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公开(公告)号：WO2013143609A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055834
申请日：2012-03-30
Applicant: ETHICON ENDO-SURGERY, INC. , FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
Inventor： FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
CPC classification number: A61N1/0509 , A61N1/36007
Abstract: A system for stimulating the release of satiety hormone in a subject comprises a stimulus device (1 1 ) having an electrical pulse generator (2) and multiple stimulus electrodes (3) adapted to apply electrical stimuli to a tissue of a gastrointestinal system of the subject, the stimulus electrodes (3) being arranged at a distance to one another in multiple positions and the stimulus device (1 ) being configured to time-dependently switch selected ones of the stimulus electrodes (3) from an energized state to a non-energized state and vice versa for time-dependently changing the location of application of the stimulus.
Abstract translation: 用于刺激受试者中饱腹感激素释放的系统包括具有电脉冲发生器（2）的刺激装置（11）和适于对受试者的胃肠系统的组织施加电刺激的多个刺激电极（3） 刺激电极（3）在多个位置彼此间隔一定距离地布置，并且刺激装置（1）构造成将刺激电极（3）中的所选择的激励电极从激励状态时间依赖地切换到非通电 状态，反之亦然，从而随时改变刺激应用的位置。
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公开(公告)号：WO2013143603A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055813
申请日：2012-03-30
Applicant: ETHICON ENDO-SURGERY, INC. , FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
Inventor： FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
CPC classification number: A61N1/0509 , A61N1/0408 , A61N1/0476 , A61N1/36007
Abstract: A system for stimulating the release of satiety hormone in a subject includes a stimulus device (1) having an electrical pulse generator (2) and stimulus electrodes (3) adapted to apply an electrical stimulus to a tissue, the stimulus device (1) being adapted to be endoluminally introduced in a gastrointestinal system of the subject, and means (9, 16, 17, 42) for anchoring the stimulus device permanently in a target location inside the gastrointestinal system in a position in which the stimulus electrodes engage a tissue of said gastrointestinal system.
Abstract translation: 用于刺激受试者中饱腹感激素释放的系统包括具有电脉冲发生器（2）的刺激装置（1）和适于对组织施加电刺激的刺激电极（3），刺激装置（1）为 适于在受试者的胃肠系统中被内窥镜引入，以及用于将刺激装置永久地固定在胃肠系统内的目标位置中的装置（9,16,17,42），其中刺激电极接合刺激电极的组织 说胃肠系统。
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公开(公告)号：WO2012087669A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/064634
申请日：2011-12-13
Applicant: ETHICON ENDO-SURGERY, INC. , ORTIZ, Mark, S. , HESS, Christopher, J. , HARRIS, Jason, L. , VOEGELE, James, W. , ZEINER, Mark, S. , OVERMYER, Mark, D. , KRAIMER, Joseph, Bernard , SHIMIZU, Jeff , CRIVELLI, Rocco , TARDY, Yanik , UTARD, Thierry , BURGER, Juergen , BORK, Toralf , PFLEIDERER, Martin , CHOSSAT, Olivier
Inventor： ORTIZ, Mark, S. , HESS, Christopher, J. , HARRIS, Jason, L. , VOEGELE, James, W. , ZEINER, Mark, S. , OVERMYER, Mark, D. , KRAIMER, Joseph, Bernard , SHIMIZU, Jeff , CRIVELLI, Rocco , TARDY, Yanik , UTARD, Thierry , BURGER, Juergen , BORK, Toralf , PFLEIDERER, Martin , CHOSSAT, Olivier
CPC classification number: A61B1/041 , A61B1/00147 , A61F5/0013 , A61M31/002
Abstract: Devices are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as "catchers," are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.
Abstract translation: 提供了用于将治疗剂控制递送到体内目标位置的装置。 更具体地，提供了用于控制经口施用的药丸通过身体的通过速率的装置，以及用于控制在体内特定位置处的丸剂内的治疗剂的递送。 提供了在本文中通常被称为“捕获器”的各种类型的装置，其可以在通过身体时主动地捕捉药丸。 捕获器可以将药丸保持在体内的特定位置，直到发生预定事件，例如在丸中部分或完全施用治疗剂。 然后，捕手可以在命令和/或发生预定事件时释放药片以允许药丸从身体中流出。 在其他实施例中，提供了可以主动地接合捕获器并保持与捕获器接合的各种类型的药丸，直到发生预定事件。
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公开(公告)号：WO2011035006A3
公开(公告)日：2011-03-24
申请号：PCT/US2010/049094
申请日：2010-09-16
Applicant: ETHICON ENDO-SURGERY, INC. , DLUGOS, Daniel, F. , BORK, Toralf , CHEN, Christine, H. , CRIVELLI, Rocco , KORVICK, Donna, L. , KRUMANAKER, David, T. , LESSEK, Timothy, P. , MARCOTTE, Amy, L. , MESSERLY, Jeffrey, D. , MUMAW, Daniel, J. , NALAGATLA, Anil, K. , PLESCIA, David, N. , SHELTON, Frederick, E. , SWAYZE, Jeffrey, S. , SWINDON, Patrick, J. , TSONTON, Mark , WOODRUFF, Scott, A.
Inventor： DLUGOS, Daniel, F. , BORK, Toralf , CHEN, Christine, H. , CRIVELLI, Rocco , KORVICK, Donna, L. , KRUMANAKER, David, T. , LESSEK, Timothy, P. , MARCOTTE, Amy, L. , MESSERLY, Jeffrey, D. , MUMAW, Daniel, J. , NALAGATLA, Anil, K. , PLESCIA, David, N. , SHELTON, Frederick, E. , SWAYZE, Jeffrey, S. , SWINDON, Patrick, J. , TSONTON, Mark , WOODRUFF, Scott, A.
Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. The tension element is composed of a flexible first member and a flexible second member, wherein the flexible first member is movable relative to the flexible second member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct.
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公开(公告)号：WO2011035021A3
公开(公告)日：2011-05-19
申请号：PCT/US2010049115
申请日：2010-09-16
Applicant: ETHICON ENDO SURGERY INC , DLUGOS DANIEL F , BYRUM RANDAL T , BORK TORALF , CRIVELLI ROCCO , GARNER DEAN L , GINGGEN ALEC , HUEIL GEOFFREY C , KORVICK DONNA L , KRUMANAKER DAVID T , MARCOTTE AMY L , MESSERLY JEFFREY D , MOORE KYLE P , MUMAW DANIEL J , NALAGATLA ANIL K , ORTIZ MARK S , SHELTON IV FREDERICK E , SMITH BRET W , SWAYZE JEFFREY S , SWINDON PATRICK J , TIMM RICHARD W , THOMPSON ERIC W , WEANER LAUREN S
Inventor： DLUGOS DANIEL F , BYRUM RANDAL T , BORK TORALF , CRIVELLI ROCCO , GARNER DEAN L , GINGGEN ALEC , HUEIL GEOFFREY C , KORVICK DONNA L , KRUMANAKER DAVID T , MARCOTTE AMY L , MESSERLY JEFFREY D , MOORE KYLE P , MUMAW DANIEL J , NALAGATLA ANIL K , ORTIZ MARK S , SHELTON IV FREDERICK E , SMITH BRET W , SWAYZE JEFFREY S , SWINDON PATRICK J , TIMM RICHARD W , THOMPSON ERIC W , WEANER LAUREN S
CPC classification number: A61F5/0053 , A61F2/0036 , A61F5/003 , A61F5/0056 , A61F5/0059
Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member (22) having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element (576,578) is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism (574) is associated with the tension element.
Abstract translation: 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件（22）。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 设置张力元件（32）以在细长构件内移动。 驱动元件（576,578）与张力元件相关联并与其接合，用于使张紧元件控制由细长构件施加的抵抗患者身体器官或管道的张力。 张力释放机构（574）与张力元件相关联。
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Patent Agency Ranking
公开(公告)号：WO2011035036A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049136
申请日：2010-09-16
Applicant: ETHICON ENDO-SURGERY, INC. , DLUGOS, Daniel, F. , ADAMS, Thomas, E. , BYRUM, Randal, T. , BORK, Toralf , CHEN, Christine, H. , CONLON, Sean, P. , CRIVELLI, Rocco , GARNER, Dean, L. , GINGGEN, Alec , KRUMANAKER, David, T. , MARCOTTE, Amy, L. , NALAGATLA, Anil, K. , SMITH, Bret, W. , SWAYZE, Jeffrey, S. , TIMM, Richard, W.
Inventor： DLUGOS, Daniel, F. , ADAMS, Thomas, E. , BYRUM, Randal, T. , BORK, Toralf , CHEN, Christine, H. , CONLON, Sean, P. , CRIVELLI, Rocco , GARNER, Dean, L. , GINGGEN, Alec , KRUMANAKER, David, T. , MARCOTTE, Amy, L. , NALAGATLA, Anil, K. , SMITH, Bret, W. , SWAYZE, Jeffrey, S. , TIMM, Richard, W.
CPC classification number: A61F5/003 , A61F2/0036 , A61F5/0053 , A61F5/0056 , A61F5/0059
Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element (32) is disposed for movement within the elongated member. A drive element is associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A release mechanism (312) is provided for the tension element.
Abstract translation: 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 设置张力元件（32）以在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张紧元件控制由细长构件施加的抵抗患者身体器官或管道的张力。 为张力元件提供释放机构（312）。
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公开(公告)号：WO2013143600A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055798
申请日：2012-03-30
Applicant: ETHICON ENDO-SURGERY, INC. , FELDER, Kevin, D. , LONG, Gary, L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik, S.
Inventor： FELDER, Kevin, D. , LONG, Gary, L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik, S.
CPC classification number: A61N1/36067 , A61N1/0509
Abstract: A system for stimulating the release of satiety hormone in a subject, the system comprising a stimulus device (11) having an electrical pulse generator (2) and multiple stimulus electrodes (3) adapted to apply electrical stimuli to a tissue of a gastrointestinal system of the subject, one or more time-dependently bioabsorbable or biofragmentable isolating layers (30) which cover at least one of the stimulus electrodes (3) such that the initially covered stimulus electrode (3) is exposed only after erosion of said one or more isolating layers (30).
Abstract translation: 一种用于刺激受试者中饱腹感激素释放的系统，所述系统包括具有电脉冲发生器（2）和多个刺激电极（3）的刺激装置（11）和适于将电刺激施加到胃肠系统组织 受试者，覆盖至少一个刺激电极（3）的一个或多个时间依赖性生物可吸收或生物可分散的隔离层（30），使得最初被覆盖的刺激电极（3）仅在所述一个或多个隔离层 层（30）。
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8.发明申请ŁIMPLANTABLE SYSTEM FOR PROVIDING ELECTRICAL STIMULATION IN RESPONSE TO DETECTING AN INGESTION OF FOOD 审中-公开用于提供电刺激以检测食物摄入的极限系统
公开(公告)号：WO2013143608A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055831
申请日：2012-03-30
Applicant: ETHICON ENDO-SURGERY, INC. , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S. , HARRIS, Jason , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele
Inventor： BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S. , HARRIS, Jason , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele
CPC classification number: A61N1/36007 , A61F5/0026 , A61F2005/0016 , A61F2005/002 , A61N1/0509 , A61N1/0517
Abstract: An implantable system for stimulating the release of satiety hormone in a subject comprises a stimulus device (11) which is implantable in the subject and adapted to apply an electrical stimulus to a tissue of a gastrointestinal system of said subject, and a detection device (2, 7, 8) which is implantable in the subject and adapted to continuously monitoring at least one of a mechanical characteristic and an electrical characteristic of the subject to detect an ingestion of food by said subject, wherein the detection device cooperates with the stimulus device (11) such that the stimulus device (11) applies said electrical stimulus in response to a detected ingestion of food.
Abstract translation: 用于刺激受试者的饱腹感激素释放的可植入系统包括刺激装置（11），所述刺激装置可植入对象并适于对所述受试者的胃肠系统的组织施加电刺激，以及检测装置（2） ，7,8），其可植入对象中并且适于连续监测所述对象的机械特性和电特性中的至少一个，以检测所述对象摄取食物，其中所述检测装置与所述刺激装置（ 11），使得刺激装置（11）响应于检测到的食物摄取而应用所述电刺激。
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公开(公告)号：WO2013143599A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055795
申请日：2012-03-30
Applicant: ETHICON ENDO-SURGERY, INC. , FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
Inventor： FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
CPC classification number: A61N1/36067 , A61N1/0509
Abstract: A system for stimulating the release of satiety hormone in a subject comprises a stimulus device (1) having an electrical pulse generator (2) and stimulus electrodes (3) adapted to apply an electrical stimulus to a tissue, the stimulus device (1) being configured to time dependently move at least one of the stimulus electrodes (3) for time-dependently changing the location of application of the stimulus.
Abstract translation: 用于刺激受试者中饱腹感激素释放的系统包括具有电脉冲发生器（2）和刺激电极（3）的刺激装置（1），刺激电极（3）适于对组织施加电刺激，刺激装置（1） 被配置为时间依赖地移动至少一个所述刺激电极（3）以随时改变所述刺激的施加位置。
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公开(公告)号：WO2011035021A2
公开(公告)日：2011-03-24
申请号：PCT/US2010/049115
申请日：2010-09-16
Applicant: ETHICON ENDO-SURGERY, INC. , DLUGOS, Daniel, F. , BYRUM, Randal, T. , BORK, Toralf , CRIVELLI, Rocco , GARNER, Dean, L. , GINGGEN, Alec , HUEIL, Geoffrey, C. , KORVICK, Donna, L. , KRUMANAKER, David, T. , MARCOTTE, Amy, L. , MESSERLY, Jeffrey, D. , MOORE, Kyle, P. , MUMAW, Daniel, J. , NALAGATLA, Anil, K. , ORTIZ, Mark, S. , SHELTON, IV, Frederick E . , SMITH, Bret, W. , SWAYZE, Jeffrey, S. , SWINDON, Patrick, J. , TIMM, Richard, W. , THOMPSON, Eric W . , WEANER, Lauren S .
Inventor： DLUGOS, Daniel, F. , BYRUM, Randal, T. , BORK, Toralf , CRIVELLI, Rocco , GARNER, Dean, L. , GINGGEN, Alec , HUEIL, Geoffrey, C. , KORVICK, Donna, L. , KRUMANAKER, David, T. , MARCOTTE, Amy, L. , MESSERLY, Jeffrey, D. , MOORE, Kyle, P. , MUMAW, Daniel, J. , NALAGATLA, Anil, K. , ORTIZ, Mark, S. , SHELTON, IV, Frederick E . , SMITH, Bret, W. , SWAYZE, Jeffrey, S. , SWINDON, Patrick, J. , TIMM, Richard, W. , THOMPSON, Eric W . , WEANER, Lauren S .
CPC classification number: A61F5/0053 , A61F2/0036 , A61F5/003 , A61F5/0056 , A61F5/0059
Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A drive element is associated with and engages the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct. A tension release mechanism is associated with the tension element.
Abstract translation: 用于调节患者器官或管道的功能的装置包括具有第一端和第二端的细长构件。 紧固件设置在细长构件的第一端上。 紧固件构造成接合细长构件的第二端，使得细长构件围绕器官或管道形成环。 张力元件设置成在细长构件内移动。 驱动元件与张力元件相关联并与其接合，用于使张力元件控制由细长构件施加的抗张力抵靠患者身体器官或管道的张力。 张力释放机构与张力元件相关联。
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