公开(公告)号：WO2023060180A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077679

申请日：2022-10-06

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  BORDOLOI, Devivasha

发明人： WEINER, David

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

摘要： The present invention provides natural killer engagers specific for activating natural killer cells through binding to a Siglec, and nucleic acid molecules encoding the same, and methods for treating or preventing a disease or disorder using the same.

公开(公告)号：WO2023060169A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/077665

申请日：2022-10-06

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  WEINER, David ,  PERALES-PUCHALT, Alfredo ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

发明人： WEINER, David ,  PERALES-PUCHALT, Alfredo ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

摘要： Disclosed herein are compositions comprising a recombinant nucleic acid sequences encoding a bispecific anti-FSHR T cell engager as well as FSHR-specific CAR molecules, fragments thereof, variants thereof, combinations thereof, and methods of use thereof.

公开(公告)号：WO2023077061A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/078863

申请日：2022-10-28

申请人： WEINER, David ,  PURWAR, Mansi ,  KULKARNI, Abhijeet ,  PARK, Daniel ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

发明人： WEINER, David ,  PURWAR, Mansi ,  KULKARNI, Abhijeet ,  PARK, Daniel ,  BORDOLOI, Devivasha ,  BHOJNAGARWALA, Pratik

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K47/68 ,  A61P37/02 ,  C07K16/10

摘要： An advance on monoclonal technology is the development of bispecific T cell engagers (BITE) which combine the specificity of monoclonal antibodies with the cytotoxic potential of T cells. Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific anti-HIV natural killer engager, a fragment thereof, a variant thereof, or a combination thereof, and methods of use thereof.