraries of compounds, or drugs or drug candidates, manufactured and selected for having a desired property such as a biological or a chemical activity, and methods for making and using them. In one embodiment, the invention provides methods for identifying desirable compounds from very large compound sets using a compound fragment as the query. In alternative embodiments, the invention provides methods of making compounds, and libraries of compounds, using a "feasible reaction" growth scheme.

Abstract translation: 在替代实施方案中，本发明提供了制造和选择用于具有所需性质例如生物或化学活性的化合物或药物或药物候选物库，以及制备和使用它们的方法。 在一个实施方案中，本发明提供了使用化合物片段作为查询从非常大的化合物组中鉴定所需化合物的方法。 在替代实施方案中，本发明提供了使用“可行反应”生长方案制备化合物和化合物文库的方法。

公开(公告)号：WO2020023393A1

公开(公告)日：2020-01-30

申请号：PCT/US2019/042829

申请日：2019-07-22

Applicant: BIOBLOCKS, INC. ,  VISIONARY PHARMACEUTICALS

Inventor： MEYER, Stephen Todd ,  WADE, Warren Stanfield ,  ZAPF, James W. ,  GERENCSÉR, János ,  GYIMÓTHY, Balázs

IPC: A61K31/395 ,  A61K31/437 ,  C07D471/04 ,  A61P35/00

Abstract: Disclosed herein are small molecule compounds that are SGK1 antagonists, formulations and pharmaceutical compositions comprising the compounds, and methods of making and using them, for treating, ameliorating, preventing, reversing or slowing the progression of: a cancer, a tumor, a metastasis or a dysplastic or a dysfunctional cell condition responsive to inhibition of a kinase enzyme of the AGC group of kinases including SGK1, by administration of an AGC kinase inhibitor or antagonist.