Abstract:
The invention provides novel compounds having the general formula: [insert formula (I)] and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X2, L, subscript m, X1, ring D, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract:
The invention relates to ureidophenyl-morpholino pyrimidine and guanidinophenyl-morpholino pyrimidine compounds of formula, and to methods for making and using the compounds.
Abstract:
A device (1) for positioning a patient with respect to the radiation beam of an X-ray device comprising: A) a reference plate (2) with a back side (11), a front side (12) and radiopaque reference means (20); B) an arm (4) connected to said reference plate (2), wherein C) said arm (4) is bendable in a single plane (5) only.
Abstract:
A device and a method for surgically manipulating a bone or bone fragment or a surgical instrument, tool or implant. Said device comprising: A) a rod shaped member (2) with a central axis (6), a rear end (3), a front end (4) and a length L2; B) a first targeting element (7) fixed to said rod shaped member (2) coaxially to said central axis (6) and having a first center (46), wherein said first targeting element (7) is arranged on said rod shaped member (2) with said first centre (46) at a distance A1 > 0 from said rear end (3); C) a second targeting element (5) with a second center (45), wherein - said second targeting element (5) is fixed to said rod shaped member (2) coaxially to said central axis (6) with said second centre (45) at a distance A2
Abstract:
The present invention relates to compounds of formula (I), wherein R4, R5, R6, R7, Q, m and n are as defined in the specification. The compounds are useful as p38 kinase inhibitors, and therefore, may be used for treatment of p38-mediated disorder.
Abstract:
The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X 2 , L, subscript m, X 1 , R 1 , R 2 , R 3 , R 4 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract:
The invention provides novel compounds having the general formula (I) and pharmaceutically acceptable salts thereof, wherein the variables RA, subscript n, ring A, X 2 , L, subscript m, X 1 , ring D, R 1 , and R N have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
Abstract:
Die Erfindung betrifft ein Implantatlager für den künstlichen Gelenkersatz nach Anspruch 1. Das erfindungsgemässe, adaptive implantatlager besteht aus einem inneren Gelenkkörper mit sphärischer Lagerfläche, einer Zwischenschicht aus einem Basispolymer mit eingebetteten Lagermitteln aus einem harten, verschleissarmen Material und einem äusseren Gelenkkörper, der sich durch seinen modularen Aufbau bei Belastung an den Lagermitteln anschmiegt und so die Kräfte grossflächig an die äussere, im Knochen verankerte Aussenoberfläche überträgt. Der modulare Aufbau des äusseren Gelenkkörpers erlaubt eine funktionale Trennung der Lagerflächenbeschaffenheit und der Körpersteifigkeit und kann ideal den verschieden Beanspruchungen durch die von aussen wirkenden Kräfte und deren grossflächige Übertragung auf den Inneren Gelenkkörper angepasst werden.
Abstract:
A method for computer assisted determination of positioning parameters of a medical device (1; 3) relative to a target structure (10) comprising the steps of A) obtaining a medical image (50) of a medical device (1) which comprises a cylindrical reference means (16) and of a target structure (10) by means of a radiographic device (20), wherein the cylindrical reference means (16) has a different density than the surrounding material of the medical device (1), B) determining an actual first position of the medical device (1) with respect to a local system of coordinates (24) fixed with the radiographic device (20), C) calculating the actual first position of the target structure (10) relative to the medical device (1), D) retrieving a desired second position of the medical device (1) relative to the target structure (10) and/or retrieving a virtual geometric representation of an additional medical device (3) using the computer (32), E) calculating values of correction parameters between the actual first position and the desired second position of the medical device (1) relative to the target structure (10) and/or values defining a desired position of the additional medical device (3) relative to the medical device (1) by means of the computer (32). A device for computer assisted positioning of a medical device (1) relative to a target structure (10) or to a reference base including a) a radiographic device (20), b) a computer (32) electronically connected to the radiographic device (20) and c) a medical device (1) comprising a cylindrical reference means (16), wherein the cylindrical reference means (16) has a different density than the surrounding material of the medical device (1), a longitudinal axis (18), a height h, a diameter d and a centre (47), wherein d) the computer (32) is suitably programmed to perform steps B) - F) of the method according to the invention.
Abstract:
Die vorliegende Erfindung betrifft neuartige Multikomponentenkristalle, deren Herstellung sowie deren Verwendung zur Behandlung von Schmerzzuständen, insbesondere unklarer Genese, durch eine gleichzeitige Wirkung auf Schmerzen, die durch Muskelverspannung oder degenerative Gelenkerkrankungen verursacht werden, als auch auf solche, die auf entzündlichen Prozessen beruhen. Die neuartigen Multikomponentenkristalle enthalten([2-Amino-6-(4-fluoro-benzylamino)- pyridin-3-yl]-carbamidsäureethylester (Flupirtin) und 2-[2-[(2,6-Dichlorphenyl)-amino]- phenyl]-essigsäure (Diclofenac)als einzige Wirkstoffkombination und lassen sich durch Lösen der beiden Komponenten in einem molaren Verhältnis von 1,0: 0,9 bis 1,0:1,1 in einem inerten organischen Lösungsmittel und anschließendes Auskristallisieren der Komplexverbindung herstellen.