公开(公告)号：WO2006094840A1

公开(公告)日：2006-09-14

申请号：PCT/EP2006/002480

申请日：2006-03-09

Applicant: GLAXO GROUP LIMITED ,  BRADLEY, Daniel, Marcus ,  BRANCH, Clive, Leslie ,  BROWN, Bethany, Joy ,  CHAN, Wai, Ngor ,  COULTON, Steven ,  DEAN, Anthony, William ,  DOYLE, Paul, Martin ,  EVANS, Brian ,  GILPIN, Martin, Leonard ,  GOUGH, Sharon, Lisa ,  MACRITCHIE, Jacqueline, Anne ,  MARSHALL, Howard, Robert ,  NASH, David, John ,  PORTER, Roderick, Alan ,  STASI, Luigi, Piero

Inventor： BRADLEY, Daniel, Marcus ,  BRANCH, Clive, Leslie ,  BROWN, Bethany, Joy ,  CHAN, Wai, Ngor ,  COULTON, Steven ,  DEAN, Anthony, William ,  DOYLE, Paul, Martin ,  EVANS, Brian ,  GILPIN, Martin, Leonard ,  GOUGH, Sharon, Lisa ,  MACRITCHIE, Jacqueline, Anne ,  MARSHALL, Howard, Robert ,  NASH, David, John ,  PORTER, Roderick, Alan ,  STASI, Luigi, Piero

IPC: C07D295/18 ,  A61P25/00 ,  A61K31/495

CPC classification number: C07D295/192

Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R 1 , n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Abstract translation: 本发明提供式（I）化合物或其盐或溶剂化物：其中R 1，n，X，Y和Z如说明书中所定义，以及这些化合物的用途。 该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。

公开(公告)号：WO2006094843A1

公开(公告)日：2006-09-14

申请号：PCT/EP2006/002485

申请日：2006-03-09

Applicant: GLAXO GROUP LIMITED ,  BRADLEY, Daniel, Marcus ,  BRANCH, Clive, Leslie ,  BROWN, Bethany, Joy ,  CHAN, Wai, Ngor ,  COULTON, Steven ,  DEAN, Anthony, William ,  DOYLE, Paul, Martin ,  EVANS, Brian ,  GILPIN, Martin, Leonard ,  GOUGH, Sharon, Lisa ,  MACRITCHIE, Jacqueline, Anne ,  MARSHALL, Howard, Robert ,  NASH, David, John ,  PORTER, Roderick, Alan ,  STASI, Luigi, Piero

Inventor： BRADLEY, Daniel, Marcus ,  BRANCH, Clive, Leslie ,  BROWN, Bethany, Joy ,  CHAN, Wai, Ngor ,  COULTON, Steven ,  DEAN, Anthony, William ,  DOYLE, Paul, Martin ,  EVANS, Brian ,  GILPIN, Martin, Leonard ,  GOUGH, Sharon, Lisa ,  MACRITCHIE, Jacqueline, Anne ,  MARSHALL, Howard, Robert ,  NASH, David, John ,  PORTER, Roderick, Alan ,  STASI, Luigi, Piero

IPC: C07D295/18 ,  C07D239/42 ,  C07D241/44 ,  C07D215/38 ,  C07D487/04 ,  C07D213/85 ,  C07D213/73 ,  C07D213/75 ,  A61P25/00 ,  A61K31/495 ,  A61K31/5377 ,  A61K31/4709 ,  A61K31/444 ,  A61K31/437 ,  A61K31/498

CPC classification number: C07D213/73 ,  C07D213/75 ,  C07D213/85 ,  C07D215/38 ,  C07D239/42 ,  C07D241/44 ,  C07D295/192 ,  C07D487/04

Abstract: The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R 1 , n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Abstract translation: 本发明提供式（I）化合物或其盐或溶剂化物：其中R 1，n，X，Y和Z如说明书中所定义，以及这些化合物的用途。 该化合物抑制GlyT1转运蛋白并且可用于治疗某些神经和神经精神障碍，包括精神分裂症。