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公开(公告)号：WO2010139692A2
公开(公告)日：2010-12-09
申请号：PCT/EP2010057636
申请日：2010-06-01
Applicant: SAVIRA PHARMACEUTICALS GMBH , ONEPHARM RES & DEV GMBH , CLASSEN-HOUBEN DIRK , KUEENBURG BERNHARD , KOSMA PAUL , JORDIS ULRICH , STANETTY CHRISTIAN , SZOLAR OLIVER , WOLKERSTORFER ANDREA
Inventor： CLASSEN-HOUBEN DIRK , KUEENBURG BERNHARD , KOSMA PAUL , JORDIS ULRICH , STANETTY CHRISTIAN , SZOLAR OLIVER , WOLKERSTORFER ANDREA
IPC: C07H15/00
CPC classification number: C07J63/008
Abstract: The present invention encompasses novel triterpene compounds of general Formula (I) wherein RN1, RN2, R11a, R11b, R4, R17, R19 and R20 are defined as in claim 1, which exhibit an antiviral effect and are therefore suitable for the treatment of diseases related thereto and the use thereof for preparing a medicament having the above-mentioned properties.
Abstract translation: 本发明包括通式（I）的新型三萜化合物，其中RN1，RN2，R11a，R11b，R4，R17，R19和R20如权利要求1中所定义，其具有抗病毒作用，因此适用于治疗疾病 以及其用于制备具有上述性质的药物的用途。
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2.发明申请
公开(公告)号：WO2011000566A3
公开(公告)日：2011-01-06
申请号：PCT/EP2010/003967
申请日：2010-06-30
Applicant: SAVIRA PHARMACEUTICALS GMBH , EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) , CLASSEN-HOUBEN, Dirk , SZOLAR, Oliver , SEHR, Peter , WENDT, Bernd , GULLIGAY, Delphine , CUSACK, Stephen , LEWIS, Joe
Inventor： CLASSEN-HOUBEN, Dirk , SZOLAR, Oliver , SEHR, Peter , WENDT, Bernd , GULLIGAY, Delphine , CUSACK, Stephen , LEWIS, Joe
IPC: C07D295/18 , C07D471/04 , A61K31/121 , A61K31/136 , A61K31/18 , A61K31/437 , A61K31/495 , C07C49/78 , C07C49/84 , C07C205/46 , C07C211/56 , C07C243/28 , C07C311/51 , A61P31/14 , A61P31/16
Abstract: The present invention relates to novel compounds and pharmaceutical compositions and the use thereof for the manufacture of a medicament for treating, ameliorating, or preventing disease conditions caused by a viral infection with negative-sense ssRNA viruses.
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3.发明申请GLYCYRRHETINIC ACID AMINE ANALOGUES FOR USE IN THE TREATMENT OF INFLAMMATION, INFECTIOUS DISEASES, CANCER, AUTOIMMUNE DISEASES, SKIN DISEASES, BONE DISEASES AND METABOLIC DISEASES 审中-公开用于治疗炎症，感染性疾病，癌症，自身免疫疾病，皮肤疾病，骨骼疾病和代谢病的甘氨酸氨基酸类似物
公开(公告)号：WO2012020021A9
公开(公告)日：2012-05-10
申请号：PCT/EP2011063702
申请日：2011-08-09
Applicant: ONEPHARM RES & DEV GMBH , CLASSEN-HOUBEN DIRK , KUEENBURG BERNHARD , KOSMA PAUL , JORDIS ULRICH , CZOLLNER LASZLO
Inventor： CLASSEN-HOUBEN DIRK , KUEENBURG BERNHARD , KOSMA PAUL , JORDIS ULRICH , CZOLLNER LASZLO
IPC: C07J63/00 , A61K31/56 , A61K31/58 , A61P3/00 , A61P17/00 , A61P19/08 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06
CPC classification number: C07J63/008
Abstract: The present invention encompasses compounds of general formula (I) wherein R3a to R31 and X are defined as in claim 1, which are suitable for the treatment of and/or prevention of chronic inflammatory diseases, autoimmune diseases, skin diseases, bone diseases, metabolic diseases, infectious diseases and cancer.
Abstract translation: 本发明包括通式（I）的化合物，其中R 3a至R 31和X如权利要求1中所定义，其适用于治疗和/或预防慢性炎性疾病，自身免疫性疾病，皮肤病，骨疾病，代谢 疾病，传染病和癌症。
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4.发明申请DIAZABICYCLO- UND DIAZASPIRO-ALKANDERIVATE ALS PHOSPHODIESTERASE-5 INHIBITOREN 审中-公开双环和螺-的烷衍生物作为磷酸二酯酶5抑制剂
公开(公告)号：WO2013057205A1
公开(公告)日：2013-04-25
申请号：PCT/EP2012/070682
申请日：2012-10-18
Applicant: TECHNISCHE UNIVERSITAET WIEN , JORDIS, Ulrich , KUEENBURG, Bernhard , LIGHTNER, Derek , CLASSEN-HOUBEN, Dirk
Inventor： JORDIS, Ulrich , KUEENBURG, Bernhard , LIGHTNER, Derek , CLASSEN-HOUBEN, Dirk
IPC: C07D487/04 , A61K31/505 , A61K31/53 , A61P9/00 , A61P15/00
CPC classification number: C07D487/04
Abstract: Die vorliegende Erfindung beschreibt neue PDE5-Hemmer welche einen Diazabicyclo- bzw. Diazaspiro-alkanrest enthalten. Diese Diazabicyclo- bzw. Diazaspiro-alkanreste können als komformativ fixierte Piperazin-Analoga aufgefasst werden, wobei einige dieser neuen Verbindungen beispielsweise im Vergleich zu Vardenafil und Sildenafil verbesserte Eigenschaften aufweisen.
Abstract translation: 本发明描述了包含一个或二氮杂二环螺烷烃结构部分新PDE5抑制剂。 此二氮杂二环或螺烷烃基团可以在具有改进的特性相比，可以视为固定komformativ哌嗪类似物，其中一些新化合物具有，例如伐地那非和西地那非。
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Patent Agency Ranking5.发明申请GLYCYRRHETINIC ACID AMINE ANALOGUES FOR USE IN THE TREATMENT OF INFLAMMATION, INFECTIOUS DISEASES, CANCER, AUTOIMMUNE DISEASES, SKIN DISEASES, BONE DISEASES AND METABOLIC DISEASES 审中-公开用于治疗感染性疾病，感染性疾病，癌症，自身免疫性疾病，皮肤疾病，骨髓疾病和代谢疾病的甘氨酸酸胺类似物
公开(公告)号：WO2012020021A1
公开(公告)日：2012-02-16
申请号：PCT/EP2011/063702
申请日：2011-08-09
Applicant: onepharm Research & Development GmbH , CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , CZOLLNER, Laszlo
Inventor： CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , CZOLLNER, Laszlo
IPC: C07J63/00 , A61K31/56 , A61K31/58 , A61P29/00 , A61P37/06 , A61P17/00 , A61P19/08 , A61P31/00 , A61P35/00 , A61P3/00
CPC classification number: C07J63/008
Abstract: The present invention encompasses compounds of general formula (I) wherein R 3a to R 31 and X are defined as in claim 1, which are suitable for the treatment of and/or prevention of chronic inflammatory diseases, autoimmune diseases, skin diseases, bone diseases, metabolic diseases, infectious diseases and cancer.
Abstract translation: 本发明包括通式（I）的化合物，其中R3a至R31和X如权利要求1中所定义，其适用于治疗和/或预防慢性炎性疾病，自身免疫疾病，皮肤病，骨骼疾病，代谢 疾病，传染病和癌症。
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公开(公告)号：WO2012020019A1
公开(公告)日：2012-02-16
申请号：PCT/EP2011/063699
申请日：2011-08-09
Applicant: ONEPHARM RESEARCH & DEVELOPMENT GMBH , CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , CZOLLNER, Laszlo
Inventor： CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , CZOLLNER, Laszlo
IPC: A61K31/41 , A61K31/55 , C07D223/30 , C07D271/06 , A61P29/00
CPC classification number: A61K31/41 , A61K31/55 , A61K45/06 , C07D223/14 , C07D271/07 , C07J63/008 , A61K2300/00
Abstract: The present invention encompasses compounds of general formula (I) wherein R 11a to R 30 and X are defined as in claim 1, which are suitable for the treatment of and/or prevention of chronic inflammatory diseases, autoimmune diseases, skin diseases, bone diseases, metabolic diseases, infectious diseases and cancer.
Abstract translation: 本发明包括其中R11a至R30和X如权利要求1中所定义的通式（I）的化合物，其适用于治疗和/或预防慢性炎性疾病，自身免疫疾病，皮肤病，骨骼疾病，代谢 疾病，传染病和癌症。
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7.发明申请COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEGATIVE-SENSE SSRNA VIRUS INFECTIONS 审中-公开用于治疗阴性SSRNA病毒感染的化合物和药物组合物
公开(公告)号：WO2011000566A2
公开(公告)日：2011-01-06
申请号：PCT/EP2010003967
申请日：2010-06-30
Applicant: SAVIRA PHARMACEUTICALS GMBH , EUROPEAN MOLECULAR BIOLOGY LAB EMBL , CLASSEN-HOUBEN DIRK , SZOLAR OLIVER , SEHR PETER , WENDT BERND , GULLIGAY DELPHINE , CUSACK STEPHEN , LEWIS JOE
Inventor： CLASSEN-HOUBEN DIRK , SZOLAR OLIVER , SEHR PETER , WENDT BERND , GULLIGAY DELPHINE , CUSACK STEPHEN , LEWIS JOE
CPC classification number: C07D471/04 , A61K31/121 , A61K31/136 , A61K31/18 , A61K31/437 , A61K31/495 , C07C49/84 , C07C205/45 , C07C259/06 , C07C309/46 , C07C311/51 , C07C2601/16 , C07D295/18
Abstract: The present invention relates to novel compounds and pharmaceutical compositions and the use thereof for the manufacture of a medicament for treating, ameliorating, or preventing disease conditions caused by a viral infection with negative-sense ssRNA viruses.
Abstract translation: 本发明涉及新型化合物和药物组合物及其用于制造用于治疗，改善或预防由负义型ssRNA病毒引起的病毒感染引起的疾病状态的药物的用途。
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公开(公告)号：WO2010139692A3
公开(公告)日：2010-12-09
申请号：PCT/EP2010/057636
申请日：2010-06-01
Applicant: SAVIRA PHARMACEUTICALS GMBH , ONEPHARM RESEARCH & DEVELOPMENT GMBH , CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , STANETTY, Christian , SZOLAR, Oliver , WOLKERSTORFER, Andrea
Inventor： CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , STANETTY, Christian , SZOLAR, Oliver , WOLKERSTORFER, Andrea
Abstract: The present invention encompasses novel triterpene compounds of general Formula (I) wherein R N1 , R N2 , R 11a , R 11b , R 4 , R 17 , R 19 and R 20 are defined as in claim 1, which exhibit an antiviral effect and are therefore suitable for the treatment of diseases related thereto and the use thereof for preparing a medicament having the above-mentioned properties.
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公开(公告)号：WO2010103046A1
公开(公告)日：2010-09-16
申请号：PCT/EP2010/053045
申请日：2010-03-10
Applicant: ONEPHARM RESEARCH & DEVELOPMENT GMBH , CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , STANETTY, Christian , CZOLLNER, Laszlo
Inventor： CLASSEN-HOUBEN, Dirk , KUEENBURG, Bernhard , KOSMA, Paul , JORDIS, Ulrich , STANETTY, Christian , CZOLLNER, Laszlo
IPC: C07J63/00 , A61K31/575 , A61P29/00 , A61P35/00 , A61P37/02
CPC classification number: C07J63/008
Abstract: The present invention encompasses novel triterpene compounds of general formula I, wherein R 3a , R 3b , R 11a , R 11 b , R 31 and R 32 are defined as in claim 1, which are suitable for the prevention and/or treatment of diseases mediated by 11 β-HSD and the use thereof for preparing a medicament having the above-mentioned properties.
Abstract translation: 本发明包括通式I的新型三萜化合物，其中R3a，R3b，R11a，R11b，R31和R32如权利要求1中所定义，其适用于预防和/或治疗11β-HSD介导的疾病 以及其用于制备具有上述性质的药物的用途。
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