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公开(公告)号：WO2023077061A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/078863
申请日：2022-10-28
申请人： WEINER, David , PURWAR, Mansi , KULKARNI, Abhijeet , PARK, Daniel , BORDOLOI, Devivasha , BHOJNAGARWALA, Pratik
发明人： WEINER, David , PURWAR, Mansi , KULKARNI, Abhijeet , PARK, Daniel , BORDOLOI, Devivasha , BHOJNAGARWALA, Pratik
IPC分类号： C07K16/28 , A61K39/395 , A61K47/68 , A61P37/02 , C07K16/10
摘要： An advance on monoclonal technology is the development of bispecific T cell engagers (BITE) which combine the specificity of monoclonal antibodies with the cytotoxic potential of T cells. Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific anti-HIV natural killer engager, a fragment thereof, a variant thereof, or a combination thereof, and methods of use thereof.
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公开(公告)号：WO2023060169A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/077665
申请日：2022-10-06
申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , WEINER, David , PERALES-PUCHALT, Alfredo , BORDOLOI, Devivasha , BHOJNAGARWALA, Pratik
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
摘要： Disclosed herein are compositions comprising a recombinant nucleic acid sequences encoding a bispecific anti-FSHR T cell engager as well as FSHR-specific CAR molecules, fragments thereof, variants thereof, combinations thereof, and methods of use thereof.
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公开(公告)号：WO2022256637A2
公开(公告)日：2022-12-08
申请号：PCT/US2022/032138
申请日：2022-06-03
IPC分类号： A61K39/205 , C07K14/005 , A61K39/12 , A61K31/417
摘要： Disclosed herein is a composition comprising one or more viral antigen or a recombinant nucleic acid sequence that encodes one or more viral antigen with enhanced immunogenicity in vivo. Also disclosed herein is a method of generating an immune response in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a viral infection in a subject using said composition and methods.
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