公开(公告)号：WO2022195615A1

公开(公告)日：2022-09-22

申请号：PCT/IN2022/050242

申请日：2022-03-15

Applicant: CIPLA LIMITED

Inventor： BHADAURIA, Pradeep ,  RAJYAGURU, Tushar ,  KUMAR, Abhinesh ,  HARDE, Harshad ,  KUMAR, Mukesh ,  WALUNJ, Manoj Mahadu ,  SINGHADEO, Arnab Kumar

IPC: A61K31/00

Abstract: The present invention discloses to a long acting injectable composition comprising cariprazine or its pharmaceutically acceptable salts thereof and process to prepare the same. The present invention also discloses to use of the long acting injectable composition comprising cariprazine or its pharmaceutically acceptable salts thereof in the treatment of psychotic disorders.

公开(公告)号：WO2022118020A1

公开(公告)日：2022-06-09

申请号：PCT/GB2021/053142

申请日：2021-12-01

Applicant: CIPLA LIMITED ,  TURNER, Craig

Inventor： JOSHI, Kalpana ,  GHOSALKAR, Jeevan ,  GAIKWAD, Deepak

IPC: A61K31/167 ,  A61K31/573 ,  A61K31/58 ,  A61K31/675 ,  A61K31/40 ,  A61P31/14

Abstract: The present invention relates to methods of treatment of infections caused by coronaviridae virus (including COVID-19) using ((((((R)-1-(6-amino-9h-purin-9-yl) propan-2-yl) oxy) methyl) (phenoxy) phosphoryl)oxy)methyl pivalate, its derivatives or metabolites thereof. The methods of the present invention can be used in patients with infections caused by coronaviridae virus (including COVID-19) administering ((((((R)-1-(6-amino-9h-purin-9-yl) propan-2-yl) oxy) methyl) (phenoxy) phosphoryl)oxy)methyl pivalate, its derivatives or metabolites in combination with one or more anti-viral drugs.

公开(公告)号：WO2022049604A1

公开(公告)日：2022-03-10

申请号：PCT/IN2021/050859

申请日：2021-09-06

Applicant: CIPLA LIMITED

Inventor： DAS, Arijit ,  SINGH, Manjinder ,  BHOSALE, Rajesh ,  SAWANT, Ashwini ,  CHAVAN, Amit ,  SUKTE, Ankush ,  TARATE, Sagar ,  THAKUR, Nitin ,  PATIL, Ravindra

IPC: C07D279/12

Abstract: The present invention relates to processes and intermediates for the synthesis of Revefenacin or pharmaceutically acceptable salts thereof.

公开(公告)号：WO2020053878A1

公开(公告)日：2020-03-19

申请号：PCT/IN2019/050649

申请日：2019-09-09

Applicant: CIPLA LIMITED

Inventor： KULKARNI, Nandan ,  SHEWALE, Pavan ,  MALHOTRA, Geena

IPC: A61M11/00 ,  A61M15/00 ,  B65D83/06 ,  B65D75/36

Abstract: The present subject matter refers a blister-strip based dispenser (100) comprising a lever arm rotatable on receiving a user-actuation. A chassis (106, 108) is provided for supporting placement of at least one blister-strip (104) in the form of the coil. The blister-strip (104) comprises medicament-pockets at at-least one side of the blister-strip (104). A plurality of interconnected-rollers (110, 114, 116) comprises at-least one roller linked to the lever-arm and rotatable by the lever arm. The plurality of interconnected rollers (110, 114, 116) are configured for anchoring the blister-strip (104) from one end for enabling the placement in a coil-form and unwinding of the blister strip (104) from the coil-form, guiding at least two split-portions of the blister-strip (104), anchoring an end of each of said at-least two portions of the blister-strip (104) for winding the at-least two portions separately, and anchoring an end of a lid-foil peeled off the at least two portions for winding the lid-foil.

公开(公告)号：WO2019193609A1

公开(公告)日：2019-10-10

申请号：PCT/IN2019/050281

申请日：2019-04-05

Applicant: CIPLA LIMITED

Inventor： MALHOTRA, Geena ,  JOSHI, Kalpana ,  RAUT, Preeti ,  GHOSALKAR, Jeevan ,  DIXIT, Neeta

IPC: A61K47/22 ,  A61K31/495

Abstract: A pharmaceutical formulation is provided comprising combination of anti-tuberculosis drug drugs optionally in combination of bioenhancers. The formulation is used for the treatment of diseases caused by mycobacterium tuberculosis. The process of preparation of the formulation is also provided.

公开(公告)号：WO2019142214A1

公开(公告)日：2019-07-25

申请号：PCT/IN2019/050045

申请日：2019-01-19

Applicant: CIPLA LIMITED

Inventor： MALHOTRA, Geena

IPC: A61K9/08 ,  A61K47/18 ,  A61K31/137 ,  A61K31/439 ,  A61K31/4704 ,  A61K31/5386 ,  A61P11/08 ,  A61P11/06

CPC classification number: A61P11/06 ,  A61K9/0078 ,  A61K31/138 ,  A61K31/439 ,  A61K31/4704 ,  A61K45/06 ,  A61K47/183 ,  A61P11/08 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition comprising tiotropium or a pharmaceutically acceptable salt thereof and long acting beta adrenergic agonists or its pharmaceutically acceptable salts thereof for inhalation via nebulization to a subject. The invention also relates to a process for preparing the pharmaceutical composition and its use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) in a subject.

公开(公告)号：WO2019130354A1

公开(公告)日：2019-07-04

申请号：PCT/IN2018/050891

申请日：2018-12-28

Applicant: CIPLA LIMITED

Inventor： RAO, Dharmaraj Ramachandra ,  MALHOTRA, Geena ,  PATHI, Srinivas Laxminarayan ,  PHULL, Manjinder Singh ,  CHENNURU, Ramanaiah

IPC: C07F9/6561 ,  A61K31/675 ,  A61P31/18

CPC classification number: C07F9/65616 ,  A61K31/675 ,  A61P31/18 ,  C07B2200/13

Abstract: The present invention discloses novel crystalline polymorphic forms of (9-[(R)-2-[[(S)-[[(S)-1- (isopropoxy carbonyl) ethyl] amino] phenoxyphosphinyl] methoxy]propyl] adenine hemifumarate and 9-[(R)-2-[[(S)-[[(S)-1- (isopropoxycarbonyl)ethyl] amino]phenoxy phosphinyl]methoxy]propyl] adenine monofumarate, methods of preparation, pharmaceutical compositions and methods of therapeutic treatment involving polymorphic forms thereof.

公开(公告)号：WO2019058386A1

公开(公告)日：2019-03-28

申请号：PCT/IN2018/050606

申请日：2018-09-19

Applicant: CIPLA LIMITED

Inventor： MALHOTRA, Geena

IPC: A61K31/519 ,  A61K9/00 ,  A61P35/00 ,  A61P35/02

CPC classification number: A61K31/519 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/4858 ,  A61K47/22

Abstract: A pharmaceutical composition is provided for the treatment of B-cell proliferative disorders. The composition comprises a therapeutically effective amount of ibrutinib and a therapeutically effective amount of at least one alkaloid or derivative thereof. Methods and kits are also provided.

公开(公告)号：WO2018193470A1

公开(公告)日：2018-10-25

申请号：PCT/IN2018/050229

申请日：2018-04-18

Applicant: CIPLA LIMITED

Inventor： MALHOTRA, Geena ,  JOSHI, Kalpana ,  RAUT, Preeti

IPC: A61K45/06 ,  A61K31/4439 ,  A61K31/513 ,  A61K31/675 ,  A61K31/683 ,  A61P31/14 ,  A61P31/18

Abstract: A pharmaceutical composition is provided comprising combination of antiretroviral drugs optionally in combination of pharmacokinetic boosters. The formulation is used for the treatment of diseases caused by retroviruses. The process of preparation of the formulation is also provided.

公开(公告)号：WO2018167515A1

公开(公告)日：2018-09-20

申请号：PCT/GB2018/050695

申请日：2018-03-16

Applicant: CIPLA LIMITED ,  KING, Lawrence

Inventor： PHULL, Manjinder Singh ,  SAWANT, Ashwini Amol ,  RAO, Dharmaraj Ramachandra ,  MALHOTRA, Geena ,  GANGRADE, Manish Gopaldas

IPC: A61K31/661 ,  C07F9/6561 ,  A61P31/18

Abstract: The present invention relates to certain acid salts of (((1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methyl)(phenoxy) phosphoryloxy)methyl pivalateof Formula (I), to processes for their preparation; to pharmaceutical compositions comprising such compounds,and methods of treating a disease which responds to inhibition of nucleotide reverse transcriptase activity.