公开(公告)号：WO2005122671A3

公开(公告)日：2007-11-08

申请号：PCT/CA2005000932

申请日：2005-06-16

Applicant: APOTEX PHARMACHEM INC ,  CHE DAQING ,  CORELLI-RENNIE NADIA ,  GUNTOORI BHASKAR REDDY ,  FAUGHT JODY

Inventor： CHE DAQING ,  CORELLI-RENNIE NADIA ,  GUNTOORI BHASKAR REDDY ,  FAUGHT JODY

IPC: C07D223/22 ,  A61K31/55 ,  C07D223/18 ,  C07D223/26 ,  C07D223/28 ,  C07D223/30

CPC classification number: C07D223/26 ,  C07D223/28

Abstract: A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifying oxcarbazepine.

Abstract translation: 一种制备奥卡西平III的方法，包括：a）使肟基芪Ⅳ与氯磺酰异氰酸酯在惰性有机溶剂中反应，并分离化合物Ⅴb）水解化合物V以形成粗制的奥卡西平III，c）纯化奥卡西平。

公开(公告)号：WO2016140971A1

公开(公告)日：2016-09-09

申请号：PCT/US2016/020269

申请日：2016-03-01

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： ZHU, Jiewen ,  LEE, Wen-Hwa ,  CHEN, Hongyuan ,  GUO, Xuning ,  QUI, Xia-Long

IPC: C07D401/04 ,  C07D403/04 ,  C07D209/44 ,  C07D217/08 ,  C07D223/30 ,  A61K31/4035 ,  A61K31/47 ,  A61K31/55

CPC classification number: C07D417/04 ,  C07D209/44 ,  C07D223/16 ,  C07D277/56 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04

Abstract: The present invention includes novel RAD51 inhibitors. The compounds of the invention may be useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.

Abstract translation: 本发明包括新型RAD51抑制剂。 本发明的化合物可用于预防或治疗有需要的受试者的癌症。 本发明还包括通过向受试者施用治疗有效量的本发明化合物来预防或治疗有此需要的受试者的癌症的方法。

公开(公告)号：WO2012020019A1

公开(公告)日：2012-02-16

申请号：PCT/EP2011/063699

申请日：2011-08-09

Applicant: ONEPHARM RESEARCH & DEVELOPMENT GMBH ,  CLASSEN-HOUBEN, Dirk ,  KUEENBURG, Bernhard ,  KOSMA, Paul ,  JORDIS, Ulrich ,  CZOLLNER, Laszlo

Inventor： CLASSEN-HOUBEN, Dirk ,  KUEENBURG, Bernhard ,  KOSMA, Paul ,  JORDIS, Ulrich ,  CZOLLNER, Laszlo

IPC: A61K31/41 ,  A61K31/55 ,  C07D223/30 ,  C07D271/06 ,  A61P29/00

CPC classification number: A61K31/41 ,  A61K31/55 ,  A61K45/06 ,  C07D223/14 ,  C07D271/07 ,  C07J63/008 ,  A61K2300/00

Abstract: The present invention encompasses compounds of general formula (I) wherein R 11a to R 30 and X are defined as in claim 1, which are suitable for the treatment of and/or prevention of chronic inflammatory diseases, autoimmune diseases, skin diseases, bone diseases, metabolic diseases, infectious diseases and cancer.

Abstract translation: 本发明包括其中R11a至R30和X如权利要求1中所定义的通式（I）的化合物，其适用于治疗和/或预防慢性炎性疾病，自身免疫疾病，皮肤病，骨骼疾病，代谢 疾病，传染病和癌症。

公开(公告)号：WO2005122671A2

公开(公告)日：2005-12-29

申请号：PCT/CA2005/000932

申请日：2005-06-16

Applicant: APOTEX PHARMACHEM INC. ,  CHE, Daqing ,  CORELLI-RENNIE, Nadia ,  GUNTOORI, Bhaskar, Reddy ,  FAUGHT, Jody

Inventor： CHE, Daqing ,  CORELLI-RENNIE, Nadia ,  GUNTOORI, Bhaskar, Reddy ,  FAUGHT, Jody

IPC: A61K31/55 ,  C07D223/18 ,  C07D223/22 ,  C07D223/26 ,  C07D223/28 ,  C07D223/30

CPC classification number: C07D223/26 ,  C07D223/28

Abstract: A process for preparing Oxcarbazepine III comprising: a) reacting oximinostilbene IV with chlorosulfonyl isocyanate in an inert organic solvent and isolating compound V b) hydrolyzing compound V to form crude Oxcarbazepine III c) purifying oxcarbazepine.

Abstract translation: 一种制备奥卡西平III的方法，包括：a）使肟基芪Ⅳ与氯代磺酰基异氰酸酯在惰性有机溶剂中反应并分离化合物Ⅴb）水解化合物V以形成粗制的奥卡西平III，c）纯化奥卡西平。