公开(公告)号：WO2004009091A8

公开(公告)日：2004-12-29

申请号：PCT/US0316016

申请日：2003-05-20

Applicant: GLAXO GROUP LTD ,  BOGGS SHARON ,  COLLINS JON L ,  FIVUSH ADAM ,  STEWART EUGENE LEE ,  WILLSON TIMOTHY MARK

Inventor： BOGGS SHARON ,  COLLINS JON L ,  FIVUSH ADAM ,  STEWART EUGENE LEE ,  WILLSON TIMOTHY MARK

IPC: C07D473/06 ,  A61K31/52 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D473/04 ,  C07D473/08 ,  C07D273/04

CPC classification number: A61K31/522 ,  A61K31/52 ,  A61K31/675 ,  C07D473/04 ,  C07D473/06

Abstract: The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cariovascular disease and atherosclerosis, novel compounds for use in such methods and pharmaceutical compositions comprising compounds for use in such methods.

公开(公告)号：WO0171361A3

公开(公告)日：2002-06-06

申请号：PCT/US0109233

申请日：2001-03-22

Applicant: GLAXO GROUP LTD ,  COLLINS JON L ,  PARKS DEREK J

Inventor： COLLINS JON L ,  PARKS DEREK J

IPC: G01N33/74 ,  G01N33/68 ,  C07K14/705

CPC classification number: G01N33/743 ,  G01N2333/723 ,  G01N2500/00 ,  G01N2500/02

Abstract: The present invention relates, in general, to nuclear receptors and, in particular, to the Constitutive Androstane Receptor (CAR; NR 1I3) and to a method of identifying ligands therefor.

Abstract translation: 本发明一般涉及核受体，特别是涉及组成型雄甾烷受体（CAR; NR1I3）以及鉴定其配体的方法。

公开(公告)号：WO2009076387A1

公开(公告)日：2009-06-18

申请号：PCT/US2008/086131

申请日：2008-12-10

Applicant: GLAXO GROUP LIMITED ,  ALLEN, Scott ,  BLACKWELL III, William C. ,  BOROS, Eric ,  COLLINS, Jon L ,  HERTZOG, Don ,  LIANG, Xi ,  RAY, John ,  REISTER, Steven Michael ,  SAMANO, Vicente ,  SHERRILL, Ron

Inventor： ALLEN, Scott ,  BLACKWELL III, William C. ,  BOROS, Eric ,  COLLINS, Jon L ,  HERTZOG, Don ,  LIANG, Xi ,  RAY, John ,  REISTER, Steven Michael ,  SAMANO, Vicente ,  SHERRILL, Ron

IPC: C07D401/14 ,  A61K31/33 ,  A61P5/04

CPC classification number: C07D401/14 ,  C07D405/14

Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

Abstract translation: 本发明提供新颖的双吡啶基吡啶酮，它们是黑色素浓缩激素受体1（MCHR1）的拮抗剂，含有它们的药物组合物，其制备方法及其在治疗和治疗肥胖症和/或糖尿病中的用途。

公开(公告)号：WO2004009091A1

公开(公告)日：2004-01-29

申请号：PCT/US2003/016016

申请日：2003-05-20

Applicant: GLAXO GROUP LIMITED ,  BOGGS, Sharon ,  COLLINS, Jon, L ,  FIVUSH, Adam ,  STEWART, Eugene, Lee ,  WILLSON, Timothy, Mark

Inventor： BOGGS, Sharon ,  COLLINS, Jon, L ,  FIVUSH, Adam ,  STEWART, Eugene, Lee ,  WILLSON, Timothy, Mark

IPC: A61K31/52

CPC classification number: A61K31/522 ,  A61K31/52 ,  A61K31/675 ,  C07D473/04 ,  C07D473/06

Abstract: The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cariovascular disease and atherosclerosis, novel compounds for use in such methods and pharmaceutical compositions comprising compounds for use in such methods.

Abstract translation: 本发明涉及用于治疗或预防LXR介导的疾病或病症的方法，包括心血管疾病和动脉粥样硬化，用于此类方法的新化合物和用于此类方法的化合物的药物组合物。

公开(公告)号：WO2004048349A1

公开(公告)日：2004-06-10

申请号：PCT/US2003/035808

申请日：2003-11-12

Applicant: SMITHKLINE BEECHAM CORPORATION ,  BOGGS, Sharon, D. ,  COLLINS, Jon, L. ,  HYATT, Stephen, M. ,  MALONEY, Patrick, R.

Inventor： BOGGS, Sharon, D. ,  COLLINS, Jon, L. ,  HYATT, Stephen, M. ,  MALONEY, Patrick, R.

IPC: C07D261/08

CPC classification number: C07D261/08 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to a compound of formula (I) useful as an agonist for FXR: wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.

Abstract translation: 本发明涉及可用作FXR激动剂的式（I）化合物：其中所有变量如本文所定义，以及药物组合物，使用方法及其制备方法。