公开(公告)号：WO2006091592A1

公开(公告)日：2006-08-31

申请号：PCT/US2006/006096

申请日：2006-02-21

Applicant: SMITHKLINE BEECHAM CORPORATION ,  RAFFERTY, Stephen, William ,  TURNBULL, Philip, Stewart ,  STEWART, Eugene, Lee ,  CALDWELL, Richard, Dana

Inventor： RAFFERTY, Stephen, William ,  TURNBULL, Philip, Stewart ,  STEWART, Eugene, Lee ,  CALDWELL, Richard, Dana

IPC: C07D237/04 ,  C07D231/04 ,  C07D243/02 ,  A61P3/00 ,  A61P25/00 ,  A61K31/495 ,  A61K31/551 ,  A61K31/415 ,  C07D409/06 ,  C07D413/06 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D417/06 ,  C07D409/14 ,  C07D405/04

CPC classification number: C07D231/04 ,  C07D237/04 ,  C07D243/02 ,  C07D401/06 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to naphthalene derivatives of formula (I) that are modulators of the glucocorticoid receptor, and to processes for the preparation and use of the same.

Abstract translation: 本发明涉及作为糖皮质激素受体的调节剂的式（I）的萘衍生物及其制备和使用方法。

公开(公告)号：WO2005000795A3

公开(公告)日：2005-03-10

申请号：PCT/US2004018252

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORP ,  BLANC JEAN-BAPTISTE E ,  CADILLA RODOLFO ,  COWAN DAVID JOHN ,  KALDOR ISTVAN ,  LARKIN ANDREW L ,  STEWART EUGENE LEE ,  TURNBULL PHILIP STEWART ,  TRUMP RYAN PAUL

Inventor： BLANC JEAN-BAPTISTE E ,  CADILLA RODOLFO ,  COWAN DAVID JOHN ,  KALDOR ISTVAN ,  LARKIN ANDREW L ,  STEWART EUGENE LEE ,  TURNBULL PHILIP STEWART ,  TRUMP RYAN PAUL

IPC: A61K31/275 ,  A61P5/26 ,  A61P5/40 ,  C07C211/52 ,  C07C211/53 ,  C07C215/76 ,  C07C217/08 ,  C07C217/20 ,  C07C217/28 ,  C07C225/22 ,  C07C247/04 ,  C07C255/58 ,  C07C255/59 ,  C07C311/05 ,  C07C323/25 ,  C07C255/50

CPC classification number: C07C323/25 ,  A61K31/275 ,  C07C211/10 ,  C07C211/11 ,  C07C211/52 ,  C07C211/53 ,  C07C215/76 ,  C07C217/08 ,  C07C217/20 ,  C07C217/28 ,  C07C225/22 ,  C07C247/04 ,  C07C255/58 ,  C07C255/59 ,  C07C311/05 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

Abstract: This invention relates to aniline derived non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及被认为是雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的苯胺衍生的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2004009091A8

公开(公告)日：2004-12-29

申请号：PCT/US0316016

申请日：2003-05-20

Applicant: GLAXO GROUP LTD ,  BOGGS SHARON ,  COLLINS JON L ,  FIVUSH ADAM ,  STEWART EUGENE LEE ,  WILLSON TIMOTHY MARK

Inventor： BOGGS SHARON ,  COLLINS JON L ,  FIVUSH ADAM ,  STEWART EUGENE LEE ,  WILLSON TIMOTHY MARK

IPC: C07D473/06 ,  A61K31/52 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D473/04 ,  C07D473/08 ,  C07D273/04

CPC classification number: A61K31/522 ,  A61K31/52 ,  A61K31/675 ,  C07D473/04 ,  C07D473/06

Abstract: The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cariovascular disease and atherosclerosis, novel compounds for use in such methods and pharmaceutical compositions comprising compounds for use in such methods.

公开(公告)号：WO2007024954A1

公开(公告)日：2007-03-01

申请号：PCT/US2006/032926

申请日：2006-08-23

Applicant: SMITHKLINE BEECHAM CORPORATION ,  COLLINS, Jon Loren ,  STEWART, Eugene Lee ,  ZUERCHER, William ,  CHAO, Esther ,  WIETHE, Robert ,  CARAVELLA, Justin

Inventor： COLLINS, Jon Loren ,  STEWART, Eugene Lee ,  ZUERCHER, William ,  CHAO, Esther ,  WIETHE, Robert ,  CARAVELLA, Justin

IPC: C07C215/68 ,  C07D213/06 ,  A61K31/137 ,  A61K31/44

CPC classification number: C07D213/53 ,  C07C215/68 ,  C07C217/58

Abstract: This invention relates to compounds that are modulators of the liver X receptors (LXRs), and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为肝脏X受体（LXR）的调节剂的化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2006133216A2

公开(公告)日：2006-12-14

申请号：PCT/US2006/021966

申请日：2006-06-06

Applicant: SMITHKLINE BEECHAM CORPORATION ,  TURNBULL, Philip Stewart ,  CADILLA, Rodolfo ,  LARKIN, Andrew Lamont ,  STEWART, Eugene Lee ,  STETSON, Katherine

Inventor： TURNBULL, Philip Stewart ,  CADILLA, Rodolfo ,  LARKIN, Andrew Lamont ,  STEWART, Eugene Lee ,  STETSON, Katherine

CPC classification number: C07D307/52 ,  C07C211/52 ,  C07C255/58 ,  C07C317/32 ,  C07C323/32 ,  C07C2601/02 ,  C07C2602/08 ,  C07D233/54 ,  C07D233/64 ,  C07D249/16 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D263/34 ,  C07D271/06 ,  C07D271/10 ,  C07D277/28 ,  C07D277/64 ,  C07D307/54 ,  C07D307/81 ,  C07D333/20 ,  C07D333/62 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素，糖皮质激素，盐皮质激素和黄体酮受体的调节剂的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2005000795A2

公开(公告)日：2005-01-06

申请号：PCT/US2004/018252

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORPORATION ,  BLANC, Jean-Baptiste, E. ,  CADILLA, Rodolfo ,  COWAN, David, John ,  KALDOR, Istvan ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TURNBULL, Philip, Stewart ,  TRUMP, Ryan, Paul

Inventor： BLANC, Jean-Baptiste, E. ,  CADILLA, Rodolfo ,  COWAN, David, John ,  KALDOR, Istvan ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TURNBULL, Philip, Stewart ,  TRUMP, Ryan, Paul

IPC: C07C255/00

CPC classification number: C07C323/25 ,  A61K31/275 ,  C07C211/10 ,  C07C211/11 ,  C07C211/52 ,  C07C211/53 ,  C07C215/76 ,  C07C217/08 ,  C07C217/20 ,  C07C217/28 ,  C07C225/22 ,  C07C247/04 ,  C07C255/58 ,  C07C255/59 ,  C07C311/05 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

Abstract: This invention relates to non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及被认为是雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的苯胺衍生的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2004110978A3

公开(公告)日：2004-12-23

申请号：PCT/US2004/018456

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORPORATION ,  CADILLA, Rodolfo ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TRUMP, Ryan, Paul ,  TURNBULL, Philip, Stewart

Inventor： CADILLA, Rodolfo ,  LARKIN, Andrew, L. ,  STEWART, Eugene, Lee ,  TRUMP, Ryan, Paul ,  TURNBULL, Philip, Stewart

IPC: C07C211/59

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

公开(公告)号：WO2004110978A2

公开(公告)日：2004-12-23

申请号：PCT/US2004018456

申请日：2004-06-09

Applicant: SMITHKLINE BEECHAM CORP ,  CADILLA RODOLFO ,  LARKIN ANDREW L ,  STEWART EUGENE LEE ,  TRUMP RYAN PAUL ,  TURNBULL PHILIP STEWART

Inventor： CADILLA RODOLFO ,  LARKIN ANDREW L ,  STEWART EUGENE LEE ,  TRUMP RYAN PAUL ,  TURNBULL PHILIP STEWART

IPC: C07C211/59 ,  C07C215/16 ,  C07C255/58 ,  C07D295/13 ,  C07C211/00

CPC classification number: C07D295/13 ,  C07C211/59 ,  C07C215/16 ,  C07C255/58 ,  C07C2601/02 ,  C07C2601/14

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2005085185A1

公开(公告)日：2005-09-15

申请号：PCT/US2005/007245

申请日：2005-03-03

Applicant: SMITHKLINE BEECHAM CORPORATION ,  TURNBULL, Phillip, Stewart ,  CADILLA, Rodolfo, ,  COWAN, David, John ,  LARKIN, Andrew, Lamont ,  KALDOR, Istvan ,  STEWART, Eugene, Lee

Inventor： TURNBULL, Phillip, Stewart ,  CADILLA, Rodolfo, ,  COWAN, David, John ,  LARKIN, Andrew, Lamont ,  KALDOR, Istvan ,  STEWART, Eugene, Lee

IPC: C07C255/58

CPC classification number: C07C255/58 ,  C07C2601/02 ,  C07C2601/14

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及作为雄激素，糖皮质激素，盐皮质激素和孕酮受体的调节剂的非甾体化合物，以及制备和使用这些化合物的方法。

公开(公告)号：WO2004009091A1

公开(公告)日：2004-01-29

申请号：PCT/US2003/016016

申请日：2003-05-20

Applicant: GLAXO GROUP LIMITED ,  BOGGS, Sharon ,  COLLINS, Jon, L ,  FIVUSH, Adam ,  STEWART, Eugene, Lee ,  WILLSON, Timothy, Mark

Inventor： BOGGS, Sharon ,  COLLINS, Jon, L ,  FIVUSH, Adam ,  STEWART, Eugene, Lee ,  WILLSON, Timothy, Mark

IPC: A61K31/52

CPC classification number: A61K31/522 ,  A61K31/52 ,  A61K31/675 ,  C07D473/04 ,  C07D473/06

Abstract: The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cariovascular disease and atherosclerosis, novel compounds for use in such methods and pharmaceutical compositions comprising compounds for use in such methods.

Abstract translation: 本发明涉及用于治疗或预防LXR介导的疾病或病症的方法，包括心血管疾病和动脉粥样硬化，用于此类方法的新化合物和用于此类方法的化合物的药物组合物。