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公开(公告)号:WO1997016471A1
公开(公告)日:1997-05-09
申请号:PCT/GB1996002650
申请日:1996-10-31
申请人: THE SECRETARY OF STATE FOR DEFENCE , HALL, Alan, William , LACEY, David , SAGE, Ian, Charles , BLACKWOOD, Keith, Moray , JONES, Michelle
IPC分类号: C08G61/00
CPC分类号: C09K19/3833 , C08G61/00 , C09K19/3895
摘要: Compounds of formula (I) are provided which may be used in a variety of devices including liquid crystal devices, piezoelectric devices, pyroelectric devices and in optical recording media, wherein X1 and X2 are independently selected from H, CN, COCH3, CO2CH3, m = at least 5; X3 and X4 are independently selected from formula (IA), wherein Y is selected from COO, OCO, O, S, CHOH, CHF, CH2; Q = (CH2)n wherein one or more non-adjacent methylenes may be replaced by O and n = 1-20; Z is selected from O, S, single covalent bond, COO, OCO; when Y is CH2 then n may also be 0; formula (A) represents any mesogenic group; X3 and X4 are also independently selected from H, OH, OCOR , COOH, CO2R , (CH2)pOH, (CH2)pCO2H, -(CH2)pOR or -(CH2)pCO2R and p = 1-20, R = H or C1-16alkyl, when R = C2-16alkyl the terminal CH3 group may be replaced by Br or Cl; provided that at least one of X3 and X4 is selected from formula (IA).
摘要翻译: 提供式(I)化合物,其可用于包括液晶装置,压电装置,热电装置和光学记录介质的各种装置中,其中X 1和X 2独立地选自H,CN,COCH 3,CO 2 CH 3,m =至少5; X 3和X 4独立地选自式(IA),其中Y选自COO,OCO,O,S,CHOH,CHF,CH 2; Q =(CH 2)n,其中一个或多个不相邻亚甲基可被O代替,n = 1-20; Z选自O,S,单共价键,COO,OCO; 当Y是CH2时,n也可以是0; 式(A)表示任何介晶组; X和X 4还独立地选自H,OH,OCOR 1,COOH,CO 2 R 1,(CH 2)p OH,(CH 2)p CO 2 H, - (CH 2)pOR 1或 - (CH 2)p CO 2 R 1 >和p = 1-20,R 1 = H或C 1-6烷基,当R 1 = C 2-6-16烷基时,末端CH 3基团可被Br或Cl取代; 条件是X3和X4中的至少一个选自式(IA)。
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公开(公告)号:WO1998008918A1
公开(公告)日:1998-03-05
申请号:PCT/GB1997002225
申请日:1997-08-20
申请人: THE SECRETARY OF STATE FOR DEFENCE , BLACKWOOD, Keith, Moray , JONES, Michelle , LACEY, David , HALL, Alan, William , TOYNE, Kenneth, Johnson , PRINGLE, Steven
IPC分类号: C09K19/38
CPC分类号: C09K19/3895 , C08F246/00 , C09K19/3842 , C09K19/3852 , Y10T428/10
摘要: Methods, based on the Wittig-Horner reaction, are provided for the synthesis of compounds of formula (I) wherein m is from 5-150, X and Y are independently selected from: CN, H, OH, COCH3, CO2H, CO2R1, where R1 is C1-12alkyl, NCS, SCN, CF3, CH2X where X is F, Cl, Br, OH, CHF2 and formula (IB), wherein J for each X and Y group is independently selected from: CH2, single covalent bond, OOC, CO2, O, CH2O, OCH2, CH2CO2, CH2OOC; p = 1-20; L for each X and Y group is independently selected from: O, CH2, OCO, CO2, S, NH; (a) is defined by formula (IC), wherein rings A, B and C are independently selected from phenyl, cyclohexyl, pyridine and pyrimidine and may be independently of each other substituted with at least one of Cl or F; linking groups A and B may be selected from single bond, CO2, OOC, CH2O, OCH2, CH2CH2, CC; Z is selected from CN, F, Cl, NO2, R, OR, CO2R, CF3, OOCR, NCS, SCN, where R = straight chain or branched chain alkyl and may include from 1-16 carbon atoms and including where one or more non-adjacent CH2 groups may be substituted by CH(CN), CH(CF3), CH(Cl), CH(CH3) in chiral or non-chiral form; provided that at least one of X and Y is selected from (IB); said method comprising the polymerisation of general formula (II), wherein X and Y are as defined for formula (I).
摘要翻译: 提供了基于Wittig-Horner反应的合成式(I)化合物,其中m为5-150,X和Y独立地选自:CN,H,OH,COCH 3,CO 2 H,CO 2 R 1, 其中R1是C1-12烷基,NCS,SCN,CF3,CH2X,其中X是F,Cl,Br,OH,CHF2和式(IB),其中每个X和Y基团的J独立地选自:CH 2,单共价键 ,OOC,CO 2,O,CH 2 O,OCH 2,CH 2 CO 2,CH 2 OOC; p = 1-20; 每个X和Y基团的L独立地选自:O,CH 2,OCO,CO 2,S,NH; (a)由式(IC)定义,其中环A,B和C独立地选自苯基,环己基,吡啶和嘧啶,并且可以彼此独立地被Cl或F中的至少一个取代; 连接基团A和B可以选自单键,CO 2,OOC,CH 2 O,OCH 2,CH 2 CH 2,CC; Z选自CN,F,Cl,NO 2,R,OR,CO 2 R,CF 3,OOCR,NCS,SCN,其中R =直链或支链烷基,并且可以包括1-16个碳原子,并且包括其中一个或多个 不相邻的CH2基可以被手性或非手性形式的CH(CN),CH(CF 3),CH(Cl),CH(CH 3)取代; 条件是X和Y中的至少一个选自(IB); 所述方法包括通式(II)的聚合,其中X和Y如式(I)所定义。
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公开(公告)号:WO0136510A2
公开(公告)日:2001-05-25
申请号:PCT/GB0004308
申请日:2000-11-10
申请人: SECR DEFENCE , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , MILNE PAUL EDWARD YOUNG , BLACKWOOD KEITH MORAY
IPC分类号: A61K31/787 , A61K47/48 , A61K49/00 , A61P1/16 , A61P3/06 , C08F26/04 , C08G61/12 , C08G73/06
CPC分类号: C08G73/0611 , A61K47/6949 , B82Y5/00 , C08G61/12
摘要: The invention provides a poly(diallylamine) polymer derived from a monomer of formula (I) wherein R is a bridging group of valency r and r is an integer of 3 or greater, or a pharmaceutically acceptable derivative of such a polymer, for use in any surgical, therapeutic or diagnostic method, in particular for use as a bile acid remover and/or for use in reducing serum cholesterol levels. The invention also provides the use of such a polymer or derivative in the preparation of a medicament for use in any surgical, therapeutic or diagnostic method, in particular where the medicament is a bile acid remover or is for use in reducing serum cholesterol levels. The invention further provides a method of treatment of a human or animal patient to reduce levels of bile acid and/or serum cholesterol, by administering such a polymer; a pharmaceutical composition containing the polymer; and a method for producing the pharmaceutical composition.
摘要翻译: 本发明提供衍生自式(I)的单体的聚(二烯丙基胺)聚合物,其中R 6是价态r的桥连基团,r是3或更大的整数,或这种聚合物的药学上可接受的衍生物, 用于任何手术,治疗或诊断方法,特别是用作胆汁酸去除剂和/或用于降低血清胆固醇水平。 本发明还提供了这种聚合物或衍生物在制备用于任何手术,治疗或诊断方法的药物中的用途,特别是其中药物是胆汁酸去除剂或用于降低血清胆固醇水平的药物。 本发明还提供了通过施用这种聚合物来治疗人或动物患者以降低胆汁酸和/或血清胆固醇水平的方法; 含有聚合物的药物组合物; 以及该药物组合物的制造方法。
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公开(公告)号:WO0006658A3
公开(公告)日:2000-05-04
申请号:PCT/GB9902432
申请日:1999-07-26
申请人: SECR DEFENCE , BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM
IPC分类号: C09K3/10 , C07C69/007 , C07C69/527 , C07C211/11 , C07C211/21 , C07C211/63 , C07C215/40 , C07C233/05 , C07C233/09 , C07C233/11 , C07C233/56 , C07C233/65 , C07C235/06 , C07C235/34 , C07C237/06 , C07C271/14 , C07C311/11 , C07F7/18 , C08F2/50 , C08F26/02 , C09J4/00 , C07C311/03 , C08F26/04
CPC分类号: C09J4/00 , C07C69/007 , C07C211/11 , C07C211/21 , C07C211/63 , C07C215/40 , C07C233/05 , C07C233/09 , C07C233/11 , C07C233/56 , C07C233/65 , C07C235/06 , C07C235/34 , C07C237/06 , C07C271/14 , C07C311/11 , C07F7/1836 , C08F238/00 , C08F222/26 , C08F216/02 , C08F226/02
摘要: An adhesive or sealant composition comprising a compound of formula (I) provided that at least one of (a) R and R or (b) R and R or (c) R and R includes an electron withdrawing group; and where necessary, a polymerisation initiator. Novel compounds of formula (I) are also described and claimed. Adhesive compositions can be used to bond for example glass and metal surfaces. Certain biocompatible adhesives for medical applications are included.
摘要翻译: 包含式(I)化合物的粘合剂或密封剂组合物,条件是(a)R 1和R 6或(b)R 2和R 3或(c) 4>和R 5包括吸电子基团; 并且在必要时聚合引发剂。 新的式(I)化合物也被描述和要求保护。 粘合剂组合物可用于结合例如玻璃和金属表面。 包括用于医疗应用的某些生物相容性粘合剂。
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公开(公告)号:WO1997016472A1
公开(公告)日:1997-05-09
申请号:PCT/GB1996002655
申请日:1996-10-31
申请人: THE SECRETARY OF STATE FOR DEFENCE , HALL, Alan, William , LACEY, David , SAGE, Ian, Charles , BLACKWOOD, Keith, Moray , JONES, Michelle
IPC分类号: C08G61/00
CPC分类号: C08G61/00 , C09K19/3895 , Y10T428/10
摘要: Compounds of formula (I) are provided which may be used in a variety of devices including liquid crystal devices, piezoelectric devices, pyroelectric devices and in optical recording media; in said formula n = at least 5; Rx, Ry, Rz are independently selected from formula (IA), wherein Y is selected from COO, OCO, O, S, CHOH, CHF, CH2; Q = (CH2)n wherein one or more non-adjacent methylenes may be replaced by O and n = 1 - 20; Z is selected from O, S, single covalent bond, COO, OCO; when Y is CH2 then n may also be 0; (IB) represents any mesogenic group; Rx, Ry, Rz are also independently selected from H, OH, OCOR , COOH, CO2R , (CH2)pOH, (CH2)pCO2H, -(CH2)pOR or -(CH2)pCO2R and p = 1 - 20, R = H or C1-16 alkyl; when R = C2-16 alkyl the terminal CH3 group may be replaced by Br or Cl; provided that at least one of Rx, Ry, Rz is selected from formula (IA).
摘要翻译: 提供式(I)化合物,其可用于包括液晶装置,压电装置,热电装置和光学记录介质的各种装置中; 在所述式中n =至少5; Rx,Ry,Rz独立地选自式(IA),其中Y选自COO,OCO,O,S,CHOH,CHF,CH 2; Q =(CH 2)n,其中一个或多个不相邻的亚甲基可被O代替,n = 1-20; Z选自O,S,单共价键,COO,OCO; 当Y是CH2时,n也可以是0; (IB)代表任何介晶组; Rx,Ry,Rz也独立地选自H,OH,OCOR 1,COOH,CO 2 R 1,(CH 2)p OH,(CH 2)p CO 2 H, - (CH 2)pOR 1或 - (CH 2)p CO 2 R 1和p = 1-20,R 1 = H或C 1-6烷基; 当R 1 = C2-16烷基时,末端CH 3基团可被Br或Cl取代; 条件是Rx,Ry,Rz中的至少一个选自式(IA)。
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公开(公告)号:WO1997004349A1
公开(公告)日:1997-02-06
申请号:PCT/GB1996001743
申请日:1996-07-19
申请人: THE SECRETARY OF STATE FOR DEFENCE , SAGE, Ian, Charles , BLACKWOOD, Keith, Moray , VERRALL, Mark, Andrew , COATES, David , BEATTIE, David, Richard
IPC分类号: G02F01/1333
CPC分类号: C09K19/388 , C08G65/22 , G02F1/133365
摘要: This invention describes a method for the loading and alignment of liquid crystal polymers in electro-optic and electro-active devices. It comprises the in-situ polymerisation between substrates of monomer material in the presence of a cationic initiator. This allows for the synthesis of liquid crystal polymers containing polyether backbones.
摘要翻译: 本发明描述了一种用于在电光和电活动装置中加载和对准液晶聚合物的方法。 它包括在阳离子引发剂存在下单体材料的底物之间的原位聚合。 这允许合成含有聚醚主链的液晶聚合物。
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公开(公告)号:WO0006610A3
公开(公告)日:2000-08-03
申请号:PCT/GB9902448
申请日:1999-07-26
申请人: SECR DEFENCE , BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , KELLY STEVEN MALCOLM
发明人: BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , KELLY STEVEN MALCOLM
IPC分类号: C07C69/50 , C07C69/347 , C07C69/54 , C07C69/708 , C07C211/21 , C07C211/62 , C07C211/63 , C07C215/08 , C07C215/40 , C07C215/90 , C07C233/05 , C07C233/09 , C07C233/11 , C07C233/56 , C07C235/08 , C07C235/46 , C07C237/06 , C07C255/19 , C07C271/12 , C07C311/03 , C07F7/18 , C08F20060101 , C08F2/46 , C08F26/02 , C08F26/04 , C08F36/20 , C08F126/00
CPC分类号: C07C69/50 , C07C69/54 , C07C69/708 , C07C211/21 , C07C215/10 , C07C233/05 , C07C233/09 , C07C233/11 , C07C233/65 , C07C235/06 , C07C235/46 , C07C237/06 , C08F26/02 , C08F26/04 , C08F283/00 , C08F283/04
摘要: A method for producing a polymeric material, said method comprising subjecting a starting material which includes two multiple bonds which are activated so that they will take part in a polymerisation reaction and wherein the multiple bonds are sufficiently close togeter to ensure that cyclopolymerisation will preferentially occur; to suitable conditions under which said polymerisation reaction will occur, provided that the starting marerial is other than triallyamine hydrochloride. The method can be used to produce polymers for various processes including adhesives, network polymers, liquid crystal polymers etc.
摘要翻译: 一种生产聚合物材料的方法,所述方法包括使包含两个重复键的起始材料经过活化以便它们参与聚合反应,并且其中多重键足够接近以确保优先发生环化聚合; 只要起始母料不是三烯丙胺盐酸盐,就可以发生所述聚合反应。 该方法可用于生产用于各种工艺的聚合物,包括粘合剂,网状聚合物,液晶聚合物等。
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公开(公告)号:WO0006533B1
公开(公告)日:2000-07-20
申请号:PCT/GB9902416
申请日:1999-07-26
申请人: SECR DEFENCE , BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , KELLY STEVEN MALCOLM
发明人: BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , KELLY STEVEN MALCOLM
IPC分类号: C07D341/00 , C07C69/007 , C07C69/347 , C07C69/50 , C07C69/708 , C07C211/09 , C07C211/21 , C07C211/63 , C07C217/08 , C07C229/20 , C07C233/05 , C07C233/06 , C07C233/09 , C07C233/18 , C07C233/36 , C07C233/89 , C07C235/06 , C07C239/06 , C07C271/20 , C07C275/20 , C07D487/22 , C07F7/10 , C08F2/38 , C08F2/46 , C08F36/22 , C08F38/00 , C08F246/00 , C08F290/06 , C09D4/00 , C07C69/34 , C07C233/41 , C07C235/08 , C07F7/08 , C08F26/04
CPC分类号: C08F246/00 , C07C69/007 , C07C69/50 , C07C69/708 , C07C211/21 , C07C233/05 , C07C233/09 , C07C233/18 , C07C233/36 , C07C239/06 , C07C271/20 , C07C275/20 , C07C2601/14 , C08F2/38 , C09D4/00 , C08F226/02
摘要: A compound of formula (I) where R is CH and R is a bond, or R and R together form an electron withdrawing group; R and R are independently selected from (CR R )n, or a group CR R , -(CR R CR R )- or -(CR R CR R )- where n is 0,1 or 2, R and R are independently selected from hydrogen or alkyl, and either one of R or R is hydrogen and the other is an electron withdrawing group, or R and R together form an electron withdrawing group, and R and R are independently selected from CH or CR where R is an electron withdrawing group; the dotted lines indicate the presence or absence of a bond, and X is a group CX X where the dotted line bond to which it is attached is absent and a group CX where the dotted line bond to which it is attached is present, Y is a group CY Y where the dotted line bond to which it is attached is absent and a group CY where the dotted line bond to which it is attached is present, and X , X , Y and Y are independently selected from hydrogen and fluorine; R is a bridging group of valency r and r is an integer of 2 or more, subject to the following provisos: (i) that at least one of (a) R and R or (b) R and R or (c) R and R includes an electron withdrawing group. These compounds are useful in the production of network polymers, for example for coatings or binders.
摘要翻译: 其中R 1为CH且R 6为键的式(I)化合物或R 1和R 6一起形成吸电子基团; R 2和R 3独立地选自(CR 7 R 8)n或基团CR 9 R 10 - , - (CR 7 R 8 CR 9) 其中n为0,1或2,R 7和R 8独立地选自C 1 -C 6烷基, 氢或烷基,R 9或R 10中的任一个为氢,另一个为吸电子基团,或R 9和R 10一起形成吸电子基团,R 4为氢, 和R 5独立地选自CH或CR 11,其中R 11是吸电子基团; 虚线表示键的存在或不存在,而X 1为不存在与其相连的虚线键的基团CX 2 X 3和基团CX 2,其中虚线 存在它所连接的线键,Y 1是不存在与其连接的虚线键的基团CY 2 Y 3和基团CY 2,其中虚线键合到 存在,X 2,X 3,Y 2和Y 3独立地选自氢和氟; (i)R 1和R 6或(b)中的至少一个,R 16是价键r的桥基基团,r是2以上的整数, )R 2和R 3或(c)R 4和R 5包括吸电子基团。 这些化合物可用于生产网络聚合物,例如用于涂料或粘合剂。
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公开(公告)号:WO0006533A3
公开(公告)日:2000-06-15
申请号:PCT/GB9902416
申请日:1999-07-26
申请人: SECR DEFENCE , BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , KELLY STEVEN MALCOLM
发明人: BLACKWOOD KEITH MORAY , MILNE PAUL EDWARD YOUNG , GOODBY JOHN WILLIAM , HALL ALAN WILLIAM , KELLY STEVEN MALCOLM
IPC分类号: C07D341/00 , C07C69/007 , C07C69/347 , C07C69/50 , C07C69/708 , C07C211/09 , C07C211/21 , C07C211/63 , C07C217/08 , C07C229/20 , C07C233/05 , C07C233/06 , C07C233/09 , C07C233/18 , C07C233/36 , C07C233/89 , C07C235/06 , C07C239/06 , C07C271/20 , C07C275/20 , C07D487/22 , C07F7/10 , C08F2/38 , C08F2/46 , C08F36/22 , C08F38/00 , C08F246/00 , C08F290/06 , C09D4/00 , C07C69/34 , C07C233/41 , C07C235/08 , C07F7/08 , C08F26/04
CPC分类号: C08F246/00 , C07C69/007 , C07C69/50 , C07C69/708 , C07C211/21 , C07C233/05 , C07C233/09 , C07C233/18 , C07C233/36 , C07C239/06 , C07C271/20 , C07C275/20 , C07C2601/14 , C08F2/38 , C09D4/00 , C08F226/02
摘要: A compound of formula (I) where R is CH and R is a bond, or R and R together form an electron withdrawing group; R and R are independently selected from (CR R )n, or a group CR R , -(CR R CR R )- or -(CR R CR R )- where n is 0,1 or 2, R and R are independently selected from hydrogen or alkyl, and either one of R or R is hydrogen and the other is an electron withdrawing group, or R and R together form an electron withdrawing group, and R and R are independently selected from CH or CR where R is an electron withdrawing group; the dotted lines indicate the presence or absence of a bond, and X is a group CX X where the dotted line bond to which it is attached is absent and a group CX where the dotted line bond to which it is attached is present, Y is a group CY Y where the dotted line bond to which it is attached is absent and a group CY where the dotted line bond to which it is attached is present, and X , X , Y and Y are independently selected from hydrogen and fluorine; R is a bridging group of valency r and r is an integer of 2 or more, subject to the following provisos: (i) that at least one of (a) R and R or (b) R and R or (c) R and R includes an electron withdrawing group. These compounds are useful in the production of network polymers, for example for coatings or binders.
摘要翻译: 式(I)化合物,其中R 1为CH且R 6为键,或者R 1和R 6一起形成吸电子基团; R 2和R 3独立地选自(CR 7 R 8)n或基团CR 9 R 10, - (CR 7 R 8 CR 9 R 10) - 或 - (CR 9 R 10 CR 7 R 8) - ,其中n是0,1或2,R 7和R 8独立地选自 氢或烷基,并且R 9或R 10中的任一个为氢且另一个为吸电子基团,或者R 9和R 10一起形成吸电子基团,并且R 4, 和R 5独立地选自CH或CR 11,其中R 11是吸电子基团; 虚线表示键的存在或不存在,并且X 1是基团CX 2 X 3,其中它所连接的虚线键不存在,并且基团CX 2其中虚线 存在与其连接的线键,Y 1是基团CY 2 Y 3,其中它所连接的虚线键不存在,而基团CY 2其中虚线键合到 其中所连接的X 2,X 3,Y 2和Y 3独立地选自氢和氟; (i)R 1和R 6中的至少一个或(b)中的至少一个是(a)R 1和R 2中的至少一个, )R 2和R 3或(c)R 4和R 5包括吸电子基团。 这些化合物可用于生产网状聚合物,例如用于涂料或粘合剂。
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公开(公告)号:WO1995001402A1
公开(公告)日:1995-01-12
申请号:PCT/GB1994001275
申请日:1994-06-14
IPC分类号: C09D04/06
CPC分类号: C08F271/00
摘要: Coated solids, for example suitable for use as the dispersed phase of an electrorheological fluid, are prepared by effecting polymerisation of at least one coating monomer in the presence of surfaces of a polymer capable itself of acting as the redox initiator for the polymerisation of the monomer.
摘要翻译: 涂覆的固体,例如适合用作电粘滞性流体的分散相,通过在本身可以用作聚合单体的氧化还原引发剂的聚合物的表面的存在下进行至少一种涂料单体的聚合来制备 。
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