公开(公告)号：WO2008130647A1

公开(公告)日：2008-10-30

申请号：PCT/US2008/005054

申请日：2008-04-18

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF) ,  JAMES, Susan, P. ,  OLDINSKI, Rachael, Kurkowski

Inventor： JAMES, Susan, P. ,  OLDINSKI, Rachael, Kurkowski

IPC: A61K38/38 ,  A61P27/02

CPC classification number: C08F255/02 ,  C08B37/0063 ,  C08B37/0072 ,  C08G81/02

Abstract: A new copolymer synthesized from a glycosaminoglycan (GAG) such as hyaluronan/ hyaluronic acid (HA), chondroitin sulfates, derma tan sulfates, keratan sulfates, heparan sulfate, and heparin, and an anhydride functionalized hydrophobic polymer, i.e., any polyolefin which has been 'functionalized' (grafted onto the backbone or incorporated into the backbone) with anhydride functional groups, such as maleic anhydride-graft-polyethylene, (or, maleated polyethylene), maleic anhydride-graft-polystyrene, maleic anhydride-graft-polypropylene, etc. The functionalized polyolefin may be a polyolefin backbone to which the anhydride functional groups have been grafted, or otherwise incorporated with the backbone. Also, a unique synthesis technique combines a modified GAG with a graft polyolefin, resulting in a unique copolymer with its constituents by-and-large covalently bound to each other.

Abstract translation: 由糖胺聚糖（GAG）如透明质酸/透明质酸（HA），硫酸软骨素，硫酸皮肤素，硫酸角质素，硫酸乙酰肝素和肝素合成的新共聚物，以及酸酐官能化的疏水性聚合物，即任何已经被 马来酸酐接枝聚乙烯（或马来酸化聚乙烯），马来酸酐接枝 - 聚苯乙烯，马来酸酐 - 接枝 - 聚丙烯等的酸酐官能团“官能化”（接枝到骨架上或并入骨架中） 官能化聚烯烃可以是聚酐主链，酸酐官能团已经被接枝或以其它方式与主链结合。 此外，独特的合成技术将改性的GAG与接枝聚烯烃结合在一起，形成独特的共聚物，其组成物彼此共价结合。

公开(公告)号：WO2005028632A2

公开(公告)日：2005-03-31

申请号：PCT/US2004/030666

申请日：2004-09-20

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF) ,  JAMES, Susan, P. ,  ZHANG, Min

Inventor： JAMES, Susan, P. ,  ZHANG, Min

IPC: C12N

CPC classification number: C08B37/0072

Abstract: A series of novel, melt- or mold-processable HA esters with varying aliphatic chain lengths are synthesized from silyl HA-quaternary (quat.) ammonium salt complex (preferably silyl HA-CTA, a silylated HA complex with cetyltrimethyl ammonium salt). Introduction of aliphatic acyl groups, preferably acid chlorides, to disrupt the strong HA intermolecular bonding, is done via acylation. Acylation takes place at the oxygen of the trimethylsilyloxy group -0-Si(CH 3 ) 3 in the silyl HA-CTA by removal of trimethylsilyl. groups therefrom. Optionally, crosslinking may be performed during the shaping/molding of the HA esters into a structure/device, or thereafter, if at all. Native HA can then be regenerated/recovered by saponification/ hydrolysis, removing acyl groups, -CH 3 (CH 2 ) 10 CO, and the cetyltrimethyl ammonium salt groups, -CTA, from HA ester. The structure/device of a preselected shape (e.g., porous or solid, bulk structure or fibers) may become a component of an assembly, a product that is further processed, integrated into another component (e.g., laminated, adhered, assembled, further shaped, chemically-intermixed/intermingled), and so on.

Abstract translation: 从甲硅烷基HA-季（铵）铵盐络合物（优选甲硅烷基HA-CTA，甲硅烷基化的HA配合物与十六烷基三甲基铵盐）合成一系列具有不同脂肪链长度的新型，熔融或可模塑加工的HA酯。 引入脂族酰基，优选酰氯，以破坏强HA分子间键，是通过酰化进行的。 通过除去三甲基甲硅烷基，在甲硅烷基HA-CTA中的三甲基甲硅烷氧基-O-Si（CH 3）3的氧上进行酰化。 组。 任选地，可以在将HA酯成型/成型成结构/装置期间或之后（如果有的话）进行交联。 然后可以通过皂化/水解再生/回收天然HA，从HA酯除去酰基，-CH 3（CH 2）10 CO和十六烷基三甲基铵盐基团-CTA。 预选形状（例如，多孔或固体，本体结构或纤维）的结构/装置可以成为组件的组件，进一步加工的产品集成到另一部件中（例如，层压，粘合，组装，进一步成形 ，化学混合/混合）等。

公开(公告)号：WO2009014643A1

公开(公告)日：2009-01-29

申请号：PCT/US2008/008772

申请日：2008-07-18

Applicant: XY, INC. ,  COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF) ,  SUH, Tae, Kwang ,  SQUIRES, Edward, L. ,  CARNEVALE, Elaine ,  GRAHAM, James, K. ,  MORENO, Juan, F.

Inventor： SUH, Tae, Kwang ,  SQUIRES, Edward, L. ,  CARNEVALE, Elaine ,  GRAHAM, James, K. ,  MORENO, Juan, F.

IPC: A01K31/19

CPC classification number: C12N15/873 ,  A01K67/027 ,  A01K2227/10

Abstract: Intracytoplasmic sperm injection utilizing sex-selected equine spermatozoa to obtain viable sex selected embryos transferable to a recipient female equine mammal to obtain sex selected foals.

Abstract translation: 利用性别选择的精子精子进行胞浆内精子注射，以获得可转移到受体雌性马哺乳动物以获得性别选择的驹的可行性选择的胚胎。