公开(公告)号：WO2022056045A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/049534

申请日：2021-09-08

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  LYNCH, Kevin R. ,  KHAREL, Yugesh ,  SANTOS, Webster L. ,  FRITZEMEIER, Russell G. ,  BURGIO, Ariel Louise ,  SHRADER, Christopher ,  FOSTER, Daniel

发明人： LYNCH, Kevin R. ,  KHAREL, Yugesh ,  SANTOS, Webster L. ,  FRITZEMEIER, Russell G. ,  BURGIO, Ariel Louise ,  SHRADER, Christopher ,  FOSTER, Daniel

IPC分类号： C07D205/04 ,  C07D207/06 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/06 ,  C07D211/34 ,  C07D211/56 ,  C07D241/04 ,  A61K31/4406 ,  A61K31/401 ,  A61P35/00 ,  A61P37/00

摘要： The present disclosure provides SPNS2 inhibitor compounds according to Formula (IA) and Formula (I), and their pharmaceutically acceptable salts, and/or tautomers as described in the disclosure, and the disclosure provides their pharmaceutical compositions and methods of use in therapy.