公开(公告)号：WO2023034828A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/075703

申请日：2022-08-30

Applicant: WEINER, David ,  ZHU, Xizhou

Inventor： WEINER, David ,  ZHU, Xizhou

IPC: A61K39/245 ,  A61P35/00 ,  C07K16/08

Abstract: The present invention generally relates to immunogenic compositions (e.g., vaccines and immunotherapies) that induce an immune response against Epstein Barr Virus (EBV)-associated antigens. The present invention also relates to methods of use thereof for the treatment and prevention of EBV infection, EBV-associated cancer, or a combination thereof. In various embodiments, the EBV antigen comprises BamHI-A rightward frame 1 (BARF1).

公开(公告)号：WO2021252620A2

公开(公告)日：2021-12-16

申请号：PCT/US2021/036606

申请日：2021-06-09

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  WEINER, David ,  MUTHUMANI, Kar ,  PARZYCH, Elizabeth

Inventor： WEINER, David ,  MUTHUMANI, Kar ,  PARZYCH, Elizabeth

IPC: A61K39/12 ,  A61K39/215 ,  A61K39/395 ,  A61P31/14 ,  C12N15/86 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K39/42 ,  C07K16/10 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2770/20034

Abstract: Disclosed herein are antibodies to SARS-CoV-2 antigens and recombinant nucleic acid sequences that encode the SARS-CoV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-CoV-2 infection or disease or disorder associated with SARS-CoV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.

公开(公告)号：WO2018102657A1

公开(公告)日：2018-06-07

申请号：PCT/US2017/064161

申请日：2017-12-01

Applicant: WEINER, David, B. ,  PATEL, Ami

Inventor： WEINER, David, B. ,  PATEL, Ami

IPC: A61K35/76 ,  A61K39/12 ,  A61K39/395 ,  A61K39/42 ,  C07K14/005 ,  C07K14/08 ,  C07K16/10 ,  C12N15/63 ,  C12N7/04 ,  C12N5/10

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.

公开(公告)号：WO2017193101A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/031449

申请日：2017-05-05

Applicant: WEINER, David ,  PATEL, Ami ,  YAN, Jian

Inventor： WEINER, David ,  PATEL, Ami ,  YAN, Jian

IPC: A61K39/40 ,  C07K16/00 ,  C07K16/12

Abstract: Disclosed herein are mono and bispecific DNA antibodies (DMAbs) targeting Pseudomonas aeruginosa. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the DMAbs to the subject. The disclosure also provides a method of preventing and/or treating Pseudomonas aeruginosa infection in a subject using said composition and method of generation.

Abstract translation: 本文公开了靶向铜绿假单胞菌的单特异性和双特异性DNA抗体（DMAbs）。 本文还公开了通过将DMAb施用于受试者而在受试者中产生合成抗体的方法。 本公开还提供了使用所述组合物和产生方法预防和/或治疗受试者中的铜绿假单胞菌感染的方法。

公开(公告)号：WO2017192947A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/031215

申请日：2017-05-05

Applicant: WEINER, David ,  PATEL, Ami ,  YAN, Jian

Inventor： PATEL, Ami ,  YAN, Jian

IPC: A61K35/76 ,  A61K39/12 ,  A61K48/00 ,  A61P31/14 ,  A61P37/04

Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.

Abstract translation: 公开了包含一个或多个编码共有埃博拉病毒糖蛋白免疫原的核酸序列的核酸分子和组合物。 编码序列任选地包括编码信号肽的可操作连接的编码序列。 公开了诱导针对埃博拉病毒的免疫反应的免疫调节方法和方法。 公开了预防埃博拉病毒的方法和治疗感染埃博拉病毒的个体的方法。 共识埃博拉病毒蛋白被公开。

公开(公告)号：WO2017165460A9

公开(公告)日：2017-09-28

申请号：PCT/US2017/023479

申请日：2017-03-21

Applicant: WEINER, David, B. ,  MUTHUMANI, Karuppiah ,  FLINGAI, Seleeke ,  SARDESAI, Niranjan ,  ELLIOTT, Sarah ,  YAN, Jian ,  PATEL, Ami

Inventor： WEINER, David, B. ,  MUTHUMANI, Karuppiah ,  FLINGAI, Seleeke ,  SARDESAI, Niranjan ,  ELLIOTT, Sarah ,  YAN, Jian ,  PATEL, Ami

IPC: A61K39/00 ,  C12N9/48 ,  C12N9/64

Abstract: Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.

公开(公告)号：WO2016123285A1

公开(公告)日：2016-08-04

申请号：PCT/US2016/015263

申请日：2016-01-28

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  INOVIO PHARMACEUTICALS, INC. ,  WEINER, David ,  MUTHUMANI, Karuppiah ,  SARDESAI, Niranjan

Inventor： WEINER, David ,  MUTHUMANI, Karuppiah ,  SARDESAI, Niranjan

IPC: A61K39/00 ,  A61K39/395

CPC classification number: A61K39/395 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/585 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/76 ,  C12N2710/20034 ,  Y02A50/412 ,  A61K2300/00

Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.

Abstract translation: 本文公开了包含抗原和检查点抑制剂的疫苗。 本文还公开了增强受试者的免疫应答的方法。 该方法可以包括向有需要的受试者施用疫苗。

公开(公告)号：WO2014152121A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/026974

申请日：2014-03-14

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David ,  SCOTT, Veronica ,  HUTNICK, Natalie

Inventor： WEINER, David ,  SCOTT, Veronica ,  HUTNICK, Natalie

IPC: A61K39/08 ,  A61K39/40 ,  C12N15/31

CPC classification number: C07K14/33 ,  A61K39/08 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55527 ,  A61K2039/55538 ,  A61K2039/575 ,  A61M37/00 ,  A61M2037/0007 ,  Y02A50/469

Abstract: Disclosed herein are compositions and methods for treating Clostridium botulinum neurotoxin intoxication and in particular, vaccines against the neurotoxin that provide protection again lethal challenge with neurotoxin from one or more serotypes of Clostridium botulinum.

Abstract translation: 本文公开了用于治疗肉毒杆菌神经毒素中毒的组合物和方法，特别是针对来自一种或多种肉毒杆菌血清型的神经毒素再次致死致死攻击的神经毒素的疫苗。

公开(公告)号：WO2014145951A2

公开(公告)日：2014-09-18

申请号：PCT/US2014030809

申请日：2014-03-17

Applicant: UNIV PENNSYLVANIA ,  INOVIO PHARMACEUTICALS INC ,  WEINER DAVID B ,  MUTHUMANI KARUPPIAH ,  YAN JIAN ,  SARDESAI NIRANJAN Y

Inventor： WEINER DAVID B ,  MUTHUMANI KARUPPIAH ,  YAN JIAN ,  SARDESAI NIRANJAN Y

IPC: A61K39/12

CPC classification number: A61K39/135 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/32134

Abstract: The present invention relates to synthetic, consensus foot-and-mouth disease virus (FMDV) immunogenic proteins and nucleic acid molecule encoding such proteins, to vaccines against FMDV, to methods for inducing immune responses against FMVD, to methods for distinguishing between individuals infected with FMDV versus those vaccinated against FMDV, and methods of prophylactically and/or therapeutically immunizing individuals against FMDV.

Abstract translation: 本发明涉及合成的口蹄疫病毒（FMDV）免疫原性蛋白质和编码这种蛋白质的核酸分子，针对FMDV的疫苗，用于诱导针对FMVD的免疫反应的方法，用于区分感染 FMDV与针对FMDV接种的FMDV，以及针对FMDV的预防和/或治疗性免疫个体的方法。

公开(公告)号：WO2014144885A2

公开(公告)日：2014-09-18

申请号：PCT/US2014/029479

申请日：2014-03-14

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ,  WEINER, David ,  MUTHUMANI, Karuppiah ,  WALTERS, Jewell ,  YAN, Jian

Inventor： WEINER, David ,  MUTHUMANI, Karuppiah ,  WALTERS, Jewell ,  YAN, Jian

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/575 ,  C12N9/0071 ,  C12N2710/20034 ,  C12N2730/10111 ,  C12N2770/24234 ,  C12Y114/18001

Abstract: Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.

Abstract translation: 本文公开了治疗癌症的组合物和方法，特别是治疗和提供针对肿瘤生长的保护的疫苗。