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公开(公告)号：WO2015058163A2
公开(公告)日：2015-04-23
申请号：PCT/US2014/061264
申请日：2014-10-17
申请人： SYROS PHARMACEUTICALS, INC. , PARAZA PHARMA, INC. , CIBLAT, Stephane , DEROY, Patrick , LEBLANC, Melissa , MARINEAU, Jason, J. , MOORE, Joel , ROY, Stephanie , SIDDIQUI, M., Arshad , SPROTT, Kevin , WINTER, Dana, K. , KABRO, Anzheliika , LEGER, Serge , MILLER, Tom , SCHMIDT, Darby , BRADLEY, Michael
发明人： CIBLAT, Stephane , DEROY, Patrick , LEBLANC, Melissa , MARINEAU, Jason, J. , MOORE, Joel , ROY, Stephanie , SIDDIQUI, M., Arshad , SPROTT, Kevin , WINTER, Dana, K. , KABRO, Anzheliika , LEGER, Serge , MILLER, Tom , SCHMIDT, Darby , BRADLEY, Michael
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/635 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/04
摘要： The present invention provides novel compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g.,leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject. (I)
摘要翻译： 本发明提供式（I）和式（II）的新化合物及其药学上可接受的盐，溶剂合物，水合物，互变异构体，立体异构体，同位素标记的衍生物及其组合物。 还提供了涉及用于治疗或预防受试者的增殖性疾病（例如，癌症（例如白血病，黑素瘤，多发性骨髓瘤），良性肿瘤，血管生成，炎性疾病，自身炎性疾病和自身免疫性疾病）的化合物或组合物的方法和试剂盒 。 使用本发明的化合物或组合物治疗具有增殖性疾病的受试者可以抑制激酶例如细胞周期蛋白依赖性激酶（CDK）（例如细胞周期蛋白依赖性激酶7（CDK7））的异常活性，因此 ，诱导受试者的细胞凋亡和/或抑制转录。 （一世）
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2.发明申请
公开(公告)号：WO2015058126A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/061206
申请日：2014-10-17
申请人： SYROS PHARMACEUTICALS, INC. , DANA-FARBER CANCER INSTITUTE, INC. , PARAZA PHARMA, INC. , CIBLAT, Stephane , DEROY, Patrick , GRAY, Nathanael , LEBLANC, Melissa , MARINEAU, Jason, J. , MOORE, Joel , SPROTT, Kevin , ZHANG, Tinghu , SIDIQUI, M., Arshad , KABRO, Anzhelika , LEGER, Serge , MILLER, Tom , ROY, Stephanie , SCHMIDT, Darby , WINTER, Dana, K. , BRADLEY, Michael
发明人： CIBLAT, Stephane , DEROY, Patrick , GRAY, Nathanael , LEBLANC, Melissa , MARINEAU, Jason, J. , MOORE, Joel , SPROTT, Kevin , ZHANG, Tinghu , SIDIQUI, M., Arshad , KABRO, Anzhelika , LEGER, Serge , MILLER, Tom , ROY, Stephanie , SCHMIDT, Darby , WINTER, Dana, K. , BRADLEY, Michael
IPC分类号： C07D401/14 , A61K31/506 , A61P35/02
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06
摘要： The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
摘要翻译： 本发明提供新的式（I）化合物及其药学上可接受的盐，溶剂合物，水合物，互变异构体，立体异构体，同位素标记的衍生物及其组合物。 还提供了涉及用于治疗或预防受试者的增殖性疾病（例如，癌症（例如白血病，黑素瘤，多发性骨髓瘤），良性肿瘤，血管生成，炎性疾病，自身炎性疾病和自身免疫性疾病）的化合物或组合物的方法和试剂盒 。 使用本发明的化合物或组合物治疗具有增殖性疾病的受试者可以抑制激酶例如细胞周期蛋白依赖性激酶（CDK）（例如细胞周期蛋白依赖性激酶7（CDK7））的异常活性，因此 ，诱导受试者的细胞凋亡和/或抑制转录。
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公开(公告)号：WO2006137924A3
公开(公告)日：2009-04-09
申请号：PCT/US2005039481
申请日：2005-11-03
IPC分类号： H01L51/50
CPC分类号： H01L51/5265
摘要： A light emitting device includes an optical cavity in resonance with an optical transition of a material disposed in the cavity. The device can form an exciton-polariton state.
摘要翻译： 发光器件包括与设置在空腔中的材料的光学转变共振的光学腔。 器件可以形成激子 - 极化子态。
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公开(公告)号：WO2008092147A9
公开(公告)日：2009-01-15
申请号：PCT/US2008052187
申请日：2008-01-28
申请人： INFORMATION RESOURCES INC , HUNT HERBERT DENNIS , WEST JOHN RANDALL , GIBBS MARSHALL ASHBY , GRIGLIONE BRADLEY MICHAEL , HUDSON GREGORY DAVID NEIL , BASILICO ANDREA , JOHNSON ARVID C , BERGEON CHERYL G , CHAPA CRAIG JOSEPH , AGOSTINELLI ALBERTO , YUSKO JAY ALAN , MASON TREVOR
发明人： HUNT HERBERT DENNIS , WEST JOHN RANDALL , GIBBS MARSHALL ASHBY , GRIGLIONE BRADLEY MICHAEL , HUDSON GREGORY DAVID NEIL , BASILICO ANDREA , JOHNSON ARVID C , BERGEON CHERYL G , CHAPA CRAIG JOSEPH , AGOSTINELLI ALBERTO , YUSKO JAY ALAN , MASON TREVOR
IPC分类号： G06F17/30
CPC分类号： G06Q30/02
摘要： In embodiments, systems and methods may involve using a platform as disclosed herein for applications described herein where the systems and methods involve receiving a dataset in an analytic platform, the dataset including fact data and dimension data for a plurality of distinct product categories. It may also involve storing the data in a flexible hierarchy, the hierarchy allowing the temporary fixing of data along a dimension and flexible querying along other dimensions of the data. It may also involve pre-aggregating certain combinations of data to facilitate rapid querying, the pre-aggregation based on the nature of common queries. It may also involve facilitating the presentation of a cross-category view of an analytic query of the dataset. In embodiments, the temporarily fixed dimension can be rendered flexible upon an action by the user.
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公开(公告)号：WO2008092149A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/052195
申请日：2008-01-28
申请人： INFORMATION RESOURCES, INC. , HUNT, Herbert, Dennis , WEST, John, Randall , GIBBS, Marshall, Ashby , GRIGLIONE, Bradley, Michael , HUDSON, Gregory, David Neil , BASILICO, Andrea , JOHNSON, Arvid, C. , BERGEON, Cheryl, G. , CHAPA, Craig, Joseph , AGOSTINELLI, Alberto , YUSKO, Jay, Alan , MASON, Trevor
发明人： HUNT, Herbert, Dennis , WEST, John, Randall , GIBBS, Marshall, Ashby , GRIGLIONE, Bradley, Michael , HUDSON, Gregory, David Neil , BASILICO, Andrea , JOHNSON, Arvid, C. , BERGEON, Cheryl, G. , CHAPA, Craig, Joseph , AGOSTINELLI, Alberto , YUSKO, Jay, Alan , MASON, Trevor
IPC分类号： G06Q10/00
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公开(公告)号：WO2007095171A3
公开(公告)日：2008-04-17
申请号：PCT/US2007003675
申请日：2007-02-14
IPC分类号： H01L51/00
CPC分类号： G02B5/288
摘要： Materials can be prepared in a layer-by-layer fashion on a patterned first substrate and subsequently transferred to a second substrate. The transfer step can preserve the pattern of the first substrate, such that the second substrate will bear a pattern of the transferred material. The material can be an electrostatic multilayer including a light absorbing dye, such as a J-aggregating cyanine dye.
摘要翻译： 材料可以在图案化的第一衬底上逐层地制备，随后转移到第二衬底。 转印步骤可以保留第一衬底的图案，使得第二衬底将承载转印材料的图案。 该材料可以是包含光吸收染料如J-聚集花青染料的静电多层。
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公开(公告)号：WO2006042034A8
公开(公告)日：2007-09-07
申请号：PCT/US2005036024
申请日：2005-10-07
申请人： ABBOTT LAB , ZHANG GEOFF G , BRADLEY MICHAEL F , BARNES DAVID M , HENRY RODGER
发明人： ZHANG GEOFF G , BRADLEY MICHAEL F , BARNES DAVID M , HENRY RODGER
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/4709 , A61K47/02 , A61K47/12 , C07C31/26
摘要： A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
摘要翻译： 公开了药物的结晶形式，其制备方法，含有它的组合物以及治疗疾病的方法以及使用其抑制不良生理事件。
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公开(公告)号：WO2007095172A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003676
申请日：2007-02-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TISCHLER, Jonathan, R. , BRADLEY, Michael, Scott , BULOVIC, Vladimir
CPC分类号： G02B5/003 , H01L51/52 , H01L51/5275 , Y10T29/49826
摘要： A critically coupled optical resonator absorbs greater than 95% of incident light of the critical wavelength with an absorber layer less than 10 run thick.
摘要翻译： 临界波长的入射光的吸收能力大于95％，吸收层小于10nm。
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公开(公告)号：WO2007095171A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003675
申请日：2007-02-14
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BRADLEY, Michael, Scott , TISCHLER, Jonathan, R. , BULOVIC, Vladimir
CPC分类号： G02B5/288
摘要： Materials can be prepared in a layer-by-layer fashion on a patterned first substrate and subsequently transferred to a second substrate. The transfer step can preserve the pattern of the first substrate, such that the second substrate will bear a pattern of the transferred material. The material can be an electrostatic multilayer including a light absorbing dye, such as a J-aggregating cyanine dye.
摘要翻译： 材料可以在图案化的第一衬底上逐层地制备，随后转移到第二衬底。 转印步骤可以保留第一衬底的图案，使得第二衬底将承载转印材料的图案。 该材料可以是包含光吸收染料如J-聚集花青染料的静电多层。
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公开(公告)号：WO2007018570A3
公开(公告)日：2007-02-15
申请号：PCT/US2005/039482
申请日：2005-11-03
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , TISCHLER, Jonathan , BRADLEY, Michael, Scott , BULOVIC, Vladimir
IPC分类号： B32B9/04
摘要： A high oscillator strength thin film has an absorption constant greater than or equal to 10 6 cm -1.
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