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公开(公告)号：WO2012012667A3
公开(公告)日：2012-01-26
申请号：PCT/US2011/044902
申请日：2011-07-21
Applicant: SANGAMO BIOSCIENCES, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , COLLINGWOOD, Trevor , COOPER, Laurence J.,N. , GREGORY, Philip D. , HOLMES, Michael C. , MILLER, Jeffrey C. , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor
Inventor： COLLINGWOOD, Trevor , COOPER, Laurence J.,N. , GREGORY, Philip D. , HOLMES, Michael C. , MILLER, Jeffrey C. , REBAR, Edward J. , REIK, Andreas , URNOV, Fyodor
IPC: C07K14/00
Abstract: Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
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公开(公告)号：WO2007136685A3
公开(公告)日：2008-05-22
申请号：PCT/US2007011799
申请日：2007-05-17
Applicant: SANGAMO BIOSCIENCES INC , COLLINGWOOD TREVOR
Inventor： COLLINGWOOD TREVOR
Abstract: Disclosed herein are methods and compositions for inactivating dihydrofolate reductase genes, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
Abstract translation: 本文公开了使用包含锌指蛋白和切割结构域或裂解半结构域的融合蛋白来灭活二氢叶酸还原酶基因的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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公开(公告)号：WO2005118614A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/012048
申请日：2005-04-08
Applicant: AVIGEN, INC. , SANGAMO BIOSCIENCES, INC. , FORSAYETH, John F.M. , CHAVEZ, Raymond A. , COLLINGWOOD, Trevor , MCNAMARA, Andrew , JOUVENOT, Yann
Inventor： FORSAYETH, John F.M. , CHAVEZ, Raymond A. , COLLINGWOOD, Trevor , MCNAMARA, Andrew , JOUVENOT, Yann
IPC: C07K1/00
CPC classification number: C07K14/4703 , A61K38/00
Abstract: Compositions and methods for the treatment of neuropathic pain are provided. Compositions of the invention may comprise proteins with a zinc-finger domain fused to a regulatory domain that is capable of either activating or repressing the expression of a target gene involved in neuropathic pain. Alternatively, compositions of the invention may comprise a nucleic acid sequence encoding a protein of the invention, which nucleic acid sequence may optionally be provided as a plasmid or within a virus or other vector for delivery to a target cell or tissue. Methods of treating neuropathic pain involving treatment of subject with the compositions of the invention are also provided. Exemplary target genes for the treatment of neuropathic pain include VR1, NaV1.8, and TrkA.
Abstract translation: 提供了治疗神经性疼痛的组合物和方法。 本发明的组合物可以包含具有融合到调节结构域的锌指结构域的蛋白质，其能够激活或抑制涉及神经性疼痛的靶基因的表达。 或者，本发明的组合物可以包含编码本发明的蛋白质的核酸序列，该核酸序列可以任选地作为质粒提供，或者在病毒或其它载体内提供用于递送至靶细胞或组织。 还提供了使用本发明的组合物治疗涉及受试者的神经性疼痛的方法。 用于治疗神经性疼痛的示例性靶基因包括VR1，NaV1.8和TrkA。
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公开(公告)号：WO0244386A3
公开(公告)日：2003-07-31
申请号：PCT/US0145098
申请日：2001-11-30
Applicant: SANGAMO BIOSCIENCES INC , TSE CHRISTIN , COLLINGWOOD TREVOR , WOLFFE ELIZABETH J LM
Inventor： TSE CHRISTIN , COLLINGWOOD TREVOR , WOLFFE ELIZABETH J LM , WOLFFE ALAN P DI
CPC classification number: C12N15/63 , C07K14/72 , C07K2319/00
Abstract: Methods and compositions are provided for targeted regulation of various genes, including activation and repression of genes encoding nuclear receptors. The ability to regulate gene expression and function will have applications in treatment of disease, for example, cancer, diabetes and cardiovascular disease.
Abstract translation: 提供方法和组合物用于各种基因的靶向调节，包括激活和抑制编码核受体的基因。 调节基因表达和功能的能力将可用于治疗疾病，例如癌症，糖尿病和心血管疾病。
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公开(公告)号：WO2007136685A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011799
申请日：2007-05-17
Applicant: SANGAMO BIOSCIENCES, INC. , COLLINGWOOD, Trevor
Inventor： COLLINGWOOD, Trevor
IPC: C07K14/435
Abstract: Disclosed herein are methods and compositions for inactivating dihydrofolate reductase genes, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
Abstract translation: 本文公开了使用包含锌指蛋白和切割结构域或裂解半结构域的融合蛋白来灭活二氢叶酸还原酶基因的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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Patent Agency Ranking
公开(公告)号：WO2006033859A3
公开(公告)日：2006-08-17
申请号：PCT/US2005032157
申请日：2005-09-08
Applicant: SANGAMO BIOSCIENCES INC , LI XIAO-YONG , JAMIESON ANDREW , BARTSEVICH VICTOR , COLLINGWOOD TREVOR
Inventor： LI XIAO-YONG , JAMIESON ANDREW , BARTSEVICH VICTOR , COLLINGWOOD TREVOR
CPC classification number: A61K48/00 , C07K14/4702 , C07K14/4705 , C07K2319/09 , C07K2319/43 , C07K2319/71 , C07K2319/81 , C12N2830/002
Abstract: Disclosed herein are methods and compositions for enhanced protein production and overexpression using engineered zinc finger proteins.
Abstract translation: 本文公开了使用工程化锌指蛋白质增强蛋白质产生和过表达的方法和组合物。
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公开(公告)号：WO03027247A3
公开(公告)日：2003-05-22
申请号：PCT/US0230413
申请日：2002-09-24
Applicant: SANGAMO BIOSCIENCES INC , WOLFFE LIZ LF , MOORE MICHAEL , FARRIES TIMOTHY , COLLINGWOOD TREVOR , URNOV FYODOR
Inventor： WOLFFE ALAN P DI , MOORE MICHAEL , FARRIES TIMOTHY , COLLINGWOOD TREVOR , URNOV FYODOR
IPC: C12N5/0735 , G01N33/50 , A01N37/18 , A01N43/04 , A01N63/00 , C07H21/04 , C07K1/00 , C12N5/00 , C12N15/63
CPC classification number: C12N15/85 , A61K35/12 , C07H21/04 , C12N5/0606 , C12N15/62 , C12N15/63 , C12N2501/40 , C12N2503/02 , G01N33/5008 , G01N33/5023 , G01N33/5073
Abstract: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stems cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
Abstract translation: 公开了使用一种或多种ZFP修饰干细胞的方法和组合物。 此类方法和组合物可用于促进过程，例如去分化细胞，使干细胞分化成所需表型，增殖干细胞和/或促进克隆。
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8.发明申请CELLS DEFICIENT IN CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE AND/OR GLYCOPROTEIN ALPHA-1,3-GALACTOSYLTRANSFERASE 审中-公开CMP- N-乙酰氨基酸羟化酶和/或谷氨酰胺ALPHA-1,3-糖蛋白酶的细胞缺失
公开(公告)号：WO2013003767A2
公开(公告)日：2013-01-03
申请号：PCT/US2012/045027
申请日：2012-06-29
Applicant: SIGMA-ALDRICH CO. LLC , LIN, Nan , GEORGE, Henry J. , MASCARENHAS, Joaquina , COLLINGWOOD, Trevor N. , KAYSER, Kevin J. , ACHTIEN, Katherine
Inventor： LIN, Nan , GEORGE, Henry J. , MASCARENHAS, Joaquina , COLLINGWOOD, Trevor N. , KAYSER, Kevin J. , ACHTIEN, Katherine
CPC classification number: C12P21/005 , C12N9/0071 , C12N9/1051 , C12N2510/00 , C12N2510/02 , C12N2510/04 , C12Y114/18002
Abstract: The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
Abstract translation: 本发明提供了缺乏CMP-Neu5Ac羟化酶（Cmah）和/或糖蛋白α-1,3-半乳糖基转移酶（Ggta1）的非人哺乳动物细胞系。 还提供了使用本文公开的细胞来生产具有人类糖基化模式的重组蛋白质的方法。
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9.发明申请
公开(公告)号：WO2009009086A3
公开(公告)日：2009-01-15
申请号：PCT/US2008/008455
申请日：2008-07-10
Applicant: SANGAMO BIOSCIENCES, INC. , COLLINGWOOD, Trevor , COST, Gregory J.
Inventor： COLLINGWOOD, Trevor , COST, Gregory J.
Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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10.发明申请METHODS AND COMPOSITIONS FOR INACTIVATING ALPHA 1,6 FUCOSYLTRANSFERASE (FUT 8) GENE EXPRESSION 审中-公开方法和组合物用于钝化ALPHA 1,6 FUCOSYLTRANSFERASE（FUT 8）基因表达
公开(公告)号：WO2009009086A2
公开(公告)日：2009-01-15
申请号：PCT/US2008008455
申请日：2008-07-10
Applicant: SANGAMO BIOSCIENCES INC , COLLINGWOOD TREVOR , COST GREGORY J
Inventor： COLLINGWOOD TREVOR , COST GREGORY J
IPC: C07K14/43
CPC classification number: C12N15/907 , C07K14/4703 , C07K16/00 , C12N9/1051 , C12N15/85 , C12N15/87 , C12N2800/80 , C12P21/00
Abstract: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
Abstract translation: 本文公开了使用包含锌指蛋白和切割结构域或切割半结构域的融合蛋白来灭活FUT8基因的方法和组合物。 还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。
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