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1.发明申请ENHANCED PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS 审中-公开通过重组微生物增强脂肪酸和脂肪酸衍生物的生产
公开(公告)号：WO2013126076A1
公开(公告)日：2013-08-29
申请号：PCT/US2012/026566
申请日：2012-02-24
申请人： EXXONMOBIL RESEARCH AND ENGINEERING COMPANY , SESHADRI, Rekha , KIT, Jennie, Lau , BAUMAN, Nicholas , BROWN, Robert, Christopher
IPC分类号： C12P7/64
CPC分类号： C12P7/64 , C12N9/1029 , C12N9/16 , C12P7/6409 , C12Y203/01051
摘要： The present invention provides for the improved production of fatty acid products in a recombinant microorganism or host cell engineered to express a non-native gene encoding a thioesterase and a non-native gene encoding a lysophosphatidic acid acyltransferase (LPAAT), in which the LPAAT is overexpressed in the recombinant microorganism compared to an otherwise identical microorganism that does not include the non-native LPAAT gene. The invention also provides methods of producing fatty acid products using such recombinant microorganisms.
摘要翻译： 本发明提供在重组微生物或宿主细胞中改进的脂肪酸产物的生产，其被工程化以表达编码硫酯酶的非天然基因和编码溶血磷脂酸酰基转移酶（LPAAT）的非天然基因，其中LPAAT是 与不包括非天然LPAAT基因的另外相同的微生物相比，在重组微生物中过表达。 本发明还提供了使用这种重组微生物生产脂肪酸产物的方法。
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2.发明申请PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS EXPRESSING POLYPEPTIDES HAVING LIPOLYTIC ACTIVITY 审中-公开通过重组微生物生成脂肪酸和脂肪酸衍生物，表达具有脂质活性的多肽
公开(公告)号：WO2012087676A2
公开(公告)日：2012-06-28
申请号：PCT/US2011064657
申请日：2011-12-13
申请人： EXXONMOBIL RES AND ENGINNERING COMPANY , CHEN YOU , WALL THOMAS E , BOWER STANLEY , BROWN ROBERT CHRISTOPHER , COPPERSMITH JENNIFER
CPC分类号： C12N1/12 , C12N1/38 , C12P7/6409
摘要： The invention provides transgenic photosynthetic microorganisms that include non-native genes encoding polypeptides having lipolytic activity for production of free fatty acids and fatty acid derivatives, and methods of producing free fatty acids and fatty acid derivatives using the transgenic microorganisms disclosed herein. The invention also provides transgenic microorganisms that include non-native genes encoding polypeptides having lipolytic activity, and novel genes encoding polypeptides demonstrating lipolytic activity.
摘要翻译： 本发明提供转基因光合微生物，其包括编码具有用于产生游离脂肪酸和脂肪酸衍生物的脂肪分解活性的多肽的非天然基因，以及使用本文公开的转基因微生物产生游离脂肪酸和脂肪酸衍生物的方法。 本发明还提供了转基因微生物，其包括编码具有脂肪分解活性的多肽的非天然基因，以及编码显示脂肪分解活性的多肽的新基因。
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3.发明申请GENETICALLY ENGINEERED MICROORGANISMS COMPRISING 4-HYDROXYBENZOLY-COA THIOESTERASES AND METHODS OF USING THE SAME FOR PRODUCING FREE FATTY ACIDS AND FATTY ACID DERIVATIVES 审中-公开包含4-羟基苯并呋喃酮的遗传工程化微生物及其生产免费脂肪酸和脂肪酸衍生物的方法
公开(公告)号：WO2012087670A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/064641
申请日：2011-12-13
申请人： EXXONMOBIL RESEARCH AND ENGINEERING COMPANY , BROWN, Robert, Christopher , SESHADRI, Rekha , CHAVEZ-TORRES, Carlos , XU, Weidong , RICHARDSON, Toby
发明人： BROWN, Robert, Christopher , SESHADRI, Rekha , CHAVEZ-TORRES, Carlos , XU, Weidong , RICHARDSON, Toby
CPC分类号： C12Y301/02023 , C12N9/16 , C12P7/6418 , Y02P20/582
摘要： The described invention provides genetically engineered microorganisms, including photosynthetic microorganisms, expressing 4-hydroxybenzoyl-CoA thioesterases and methods of using the genetically engineered microorganisms for producing free fatty acids and/or fatty acid derivatives.
摘要翻译： 所描述的发明提供了表达4-羟基苯甲酰-CoA硫酯酶的遗传工程微生物，包括光合微生物，以及使用遗传工程微生物产生游离脂肪酸和/或脂肪酸衍生物的方法。
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4.发明申请PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES BY RECOMBINANT MICROORGANISMS 审中-公开通过重组微生物生产脂肪酸和脂肪酸衍生物
公开(公告)号：WO2012087676A3
公开(公告)日：2012-09-27
申请号：PCT/US2011064657
申请日：2011-12-13
申请人： EXXONMOBIL RES AND ENGINNERING COMPANY , CHEN YOU , WALL THOMAS E , BOWER STANLEY , BROWN ROBERT CHRISTOPHER , COPPERSMITH JENNIFER
CPC分类号： C12N1/12 , C12N1/38 , C12P7/6409
摘要： The invention provides transgenic photosynthetic microorganisms that include non-native genes encoding polypeptides having lipolytic activity for production of free fatty acids and fatty acid derivatives, and methods of producing free fatty acids and fatty acid derivatives using the transgenic microorganisms disclosed herein. The invention also provides transgenic microorganisms that include non-native genes encoding polypeptides having lipolytic activity, and novel genes encoding polypeptides demonstrating lipolytic activity.
摘要翻译： 本发明提供转基因光合微生物，其包括编码具有用于产生游离脂肪酸和脂肪酸衍生物的脂肪分解活性的多肽的非天然基因，以及使用本文公开的转基因微生物产生游离脂肪酸和脂肪酸衍生物的方法。 本发明还提供了转基因微生物，其包括编码具有脂肪分解活性的多肽的非天然基因，以及编码显示脂肪分解活性的多肽的新基因。
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公开(公告)号：WO2009134814A3
公开(公告)日：2010-01-28
申请号：PCT/US2009041998
申请日：2009-04-28
申请人： SYNTHETIC GENOMICS INC , ZIELER HELGE , BROWN ROBERT CHRISTOPHER , RICHARDSON TOBY HOWARD , SMITH DOUGLAS GILLETTE
CPC分类号： C12Q1/6804 , C12Q2535/101
摘要： Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes.
摘要翻译： 本文提供了通过这种方法鉴定的着丝粒和着丝点的方法。 可以使用例如藻类，真菌和原生生物等生物体的中心体，例如用于构建人造染色体和含有这种人造染色体的细胞。
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公开(公告)号：WO2009134814A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/041998
申请日：2009-04-28
申请人： SYNTHETIC GENOMICS, INC. , ZIELER, Helge , BROWN, Robert, Christopher , RICHARDSON, Toby, Howard , SMITH, Douglas, Gillette
发明人： ZIELER, Helge , BROWN, Robert, Christopher , RICHARDSON, Toby, Howard , SMITH, Douglas, Gillette
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2535/101
摘要： Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes.
摘要翻译： 本文提供了通过这种方法鉴定的着丝粒和着丝点的方法。 可以使用例如藻类，真菌和原生生物等生物体的中心体，例如用于构建人造染色体和含有这种人造染色体的细胞。
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7.发明申请GENETICALLY ENGINEERED MICROORGANISMS COMPRISING 4-HYDROXYBENZOYL-COA THIOESTERASES AND METHODS OF USING THE SAME 审中-公开包含4-羟基苯甲酰基噻唑酮的基因工程化微生物及其使用方法
公开(公告)号：WO2012087670A3
公开(公告)日：2014-04-10
申请号：PCT/US2011064641
申请日：2011-12-13
申请人： EXXONMOBIL RES & ENG CO , BROWN ROBERT CHRISTOPHER , SESHADRI REKHA , CHAVEZ-TORRES CARLOS , XU WEIDONG , RICHARDSON TOBY
发明人： BROWN ROBERT CHRISTOPHER , SESHADRI REKHA , CHAVEZ-TORRES CARLOS , XU WEIDONG , RICHARDSON TOBY
CPC分类号： C12Y301/02023 , C12N9/16 , C12P7/6418 , Y02P20/582
摘要： The described invention provides genetically engineered microorganisms, including photosynthetic microorganisms, expressing 4-hydroxybenzoyl-CoA thioesterases and methods of using the genetically engineered microorganisms for producing free fatty acids and/or fatty acid derivatives.
摘要翻译： 所描述的发明提供了表达4-羟基苯甲酰-CoA硫酯酶的遗传工程微生物，包括光合微生物，以及使用遗传工程微生物产生游离脂肪酸和/或脂肪酸衍生物的方法。
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公开(公告)号：WO2012087676A4
公开(公告)日：2012-06-28
申请号：PCT/US2011/064657
申请日：2011-12-13
申请人： EXXONMOBIL RESEARCH AND ENGINNERING COMPANY , CHEN, You , WALL, Thomas, E. , BOWER, Stanley , BROWN, Robert, Christopher , COPPERSMITH, Jennifer
发明人： CHEN, You , WALL, Thomas, E. , BOWER, Stanley , BROWN, Robert, Christopher , COPPERSMITH, Jennifer
摘要： The invention provides transgenic photosynthetic microorganisms that include non-native genes encoding polypeptides having lipolytic activity for production of free fatty acids and fatty acid derivatives, and methods of producing free fatty acids and fatty acid derivatives using the transgenic microorganisms disclosed herein. The invention also provides transgenic microorganisms that include non-native genes encoding polypeptides having lipolytic activity, and novel genes encoding polypeptides demonstrating lipolytic activity.
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公开(公告)号：WO2009076480A3
公开(公告)日：2009-12-30
申请号：PCT/US2008086296
申请日：2008-12-10
申请人： SYNTHETIC GENOMICS INC , PICATAGGIO STEPHEN , BROWN ROBERT CHRISTOPHER , KRISTOF JESSICA ROXANE , LEE GENA , PRAKASH PRACHEE , UNDERWOOD STUART ALAN , WATTS KEVIN
发明人： PICATAGGIO STEPHEN , BROWN ROBERT CHRISTOPHER , KRISTOF JESSICA ROXANE , LEE GENA , PRAKASH PRACHEE , UNDERWOOD STUART ALAN , WATTS KEVIN
CPC分类号： C12P7/16 , C10L1/02 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , Y02E50/343
摘要： This invention describes genes, metabolic pathways, microbial strains and methods to produce methyl butanol and other compounds of interest from renewable feedstocks.
摘要翻译： 本发明描述了可再生原料生产甲基丁醇和其他化合物的基因，代谢途径，微生物菌株和方法。
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公开(公告)号：WO2009076480A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/086296
申请日：2008-12-10
申请人： SYNTHETIC GENOMICS, INC. , PICATAGGIO, Stephen , BROWN, Robert, Christopher , KRISTOF, Jessica, Roxane , LEE, Gena , PRAKASH, Prachee , UNDERWOOD, Stuart, Alan , WATTS, Kevin
发明人： PICATAGGIO, Stephen , BROWN, Robert, Christopher , KRISTOF, Jessica, Roxane , LEE, Gena , PRAKASH, Prachee , UNDERWOOD, Stuart, Alan , WATTS, Kevin
IPC分类号： C12N1/19
CPC分类号： C12P7/16 , C10L1/02 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/88 , C12N9/93 , C12P7/04 , Y02E50/343
摘要： This invention describes genes, metabolic pathways, microbial strains and methods to produce methyl butanol and other compounds of interest from renewable feedstocks.
摘要翻译： 本发明描述了从可再生原料生产甲基丁醇和其他感兴趣的化合物的基因，代谢途径，微生物菌株和方法。
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